Chronic Pain: Clinical Trials

1729 completed, 432 unknown, 389 recruiting, 159 not yet recruiting. 1842 Not applicable, 187 Phase 2, 156 Phase 3, 118 Phase 4, 108 Phase 1.

By phase and status

Phase	Trials	Status
Not applicable	1842	Completed 997, Unknown 261, Recruiting 243, Not yet recruiting 105, Active not recruiting 91, Terminated 69, Withdrawn 49, Enrolling by invitation 23, Suspended 4
Phase 2	187	Completed 103, Recruiting 27, Terminated 18, Unknown 18, Withdrawn 11, Active not recruiting 5, Not yet recruiting 3, Enrolling by invitation 2
Phase 3	156	Completed 97, Unknown 19, Terminated 15, Recruiting 8, Withdrawn 8, Active not recruiting 5, Not yet recruiting 2, Suspended 2
Phase 4	118	Completed 74, Unknown 13, Terminated 12, Recruiting 8, Withdrawn 5, Active not recruiting 2, Suspended 2, Enrolling by invitation 1, Not yet recruiting 1
Phase 1	108	Completed 79, Unknown 8, Recruiting 7, Not yet recruiting 5, Active not recruiting 3, Terminated 3, Withdrawn 2, Enrolling by invitation 1
Early Phase 1	26	Completed 16, Not yet recruiting 3, Recruiting 3, Active not recruiting 2, Terminated 1, Unknown 1

Follow Chronic Pain: new trials by email Literature Review of Chronic Pain trials Research Report on Chronic Pain

