1278 completed. 1278 Phase 2, 185 Phase 3, 149 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 1278 | Completed 1278 |
| Phase 3 | 185 | Completed 185 |
| Phase 1 | 149 | Completed 149 |
Follow Pain: new trials by email Literature Review of Pain trials Research Report on Pain
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Evaluate the Use of Topical Ocular BL1332 for the Management of Postoperative Ocular Pain Following Photorefractive Keratectomy Topical Ocular BL1332 low dose, Topical Ocular BL1332 high dose, BL1332 Vehicle ophthalmic vehicle - Pain, Postoperative | Phase 2 | Completed | Bausch & Lomb Incorporated | 130 | 2026-03-31 | 2026-10-22 |
| A Randomized Comparison Between 0.67 mcg/kg, 1 mcg/kg, and 1.33 mcg/kg of Perineural Dexmedetomidine for Ultrasound-Guided Infraclavicular Block dexmedetomidine (perineural) 0.67 mcg/kg, dexmedetomidine (perineural) 1 mcg/kg, dexmedetomidine (perineural) 1.33 mcg/kg - Analgesia, Pain, Acute | Phase 2 | Completed | McGill University Health Centre/Research Institute of the McGill University Health Centre | 69 | 2025-12-28 | 2026-07-07 |
| Intranasal and Intravenous Oxytocin for Analgesia to Noxious Heat Pain Intravenous oxytocin, Intravenous placebo, Intranasal oxytocin - Pain, Acute | Phase 2 | Completed | Wake Forest University Health Sciences | 24 | 2025-11-05 | 2026-06-30 |
| An Efficacy and Safety Study of LTG-001 Following Abdominoplasty Experimental: LTG-001 High Dose, Experimental: LTG-001 Low Dose, Active Comparator: HB/APAP - Acute Pain, Postoperative Pain Control | Phase 2 | Completed | Latigo Biotherapeutics | 343 | 2025-07-24 | 2026-04-29 |
| Opiranserin Injections PCA Regimens for Postoperative Pain VVZ-149 Injections, Fentanyl - Pain, Postoperative / Acute Pain | Phase 2 | Completed | Samsung Medical Center | 66 | 2025-07-22 | 2026-09-15 |
| Effects of CBD/CBD-A Oral Extract on Resting-state EEG and Neuropathic Pain Symptoms After SCI CBD/CBD-A, Placebo - SCI - Spinal Cord Injury, Neuropathic Pain | Phase 1 / Phase 2 | Completed | University of Miami | 6 | 2025-06-16 | 2026-08-14 |
| Unique Treatment of Oncology Pain in Advanced Cancer Trichomylin® capsule (5 mg delta-9-tetrahydrocannabinol: 5 mg cannabidiol: 5 mg cannabichromene) - Cancer Pain | Phase 2 | Completed | ZYUS Life Sciences Inc. | 11 | 2025-06-12 | 2026-09-01 |
| A Study of YZJ-4729 Tartrate Injection for the Treatment of Pain After Orthopedic Surgery YZJ-4729, Placebo Comparator: Saline, Active Comparator: Morphine - Pain | Phase 2 | Completed | Shanghai Haiyan Pharmaceutical Technology Co., Ltd. | 150 | 2025-05-23 | 2026-06-29 |
| Ultrasound Guided Lumbar Erector Spinae Block Using Bupivacaine - Magnesium Sulphate Versus Bupivacaine - Dexamethasone in Total Hip Replacement Surgery Bupivacaine-Magnesium Sulphate, Bupivacaine-Dexamethasone, Bupivacaine-Saline - Post-operative Pain, Total Hip Arthroplasty (THA) | Phase 2 | Completed | Ain Shams University | 66 | 2025-05-01 | 2026-02-18 |
| Impact of Cannabinoids on Menopause Symptoms Active Cannabinoid Product, Placebo - Perimenopause, Menopause | Phase 2 | Completed | Washington State University | 104 | 2025-03-03 | 2026-06-02 |
| Safety and Efficacy Trial of MTX101 2mg for the Acute Treatment of Migraine in Adults MTX101, Placebo - Migraine | Phase 2 | Completed | Manistee Therapeutics | 78 | 2025-02-24 | 2025-10-07 |
| A Study of ONO-1110 in Patients With Postherpetic Neuralgia ONO-1110, Placebo - Postherpetic Neuralgia | Phase 2 | Completed | Ono Pharmaceutical Co., Ltd. | 142 | 2025-02-12 | 2026-07-15 |
| The Impact of Vericiguat on Microvascular Function in Patients With Documented Vasospastic Angina Pectoris Vericiguat - Vasospastic Angina | Phase 2 | Completed | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 57 | 2025-02-10 | 2026-07-29 |
| Phase 2B Study Assessing Pain Relief After Replacement of the Knee ATX101, bupivacaine hydrochloride, saline placebo - Total Knee Arthroplasty (Postoperative Pain) | Phase 2 | Completed | Allay Therapeutics, Inc. | 226 | 2025-02-03 | 2026-10-19 |
| A Study to Evaluate the Efficacy and Safety of CIN-102 (Deudomperidone) in Adult Subjects With Idiopathic Gastroparesis. CIN-102 Dose 15mg, Placebo, CIN-102 Dose 10mg - Idiopathic Gastroparesis | Phase 2 | Completed | CinDome Pharma, Inc. | 416 | 2025-01-29 | 2026-07-13 |
