1313 completed, 252 unknown, 170 terminated, 83 recruiting. 1987 Phase 3, 309 Phase 2.
Follow Pain: new trials by email Literature Review of Pain trials Research Report on Pain
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Methadone as an Alternative Treatment for Children Underdoing HSCT PCA plus methadone (Experimental), PCA Alone (SOC) - Leukemia, Aplastic Anemia | Phase 3 | Suspended | University of Texas Southwestern Medical Center | 60 | 2028-01-01 | 2025-10-23 |
| Efficacy and Safety of GNSC-001 Intra-articular Injection for Knee Osteoarthritis Gene Therapy GNSC-001, Placebo - Knee Arthritis Osteoarthritis, Knee Arthritis, Osteoarthritis | Phase 2 / Phase 3 | Not yet recruiting | Genascence Corporation | 240 | 2027-07-01 | 2026-09-21 |
| Phase 3 Bunionectomy Study CPL-01, saline placebo - Postoperative Pain, Bunion | Phase 3 | Not yet recruiting | Cali Pharmaceuticals LLC | 112 | 2027-03-01 | 2026-10-21 |
| Corticosteroid Lumbar Epidural Analgesia for Radicular Pain 2 SP-102, Placebo, Dexamethasone Sodium Phosphate 10 MG/ML - Lumbosacral Radicular Pain | Phase 3 | Not yet recruiting | Semnur Pharmaceuticals, Inc. | 755 | 2027-02-01 | 2026-09-09 |
| "Evaluation of the Efficacy of Intravenous Lidocaine on Chronic Post-operative Pain in Patients Requiring Emergency Abdominal Surgery. A Multicentre, Randomised, Controlled, Double-blind Study." Lidocain, Placebo - Chronic Pain | Phase 3 | Not yet recruiting | Nantes University Hospital | 266 | 2027-01-15 | 2026-10-09 |
| Dexmedetomidine for Invasive Ventilation In the NEOnate Dexmedetomidine Injectable Solution, Glucose 5% Injectable Solution - Invasive Ventilation, Infant Pain | Phase 2 / Phase 3 | Not yet recruiting | Centre Hospitalier Intercommunal Creteil | 246 | 2027-01-01 | 2026-08-26 |
| Safety of F14 Following Total Knee Replacement F14 (sustained release celecoxib) - Analgesia | Phase 2 / Phase 3 | Suspended | Arthritis Innovation Corporation | 100 | 2027-01-01 | 2026-06-05 |
| CBD Supplementation in Brazilian Jiu-Jitsu Athletes CBD Isolate 100mg BID, Placebo - Pro and Anti Inflamatory Cytokines, Pain | Phase 2 / Phase 3 | Not yet recruiting | Associação Pan-Americana Multidisciplinar de Endocanabinologia | 100 | 2027-01-01 | 2026-07-27 |
| Extended Post-Operative Oral Tranexamic Acid Dosing After ACL Reconstruction Tranexamic Acid, Placebo - Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture | Phase 3 | Not yet recruiting | Dave Bernholt | 100 | 2026-11-01 | 2026-10-26 |
| Effect of Nebulized Lignocaine on Emergence Agitation After Sevoflurane Anesthesia in Pediatric Patients Undergoing Tonsillectomy Lidocaine, 0.9% Normal Saline - Emergence Agitation, Emergence Delirium | Phase 3 | Not yet recruiting | Assiut University | 60 | 2026-11-01 | 2026-10-13 |
| Interest of Cryotherapy in Reducing Pain During Radial Arterial Blood Sampling Apllication of medical device ice pack, Apllication of cream - Chronic Respiratory Diseases | Phase 3 | Not yet recruiting | University Hospital, Brest | 258 | 2026-11-01 | 2026-10-30 |
| Veterans' Intervention Blending NeuRomodulation and YogA for Chronic Low BackPaiN Treatment: VIBRANT intermittent theta burst stimulation, LoveYourBrain Yoga Program - Chronic Low Back Pain, Musculoskeletal Pain | Phase 3 | Not yet recruiting | VA Office of Research and Development | 213 | 2026-10-30 | 2026-10-26 |
| Efficacy and Safety of DNN.63.18.040 for the Treatment of Moderate to Severe Pain Product DNN.63.18.040, Tramal® - Acute Pain | Phase 3 | Not yet recruiting | Ache Laboratorios Farmaceuticos S.A. | 370 | 2026-10-19 | 2026-10-19 |
| Morphine or Ketamine for Analgesia Ketamine hydrochloride, Morphine sulphate - Abdominal Pain, Isolated Extremity Fracture | Phase 3 | Recruiting | Columbia University | 1010 | 2026-10-17 | 2026-10-20 |
| Suzetrigine in TKA Placebo, Suzetrigine - Total Knee Arthroplasty (TKA), Total Knee Arthroplasty \(TKA\) | Phase 3 | Recruiting | Hospital for Special Surgery, New York | 148 | 2026-10-15 | 2026-10-13 |
