483 completed, 100 unknown, 68 terminated, 38 recruiting. 254 Phase 4, 200 Not applicable, 135 Phase 3, 124 Phase 2, 49 Phase 1.
Follow Morphine: new trials by email Literature Review of Morphine trials Research Report on Morphine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Methadone as an Alternative Treatment for Children Underdoing HSCT PCA plus methadone (Experimental), PCA Alone (SOC) - Leukemia, Aplastic Anemia | Phase 3 | Suspended | University of Texas Southwestern Medical Center | 60 | 2028-01-01 | 2025-10-23 |
| Evaluation of the Efficacy of Sublingual Sufentanil (Prescribed as Rescue Analgesia for Acute Postoperative Pain) on the Quality of Health Recovery After Surgery: a Randomized, Controlled, Multicenter, Open-label Trial Against an Active Comparator (SUBLIME) Sublingual sufentanil 30 µg (one dose per hour, as needed), Morphine sulfate (10 mg every 4 hours as needed) - Postoperative Pain | Phase 4 | Not yet recruiting | University Hospital, Strasbourg, France | 1150 | 2027-01-01 | 2026-06-03 |
| Intraoperative Placement of Vancomycin-impregnated Calcium Sulfate Beads Conjugated With Analgesics to Improve Spine Surgery Outcomes Vancomycin (local, via calcium sulfate beads), Morphine (local, via calcium sulfate beads), Bupivacaine (local, via calcium sulfate beads) - Spine Surgery, Postoperative Pain Management | Phase 2 | Not yet recruiting | Ganesh M. Shankar | 100 | 2027-01-01 | 2026-04-16 |
| Morphine or Ketamine for Analgesia Ketamine hydrochloride, Morphine sulphate - Abdominal Pain, Isolated Extremity Fracture | Phase 3 | Recruiting | Columbia University | 1010 | 2026-10-17 | 2026-10-20 |
| BUprenorphine Versus Morphine for Postcesarean Analgesia (BUMP) buprenorphine, morphine - Cesarean Delivery | Phase 4 | Recruiting | Icahn School of Medicine at Mount Sinai | 180 | 2026-10-07 | 2026-10-16 |
| Adaptive Platform Trial for Pain Management in Sickle Cell Vaso-Occlusive Crisis Group 02 Paracetamol + Morphine + Ketamine, Group 01 Control: Paracetamol + Morphine, Group 03 : Paracetamol + Morphine + Nefopam - Sickle Cell Disease, Vaso-occlusive Crisis | Phase 4 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 400 | 2026-10-01 | 2026-09-18 |
| An Artificial Intelligence Driven Approach to Optimize Patient Selection for a Transitional Pain Service TPS-Select, Pharmacologic Pain Management, Interventional Pain Procedures - Postsurgical Pain Management, Postsurgical Pain, Chronic | Phase 3 | Not yet recruiting | University of California, San Francisco | 474 | 2026-10-01 | 2026-10-09 |
| A 2x2 Factorial, Randomized, Open-label Trial to Evaluate Neuromodulators and Cough Control Therapy in Patients With Refractory or Unexplained Chronic Cough Morphine Sulphate, Morphine Sulphate + Cough Control Therapy, Pregabalin - Cough, Refractory Chronic Cough | Phase 4 | Not yet recruiting | McMaster University | 124 | 2026-09-30 | 2026-10-19 |
| How Does the Opioid System Shape Stress and Social Behaviour in Men and Women and What Role Does Childhood Unpredictability Play? Morphine, Placebo - Stress, Early Life Stress | Not applicable | Recruiting | Sara L. Kroll | 72 | 2026-09-24 | 2026-09-28 |
| Efficacy and Safety of Intravenous Lidocaine Versus Placebo in Patients Receiving Morphine-rachi Analgesia rachi morphine anesthesia, laparotomy, Lidocaine IV - Digestive System Disease, Surgery | Phase 3 | Not yet recruiting | GCS Ramsay Santé pour l'Enseignement et la Recherche | 76 | 2026-09-01 | 2026-08-25 |
| Subcutaneous Methadone for Cesarean Analgesia: a Non Inferiority Study Using QoR-10 Methadone 0.15 mg/kg, morphine - Cesarean Section Pain | Not applicable | Not yet recruiting | Clinica Alemana de Santiago | 128 | 2026-08-21 | 2026-08-20 |
| Use of the Methoxyflurane as Pain-killer in the Prehospital Management of Acute Myocardial Infarction Methoxyflurane, Morphine - STEMI - ST Elevation Myocardial Infarction | Phase 3 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 700 | 2026-06-01 | 2026-03-03 |
| Phase II Clinical Study of the Efficacy and Safety of HSK55718 in the Treatment of Abdominal Postoperative Pain Low dose HSK55718, Medium Dose HSK55718, High dose HSK55718 - Pain After Abdominal Surgery | Phase 2 | Recruiting | Yingyong Zhou,MD,PhD | 200 | 2026-05-23 | 2026-07-21 |
