Pain, Postoperative: Clinical Trials

3195 completed, 932 unknown, 537 recruiting, 381 not yet recruiting. 2937 Not applicable, 1050 Phase 4, 451 Phase 3, 403 Phase 2, 124 Phase 1.

By phase and status

Phase	Trials	Status
Not applicable	2937	Completed 1625, Unknown 497, Recruiting 348, Not yet recruiting 251, Terminated 76, Active not recruiting 65, Withdrawn 49, Enrolling by invitation 22, Suspended 4
Phase 4	1050	Completed 597, Unknown 174, Recruiting 78, Terminated 68, Not yet recruiting 55, Withdrawn 48, Active not recruiting 20, Enrolling by invitation 8, Suspended 2
Phase 3	451	Completed 277, Unknown 72, Recruiting 29, Terminated 25, Not yet recruiting 15, Withdrawn 14, Active not recruiting 9, Enrolling by invitation 5, Suspended 5
Phase 2	403	Completed 250, Unknown 63, Recruiting 28, Terminated 25, Not yet recruiting 15, Withdrawn 13, Active not recruiting 4, Enrolling by invitation 3, Suspended 2
Phase 1	124	Completed 68, Unknown 22, Not yet recruiting 8, Terminated 8, Recruiting 7, Withdrawn 4, Active not recruiting 3, Enrolling by invitation 3, Suspended 1
Early Phase 1	54	Completed 30, Unknown 8, Withdrawn 6, Not yet recruiting 3, Recruiting 3, Terminated 2, Active not recruiting 1, Enrolling by invitation 1

Follow Pain, Postoperative: new trials by email Literature Review of Pain, Postoperative trials Research Report on Pain, Postoperative

