746 completed, 199 unknown, 153 recruiting, 102 terminated. 561 Not applicable, 242 Phase 2, 122 Phase 3, 97 Phase 4, 90 Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Ketamine and Midazolam Infusions for CRPS: Feasibility Study Ketamine, Midazolam, Normal Saline - Complex Regional Pain Syndromes | Phase 2 | Withdrawn | Stanford University | 2099-01-01 | 2024-11-22 | |
| Hypersound Treatment for Chronic Neuropathic and Radicular Pain Hypersound RF-PNS system, Sham Hypersound - Chronic Neuropathic Pain, Radiculopathy | Not applicable | Not yet recruiting | Hypersound Medical Inc | 71 | 2027-06-01 | 2026-09-21 |
| Safety and Efficacy Study on AFA-281 for the Treatment of Low Back Pain AFA-281 - Lumbosacral Radiculopathy | Phase 2 | Not yet recruiting | Afasci Inc | 408 | 2027-04-01 | 2025-06-26 |
| Corticosteroid Lumbar Epidural Analgesia for Radicular Pain 2 SP-102, Placebo, Dexamethasone Sodium Phosphate 10 MG/ML - Lumbosacral Radicular Pain | Phase 3 | Not yet recruiting | Semnur Pharmaceuticals, Inc. | 755 | 2027-02-01 | 2026-09-09 |
| Randomized Evaluation of Lumbar Injection Effectiveness and Function Triojection® System, Selective Nerve Root Block (SNRB) - Lumbar Radiculopathy, Lumbar Disc Herniation | Not applicable | Not yet recruiting | SpinaFX Medical Inc. | 300 | 2027-01-15 | 2026-10-07 |
| BreEStim in Managing Neuropathic Pain After Spinal Cord Injury (SCI) Active BreEStim Treatment, Sham BreEStim Treatment, The TENS Treatment - Pain Management | Not applicable | Not yet recruiting | The University of Texas Health Science Center, Houston | 66 | 2027-01-04 | 2026-10-14 |
| Efficacy of Botulinum Toxin Versus Placebo on Pain and Health Related Quality of Life of Patients With Piriformis Muscle Syndrome Botulinum Toxin - A injections, Placebo - Piriformis Muscle Syndrome | Phase 2 | Not yet recruiting | Centre Hospitalier Universitaire de Nīmes | 108 | 2027-01-01 | 2026-10-21 |
| Selective Nerve Root Block Versus Sham to Reduce Surgery for Lumbar Disc Herniation Selective Nerve Root Block, Sham Procedure - Lumbar Disc Herniation, Lumbar Radiculopathy | Not applicable | Not yet recruiting | Karolinska Institutet | 262 | 2027-01-01 | 2026-10-27 |
| Pediatric Electrocutaneous Analgesia for Children Experiencing Neuropathic Pain Scrambler Therapy MC-5A Device - Neuropathic Pain, Chronic Pain | Not applicable | Not yet recruiting | Johns Hopkins University | 70 | 2027-01-01 | 2026-10-30 |
| Simultaneous Engagement of Networks for Alleviating Pain (SENAP) PFM-guided cortical stimulation - Neuropathic Pain, Postherpetic Neuralgia | Phase 1 | Not yet recruiting | University of Minnesota | 20 | 2027-01-01 | 2026-11-03 |
| Trial of Self-Applied Transcutaneous Auricular Vagus Nerve Stimulation for Chemotherapy-Induced Peripheral Neuropathy Sparrow Link (taVNS) - Chemotherapy Induced Peripheral Neuropathy (CIPN) | Not applicable | Not yet recruiting | University of Miami | 55 | 2027-01-01 | 2026-11-09 |
| Efficacy of Topical Lidocaine Gel vs. Oral Duloxetine for Painful Diabetic Peripheral Neuropathy Topical Lidocaine 2% Gel, Duloxetine (60 MG) - Painful Diabetic Neuropathy (PDN), Diabetic Neuropathies | Phase 4 | Not yet recruiting | Wah Medical college , POF hospital | 80 | 2026-12-01 | 2026-09-02 |
| SERENITY Study of Chronic Pain Interference in Adults Chronic Low Back Pain, Spinal Cord Injury | Not yet recruiting | University of Minnesota | 400 | 2026-11-21 | 2026-11-03 | |
| Auricular Vagus Nerve Stimulation Mechanisms for HIV-Associated Peripheral Neuropathy Transcutaneous Auricular Vagus Nerve Stimulation (AVNS) - HIV Associated Polyneuropathy | Not applicable | Recruiting | University of Miami | 70 | 2026-11-01 | 2026-10-06 |
