1777 completed, 566 unknown, 248 terminated, 208 recruiting. 902 Not applicable, 794 Phase 2, 737 Phase 4, 572 Phase 3, 398 Phase 1.
Follow Saline Solution: new trials by email Literature Review of Saline Solution trials Research Report on Saline Solution
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Ketamine and Midazolam Infusions for CRPS: Feasibility Study Ketamine, Midazolam, Normal Saline - Complex Regional Pain Syndromes | Phase 2 | Withdrawn | Stanford University | 2099-01-01 | 2024-11-22 | |
| Postoperative Analgesia Using Ganglion Impar Block After Anal Surgery Ganglion impar block with Bupivacaine., Ganglion impar block with normal saline - Postoperative Pain | Not applicable | Not yet recruiting | University of Alexandria | 60 | 2028-07-01 | 2025-04-03 |
| Magnesium Sulfate in Pediatric Burn Dressing Changes magnesium sulfate, Normal Saline (0.9% NaCl) - Pediatric Burns | Phase 1 | Not yet recruiting | Hennepin Healthcare Research Institute | 10 | 2027-12-01 | 2026-10-09 |
| A Study to Determine the Safety and Efficacy of TG-C in Subjects With Symptomatic Early Hip Osteoarthritis TG-C, Placebo Control - Degenerative Osteoarthritis | Phase 2 | Not yet recruiting | Kolon TissueGene, Inc. | 255 | 2027-10-01 | 2026-08-20 |
| GV1001 Subcutaneous for the Treatment of Moderate to Severe Alzheimer's Disease(AD) GV1001 Placebo, GV1001 1.12mg - Moderate to Severe Alzheimer's Disease | Phase 3 | Not yet recruiting | Samsung Pharmaceutical Co., Ltd. | 750 | 2027-07-01 | 2026-06-10 |
| Multicentric, Randomized Study to Assess Safety and Efficacy of Centhaquine in Patients With ARDS Normal Saline, Centhaquine - Acute Respiratory Distress Syndrome (ARDS) | Phase 2 | Not yet recruiting | Pharmazz, Inc. | 80 | 2027-05-01 | 2026-09-17 |
| Valproic AcId for Traumatic BRAin INjury Trial Valproic Acid (VPA), Standard of care treatment + normal saline - Moderate Traumatic Brain Injury (TBI), Severe Traumatic Brain Injury | Phase 2 / Phase 3 | Not yet recruiting | Northwestern University | 432 | 2027-05-01 | 2026-08-13 |
| Challenge Trial of PfSPZ-LARC2 Vaccine in Burkina Faso PfSPZ-LARC2 Vaccine, PfSPZ Challenge, Normal Saline - Malaria (Plasmodium Falciparum) | Phase 1 | Not yet recruiting | Sanaria Inc. | 45 | 2027-03-01 | 2026-07-31 |
| A Study to Assess Safety and Efficacy of Centhaquine as a Resuscitative Agent Normal Saline, Centhaquine - Hypovolemic Shock | Phase 3 | Not yet recruiting | Pharmazz, Inc. | 430 | 2027-02-01 | 2026-09-17 |
| A Phase 1 Clinical Trial of Adjuvanted Protein-based HCV Vaccine Candidates (HCV Vaccine Trial) AVIHepC1, Normal Saline - Hepatitis C | Phase 1 | Not yet recruiting | University of Alberta | 27 | 2027-01-15 | 2026-09-25 |
| Study of DWP450 in Japanese Subjects With Glabellar Lines DWP450 20 U, 0.9% Saline Solution 0.5 mL - Glabellar Lines | Phase 3 | Not yet recruiting | Daewoong Pharmaceutical Co. LTD. | 120 | 2027-01-01 | 2026-08-26 |
| Effect Of Intracuff Dexamethasone On Postoperative Sore Throat In Patients Undergoing Laparoscopic Cholecystectomy Dexamethasone (0.1 mg/kg), Normal Saline (0.9% NaCl) - Postoperative Sore Throat, Cough, Hoarseness | Not applicable | Not yet recruiting | B.P. Koirala Institute of Health Sciences | 40 | 2027-01-01 | 2026-08-24 |
| Nebulised Colistimethate Sodium to Prevent Pediatric Ventilator-associated Pneumonia colistimethate sodium, 0.9% Saline - Ventilator Associated Pneumonia | Phase 2 / Phase 3 | Not yet recruiting | University Hospital Fattouma Bourguiba | 400 | 2027-01-01 | 2026-10-08 |
| Lumbar Drain With Intrathecal Nicardipine in Aneurysmal Subarachnoid Hemorrhage Normal Saline, Nicardipine - Subarachnoid Hemorrhage | Phase 4 | Not yet recruiting | Wake Forest University Health Sciences | 214 | 2027-01-01 | 2026-10-01 |
