Osteoarthritis: Clinical Trials

3168 completed, 923 unknown, 485 recruiting, 333 terminated. 2872 Not applicable, 571 Phase 2, 494 Phase 3, 473 Phase 4, 289 Phase 1.

By phase and status

Phase	Trials	Status
Not applicable	2872	Completed 1592, Unknown 491, Recruiting 279, Not yet recruiting 146, Active not recruiting 142, Terminated 122, Withdrawn 72, Enrolling by invitation 18, Suspended 10
Phase 2	571	Completed 348, Unknown 83, Terminated 42, Withdrawn 35, Recruiting 31, Not yet recruiting 14, Active not recruiting 13, Enrolling by invitation 3, Suspended 2
Phase 3	494	Completed 333, Unknown 60, Terminated 35, Recruiting 20, Withdrawn 15, Active not recruiting 14, Not yet recruiting 13, Enrolling by invitation 3, Suspended 1
Phase 4	473	Completed 278, Unknown 83, Terminated 50, Recruiting 22, Not yet recruiting 17, Withdrawn 15, Active not recruiting 7, Enrolling by invitation 1
Phase 1	289	Completed 179, Unknown 57, Withdrawn 15, Recruiting 12, Active not recruiting 11, Terminated 8, Not yet recruiting 6, Enrolling by invitation 1
Early Phase 1	41	Completed 13, Unknown 11, Recruiting 6, Not yet recruiting 4, Withdrawn 4, Active not recruiting 2, Terminated 1

Follow Osteoarthritis: new trials by email Literature Review of Osteoarthritis trials Research Report on Osteoarthritis

