Pain: Clinical Trials

15876 completed, 4010 unknown, 2286 recruiting, 1455 not yet recruiting. 14878 Not applicable, 2628 Phase 4, 2047 Phase 2, 1988 Phase 3, 910 Phase 1.

By phase and status

Phase	Trials	Status
Not applicable	14878	Completed 8786, Unknown 2236, Recruiting 1478, Not yet recruiting 1024, Terminated 469, Active not recruiting 374, Withdrawn 299, Enrolling by invitation 169, Suspended 43
Phase 4	2628	Completed 1574, Unknown 403, Terminated 240, Recruiting 141, Withdrawn 126, Not yet recruiting 93, Active not recruiting 33, Enrolling by invitation 11, Suspended 7
Phase 2	2047	Completed 1278, Unknown 251, Terminated 196, Recruiting 120, Withdrawn 102, Not yet recruiting 54, Active not recruiting 27, Suspended 10, Enrolling by invitation 9
Phase 3	1988	Completed 1313, Unknown 252, Terminated 170, Recruiting 81, Withdrawn 81, Not yet recruiting 46, Active not recruiting 26, Enrolling by invitation 10, Suspended 9
Phase 1	910	Completed 637, Unknown 96, Recruiting 48, Terminated 46, Withdrawn 28, Not yet recruiting 26, Active not recruiting 20, Enrolling by invitation 5, Suspended 4
Early Phase 1	222	Completed 116, Unknown 31, Recruiting 28, Terminated 13, Withdrawn 13, Not yet recruiting 10, Active not recruiting 8, Suspended 2, Enrolling by invitation 1

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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Ketamine and Midazolam Infusions for CRPS: Feasibility Study Ketamine, Midazolam, Normal Saline - Complex Regional Pain Syndromes	Phase 2	Withdrawn	Stanford University		2099-01-01	2024-11-22
Acupuncture in Infantile Colic - A Randomised Trial. Acupuncture - Infant, Newborn, Diseases, Colic, Infantile	Not applicable	Withdrawn	Region Skane		2050-12-01	2026-02-17
Personalizing Veteran Pain Care: Adapting Coaching Interventions to Support Maintenance of Self-Care Coaching - Chronic Pain, Musculoskeletal Pain	Phase 1	Not yet recruiting	VA Office of Research and Development	30	2029-01-01	2026-03-06
Postoperative Analgesia Using Ganglion Impar Block After Anal Surgery Ganglion impar block with Bupivacaine., Ganglion impar block with normal saline - Postoperative Pain	Not applicable	Not yet recruiting	University of Alexandria	60	2028-07-01	2025-04-03
Collaborative Care Intervention for Cancer Patients and Their Family Caregivers -LITE Stepped collaborative care intervention, Enhanced Usual Care - Cancer, Depression	Not applicable	Not yet recruiting	University of Pittsburgh	40	2028-01-14	2026-04-09
Methadone as an Alternative Treatment for Children Underdoing HSCT PCA plus methadone (Experimental), PCA Alone (SOC) - Leukemia, Aplastic Anemia	Phase 3	Suspended	University of Texas Southwestern Medical Center	60	2028-01-01	2025-10-23
Effectiveness of Non-surgical Management in Rotator Cuff Calcific Tendinopathy (THE EFFECT TRIAL) Exercise Therapy, Extracorporeal Shockwave Therapy, Ultrasound-Guided Percutaneous Irrigation - Rotator Cuff Tendinosis, Rotator Cuff Injuries	Not applicable	Suspended	University of Valencia	116	2028-01-01	2026-06-26
Perioperative Esketamine Safety and Efficacy in Reducing Postoperative ENDometriosis PAIN (the ENDPAIN Trial): a Randomized Controlled Trial. Esketamine, Placebo - Endometriosis	Phase 4	Not yet recruiting	Region Skane	1000	2028-01-01	2026-10-19
Psilocybin After Trauma Surgery for Pain Psilocybin (Usona Institute), Postoperative analgesia - Pain Management, Postoperative Pain	Phase 1	Not yet recruiting	Trent Emerick	70	2027-12-31	2026-08-06
Effect of Music Therapy on Postoperative Health Outcomes Music therapy - Music Therapy	Not applicable	Not yet recruiting	Cairo University	60	2027-12-01	2025-08-14
VibraCool Device to Reduce Pain and Opioid Use After Anterior Cruciate Ligament Reconstruction (ACLR) VibraCool mechanical stimulation and neuromodulatory therapeutic device, Cryocompression (Game Ready, Bregs) device, Standard ice packs - ACL, Opioid Use	Not applicable	Not yet recruiting	Columbia University	130	2027-11-01	2026-10-28
Self-administered Acupressure in Patients With Sickle Cell Disease Verum Acupressure (using AcuWand), Sham Acupressure (using AcuWand) - Sickle Cell Disease (SCD)	Not applicable	Not yet recruiting	University of Cincinnati	300	2027-10-01	2026-10-15
Behavior Therapy vs Education for Persistent Headache After Mild TBI Headache reprocessing, Headache education - Post-Traumatic Headache	Not applicable	Not yet recruiting	VA Office of Research and Development	60	2027-10-01	2025-12-26
Does MI Have a Therapeutic Role in Arthroscopic Rotator Cuff Repair? Motor Imagery, Physical Therapy - Rotator Cuff Tears, Motor Imagery	Not applicable	Suspended	Alanya Alaaddin Keykubat University	36	2027-09-15	2026-10-28
Preventing the Transition From Acute to Persistent Disabling Low Back Pain Through Cognitive Functional Therapy Cognitive Functional Therapy (CFT), Usual Care - Acute Low Back Pain (Low Back Pain for Less Than 3 Months)	Not applicable	Not yet recruiting	University of Oulu	461	2027-09-01	2026-10-16
DockTales for Chronic Pain DockTales, REDCap monitoring - Chronic Pain, Chronic Pain Syndrome	Not applicable	Not yet recruiting	University of Maryland, Baltimore	60	2027-07-17	2026-09-03
Efficacy of Different Disinfection Technologies in Molar Non-Surgical Retreatment GentleWave System, Conventional rotary instrumentation with passive ultrasonic irrigation - Apical Periodontitis	Not applicable	Not yet recruiting	University of Alabama at Birmingham	60	2027-07-01	2026-04-08
Mindfulness Therapy for Chronic Pain After Intimate Partner Violence Mindfulness-Based Cognitive Therapy for Trauma-Informed Pain (MBCT-TIP), Health Enhancement Program (HEP) - Chronic Pain	Not applicable	Not yet recruiting	Brigham and Women's Hospital	58	2027-07-01	2026-07-14
Efficacy and Safety of GNSC-001 Intra-articular Injection for Knee Osteoarthritis Gene Therapy GNSC-001, Placebo - Knee Arthritis Osteoarthritis, Knee Arthritis, Osteoarthritis	Phase 2 / Phase 3	Not yet recruiting	Genascence Corporation	240	2027-07-01	2026-09-21
VR-PAT and fNIRS to Identify CNS Biomarkers of Pain VR-PAT - Acute Pain, Pediatric ALL	Not applicable	Not yet recruiting	Nationwide Children's Hospital	4	2027-07-01	2026-09-09