| CD19-B Cell Depletion in PAIS-ME/CFS Patients Inebilizumab, Placebo - Post-acute Infectious Syndrome (PAIS), Post-COVID 19 Condition (PCC or Long COVID) | Phase 2 | Not yet recruiting | Charite University, Berlin, Germany | 38 | 2026-12-01 | 2026-07-24 |
| The Effects of Timolol On Healing and Cosmesis of Mohs Scalp Wounds: An Open Label Trial Topical Timolol, Normal Saline - Surgical Wounds, Mohs Surgery | Phase 2 | Not yet recruiting | Geisinger Clinic | 45 | 2026-12-01 | 2026-10-14 |
| The Use of Tranexamic Acid in Decreasing Wound Complication in Total Ankle Replacement. Transexamic acid, Normal Saline (0.9% NaCl) - Ankle Arthritis, Wound Complication | Phase 2 | Not yet recruiting | Ottawa Hospital Research Institute | 40 | 2026-12-01 | 2026-10-22 |
| Study of a Combination SARS-CoV-2 Recombinant Spike and High-Dose Inactivated Influenza Vaccine With Matrix-M Adjuvant in Adult Participants 60 Years of Age and Older IIV-HD (standalone), NVXC19 (EU licensed, standalone), IIV-HD + NVXC19 combination - Immunization, Healthy Volunteers | Phase 3 | Not yet recruiting | Sanofi | 6000 | 2026-11-09 | 2026-10-22 |
| Induced Suppression of Platelet Activity in Aneurysmal Subarachnoid Hemorrhage Management-2 (iSPASM-2) Tirofiban, Placebo - Aneurysmal Subarachnoid Hemorrhage | Phase 1 / Phase 2 | Not yet recruiting | Dr David Hasan, M.D. | 82 | 2026-11-05 | 2026-10-19 |
| A Double-Blind, Placebo-Controlled Study of Nebulized Bacteriophages in Patients With Ventilator-Associated Pneumonia Due to Pseudomonas Aeruginosa Bacteriophages GMP, saline solution (placebo) - Ventilator Associated Bacterial Pneumonia, Pseudomonas Aeruginosa Infection | Phase 3 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 184 | 2026-11-03 | 2026-09-04 |
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Pain, Postoperative (189) · Pain (146) · Agnosia (89) · COVID-19 (73) · Emergence Delirium (54) · Acute Kidney Injury (47) · Hemorrhage (46) · Sepsis (43) · Osteoarthritis (40) · Shock, Septic (39) · Postoperative Nausea and Vomiting (38) · Osteoarthritis, Knee (37) · Breast Neoplasms (32) · Obesity (31) · Stroke (30)
Assiut University (70) · Yonsei University (47) · Seoul National University Hospital (42) · Peking University First Hospital (37) · Allergan (34) · Ain Shams University (33) · Cairo University (33) · Tanta University (25) · Merck Sharp & Dohme LLC (21) · Mahidol University (20) · Northwestern University (20) · General Hospital of Ningxia Medical University (19) · Sanaria Inc. (19) · Mayo Clinic (18) · Chang Gung Memorial Hospital (17)
United States (985) · China (382) · South Korea (245) · Canada (236) · Egypt (220) · United Kingdom (100) · Taiwan (93) · France (88) · Australia (85) · Germany (79) · Italy (76) · Brazil (71) · Spain (71) · Turkey (Türkiye) (67) · Thailand (61)
Dong-Xin Wang, MD, PhD (27) · Yung-Tsan Wu, MD (8) · Dong-Xin Wang, MD,PhD (6) · Guolin Wang (6) · Omar Soliman, MD (6) · Guolin Wang, MD (5) · Patrick E Duffy, M.D. (5) · Xiaochun Zheng, MD (5) · Jenny Low, MBBS (4) · Michael W Donnino, MD (4)
PMID 39428602, PMID 34473343, PMID 38063346, PMID 39301879, PMID 33990512, PMID 37870112, PMID 38757725, PMID 41604274, PMID 16275600, PMID 16324031, PMID 18809959, PMID 19411668, PMID 19478674, PMID 19802513, PMID 20027030, PMID 21300053, PMID 21623291, PMID 21670611, PMID 21675055, PMID 22939099, PMID 23371895, PMID 23741350, PMID 24052307, PMID 24754838, PMID 25072443, PMID 25184864, PMID 25288099, PMID 25336707, PMID 25932413, PMID 25971957, PMID 26220293, PMID 26231052, PMID 26305798, PMID 26706294, PMID 26807124, PMID 27488394, PMID 28183547, PMID 28279391, PMID 28302179, PMID 28369198, PMID 28778254, PMID 29253090, PMID 29485925, PMID 29784145, PMID 30116551, PMID 30339737, PMID 30524702, PMID 30957581, PMID 32187462, PMID 32665528
2015 (14), 2016 (12), 2019 (11), 2014 (10), 2017 (9), 2018 (8), 2023 (8), U01HL077863 (5), 2025 (4), 2008 (2), 2009 (2), K23DA029609 (2), U01AI131310 (2), 1UG3HL147011-01A1 (1), 2005 (1)