637 completed, 96 unknown, 48 recruiting, 46 terminated. 910 Phase 1, 244 Phase 2.
Follow Pain: new trials by email Literature Review of Pain trials Research Report on Pain
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Personalizing Veteran Pain Care: Adapting Coaching Interventions to Support Maintenance of Self-Care Coaching - Chronic Pain, Musculoskeletal Pain | Phase 1 | Not yet recruiting | VA Office of Research and Development | 30 | 2029-01-01 | 2026-03-06 |
| Psilocybin After Trauma Surgery for Pain Psilocybin (Usona Institute), Postoperative analgesia - Pain Management, Postoperative Pain | Phase 1 | Not yet recruiting | Trent Emerick | 70 | 2027-12-31 | 2026-08-06 |
| Regenerative Medicine for Joint Hypermobility and Instability Dextrose 20% Prolotherapy, Autologous Platelet-Rich Plasma, Doxycycline Hyclate Injectable (Investigational) - Ehlers-Danlos Syndrome Hypermobility Type (hEDS), Ehlers-Danlos Syndrome (EDS) | Phase 1 / Phase 2 | Not yet recruiting | Manhattan Pain Medicine, PLLC | 100 | 2027-01-15 | 2026-10-06 |
| Noninvasive Neuromodulation Of The Subjective Value Network In Chronic Pain Transcranial magnetic stimulation, Sham - Chronic Neurogenic Pain | Phase 1 | Not yet recruiting | National Institute of Neurological Disorders and Stroke (NINDS) | 9 | 2026-12-01 | 2026-09-28 |
| Periganglionic Resiniferatoxin for the Treatment of Intractable Pain Due to Cancer-induced Bone Pain Resiniferatoxin - Intractable Pain, Palliative Care | Phase 1 / Phase 2 | Not yet recruiting | National Institute of Neurological Disorders and Stroke (NINDS) | 30 | 2026-11-27 | 2026-10-29 |
| Simultaneous Engagement of Networks for Alleviating Pain (SENAP) PFM-guided cortical stimulation - Neuropathic Pain, Postherpetic Neuralgia | Phase 1 | Not yet recruiting | University of Minnesota | 20 | 2026-11-01 | 2026-07-23 |
| Preoperative Celecoxib and Acetaminophen Versus Acetaminophen Alone for Pain Control After Pediatric Adenotonsillectomy Celecoxib, Acetaminophen, Dexamethasone - Adenotonsillectomy, Postoperative Pain | Phase 1 / Phase 2 | Not yet recruiting | NYU Langone Health | 500 | 2026-11-01 | 2026-10-13 |
| Buprenorphine for the Management of Pain in Children With Sickle Cell Disease Buprenorphine Buccal Film [Belbuca] - Sickle Cell Disease (SCD), Sickle Cell Disease Vaso-occlusive Crisis | Phase 1 | Not yet recruiting | Natasha Archer | 25 | 2026-10-01 | 2026-09-02 |
| The Effect of Dexamethasone on Short Term Patient Response: IV vs Oral Administration Dexamethasone IV injection, Dexamethasone Capsule, Placebo IV administration - Post Operative Pain, Acute, Periodontitis | Phase 1 / Phase 2 | Not yet recruiting | The University of Texas Health Science Center at San Antonio | 40 | 2026-10-01 | 2026-09-21 |
| Vaginal Sildenafil for Primary Dysmenorrhea Sildenafil citrate vaginal suppository - Dysmenorrhea, Menstrual Pain | Phase 1 | Not yet recruiting | Kevin Hellman | 10 | 2026-10-01 | 2026-09-25 |
| A Phase 1 Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single Intravenous Doses of NH302 Injection in Healthy Participants NH302 injection, Placebo - Healthy Volunteers | Phase 1 | Not yet recruiting | The Third Xiangya Hospital of Central South University | 62 | 2026-09-30 | 2026-10-23 |
| Daily, Encapsulated, Green Tea Extract to Mitigate Neuropathic Pain in Patients With Established Cancer-Associated Neuropathic Pain Green Tea Leaf Extract Decaffeinated, Placebo Control - Neuropathic Pain, Cancer Treatment | Phase 1 | Not yet recruiting | University of Alabama at Birmingham | 20 | 2026-09-30 | 2026-08-21 |
| A Study of CYT-1010 in Healthy Volunteers and Participants With Acute Pain After Third Molar Extraction CYT-1010, Placebo - Acute Postoperative Pain, Dental Pain | Phase 1 / Phase 2 | Recruiting | Cytogel Pharma, LLC | 32 | 2026-09-25 | 2026-10-29 |