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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Postoperative Analgesia Using Ganglion Impar Block After Anal Surgery Ganglion impar block with Bupivacaine., Ganglion impar block with normal saline - Postoperative Pain	Not applicable	Not yet recruiting	University of Alexandria	60	2028-07-01	2025-04-03
Perioperative Esketamine Safety and Efficacy in Reducing Postoperative ENDometriosis PAIN (the ENDPAIN Trial): a Randomized Controlled Trial. Esketamine, Placebo - Endometriosis	Phase 4	Not yet recruiting	Region Skane	1000	2028-01-01	2026-10-19
Psilocybin After Trauma Surgery for Pain Psilocybin (Usona Institute), Postoperative analgesia - Pain Management, Postoperative Pain	Phase 1	Not yet recruiting	Trent Emerick	70	2027-12-31	2026-08-06
VibraCool Device to Reduce Pain and Opioid Use After Anterior Cruciate Ligament Reconstruction (ACLR) VibraCool mechanical stimulation and neuromodulatory therapeutic device, Cryocompression (Game Ready, Bregs) device, Standard ice packs - ACL, Opioid Use	Not applicable	Not yet recruiting	Columbia University	130	2027-11-01	2026-10-28
Efficacy of Different Disinfection Technologies in Molar Non-Surgical Retreatment GentleWave System, Conventional rotary instrumentation with passive ultrasonic irrigation - Apical Periodontitis	Not applicable	Not yet recruiting	University of Alabama at Birmingham	60	2027-07-01	2026-04-08
The IMPACT Study: Personalized Physical Therapy for Better Recovery and a Stronger Core After Hernia Surgery PT Group, Usual Care - Ventral Hernia, Ventral Incisional Hernia	Not applicable	Not yet recruiting	Thomas Jefferson University	60	2027-07-01	2026-10-22
ESP vs Subcostal TAP Block for Analgesia After Laparoscopic Cholecystectomy Erector Spinae Plane Block, Subcostal Transversus Abdominis Plane Block - Cholelithiasis, Postoperative Pain, Laparoscopic Cholecystectomy	Not applicable	Not yet recruiting	Gaziantep City Hospital	100	2027-06-15	2026-06-22
Suzetrigine Versus Standard Analgesia After Skin Cancer Surgery Suzetrigine, Acetaminophen Plus Ibuprofen - Postoperative Pain, Acute Pain	Phase 4	Not yet recruiting	University of Minnesota	230	2027-04-01	2026-09-25
Phase 3 Bunionectomy Study CPL-01, saline placebo - Postoperative Pain, Bunion	Phase 3	Not yet recruiting	Cali Pharmaceuticals LLC	112	2027-03-01	2026-10-21
Opioid Reduction and Enhanced Recovery in Orthopaedic Surgery (OREOS)-Knee Standard care, Multicomponent opioid reduction and pain management pathway - Knee Arthroplasty, Total, Partial Knee Arthroplasty	Not applicable	Not yet recruiting	McMaster University	170	2027-02-01	2026-10-30
Two Bupivacaine Concentrations for Recto-Intercostal Fascial Plane Block After Laparoscopic Cholecystectomy Bupivacaine 0.25% - recto-intercostal fascial plane block, Bupivacaine 0.125% - recto-intercostal fascial plane block, Bupivacaine 0.25% - port-site infiltration - Postoperative Pain, Acute Pain	Not applicable	Not yet recruiting	Medipol University	90	2027-01-30	2026-10-29
Suzetrigine (Journavx) as Multimodal Therapy for Pain Management in Adults Undergoing Surgery for Hip Fracture Suzetrigine (Journavx) - Hip Fractures (ICD-10 72.01-72.2), Post Operative Analgesia	Phase 4	Not yet recruiting	Beth Israel Deaconess Medical Center	79	2027-01-05	2026-10-29
Use of a Vibration Tool for Postoperative Pain Control in Distal Radius Fractures Vibration tool - Distal Radius Fracture, Radius Fracture Distal	Not applicable	Not yet recruiting	Northwestern University	100	2027-01-01	2026-07-10
Safety of F14 Following Total Knee Replacement F14 (sustained release celecoxib) - Analgesia	Phase 2 / Phase 3	Suspended	Arthritis Innovation Corporation	100	2027-01-01	2026-06-05
Evaluation of the Efficacy of Sublingual Sufentanil (Prescribed as Rescue Analgesia for Acute Postoperative Pain) on the Quality of Health Recovery After Surgery: a Randomized, Controlled, Multicenter, Open-label Trial Against an Active Comparator (SUBLIME) Sublingual sufentanil 30 µg (one dose per hour, as needed), Morphine sulfate (10 mg every 4 hours as needed) - Postoperative Pain	Phase 4	Not yet recruiting	University Hospital, Strasbourg, France	1150	2027-01-01	2026-06-03
A Predictive Model for Postoperative Analgesic Requirements After Abdominal Surgery Intravenous Morphine Patient-Controlled Analgesia - Postoperative Pain, Postoperative Analgesia		Not yet recruiting	Chaw Sook Hui	65	2027-01-01	2026-09-03
Study of QL Analgesic Response and Extent Quadratus Lumborum with 1.5% Lidocaine - Acute Pain, Postoperative Pain	Phase 4	Not yet recruiting	Duke University	25	2027-01-01	2026-07-08
Relaxation Exercise Interventions for Individuals Who Have Undergone Urinary Tract Stone Surgery Benson Relaxation Exercise Group, Jacobson Relaxation Exercise Group - Urinary Tract Stone Surgery, Relaxation Exercise	Not applicable	Not yet recruiting	Ondokuz Mayıs University	120	2027-01-01	2026-10-14
Postsurgical Pain and Opioid Use in Older Adults: Effects of Mild Cognitive Impairment Mild Cognitive Impairment (MCI), Opioid Use		Not yet recruiting	Miklos Kertai	552	2027-01-01	2026-10-21
Bilateral Pecto-Intercostal Fascial Plane Block for Prevention of Chronic Poststernotomy Pain After CABG Pecto-Intercostal Fascial Plane Block, Standardized Multimodal Systemic Analgesia - Chronic Poststernotomy Pain	Not applicable	Not yet recruiting	Izmir Katip Celebi University	180	2027-01-01	2026-10-20

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Narrower conditions

Agnosia (563)  ·  Pain (548)  ·  Acute Pain (192)  ·  Chronic Pain (164)  ·  Phantom Limb (159)  ·  Postoperative Nausea and Vomiting (154)  ·  Postoperative Complications (107)  ·  Anxiety Disorders (106)  ·  Breast Neoplasms (102)  ·  Neuralgia (83)  ·  Hernia, Inguinal (81)  ·  Osteoarthritis, Knee (53)  ·  Patient Satisfaction (45)  ·  Periapical Periodontitis (42)

