1434 completed, 405 unknown, 185 recruiting, 114 not yet recruiting. 1573 Not applicable, 134 Phase 3, 110 Phase 2, 101 Phase 4, 55 Phase 1.
Follow Low Back Pain: new trials by email Literature Review of Low Back Pain trials Research Report on Low Back Pain
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Preventing the Transition From Acute to Persistent Disabling Low Back Pain Through Cognitive Functional Therapy Cognitive Functional Therapy (CFT), Usual Care - Acute Low Back Pain (Low Back Pain for Less Than 3 Months) | Not applicable | Not yet recruiting | University of Oulu | 461 | 2027-09-01 | 2026-10-16 |
| Therapeutic Exercise and Education for Low Back Pain Therapeutic Exercise, Education on the self-management of low back pain, Usual Care - Low Back Pain | Not applicable | Not yet recruiting | University of Valladolid | 132 | 2027-03-01 | 2026-10-20 |
| Semaglutide for Low Back Pain Semaglutide (administered by PDS290 pen-injector), Placebo (administered by PDS290 pen-injector) - Lower Back Pain, Obesity (BMI>30) | Phase 2 | Not yet recruiting | Washington University School of Medicine | 250 | 2027-02-01 | 2026-07-28 |
| Randomized Evaluation of Lumbar Injection Effectiveness and Function Triojection® System, Selective Nerve Root Block (SNRB) - Lumbar Radiculopathy, Lumbar Disc Herniation | Not applicable | Not yet recruiting | SpinaFX Medical Inc. | 300 | 2027-01-15 | 2026-10-07 |
| A Comparison Between Ischial-Containment and Sub-Ischial Prosthetic Sockets to Determine Their Effects on Secondary Health Conditions Unilateral Transfemoral Amputation | Not yet recruiting | VA Office of Research and Development | 45 | 2027-01-01 | 2026-08-17 | |
| Differences in Mechanistic Measures (Oxytocin and Cortisol) of Therapeutic Alliance Between A Talk-Based Therapy and Soft-Tissue Mobilization in Individuals With Chronic Spinal Pain Massage, Talk-based therapy - Spine, Low Back Pain | Not applicable | Not yet recruiting | Duke University | 25 | 2026-12-01 | 2026-10-16 |
| Effect of Dry Needling Plus Vibration on Myofascial Trigger Points in Individuals With Nonspecific Low Back Pain Dry Needling with Vibration + Exercise, Conventional Dry Needling + Exercise - Low Back Pain, Dry Needling | Not applicable | Not yet recruiting | Universidad de Zaragoza | 108 | 2026-12-01 | 2026-10-05 |
| Effect of Kinesio Taping Versus Myofascial Release on Menstrual Low Back Pain kinesio taping, myofascial release technique - Low Back Pain | Not applicable | Not yet recruiting | Cairo University | 44 | 2026-11-15 | 2026-04-02 |
| Magnetic Resonance Elastography Of Chronic Low Back Pain Before And After Therapy EMMA (Expert Manipulative Massage Automation) - Low Back Pain, Recurrent, Chronic Low Back Pain (CLBP) | Not applicable | Not yet recruiting | Mayo Clinic | 38 | 2026-11-01 | 2026-09-17 |
| Gamified Home-Based Core Neuromuscular Training for Chronic Low Back Pain Gamified Intervention Group: core neuromuscular exercise program using a digital application with gamification features, Non-Gamified Control Group - Low Back Pain, Core Muscles | Not applicable | Not yet recruiting | Princess Nourah Bint Abdulrahman University | 60 | 2026-11-01 | 2026-10-26 |
| The Effect of Core Stabilization Exercises on Balance in Older Adults With Low Back Pain Core stabilisation exercises + usual physiotherapy care, Usual physiotherapy care + general exercise programme - Chronic Non-Specific Low Back Pain | Not applicable | Not yet recruiting | University of West Attica | 60 | 2026-10-25 | 2026-09-29 |
| TECAR Therapy and Chronic Low Back Pain Control Group, TECAR therapy - TECAR Therapy, Low Back Pain | Not applicable | Not yet recruiting | Cairo University | 80 | 2026-10-20 | 2026-09-17 |
| Effects of Motor Control Exercises With and Without Pressure Biofeedback in Recurrent Low Back Pain (MCE) Motor Control Exercise with Pressure Biofeedback-Guided Training, Motor Control Exercise - Low Back Pain | Not applicable | Not yet recruiting | University of Management and Technology Lahore | 48 | 2026-10-20 | 2026-10-23 |
| The Ultrasound-Guided Dextrose Prolotherapy in Ehlers-Danlos Syndrome Patients Dextrose 50% Intravenous Solution, Lidocaine 1% Injectable Solution - Ehlers-Danlos Syndrome, Low Back Pain | Phase 3 | Withdrawn | Tulane University | 2026-10-05 | 2026-10-08 | |
| Pain Neuroscience Education and Neuromuscular Exercise in Individuals With Chronic Low Back Pain and Central Sensitization Pain Neuroscience Education, Neuromuscular Exercise - Low Back Pain, Chronic Low Back Pain | Not applicable | Not yet recruiting | Izmir Katip Celebi University | 66 | 2026-10-01 | 2026-10-15 |