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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Study of AQUACEL™ Ag Surgical Cover Dressing Following Total Knee Replacement Aquacel Ag dressing - Osteoarthritis	Not applicable	Withdrawn	Golden Jubilee National Hospital		2050-01-01	2019-07-31
Evaluating the Effect of Adipose Tissue Processed With the SyntrFuge™ System for Knee Osteoarthritis SyntrFuge System, Triamcinolone Injection - Knee Osteoarthritis	Not applicable	Not yet recruiting	Syntr Health Technologies, Inc.	180	2027-12-01	2026-08-20
Clinical Outcomes of Focused Shockwave Therapy Without Adjunct Rehabilitation Compared to Standard Physical Rehabilitation in Patients With Grade I-III Knee Osteoarthritis: A Single-Blind Randomized Study Physical Rehab, Focused Shockwave Therapy - Knee Osteoarthristis	Not applicable	Not yet recruiting	Pulse Wave USA	60	2027-09-25	2026-05-05
Efficacy and Safety of GNSC-001 Intra-articular Injection for Knee Osteoarthritis Gene Therapy GNSC-001, Placebo - Knee Arthritis Osteoarthritis, Knee Arthritis, Osteoarthritis	Phase 2 / Phase 3	Not yet recruiting	Genascence Corporation	240	2027-07-01	2026-09-21
Duloxetine and aeRobic Exercise to Improve Function in VEterans With Knee Osteoarthritis (DRIVE) Exercise, Duloxetine, Placebo - Knee Osteoarthritis, Pain	Phase 2	Not yet recruiting	VA Office of Research and Development	102	2027-03-01	2026-06-16
Undenatured Type II Collagen for Knee Osteoarthritis Pain Placebo, Nuvicol II, Nuvicol SII - Osteoarthritis, Knee	Not applicable	Recruiting	Universidad Católica San Antonio de Murcia	120	2027-03-01	2026-10-22
Comparing Pain Science Education to Biomedical Education for People With Knee Osteoarthritis: A Randomized Controlled Trial Pain Science Education, Biomedical Education - Knee Arthritis Osteoarthritis	Not applicable	Not yet recruiting	McMaster University	82	2027-02-01	2026-09-16
HTO and Tranexamic Acid Study Tranexamic Acid, Routine medial opening wedge high tibial osteotomy - Osteoarthritis, Knee	Phase 3	Not yet recruiting	Western University, Canada	200	2027-01-01	2026-09-17
Zynrelef Versus Adductor Canal Block ZYNRELEF 400Mg-12Mg Extended-Release Solution, Ultrasound-Guided Adductor Canal Block, Ropivacaine 0.5% Injectable Solution - Knee Osteoarthritis, Arthritis Knee	Phase 4	Not yet recruiting	University of Miami	120	2027-01-01	2026-06-12
Pilot and Feasibility Study of Anti-CD14 for the Treatment of Knee Osteoarthritis Atibuclimab, saline placebo - Knee Osteoarthritis (Knee OA)	Phase 1	Not yet recruiting	VA Office of Research and Development	40	2027-01-01	2026-07-15
Heart Rate Variability Guided Physical Activity and Exercise Prescription in Individuals With Knee Osteoarthritis HRV-guided home exercise prescription, Traditional Home Exercise - Knee Osteoarthritis	Not applicable	Not yet recruiting	The Hong Kong Polytechnic University	240	2027-01-01	2026-02-12
Mechanical Alignment Versus Kinematic Alignment Total Knee Arthroplasty Total knee arthroplasty - Knee Osteoarthritis	Not applicable	Not yet recruiting	Loyola University	96	2027-01-01	2026-08-27
IMAGES: Identifying Metabolic Imaging Association With Genicular Artery Embolization Success Embolization - Knee Osteoarthritis, Knee Discomfort	Not applicable	Not yet recruiting	Lucas R. Cusumano, MD	25	2026-12-30	2026-09-21
Efficacy of Autologous Adipose Derived Stromal Vascular Fraction for Musculoskeletal Conditions stromal vascular fraction injection in the osteoarthritic knee - Knee Osteoarthritis	Not applicable	Not yet recruiting	Dubai Health Authority	300	2026-12-30	2025-08-26
Pain Perception During Intra-Articular Knee Joint Injection: What is the Effect of Needle Gauge and the Use of Ethyl Chloride? 25 gauge needle, 22 gauge needle, +/- Ethyl Chloride Topical Aerosol Anesthetic - Osteoarthritis (OA) of the Knee, Fear of Needles	Phase 4	Not yet recruiting	University of California, Davis	88	2026-12-01	2026-09-16
Perioperative Colchicine for TKA Colchicine 1.8 mg (loading dose) + Dextrose Oral Placebo, Colchicine 1.8 mg + 0.6 mg, Dextrose Oral Placebo - Osteoarthritis of Knee, Recovery Following Primary Total Knee Arthroplasty	Phase 4	Not yet recruiting	Geisinger Clinic	75	2026-12-01	2026-09-03
DEXA Bone Density Analysis of the CoreHip® Prosthesis System Primary hip replacement with cementless stem - Primary Osteoarthritis, Cartilage Degeneration	Not applicable	Not yet recruiting	Aesculap AG	40	2026-12-01	2026-10-16
Clinical Evaluation of TrHCROSS® for Different Joints TrHCROSS®, Monovisc - Joint Osteoarthritis, Knee Osteoarthristis	Not applicable	Not yet recruiting	i+Med S.Coop.	150	2026-12-01	2026-10-13
Alexis Retractor in Total Hip Arthroplasty Alexis wound retractor, Standard wound retractor - Hip Osteoarthritis, Hip Arthritis	Not applicable	Not yet recruiting	University of Miami	202	2026-12-01	2026-02-05
Clinical Importance of Occult Suprapatellar Effusion in Knee Osteoarthritis Static and Dynamic Suprapatellar Ultrasonography - Knee Osteoarthritis		Not yet recruiting	Mardin Artuklu University	105	2026-11-30	2026-10-20

Showing 20 of 5623. Sign in to see all of them.