| A Clinical Trial Evaluating the Efficacy and Safety of HSK55718 in Patients for Postoperative Pain Treatment in Abdominal Surgery HSK55718 dose level1, HSK55718 dose level2, HSK55718 dose level 3 - Pain After Surgery | Phase 2 | Recruiting | Haisco Pharmaceutical Group Co., Ltd. | 200 | 2026-05-22 | 2026-05-28 |
| Comparison of Spinal Anesthesia With Intrathecal Morphine Versus PENG Block With or Without Dexamethasone in Hip Arthroplasty Intrathecal Morphine, Pericapsular Nerve Group Block, Dexamethasone - Arthropathy of Hip, Hip Osteoarthritis | Not applicable | Recruiting | Poznan University of Medical Sciences | 90 | 2026-05-07 | 2026-11-05 |
| Analgesic Effect of Parecoxib Versus Morphine in SCD Patients Presenting to the Emergency Department Parecoxib, Morphine - Sickle-Cell Disease with Crisis | Phase 3 | Not yet recruiting | Oman Medical Speciality Board | 226 | 2026-05-01 | 2025-03-20 |
| Anrikefon-based Patient-controlled Intravenous Analgesia Following Laparoscopic Surgery High-dose anrikefon, Medium-dose anrikefon, Low-dose anrikefon - Laparoscopic Surgery, Visceral Pain, Postoperative | Phase 4 | Recruiting | Peking University First Hospital | 140 | 2026-04-14 | 2026-10-30 |
| Tegileridine for Postoperative Pain After Adolescent Scoliosis Surgery Tegileridine, morphine - Scoliosis; Adolescence, Pain After Surgery | Phase 4 | Recruiting | Peking Union Medical College Hospital | 171 | 2026-04-08 | 2026-10-13 |
| Optimal Intrathecal Morphine Dose for Better Post Cesarean Section Analgesia 0.5% bupivacaine heavy with fentanyl, 0.5% bupivacaine heavy with fentanyl plus morphine 50 mcg, 0.5% bupivacaine heavy with fentanyl plus morphine100 mcg - Post Cesarean Section Pain | Phase 4 | Not yet recruiting | Tribhuvan University Teaching Hospital, Institute Of Medicine. | 180 | 2026-04-01 | 2026-05-01 |
| A Clinical Trial Evaluating the Efficacy and Safety of HSK55718 in Patients for Postoperative Pain Treatment in Orthopedic Surgery HSK55718 dose level 1, HSK55718 dose level 2, HSK55718 dose level 3 - Pain After Surgery | Phase 2 | Not yet recruiting | Haisco Pharmaceutical Group Co., Ltd. | 200 | 2026-04-01 | 2026-04-27 |
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Pain, Postoperative (173) · Pain (140) · Agnosia (109) · Acute Pain (40) · Chronic Pain (29) · Neoplasms (19) · Opioid-Related Disorders (19) · Cancer Pain (16) · Emergencies (16) · Neonatal Abstinence Syndrome (14) · Osteoarthritis (14) · Renal Colic (13) · Anemia, Sickle Cell (10) · Postoperative Nausea and Vomiting (9) · Pruritus (8)
Assiut University (25) · Mahidol University (8) · Pfizer (8) · Actavis Inc. (7) · Cairo University (7) · Pacira Pharmaceuticals, Inc (7) · Istanbul University (6) · M.D. Anderson Cancer Center (6) · Medical College of Wisconsin (6) · QRxPharma Inc. (6) · Antonios Likourezos (5) · Assistance Publique - Hôpitaux de Paris (5) · Collegium Medicum w Bydgoszczy (5) · Columbia University (5) · Copenhagen University Hospital, Rigshospitalet (5)
United States (239) · Egypt (56) · Canada (47) · China (32) · France (31) · Turkey (Türkiye) (29) · Denmark (20) · Italy (17) · Poland (15) · Israel (14) · Netherlands (13) · Sweden (11) · Thailand (11) · South Korea (9) · United Kingdom (9)
Patricia T. Richards, MD, Ph.D. (4) · Sergey Motov, MD (4) · Daniel V. Freeland, DO (3) · Franck Skobieranda, MD (3) · Guido Fanelli, MD (3) · Andrea Cornini, MD (2) · Andrew Herring, MD (2) · Andrew K Chang, MD (2) · Bozidar Duplancic (2) · Dan Marinescu, MD (2) · David C Currow, MD, PhD (2) · Dong-Xin Wang, MD, PhD (2) · Eduardo Bruera, MD (2)
PMID 34231914, PMID 33238043, PMID 25018650, PMID 12411815, PMID 19214642, PMID 21519308, PMID 22506940, PMID 23360885, PMID 24106351, PMID 24238862, PMID 25774458, PMID 26695349, PMID 27782769, PMID 31162798, PMID 10150800, PMID 1015603, PMID 10353500, PMID 10422923, PMID 10598635, PMID 10690153, PMID 10740539, PMID 11050519, PMID 11133630, PMID 11331167, PMID 11331334, PMID 11374619, PMID 11402405, PMID 11472277, PMID 11929206, PMID 11940739, PMID 12006425, PMID 12160502, PMID 12298311, PMID 12548273, PMID 12560416, PMID 12761013, PMID 12770663, PMID 12934209, PMID 12961065, PMID 14117648, PMID 1421731, PMID 14622770, PMID 14667752, PMID 14690106, PMID 14999112, PMID 15059702, PMID 15471273, PMID 15513495, PMID 15566593, PMID 15983470
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