| Impact of the Receptive Music Intervention Tool (MUSIC CARE©) on Changes in the Functional Abilities of Patients With Chronic Low Back Pain Receptive Music Therapy - Low Back Pain, Kinesiophobia (Fear of Movement) | Not applicable | Not yet recruiting | LNA SANTE | 34 | 2026-10-01 | 2026-07-28 |
| Virtual Tai Chi for Chronic Low Back Pain (Spine 2027) Virtually Delivered Integrated Tai Chi, Qigong, and Meditation (VDTQM) - Low Back Pain, Chronic Low-back Pain (cLBP) | Not applicable | Not yet recruiting | New York Medical College | 600 | 2026-10-01 | 2026-08-19 |
| Comparing Non-Medicine Strategies for Improving Low Back Pain ENCompaSS (Education, Navigated Care, and Supported Self-Management) with VA Stepped Usual Care - Chronic Low-back Pain (cLBP), High-Impact Chronic Pain (HICP) | Not applicable | Not yet recruiting | Duke University | 530 | 2026-10-01 | 2026-07-28 |
| Image-Guided Intra-Articular Versus Periarticular Injection in Sacroiliac Joint Pain Fluoroscopy-Guided Intra-Articular SIJ Injection, Fluoroscopy-Guided Periarticular SIJ Injection - Sacroiliac Joint Pain, Sacroiliac Joint Dysfunction | Not applicable | Not yet recruiting | Assiut University | 90 | 2026-10-01 | 2026-09-22 |
| The Intervention Effect of Exercise on Lumbar Multifidus Muscle Injuries Lumbar multifidus muscle rehabilitation exercise - Chronic Non-specific Low Back Pain With Lumbar Multifidus Muscle Injury or Dysfunction | Not applicable | Not yet recruiting | Chinese PLA General Hospital | 40 | 2026-10-01 | 2026-10-23 |
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Back Pain (189) · Pain (182) · Chronic Pain (181) · Motor Activity (137) · Neck Pain (83) · Intervertebral Disc Displacement (71) · Radiculopathy (67) · Intervertebral Disc Degeneration (62) · Sciatica (47) · Bronchiolitis Obliterans Syndrome (43) · Spinal Stenosis (40) · Musculoskeletal Pain (39) · Neuralgia (33) · Agnosia (31)
Pathological Conditions, Signs and Symptoms (2358) · Neurologic Manifestations (2355) · Signs and Symptoms (2352) · Pain (2176) · Back Pain (2169) · Musculoskeletal Diseases (310) · Nervous System Diseases (230) · Bone Diseases (194) · Behavior (184) · Spinal Diseases (180) · Neuromuscular Diseases (156) · Peripheral Nervous System Diseases (139) · Pathological Conditions, Anatomical (81) · Pathologic Processes (77) · Muscular Diseases (74)
Exercise (83) · Physical Therapy Modalities (54) · Musculoskeletal Manipulations (37) · Exercise Therapy (35) · Transcutaneous Electric Nerve Stimulation (31) · Control Groups (28) · Manipulation, Spinal (27) · Dry Needling (24) · Acupuncture Therapy (23) · Educational Status (20) · Ibuprofen (20) · Acetaminophen (19) · Manipulation, Osteopathic (19) · Myofascial Release Therapy (18) · Surveys and Questionnaires (15)
Riphah International University (102) · Cairo University (55) · Foundation University Islamabad (24) · Hacettepe University (23) · University of Florida (19) · University of Utah (19) · Assistance Publique - Hôpitaux de Paris (15) · VA Office of Research and Development (15) · Johns Hopkins University (14) · Kovacs Foundation (14) · Superior University (13) · Uskudar University (13) · Istanbul Medipol University Hospital (12) · Montefiore Medical Center (12) · Universidad de Almeria (12)
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Francisco M Kovacs, MD, PhD (12) · Laxmaiah Manchikanti, MD (8) · Steven P Cohen, MD (8) · Muhammad Osama, PhD* (6) · Andrew Finn, PharmD (5) · Kevin Farrell (4) · Mario Gestoso, MD (4) · Simon Brumagne, PhD (4) · Aisha Razzaq, PHD* (3) · Aldo Scafoglieri, PhD (3) · Arnaud Dupeyron, MD, PhD (3)
PMID 27745712, PMID 11172169, PMID 22048651, PMID 31631992, PMID 11074683, PMID 11124727, PMID 11175676, PMID 11733293, PMID 15129077, PMID 15207508, PMID 16550448, PMID 18165754, PMID 20567613, PMID 21120303, PMID 21256073, PMID 21982256, PMID 22231424, PMID 22236541, PMID 23340531, PMID 24985410, PMID 25380224, PMID 25932092, PMID 26501533, PMID 26554876, PMID 26814279, PMID 27825292, PMID 28192789, PMID 29573870, PMID 30217693, PMID 31960773, PMID 32411374, PMID 34854473, PMID 35346331, PMID 35507483, PMID 36045306, PMID 36775506, PMID 37395948, PMID 40891888, PMID 8455963, PMID 10360702, PMID 10399508, PMID 10470716, PMID 10488513, PMID 10534584, PMID 10619108, PMID 10707404, PMID 10709302, PMID 10744172, PMID 10826123, PMID 10872758
2019 (5), 2023 (5), 2009 (3), U01AR045444 (3), 2015 (2), 2017 (2), 2018 (2), 4UH3AR076731-02 (2), K01HD053632 (2), K12NS130673 (2), R01AT006334 (2), R01MD018937 (2), R44DA049631 (2), R44NS125745 (2), U19AT004663 (2)