| Phase 3, Open-Label Extension Study of AMBTX-01 (Neridronate) for Complex Regional Pain Syndrome Type 1 Neridronate - Complex Regional Pain Syndrome Type I | Phase 3 | Recruiting | Ambros Therapeutics, Inc. | 135 | 2026-10-13 | 2026-10-16 |
| Atomized Intranasal Ketorolac at 30 mg Versus 20 mg for the Treatment of Acute Pain in the Emergency Department 20mg intranasal ketorolac, 30mg Intranasal Ketorolac - Pain, Ketorolac | Phase 3 | Not yet recruiting | Tehran University of Medical Sciences | 100 | 2026-10-10 | 2026-09-16 |
| Effect of S-Ibuprofen Gel on Pain in Acute Soft Tissue Contusions S-Ibuprofen Gel 5%, Vehicle Topical Gel - Acute Pain Due to Trauma | Phase 3 | Recruiting | Aponia Laboratories, Inc. | 240 | 2026-10-08 | 2026-11-12 |
| The Ultrasound-Guided Dextrose Prolotherapy in Ehlers-Danlos Syndrome Patients Dextrose 50% Intravenous Solution, Lidocaine 1% Injectable Solution - Ehlers-Danlos Syndrome, Low Back Pain | Phase 3 | Withdrawn | Tulane University | 2026-10-05 | 2026-10-08 | |
| A Study of Combogesic® 325 in Adolescent Patients With Moderate to Severe Postoperative Pain Associated With Orthopedic Surgery Combogesic® tablets, Acetaminophen 500mg, Placebo - Post Operative Pain, Acute | Phase 3 | Not yet recruiting | AFT Pharmaceuticals, Ltd. | 180 | 2026-10-01 | 2026-07-01 |
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Pain, Postoperative (443) · Chronic Pain (156) · Low Back Pain (134) · Agnosia (124) · Acute Pain (110) · Headache (101) · Neuralgia (85) · Osteoarthritis (78) · Neoplasms (67) · Migraine Disorders (63) · Back Pain (58) · Angina, Unstable (43) · Abdominal Pain (42) · Cancer Pain (41)
Pathological Conditions, Signs and Symptoms (1987) · Signs and Symptoms (1986) · Neurologic Manifestations (1981) · Pathologic Processes (629) · Nervous System Diseases (466) · Postoperative Complications (450) · Musculoskeletal Diseases (260) · Neuromuscular Diseases (206) · Joint Diseases (154) · Neurobehavioral Manifestations (140) · Peripheral Nervous System Diseases (138) · Vascular Diseases (138) · Rheumatic Diseases (133) · Cardiovascular Diseases (131)
Acetaminophen (97) · Morphine (87) · Bupivacaine (82) · Saline Solution (74) · Lidocaine (70) · Sodium Chloride (68) · Pregabalin (63) · Ketamine (60) · Ibuprofen (57) · Ropivacaine (54) · Fentanyl (48) · Oxycodone (46) · Dexamethasone (38) · Dexmedetomidine (31) · Tramadol (31)
Pfizer (40) · Assiut University (34) · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (26) · Pfizer's Upjohn has merged with Mylan to form Viatris Inc. (24) · Assistance Publique - Hôpitaux de Paris (22) · Purdue Pharma LP (22) · Bayer (19) · Jazz Pharmaceuticals (18) · Grünenthal GmbH (17) · Cairo University (16) · Eli Lilly and Company (16) · Endo USA Inc., a Keenova Therapeutics Company (15) · Alza Corporation, DE, USA (13) · Hospital General Universitario Elche (12) · Pacira Pharmaceuticals, Inc (12)
United States (792) · Canada (166) · France (153) · Germany (111) · United Kingdom (105) · Spain (92) · Egypt (81) · Poland (78) · Brazil (75) · Italy (70) · Denmark (60) · China (58) · Belgium (52) · Hungary (52) · Netherlands (52)
Andrew Finn, PharmD (6) · Anna Taddio, PhD (5)
PMID 37460782, PMID 23340531, PMID 24985410, PMID 25526232, PMID 29476499, PMID 30936738, PMID 31284771, PMID 31387410, PMID 31482569, PMID 31952501, PMID 32576229, PMID 32621325, PMID 32945631, PMID 33963686, PMID 34264500, PMID 34878624, PMID 35076090, PMID 35978286, PMID 37523477, PMID 17825712, PMID 22900785, PMID 23709304, PMID 24353047, PMID 24916058, PMID 25565885, PMID 27448285, PMID 29492863, PMID 30462830, PMID 30594122, PMID 30737315, PMID 32871021, PMID 33069214, PMID 33143451, PMID 33544305, PMID 33549036, PMID 33950375, PMID 39316284, PMID 39428602, PMID 12424394, PMID 14977340, PMID 17180268, PMID 19546766, PMID 20353434, PMID 20521870, PMID 20920236, PMID 21208106, PMID 21519308, PMID 21521204, PMID 22437221, PMID 22587481
2014 (18), 2009 (15), 2015 (12), 2005 (9), 2008 (8), 2019 (7), 2023 (7), 2017 (6), 2018 (5), 2016 (4), U10CA037429 (4), 2025 (3), U10CA037404 (2), U10CA037420 (2), U10CA037447 (2)