Showing 20 of 26552. Sign in to see all of them.

Narrower conditions

Pain, Postoperative (5431)  ·  Chronic Pain (3112)  ·  Low Back Pain (2359)  ·  Agnosia (1445)  ·  Anxiety Disorders (1191)  ·  Neck Pain (1175)  ·  Acute Pain (1058)  ·  Neuralgia (981)  ·  Headache (743)  ·  Back Pain (699)  ·  Shoulder Pain (685)  ·  Motor Activity (604)  ·  Musculoskeletal Pain (471)  ·  Fibromyalgia (453)

Broader conditions

Pathological Conditions, Signs and Symptoms (26546)  ·  Neurologic Manifestations (26521)  ·  Signs and Symptoms (26518)  ·  Pathologic Processes (7534)  ·  Nervous System Diseases (5653)  ·  Postoperative Complications (5631)  ·  Musculoskeletal Diseases (3757)  ·  Neuromuscular Diseases (2410)  ·  Mental Disorders (2297)  ·  Back Pain (2256)  ·  Joint Diseases (2047)  ·  Behavior (1764)  ·  Neurobehavioral Manifestations (1753)  ·  Peripheral Nervous System Diseases (1642)

Interventions

Bupivacaine (675)  ·  Acetaminophen (491)  ·  Lidocaine (464)  ·  Sodium Chloride (464)  ·  Saline Solution (411)  ·  Exercise (394)  ·  Ropivacaine (392)  ·  Morphine (389)  ·  Ketamine (276)  ·  Fentanyl (273)  ·  Ibuprofen (273)  ·  Dexamethasone (260)  ·  Control Groups (233)  ·  Pregabalin (226)  ·  Dexmedetomidine (219)

Sponsors

Riphah International University (460)  ·  Cairo University (347)  ·  Assiut University (196)  ·  Hacettepe University (140)  ·  Stanford University (136)  ·  VA Office of Research and Development (126)  ·  Ain Shams University (122)  ·  Duke University (117)  ·  Pfizer (110)  ·  Istanbul University - Cerrahpasa (108)  ·  Mayo Clinic (108)  ·  Northwestern University (105)  ·  University Hospital, Clermont-Ferrand (103)  ·  Ataturk University (102)  ·  Wake Forest University Health Sciences (98)

Countries

United States (7202)  ·  Turkey (Türkiye) (3879)  ·  Canada (1146)  ·  Egypt (1113)  ·  Spain (1040)  ·  France (1039)  ·  Pakistan (906)  ·  China (765)  ·  Denmark (731)  ·  United Kingdom (684)  ·  Italy (618)  ·  Brazil (560)  ·  Germany (532)  ·  Belgium (453)  ·  South Korea (443)

Top investigators

Jose CA Carvalho, MD (19)  ·  Muhammad Kashif (16)  ·  Francisco M Kovacs, MD, PhD (15)

Results publications

PMID 34854473, PMID 32871021, PMID 27501016, PMID 22900785, PMID 30063657, PMID 36729473, PMID 17106618, PMID 22588748, PMID 24482784, PMID 25794202, PMID 26225500, PMID 27745712, PMID 30737315, PMID 37460782, PMID 37523477, PMID 40590244, PMID 16698416, PMID 18443635, PMID 18448749, PMID 18804003, PMID 19903919, PMID 20961685, PMID 22536282, PMID 22892729, PMID 23121612, PMID 23340531, PMID 23411725, PMID 23762142, PMID 24985410, PMID 25526232, PMID 2748771, PMID 27777598, PMID 29476499, PMID 30936738, PMID 31284771, PMID 31387410, PMID 31482569, PMID 31952501, PMID 32576229, PMID 32621325, PMID 32945631, PMID 33078388, PMID 33238043, PMID 33963686, PMID 34264500, PMID 34878624, PMID 35076090, PMID 35397973, PMID 35641327, PMID 35978286

NIH funding

2019 (53), 2014 (47), 2023 (42), 2009 (35), 2017 (33), 2015 (29), 2016 (29), 2008 (28), 2018 (26), 2025 (23), 2005 (15), P30AG022845 (12), P30CA015083 (8), P01NS119159 (6), R35GM146822 (6)