| Krill Oil for Pain in Elders Krill oil, Mixed vegetable oil - Chronic Musculoskeletal Pain | Phase 2 | Completed | University of Florida | 40 | 2025-01-17 | 2026-06-17 |
| Effect of Magnesium Sulfate on Hemodynamics on Laparoscopic Cholecystectomy Patients Placebo, Magnesium - Hemodynamics Instability, Pain After Surgery | Phase 1 / Phase 2 | Completed | Ziauddin University | 60 | 2025-01-06 | 2026-09-02 |
| This is a Study Evaluating the Efficacy and Safety of LTG-001 for Acute Pain After Surgical Removal of Impacted Third Molars LTG-001 High Dose, LTG-001 Mid Dose, LTG-001 Low Dose - Acute Pain, Postoperative | Phase 2 | Completed | Latigo Biotherapeutics | 250 | 2024-12-19 | 2026-05-22 |
| A Randomized Controlled Trial to Test the Effects Oxytocin and Vibration Have on Heat Pain Threshold After UV-B Burn oxytocin, placebo - Sunburn | Phase 2 | Completed | Wake Forest University Health Sciences | 38 | 2024-12-05 | 2026-01-12 |
| A Study Evaluating Efficacy and Safety of VX-993 for Acute Pain After a Bunionectomy VX-993, HB/APAP, Placebo (matched to VX-993) - Acute Pain | Phase 2 | Completed | Vertex Pharmaceuticals Incorporated | 367 | 2024-10-29 | 2026-05-28 |
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Pain, Postoperative (246) · Chronic Pain (101) · Neuralgia (98) · Agnosia (79) · Low Back Pain (79) · Acute Pain (76) · Neuralgia, Postherpetic (48) · Osteoarthritis (45) · Headache (43) · Back Pain (35) · Abdominal Pain (34) · Neoplasms (32) · Migraine Disorders (30) · Diabetic Neuropathies (27)
Neurologic Manifestations (1278) · Pathological Conditions, Signs and Symptoms (1278) · Signs and Symptoms (1277) · Nervous System Diseases (381) · Pathologic Processes (371) · Postoperative Complications (251) · Neuromuscular Diseases (214) · Musculoskeletal Diseases (167) · Peripheral Nervous System Diseases (159) · Joint Diseases (93) · Neurobehavioral Manifestations (87) · Perceptual Disorders (82) · Rheumatic Diseases (81) · Cardiovascular Diseases (75)
Bupivacaine (59) · Acetaminophen (44) · Morphine (43) · Lidocaine (41) · Saline Solution (35) · Ketamine (28) · Ibuprofen (27) · Sodium Chloride (25) · Fentanyl (22) · Pregabalin (21) · Ropivacaine (17) · Celecoxib (16) · Dexmedetomidine (16) · Naproxen (16) · Oxycodone (16)
Assiut University (27) · National Institute of Dental and Craniofacial Research (NIDCR) (16) · Pfizer (15) · Pacira Pharmaceuticals, Inc (14) · Mayo Clinic (12) · Cairo University (11) · GlaxoSmithKline (10) · Heron Therapeutics (10) · Johns Hopkins University (10) · AstraZeneca (9) · Montefiore Medical Center (9) · National Center for Complementary and Integrative Health (NCCIH) (9) · University of Florida (8) · AbbVie (prior sponsor, Abbott) (7) · Abbott (7)
United States (639) · Canada (86) · Egypt (65) · Germany (63) · United Kingdom (55) · France (49) · Spain (49) · Poland (41) · Denmark (35) · Czechia (29) · Australia (28) · Israel (25) · Netherlands (25) · Belgium (24) · Italy (24)
David Prior (5) · Hala S Abdel-Ghaffar, MD (5) · Bror Jonzon (4) · Gert Bronfort, DC, PhD (4) · Andrew K Chang, MD (3) · Aziz Shaibani, MD (3) · Claudia Campbell, PhD (3)
PMID 22900785, PMID 36729473, PMID 37523477, PMID 17877825, PMID 21079055, PMID 22212857, PMID 22510183, PMID 22792007, PMID 22795280, PMID 27720917, PMID 27747583, PMID 27893109, PMID 28159728, PMID 30737315, PMID 32871021, PMID 34532852, PMID 37530822, PMID 10353500, PMID 10613619, PMID 11145807, PMID 11323325, PMID 12145072, PMID 12148679, PMID 12384756, PMID 12779107, PMID 12807853, PMID 12897484, PMID 14665993, PMID 15115710, PMID 15230906, PMID 15454701, PMID 15556826, PMID 15560360, PMID 15616047, PMID 15680647, PMID 15798411, PMID 15834546, PMID 15943960, PMID 15963313, PMID 16192528, PMID 16275600, PMID 16371894, PMID 16436839, PMID 16698416, PMID 16959427, PMID 17174178, PMID 17320744, PMID 17342504, PMID 17414235, PMID 17437870
2008 (7), 2015 (5), 2018 (5), 2019 (5), 2009 (4), 2016 (4), 2014 (3), 2017 (3), 2023 (3), P30CA015083 (3), 2004 (2), 2005 (2), K23HL151880 (2), P01NS041386 (2), P01NS119159 (2)