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Ketamine and Midazolam Infusions for CRPS: Feasibility Study Ketamine, Midazolam, Normal Saline - Complex Regional Pain Syndromes	Phase 2	Withdrawn	Stanford University		2099-01-01	2024-11-22
Personalizing Veteran Pain Care: Adapting Coaching Interventions to Support Maintenance of Self-Care Coaching - Chronic Pain, Musculoskeletal Pain	Phase 1	Not yet recruiting	VA Office of Research and Development	30	2029-01-01	2026-03-06
DockTales for Chronic Pain DockTales, REDCap monitoring - Chronic Pain, Chronic Pain Syndrome	Not applicable	Not yet recruiting	University of Maryland, Baltimore	60	2027-07-17	2026-09-03
Mindfulness Therapy for Chronic Pain After Intimate Partner Violence Mindfulness-Based Cognitive Therapy for Trauma-Informed Pain (MBCT-TIP), Health Enhancement Program (HEP) - Chronic Pain	Not applicable	Not yet recruiting	Brigham and Women's Hospital	58	2027-07-01	2026-07-14
Mantram Repetition Versus Health Education for Veterans With PTSD and Chronic Pain Mantram Repetition Program for PTSD + Pain, Health Education while Living with Pain - Stress Disorders, Post-Traumatic, Pain, Chronic	Not applicable	Not yet recruiting	VA Office of Research and Development	170	2027-04-01	2026-07-27
Music Listening for Chronic Pain in Adults With Early-Stage Dementia MUSIC CARE® Standardized Music Listening, Neutral Spoken-Word Audiobook Control - Chronic Pain, Alzheimer Disease	Not applicable	Not yet recruiting	Florida State University	40	2027-03-30	2026-11-05
Nurse-Delivered Brief Pain Relief Skills Treatment in Rural Communities Pain relief skills training, Health Education - Chronic Pain	Not applicable	Not yet recruiting	Washington State University	400	2027-03-01	2026-10-15
Multicomponent Pain Self-Management in Adults With Haemophilic Arthropathy Multicomponent pain self-management programme - Hemophilic Arthropathy, Chronic Pain	Not applicable	Not yet recruiting	Investigación en Hemofilia y Fisioterapia	70	2027-03-01	2026-10-06
Healing Gardens: Leveraging Serious Games to Deliver Accessible Pain-CBT and Pharmacologic Support for Patients With Advanced Cancer Managing Pain Healing Gardens content development/refinement activities, Healing Gardens serious game - Advanced Cancer, Cancer Pain	Not applicable	Not yet recruiting	Dana-Farber Cancer Institute	46	2027-02-13	2026-09-17
MBI for Pain and Sleep in Adolescents and Young Adults With Sickle Cell Disease Mindfulness-based intervention - Chronic Pain, Sickle Cell Disease	Not applicable	Not yet recruiting	University of Illinois at Chicago	48	2027-02-01	2026-09-21
Integrated Digital Health Approach to Reduce Hazardous Alcohol Use and Chronic Pain Among Rural Populations Mobile Intervention for Alcohol and Pain, Control Intervention - Chronic Pain, Unhealthy Alcohol Use	Not applicable	Not yet recruiting	Boston University Charles River Campus	260	2027-02-01	2026-09-04
"Evaluation of the Efficacy of Intravenous Lidocaine on Chronic Post-operative Pain in Patients Requiring Emergency Abdominal Surgery. A Multicentre, Randomised, Controlled, Double-blind Study." Lidocain, Placebo - Chronic Pain	Phase 3	Not yet recruiting	Nantes University Hospital	266	2027-01-15	2026-10-09
Effects of Expectancy and Mindfulness Instructions on Chronic Pain Mindfulness of Breath Practice (15 min), Sham-Mindfulness Practice - Chronic Pain	Not applicable	Not yet recruiting	Florida State University	60	2027-01-15	2026-11-04
Virtual Pain Education for Spinal Cord Stimulation Patients SCS-PNE intervention - Chronic Pain, Chronic Pain Due to Injury	Not applicable	Not yet recruiting	University of Arkansas	50	2027-01-05	2026-10-20
Focused Ultrasound Neuromodulation for Chronic Pain Focused PCM-Guided CMN LIFU, Unfocused Control LIFU - Chronic Pain, Sickle Cell Disease	Not applicable	Not yet recruiting	University of Minnesota	80	2027-01-04	2026-11-02
Digital Treatment for Chronic Pain and Addiction in Veterans With Opioid Use Disorder Receiving Buprenorphine Integrating the Management of Pain and Addiction via Collaborative Treatment (IMPACT), Enhanced Treatment as Usual (ETAU) - Opioid Use Disorder, Chronic Pain	Phase 3	Not yet recruiting	VA Office of Research and Development	250	2027-01-04	2026-11-09
Neurobiology of Pain in Burn Survivors Cognitive Behavioral Therapy, Pain Education - Burn, Chronic Pain	Not applicable	Not yet recruiting	Spaulding Rehabilitation Hospital	92	2027-01-01	2026-09-22
The Application of Lifestyle Enhancing Validated Integrative Therapies for Everyday Pain in Cirrhosis High-touch self-management program, Low-touch self-management program - Cirrhoses, Liver	Not applicable	Not yet recruiting	University of Pennsylvania	625	2027-01-01	2026-10-02
Medication vs. Meditation for Chronic Knee Osteoarthritis Oral diclofenac potassium 50 mg, Mindfulness meditation - Knee Osteoarthristis	Early Phase 1	Not yet recruiting	Florida State University	30	2027-01-01	2026-11-04
Empowered Relief® for Cancer Survivors With Chronic Pain Empowered Relief Course (Zoom) - Chronic Pain Due to Cancer, Pain Catastrophizing	Not applicable	Recruiting	University of Oklahoma	215	2027-01-01	2026-11-06

Showing 20 of 3124. Sign in to see all of them.

Narrower conditions

Pain (401)  ·  Fibromyalgia (197)  ·  Low Back Pain (181)  ·  Neuralgia (169)  ·  Agnosia (157)  ·  Pain, Postoperative (146)  ·  Acute Pain (132)  ·  Musculoskeletal Pain (112)  ·  Back Pain (109)  ·  Depression (108)  ·  Opioid-Related Disorders (105)  ·  Anxiety Disorders (96)  ·  Neck Pain (92)  ·  Motor Activity (84)

