8117 completed, 2272 unknown, 1284 recruiting, 788 terminated. 5998 Not applicable, 1628 Phase 2, 1410 Phase 3, 1102 Phase 4, 906 Phase 1.
Follow Joint Diseases: new trials by email Literature Review of Joint Diseases trials Research Report on Joint Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study of AQUACEL™ Ag Surgical Cover Dressing Following Total Knee Replacement Aquacel Ag dressing - Osteoarthritis | Not applicable | Withdrawn | Golden Jubilee National Hospital | 2050-01-01 | 2019-07-31 | |
| Cannabichromene Safety in Rheumatoid Arthritis Cannabichromene - Arthritis, Rheumatoid | Phase 1 / Phase 2 | Withdrawn | Crystal Lederhos Smith | 2028-07-15 | 2026-09-23 | |
| Effectiveness of Non-surgical Management in Rotator Cuff Calcific Tendinopathy (THE EFFECT TRIAL) Exercise Therapy, Extracorporeal Shockwave Therapy, Ultrasound-Guided Percutaneous Irrigation - Rotator Cuff Tendinosis, Rotator Cuff Injuries | Not applicable | Suspended | University of Valencia | 116 | 2028-01-01 | 2026-06-26 |
| An Open-label Study of GC012F in Rheumatoid Arthritis. LD and GC012F CAR-T Cell Injection, GC012F CAR-T Cell Injection - Rheumatoid Arthritis | Early Phase 1 | Withdrawn | Institute of Hematology & Blood Diseases Hospital, China | 2027-12-01 | 2026-06-10 | |
| Evaluating the Effect of Adipose Tissue Processed With the SyntrFuge™ System for Knee Osteoarthritis SyntrFuge System, Triamcinolone Injection - Knee Osteoarthritis | Not applicable | Not yet recruiting | Syntr Health Technologies, Inc. | 180 | 2027-12-01 | 2026-08-20 |
| Neoadjuvant Pimicotinib Combined With Surgery Versus Upfront Surgery for Diffuse Tenosynovial Giant Cell Tumor Pimicotinib, Tumor resection surgery - Tenosynovial Giant Cell Tumor, Diffuse | Phase 2 | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 84 | 2027-10-01 | 2026-07-16 |
| A Study to Determine the Safety and Efficacy of TG-C in Subjects With Symptomatic Early Hip Osteoarthritis TG-C, Placebo Control - Degenerative Osteoarthritis | Phase 2 | Not yet recruiting | Kolon TissueGene, Inc. | 255 | 2027-10-01 | 2026-08-20 |
| Clinical Outcomes of Focused Shockwave Therapy Without Adjunct Rehabilitation Compared to Standard Physical Rehabilitation in Patients With Grade I-III Knee Osteoarthritis: A Single-Blind Randomized Study Physical Rehab, Focused Shockwave Therapy - Knee Osteoarthristis | Not applicable | Not yet recruiting | Pulse Wave USA | 60 | 2027-09-25 | 2026-05-05 |
| Feasibility and Acceptability of OLP-EXP in Chronic Pain OLP-EXP, OLP, EXP - Temporomandibular Disorders (TMD) | Not applicable | Not yet recruiting | University of Maryland, Baltimore | 57 | 2027-07-01 | 2026-08-25 |
| Efficacy and Safety of GNSC-001 Intra-articular Injection for Knee Osteoarthritis Gene Therapy GNSC-001, Placebo - Knee Arthritis Osteoarthritis, Knee Arthritis, Osteoarthritis | Phase 2 / Phase 3 | Not yet recruiting | Genascence Corporation | 240 | 2027-07-01 | 2026-09-21 |
| Duloxetine and aeRobic Exercise to Improve Function in VEterans With Knee Osteoarthritis (DRIVE) Exercise, Duloxetine, Placebo - Knee Osteoarthritis, Pain | Phase 2 | Not yet recruiting | VA Office of Research and Development | 102 | 2027-03-01 | 2026-06-16 |
| Undenatured Type II Collagen for Knee Osteoarthritis Pain Placebo, Nuvicol II, Nuvicol SII - Osteoarthritis, Knee | Not applicable | Recruiting | Universidad Católica San Antonio de Murcia | 120 | 2027-03-01 | 2026-10-22 |
| Ultrasound Assessment of Joint Health in Patients With Mild Hemophilia (Factor Levels 5-40%) Joint Ultrasound (HEAD-US), Blood Sample for Coagulation Factor Measurement - Mild Hemophilia | Not applicable | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 150 | 2027-02-01 | 2026-08-17 |
