259 completed, 39 unknown, 29 terminated, 25 recruiting. 132 Phase 4, 69 Phase 1, 67 Phase 3, 48 Not applicable, 48 Phase 2.
Follow Oxycodone: new trials by email Literature Review of Oxycodone trials Research Report on Oxycodone
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| 3D1002 in Combination With Oxycodone Hydrochloride Sustained-release Tablets in Patients With Moderate to Severe Cancer Pain 3D1002 (50 mg)(Phase IIa), 3D1002 (100 mg)(Phase IIa), 3D1002 (150 mg)(Phase IIa) - Cancer Pain | Phase 2 | Not yet recruiting | 3D Medicines | 177 | 2026-12-01 | 2026-03-11 |
| Suzetrigine for Opioid-Sparing Postoperative Analgesia Following Transvaginal Pelvic Reconstructive Surgery Suzetrigine, Opioid Analgesics (Tramadol or Oxycodone), Scheduled Acetaminophen and Ibuprofen - Pelvic Organ Prolapse (POP), Stress Urinary Incontinence (SUI) | Phase 4 | Not yet recruiting | University of California, Los Angeles | 120 | 2026-11-01 | 2026-09-15 |
| Suzetrigine in Tonsillectomy for Opioid-sparing Pain Management Suzetrigine, Acetaminophen, oxycodone - Tonsillectomy, Pharyngoplasty | Phase 4 | Not yet recruiting | Stanford University | 58 | 2026-11-01 | 2026-09-16 |
| Examining Analgesic Synergy and Efficacy in Trauma Care Buprenorphine, Oxycodone - Opioid Use Disorder | Phase 4 | Not yet recruiting | Wake Forest University Health Sciences | 282 | 2026-10-01 | 2026-08-28 |
| An Artificial Intelligence Driven Approach to Optimize Patient Selection for a Transitional Pain Service TPS-Select, Pharmacologic Pain Management, Interventional Pain Procedures - Postsurgical Pain Management, Postsurgical Pain, Chronic | Phase 3 | Not yet recruiting | University of California, San Francisco | 474 | 2026-10-01 | 2026-10-09 |
| Post-Vasectomy Pain Study Acetaminophen, ibuprofen, oxycodone - Vasectomy, NSAIDs | Phase 1 | Recruiting | Columbia University | 200 | 2026-09-10 | 2026-09-24 |
| Evaluation of the Safety and Effects of Psychoactive Substances in People With Past Opioid Use Placebo, Oxycodone HCl, Kratom 8g - Opioid Use, Substance Use Disorders | Phase 1 | Recruiting | Christopher D. Verrico | 72 | 2026-09-01 | 2026-09-28 |
| Abuse Potential of Gabapentin Taken Orally Concomitantly With Oxycodone Hydrochloride in Healthy, Non-Drug-Dependent, Recreational Opioid Users Placebo, Oxycodone 20mg, gabapentin 600 mg - Healthy | Phase 4 | Recruiting | Viatris Inc. | 60 | 2026-08-03 | 2026-10-15 |
| Pilot Randomized Control Trial Comparing Oral Ketamine and Oral Oxycodone for Pain Control in Emergency Department Patients oral ketamine, oxycodone - Pain Management | Phase 2 / Phase 3 | Not yet recruiting | Albany Medical College | 60 | 2026-06-24 | 2026-06-26 |
| Effect of Liposomal Bupivacaine TAPB Combined With Oxycodone PCIA on Postoperative Gastrointestinal Recovery in Patients Undergoing Major Abdominal Surgery ropivacaine hydrochloride, Liposomal bupivacaine (LB), Sufentanil citrate - Postoperative Pain, Postoperative Ileus | Not applicable | Recruiting | Tianjin First Central Hospital | 132 | 2026-06-16 | 2026-06-25 |
| Opioid-Sparing Joint Replacement Placebo, Oxycodone 5 mg, Multimodal Non-Opioid Analgesia - Pain Management, Opioid Consumption | Phase 3 | Recruiting | Emory University | 120 | 2026-03-19 | 2026-04-17 |
| Comparison of the Efficacy and Safety of Intravenous Buprenorphine Administered Via PCA System Versus Oxycodone in the Management of Postoperative Pain After Video-Assisted Thoracoscopic Surgery Group B (Buprenorphine), Group O (Oxycodone) - Acute Postoperative Pain, Chronic Postoperative Pain | Phase 4 | Recruiting | Medical University of Silesia | 200 | 2026-03-18 | 2026-09-25 |