Broader conditions

Pathological Conditions, Signs and Symptoms (3123)  ·  Neurologic Manifestations (3117)  ·  Signs and Symptoms (3117)  ·  Pain (2723)  ·  Nervous System Diseases (787)  ·  Musculoskeletal Diseases (541)  ·  Neuromuscular Diseases (447)  ·  Mental Disorders (436)  ·  Muscular Diseases (351)  ·  Rheumatic Diseases (340)  ·  Pathologic Processes (327)  ·  Behavior (293)  ·  Peripheral Nervous System Diseases (237)  ·  Joint Diseases (232)  ·  Postoperative Complications (188)

Interventions

Cognitive Behavioral Therapy (57)  ·  Exercise (56)  ·  Transcranial Direct Current Stimulation (48)  ·  Therapeutics (44)  ·  Ketamine (40)  ·  Surveys and Questionnaires (40)  ·  Spinal Cord Stimulation (35)  ·  Morphine (29)  ·  Transcutaneous Electric Nerve Stimulation (28)  ·  Sodium Chloride (25)  ·  Acceptance and Commitment Therapy (23)  ·  Fentanyl (23)  ·  Lidocaine (22)  ·  Physical Therapy Modalities (22)  ·  Transcranial Magnetic Stimulation (22)

Sponsors

VA Office of Research and Development (57)  ·  Stanford University (46)  ·  University of Washington (39)  ·  Boston Scientific Corporation (33)  ·  University of Michigan (29)  ·  University of Utah (26)  ·  Assiut University (25)  ·  Massachusetts General Hospital (25)  ·  University Hospital, Clermont-Ferrand (22)  ·  Wake Forest University Health Sciences (21)  ·  Abbott Medical Devices (19)  ·  Duke University (18)  ·  University Health Network, Toronto (18)  ·  Weill Medical College of Cornell University (18)  ·  Brigham and Women's Hospital (17)

Countries

United States (1255)  ·  Canada (197)  ·  Turkey (Türkiye) (193)  ·  Spain (173)  ·  France (128)  ·  United Kingdom (114)  ·  Sweden (87)  ·  Denmark (86)  ·  Belgium (78)  ·  Germany (68)  ·  Brazil (65)  ·  Italy (64)  ·  Netherlands (53)  ·  Egypt (49)  ·  China (42)

Top investigators

Roshini Jain (9)  ·  Natalie Bloom Lyons (7)  ·  Alejandro Luque Suarez, PhD (6)  ·  Ana-Maria Vranceanu, PhD (6)  ·  James C Eisenach, MD (5)  ·  Jo Nijs, PhD (5)  ·  Kassiani Theodoraki, PhD, DESA (5)  ·  Wolnei Caumo, PhD (5)  ·  Asokumar Buvanendran, MD (4)  ·  Beth Darnall, PhD (4)  ·  Cary Reid, MD, PhD (4)

Results publications

PMID 34854473, PMID 36438970, PMID 39428602, PMID 41766528, PMID 14715402, PMID 15992242, PMID 19903919, PMID 20104399, PMID 20521870, PMID 20699159, PMID 22105041, PMID 22437221, PMID 22607834, PMID 23102757, PMID 23215625, PMID 23340531, PMID 23370085, PMID 23709304, PMID 24353047, PMID 24916058, PMID 24985410, PMID 26357522, PMID 26695349, PMID 27574837, PMID 27720917, PMID 28214943, PMID 28440034, PMID 30271455, PMID 30908578, PMID 32379556, PMID 33045706, PMID 33661130, PMID 33738491, PMID 35295458, PMID 36892929, PMID 36971108, PMID 37624900, PMID 39745877, PMID 40121179, PMID 41212507, PMID 41505067, PMID 8080219, PMID 10025495, PMID 10348007, PMID 10499210, PMID 10576479, PMID 10618804, PMID 10685584, PMID 10781919, PMID 10811152

NIH funding

2019 (10), 2009 (9), 2023 (9), P30AG022845 (8), 2014 (4), 2017 (4), 1RM1DA055310-01 (3), 2016 (3), 2025 (3), K24DA053564 (3), P01NS041386 (3), P01NS119159 (3), R90HD118650 (3), RM1DA055301 (3), RM1DA055437 (3)