| Evaluating Avive+ Soft Tissue Matrix for Prevention of Superficial Radial Nerve Morbidity Following Radial Forearm Free Flap Harvest Standard Closure (Control), Avive+ Intervention - Head and Neck Cancer (H&N) | Not applicable | Not yet recruiting | University of Alabama at Birmingham | 80 | 2026-11-01 | 2026-09-25 |
| Perineural Botulinum Toxin Injection Versus Oral Duloxetine in Relief of Foot Pain in Painful Peripheral Diabetic Neuropathy Botulinum Toxin Type A, Duloxetine, Oral Placebo Tablet - Diabetic Peripheral Neuropathy, Painful Diabetic Neuropathy | Phase 2 | Not yet recruiting | Assiut University | 56 | 2026-11-01 | 2026-10-20 |
| Transcranial Direct Current Stimulation for Chemotherapy-Related Chronic Pain in Cancer Survivors Active tDCS with Sternberg task, Sham tDCS with Sternberg task - Chronic Pain, Neuropathic Pain | Not applicable | Not yet recruiting | Instituto de investigación e innovación biomédica de Cádiz | 60 | 2026-11-01 | 2026-11-03 |
| Comparative Effects of tDCS and tACS on Pain, Dexterity, and Strength in Diabetic Peripheral Neuropathy Transcranial Direct Current Stimulation (tDCS), Transcranial Alternating Current Stimulation (tACS) - Diabetic Peripheral Neuropathy (DPN) | Not applicable | Active not recruiting | University of Management and Technology Lahore | 46 | 2026-10-22 | 2026-11-03 |
| Comparison of Two Postoperative Care Strategies After Breast Surgery Patient Education, Paracetamol, Dexketoprofen - Postoperative Pain, Pain Management | Not applicable | Recruiting | Moumtzidou Maria Aikaterini | 108 | 2026-10-19 | 2026-10-20 |
| BreEStim Pre-trial Single-pulse BreEStim Treatment, Multiple-pulse BreEStim Treatment - Neuropathic Pain | Not applicable | Not yet recruiting | The University of Texas Health Science Center, Houston | 32 | 2026-10-19 | 2026-10-20 |
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Neuralgia, Postherpetic (195) · Pain (192) · Chronic Pain (187) · Sciatica (144) · Low Back Pain (81) · Spinal Cord Injuries (75) · Diabetic Neuropathies (71) · Herpes Zoster (63) · Pain, Postoperative (61) · Piriformis Muscle Syndrome (58) · Agnosia (55) · Peripheral Nervous System Diseases (50) · Radiculopathy (49) · Complex Regional Pain Syndromes (44)
Neuromuscular Diseases (1370) · Nervous System Diseases (1368) · Pathological Conditions, Signs and Symptoms (1367) · Neurologic Manifestations (1364) · Signs and Symptoms (1363) · Peripheral Nervous System Diseases (1323) · Pain (1174) · Mononeuropathies (213) · Sciatic Neuropathy (197) · Musculoskeletal Diseases (137) · Pathologic Processes (137) · Wounds and Injuries (129) · Central Nervous System Diseases (104) · Postoperative Complications (104)
Pregabalin (84) · Lidocaine (42) · Gabapentin (27) · Capsaicin (22) · Ketamine (20) · Transcranial Magnetic Stimulation (19) · Transcranial Direct Current Stimulation (17) · Transcutaneous Electric Nerve Stimulation (17) · Acupuncture Therapy (16) · Botulinum Toxins, Type A (16) · Saline Solution (16) · Sodium Chloride (16) · Spinal Cord Stimulation (16) · Surveys and Questionnaires (14) · Electroacupuncture (12)
Pfizer's Upjohn has merged with Mylan to form Viatris Inc. (29) · University Hospital, Clermont-Ferrand (25) · Riphah International University (21) · Copenhagen University Hospital, Rigshospitalet (14) · Stanford University (12) · Cairo University (11) · GlaxoSmithKline (11) · Grünenthal GmbH (11) · NeurogesX (11) · Pfizer (11) · Centre Hospitalier Universitaire de Saint Etienne (10) · Danish Pain Research Center (10) · Assistance Publique - Hôpitaux de Paris (9) · Icahn School of Medicine at Mount Sinai (9) · Johns Hopkins University (9)
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Kassiani Theodoraki, PhD, DESA (4) · Steven P Cohen, MD (4) · Hal Siden, MD (3) · Jeffrey Tobias, MD (3) · Ralf Baron, Prof. Dr. (3)
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