Broader conditions

Pathological Conditions, Signs and Symptoms (5588)  ·  Neurologic Manifestations (5585)  ·  Pathologic Processes (5585)  ·  Signs and Symptoms (5585)  ·  Postoperative Complications (5481)  ·  Pain (5040)  ·  Nervous System Diseases (936)  ·  Neurobehavioral Manifestations (759)  ·  Perceptual Disorders (710)  ·  Mental Disorders (258)  ·  Wounds and Injuries (253)  ·  Musculoskeletal Diseases (252)  ·  Neoplasms (245)  ·  Neoplasms by Site (223)  ·  Signs and Symptoms, Digestive (194)

Interventions

Bupivacaine (458)  ·  Ropivacaine (255)  ·  Acetaminophen (228)  ·  Sodium Chloride (226)  ·  Saline Solution (193)  ·  Morphine (173)  ·  Dexamethasone (167)  ·  Dexmedetomidine (140)  ·  Lidocaine (124)  ·  Ketamine (111)  ·  Ibuprofen (99)  ·  Fentanyl (89)  ·  Oxycodone (77)  ·  Ketorolac (73)  ·  Epinephrine (71)

Sponsors

Cairo University (127)  ·  Assiut University (100)  ·  Ain Shams University (94)  ·  Seoul National University Hospital (35)  ·  University of California, San Diego (35)  ·  Tanta University (34)  ·  Ataturk University (32)  ·  Cukurova University (31)  ·  Ondokuz Mayıs University (29)  ·  Istanbul University (28)  ·  Beijing Tiantan Hospital (27)  ·  Minia University (27)  ·  Cumhuriyet University (26)  ·  Mahidol University (26)  ·  Ankara City Hospital Bilkent (25)

Countries

United States (1220)  ·  Turkey (Türkiye) (1059)  ·  Egypt (553)  ·  China (228)  ·  Canada (193)  ·  Denmark (183)  ·  Pakistan (128)  ·  Italy (118)  ·  South Korea (112)  ·  France (103)  ·  Spain (86)  ·  Belgium (70)  ·  Thailand (66)  ·  Taiwan (65)  ·  Greece (60)

Top investigators

Brian M Ilfeld, M.D., M.S. (9)  ·  Musa Zengin, MD (8)  ·  Brian M Ilfeld, MD, MS (7)  ·  Fang Luo, M.D. (7)  ·  David Prior (6)  ·  Guolin Wang, MD (6)  ·  Rainer Nitzschke, MD (6)  ·  Sirilak Suksompong, MD (6)  ·  XiaoFeng Shen, MD (6)  ·  Arzu Karaveli (5)

Results publications

PMID 27501016, PMID 22900785, PMID 30063657, PMID 32871021, PMID 26225500, PMID 23121612, PMID 30737315, PMID 38148266, PMID 38345071, PMID 11756886, PMID 12873949, PMID 16698416, PMID 17678782, PMID 18443635, PMID 23360885, PMID 23392233, PMID 23411725, PMID 23471754, PMID 24012235, PMID 24121608, PMID 24535604, PMID 25032676, PMID 25565885, PMID 26241763, PMID 26827847, PMID 27755488, PMID 29492863, PMID 29498951, PMID 29571915, PMID 29670771, PMID 30665850, PMID 36109206, PMID 36351741, PMID 36883093, PMID 38459608, PMID 39039833, PMID 10486687, PMID 10551571, PMID 10794256, PMID 11020770, PMID 11020772, PMID 11323122, PMID 12355695, PMID 12567343, PMID 12600800, PMID 14612482, PMID 14622708, PMID 14984863, PMID 15041597, PMID 15733628

NIH funding

2019 (14), 2014 (13), 2017 (10), 2009 (7), 2025 (6), 2016 (5), 2008 (4), 2015 (4), 2018 (4), 2005 (3), 2023 (2), K23AT011569 (2), K24DA053564 (2), R01DA044245 (2), R01HD089458 (2)