| Comparing Pain Science Education to Biomedical Education for People With Knee Osteoarthritis: A Randomized Controlled Trial Pain Science Education, Biomedical Education - Knee Arthritis Osteoarthritis | Not applicable | Not yet recruiting | McMaster University | 82 | 2027-02-01 | 2026-09-16 |
| Regenerative Medicine for Joint Hypermobility and Instability Dextrose 20% Prolotherapy, Autologous Platelet-Rich Plasma, Doxycycline Hyclate Injectable (Investigational) - Ehlers-Danlos Syndrome Hypermobility Type (hEDS), Ehlers-Danlos Syndrome (EDS) | Phase 1 / Phase 2 | Not yet recruiting | Manhattan Pain Medicine, PLLC | 100 | 2027-01-15 | 2026-10-06 |
| A Study of Zasocitinib in Adults With Psoriatic Arthritis (LATITUDE PsA NeXt) Placebo, Zasocitinib - Psoriatic Arthritis | Phase 3 | Not yet recruiting | Takeda | 644 | 2027-01-11 | 2026-10-13 |
| Improving Management and Secondary Prevention Through Azithromycin Comparative Trial in Rheumatic Heart Disease in Nigeria)- IMPACT-RHD Nigeria Benzathine Penicillin, Azithromycin (Azithro) - Rheumatic Fever, Valvular Heart Diseases | Not applicable | Not yet recruiting | Ladoke Akintola University of Technology, Ogbomoso, Nigeria | 474 | 2027-01-05 | 2026-06-04 |
| 8 vs 12 Weeks: A Pavlik Harness Trial Pavlik Harness - Developmental Dysplasia of Hip, DDH | Not applicable | Not yet recruiting | The Hospital for Sick Children | 110 | 2027-01-01 | 2026-09-29 |
| Evaluation of the Efficacy and Acceptability of a Phytotherapy Combining Devil's Claw, Blackcurrant and Meadowsweet for the Management of Aromatase Inhibitor-induced Arthralgia in Patients Treated for Localized Breast Cancer in the Adjuvant Setting Phytotherapy Dietary Supplement (Harpagophytum, Meadowsweet, and Blackcurrant), Patient Experience Questionnaire - Hormone Therapy-induced Arthralgia, Phytotherapy | Phase 4 | Not yet recruiting | Hospices Civils de Lyon | 105 | 2027-01-01 | 2026-10-05 |
| HTO and Tranexamic Acid Study Tranexamic Acid, Routine medial opening wedge high tibial osteotomy - Osteoarthritis, Knee | Phase 3 | Not yet recruiting | Western University, Canada | 200 | 2027-01-01 | 2026-09-17 |
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Methotrexate (350) · Exercise (292) · Adalimumab (236) · Etanercept (221) · tocilizumab (193) · Sodium Chloride (158) · Arthroplasty, Replacement, Knee (135) · Physical Therapy Modalities (135) · Infliximab (131) · Hyaluronic Acid (111) · Saline Solution (109) · Abatacept (107) · tofacitinib (100) · Rituximab (97) · Arthroplasty, Replacement, Hip (92)
Pfizer (212) · Hoffmann-La Roche (202) · Riphah International University (184) · Cairo University (161) · Zimmer Biomet (150) · Novartis Pharmaceuticals (118) · Assiut University (115) · Bristol-Myers Squibb (106) · Amgen (104) · Assistance Publique - Hôpitaux de Paris (88) · AbbVie (84) · Istituto Ortopedico Rizzoli (78) · Eli Lilly and Company (70) · Hacettepe University (61) · University Hospital, Montpellier (58)
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PMID 36931693, PMID 36526796, PMID 32816215, PMID 34870800, PMID 36600185, PMID 36601090, PMID 33127856, PMID 28143815, PMID 39192350, PMID 25047021, PMID 27338778, PMID 38958913, PMID 29244149, PMID 30649524, PMID 37453736, PMID 37982966, PMID 40194794, PMID 40875187, PMID 41807031, PMID 26275429, PMID 30936738, PMID 33263165, PMID 34706874, PMID 36754548, PMID 37460782, PMID 37945286, PMID 29463520, PMID 34041702, PMID 36814062, PMID 31203228, PMID 31610021, PMID 34921355, PMID 36205910, PMID 37316690, PMID 37747626, PMID 38446397, PMID 28941219, PMID 30177460, PMID 35577477, PMID 36715850, PMID 37308218, PMID 41965705, PMID 42386286, PMID 21055873, PMID 22491018, PMID 24482784, PMID 26554876, PMID 27803138, PMID 27889300, PMID 29949132
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