| Long-acting Local Vaginal Cuff Anesthesia Following Hysterectomy Combined Bupivacaine and Exparel, Normal Saline (NS) - Pain, Postoperative | Phase 1 / Phase 2 | Not yet recruiting | The University of Texas Health Science Center, Houston | 104 | 2026-09-17 | 2026-09-25 |
| Fentanyl Intranasal for Retinopathy of Prematurity Screening in Preterm Infants Fentanyl Citrate (Intranasal), Normal Saline (Placebo, Intranasal) - Neonatal Pain, Retinopathy of Prematurity (ROP) | Phase 1 / Phase 2 | Not yet recruiting | Marsha Campbell-Yeo | 58 | 2026-09-09 | 2026-06-30 |
| OER Glibenclamide for Neuropathic Pain in Multiple Sclerosis glibenclamide, Placebo - Multiple Sclerosis, Neuropathic Pain | Phase 1 | Not yet recruiting | University of Maryland, Baltimore | 10 | 2026-09-01 | 2025-10-28 |
| Psilocybin to Treat Depression in Spinal Cord Injury Psilocybin (Usona Institute) - Spinal Cord Injury, Depression - Major Depressive Disorder | Phase 1 / Phase 2 | Recruiting | James J. Peters Veterans Affairs Medical Center | 30 | 2026-08-06 | 2026-08-10 |
| Two Different Therapeutic Interventions Applied During Blood Sampling in Children experimental group, experiment group, Control Group - Blood Sampling, Child, Only | Phase 1 | Recruiting | Igdir University | 105 | 2026-08-01 | 2026-09-09 |
| A Study to Evaluate the Drug-Drug Interaction Between KL0011034 Injection and Alfentanil Hydrochloride Injection in Participants With Moderate-to-Severe Non-Cancer Chronic Pain KL0011034 injection, Alfentanil Hydrochloride Injection - Chronic Pain | Phase 1 | Not yet recruiting | The Third Xiangya Hospital of Central South University | 27 | 2026-07-30 | 2026-08-07 |
| A Study Evaluating the Drug-Drug Interaction Between KL0011034 Injection and Alfentanil Hydrochloride Injection KL0011034 injection, Alfentanil Hydrochloride Injection - Chronic Pain | Phase 1 | Completed | Hunan Kelun Pharmaceutical Co., Ltd. | 27 | 2026-07-15 | 2026-09-17 |
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Pain, Postoperative (120) · Chronic Pain (108) · Neuralgia (70) · Low Back Pain (55) · Agnosia (50) · Acute Pain (47) · Headache (27) · Back Pain (26) · Neck Pain (22) · Neoplasms (20) · Opioid-Related Disorders (20) · Osteoarthritis (20) · Angina Pectoris (19) · Abdominal Pain (15)
Neurologic Manifestations (910) · Pathological Conditions, Signs and Symptoms (910) · Signs and Symptoms (910) · Nervous System Diseases (226) · Pathologic Processes (190) · Postoperative Complications (125) · Neuromuscular Diseases (118) · Musculoskeletal Diseases (99) · Peripheral Nervous System Diseases (98) · Mental Disorders (65) · Neurobehavioral Manifestations (59) · Perceptual Disorders (54) · Joint Diseases (53) · Back Pain (52)
Bupivacaine (30) · Sodium Chloride (26) · Saline Solution (25) · Acetaminophen (24) · Lidocaine (23) · Ketamine (20) · Oxycodone (19) · Fentanyl (18) · Ibuprofen (16) · Morphine (16) · Pregabalin (13) · Acupuncture Therapy (12) · Dexamethasone (12) · Tramadol (12) · Midazolam (11)
Vertex Pharmaceuticals Incorporated (25) · Pfizer (22) · GlaxoSmithKline (20) · AstraZeneca (17) · National Center for Complementary and Integrative Health (NCCIH) (11) · Ain Shams University (10) · Mayo Clinic (9) · University of Florida (9) · Grünenthal GmbH (8) · University of British Columbia (8) · Assiut University (7) · Bayer (7) · Biogen (7) · Johns Hopkins University (7) · Mundipharma (China) Pharmaceutical Co. Ltd (7)
United States (385) · Canada (52) · United Kingdom (47) · China (39) · Egypt (32) · Australia (31) · Germany (24) · South Korea (23) · Israel (17) · Belgium (16) · Brazil (15) · Denmark (15) · Spain (15) · France (14) · Netherlands (14)
Ziva Cooper, PhD (4) · Elisabeth Kruse, PhD (3) · Keith M Vogt, MD, PhD (3) · Rolf Karlsten (3) · Simon Haroutounian, PhD (3) · Stuart Kahn, MD (3)
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