Narrower conditions

Osteoarthritis, Knee (3211)  ·  Osteoarthritis, Hip (634)  ·  Pain (430)  ·  Arthritis, Rheumatoid (277)  ·  Arthritis (252)  ·  Motor Activity (219)  ·  Joint Diseases (171)  ·  Osteonecrosis (148)  ·  Chronic Pain (133)  ·  Pain, Postoperative (84)  ·  Musculoskeletal Diseases (81)  ·  Obesity (78)  ·  Agnosia (68)  ·  Inflammation (47)

Broader conditions

Rheumatic Diseases (5586)  ·  Musculoskeletal Diseases (5542)  ·  Joint Diseases (5452)  ·  Arthritis (5371)  ·  Pathological Conditions, Signs and Symptoms (1186)  ·  Signs and Symptoms (901)  ·  Neurologic Manifestations (806)  ·  Pathologic Processes (421)  ·  Skin and Connective Tissue Diseases (343)  ·  Connective Tissue Diseases (327)  ·  Behavior (296)  ·  Immune System Diseases (295)  ·  Bone Diseases (291)  ·  Pain (281)

Interventions

Exercise (135)  ·  Arthroplasty, Replacement, Knee (125)  ·  Sodium Chloride (118)  ·  Hyaluronic Acid (92)  ·  Arthroplasty, Replacement, Hip (82)  ·  Saline Solution (70)  ·  Celecoxib (60)  ·  Ropivacaine (59)  ·  Adrenal Cortex Hormones (48)  ·  Naproxen (47)  ·  Physical Therapy Modalities (46)  ·  Resistance Training (43)  ·  Bupivacaine (37)  ·  Exercise Therapy (36)  ·  Tranexamic Acid (36)

Sponsors

Zimmer Biomet (113)  ·  Riphah International University (75)  ·  Istituto Ortopedico Rizzoli (59)  ·  Pfizer (40)  ·  DePuy International (36)  ·  Poznan University of Medical Sciences (35)  ·  Smith & Nephew, Inc. (34)  ·  DePuy Orthopaedics (32)  ·  University of Aarhus (30)  ·  Assiut University (29)  ·  Ottawa Hospital Research Institute (29)  ·  University of British Columbia (29)  ·  Cairo University (28)  ·  Hospital for Special Surgery, New York (28)  ·  Mayo Clinic (28)

Countries

United States (1561)  ·  Canada (339)  ·  Turkey (Türkiye) (332)  ·  United Kingdom (263)  ·  France (241)  ·  Denmark (222)  ·  China (190)  ·  Italy (185)  ·  Germany (184)  ·  South Korea (176)  ·  Spain (171)  ·  Poland (147)  ·  Pakistan (143)  ·  Brazil (121)  ·  Taiwan (119)

Top investigators

Hillary Overholser (14)  ·  Hassan Achakri (11)  ·  Yong In, MD, PhD (11)  ·  Jianhao Lin, MD (10)  ·  Malgorzata Reysner, MD PhD (10)  ·  James C Eisenach, MD (8)  ·  Kelli Dominick Allen, PhD (8)

Results publications

PMID 30936738, PMID 37460782, PMID 21055873, PMID 26554876, PMID 36269595, PMID 40826764, PMID 17403800, PMID 31387410, PMID 39495154, PMID 15039276, PMID 19734131, PMID 21174485, PMID 21518322, PMID 23340531, PMID 23559821, PMID 23973136, PMID 24985410, PMID 26058927, PMID 26403468, PMID 3068365, PMID 33973384, PMID 34626502, PMID 35232805, PMID 35960482, PMID 35980115, PMID 36301512, PMID 36422666, PMID 36474952, PMID 37470295, PMID 37652258, PMID 38343426, PMID 38650049, PMID 39004211, PMID 12086165, PMID 14710506, PMID 15611487, PMID 16651569, PMID 16950057, PMID 17076974, PMID 17159021, PMID 17266764, PMID 17823032, PMID 18196427, PMID 18211593, PMID 19214642, PMID 19433134, PMID 19554094, PMID 19844772, PMID 20064249, PMID 20175977

NIH funding

2009 (15), 2014 (11), 2017 (10), 2023 (8), 2016 (7), 2015 (5), 2018 (5), 2019 (5), 2008 (3), 2025 (3), R01AT004623 (3), 2005 (2), K23AG029978 (2), K23AG030945 (2), P01AR043584 (2)