| Comparison of Suzetrigine and Oxycodone for Postoperative Pain After Primary Total Knee Arthroplasty oral suzetrigine, oral Oxycodone - Osteoarthritis (OA) of the Knee | Phase 4 | Enrolling by invitation | University of Louisville | 140 | 2026-02-09 | 2026-05-04 |
| Efficacy And Safety Of Tramadol And Oxycodone Versus Oxycodone Monotherapy For Pain Control After Primary Total Knee And Total Hip Arthroplasty Oxycodone, Tramadol and Oxycodone - Post Operative Pain | Phase 4 | Enrolling by invitation | Mayo Clinic | 560 | 2026-02-02 | 2026-03-18 |
| Non-Narcotic Pain Control After ACL Reconstruction dispense of study drug, Ketorolac - ACL - Anterior Cruciate Ligament Rupture, ACL Injuries | Phase 2 | Active not recruiting | The Cleveland Clinic | 30 | 2025-07-15 | 2026-08-24 |
| Analgesic Effect and Safety of Oliceridine and Oxycodone in Vitrectomy Oliceridine, Oxycodone - Vitrectomy | Not applicable | Not yet recruiting | Henan Provincial People's Hospital | 120 | 2025-07-01 | 2025-07-31 |
| A Study on Oral and Intranasal Forms of Oxycodone in Healthy Volunteers Using Pharmacokinetic Modeling Oxycodone IN, oxycodone - Physiologically Based Pharmacokinetic, Healthy Volunteers | Phase 1 | Completed | Parc de Salut Mar | 8 | 2025-06-12 | 2026-05-06 |
| Multimodal Pain Management After Wide Awake Local Anesthesia No Tourniquet Orthopedic Hand Surgery: A Randomized Control Trial Oxycodone 5mg taken first, Acetaminophen, Naproxen Tablets, 500 mg - Pain Management | Not applicable | Not yet recruiting | University of Puerto Rico | 100 | 2025-05-01 | 2025-04-08 |
| Opioid Drug Interaction Study Alprazolam, Oxycodone, Placebo - Drug Interactions, Drug Kinetics | Phase 1 / Phase 2 | Recruiting | Shanna Babalonis, PhD | 25 | 2025-04-01 | 2026-05-14 |
| Real World Study of Oxycodone/Naloxone Sustained-Release Tablets (Mimeixin) for Patients With Severe Cancer Pain Oxycodone Hydrochloride and Naloxone Hydrochloride Sustained-release Tablets - Opioid-Induced Constipation, Pain Cancer | Phase 4 | Not yet recruiting | Henan Cancer Hospital | 203 | 2025-04-01 | 2025-03-27 |
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Pain (84) · Pain, Postoperative (77) · Agnosia (41) · Opioid-Related Disorders (24) · Chronic Pain (20) · Acute Pain (16) · Cancer Pain (14) · Neoplasms (13) · Osteoarthritis (11) · Constipation (10) · Low Back Pain (10) · Substance-Related Disorders (8) · Back Pain (5) · Neuralgia (5) · Osteoarthritis, Knee (5)
Pfizer (13) · Purdue Pharma LP (13) · Pain Therapeutics (12) · Mundipharma (China) Pharmaceutical Co. Ltd (9) · Kuopio University Hospital (6) · Mundipharma Korea Ltd (6) · QRxPharma Inc. (6) · Mallinckrodt (5) · Mayo Clinic (5) · Mundipharma Research GmbH & Co KG (5) · New York State Psychiatric Institute (5) · Rothman Institute Orthopaedics (5) · Ensysce Biosciences (4) · M.D. Anderson Cancer Center (4) · Medical University of Lublin (4)
United States (221) · China (23) · Canada (13) · South Korea (13) · Finland (12) · Poland (10) · United Kingdom (10) · Italy (9) · Norway (8) · Denmark (7) · Netherlands (7) · Belgium (6) · Germany (6) · Sweden (6) · Israel (5)
Merja Kokki, MD, PhD (4) · Patricia T. Richards, MD, Ph.D. (4) · Herbert Neuman, MD (3) · Ajay D Wasan, MD, MSc (2) · Anurag Singh (2) · Chi Hornik, PharmD (2) · Christopher R. Longnecker,, M.D. (2) · David H Chi, MD (2) · Doo-Yeoun Cho, MD (2) · Erol Onel (2) · Eva-Corina Caragounis, MD (2) · Hans Granhed, MD PhD (2)
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