1280 completed, 250 unknown, 196 terminated, 125 recruiting. 2050 Phase 2, 309 Phase 3, 244 Phase 1.
Follow Pain: new trials by email Literature Review of Pain trials Research Report on Pain
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Ketamine and Midazolam Infusions for CRPS: Feasibility Study Ketamine, Midazolam, Normal Saline - Complex Regional Pain Syndromes | Phase 2 | Withdrawn | Stanford University | 2099-01-01 | 2024-11-22 | |
| Efficacy and Safety of GNSC-001 Intra-articular Injection for Knee Osteoarthritis Gene Therapy GNSC-001, Placebo - Knee Arthritis Osteoarthritis, Knee Arthritis, Osteoarthritis | Phase 2 / Phase 3 | Not yet recruiting | Genascence Corporation | 240 | 2027-07-01 | 2026-09-21 |
| Safety and Efficacy Study on AFA-281 for the Treatment of Low Back Pain AFA-281 - Lumbosacral Radiculopathy | Phase 2 | Not yet recruiting | Afasci Inc | 408 | 2027-04-01 | 2025-06-26 |
| Duloxetine and aeRobic Exercise to Improve Function in VEterans With Knee Osteoarthritis (DRIVE) Exercise, Duloxetine, Placebo - Knee Osteoarthritis, Pain | Phase 2 | Not yet recruiting | VA Office of Research and Development | 102 | 2027-03-01 | 2026-06-16 |
| Semaglutide for Low Back Pain Semaglutide (administered by PDS290 pen-injector), Placebo (administered by PDS290 pen-injector) - Lower Back Pain, Obesity (BMI>30) | Phase 2 | Not yet recruiting | Washington University School of Medicine | 250 | 2027-02-01 | 2026-07-28 |
| Impact of the Antihistamine Desloratadine on the Quality of Life and Dysmenorrhea in Patients With Endometriosis Desloratadine, Placebo - Endometriosis, Endometriosis (Diagnosis) | Phase 2 | Not yet recruiting | Medical University of Vienna | 60 | 2027-02-01 | 2026-09-18 |
| PRECISION-E2: Teverelix in Women With Endometriosis - Pharmacodynamics, Safety and Precision Medicine Correlates Teverelix DP, Teverelix DP Placebo - Endometriosis Pelvic, Endometriosis Ovaries | Phase 2 | Not yet recruiting | Antev Ltd. | 84 | 2027-02-01 | 2026-11-03 |
| Regenerative Medicine for Joint Hypermobility and Instability Dextrose 20% Prolotherapy, Autologous Platelet-Rich Plasma, Doxycycline Hyclate Injectable (Investigational) - Ehlers-Danlos Syndrome Hypermobility Type (hEDS), Ehlers-Danlos Syndrome (EDS) | Phase 1 / Phase 2 | Not yet recruiting | Manhattan Pain Medicine, PLLC | 100 | 2027-01-15 | 2026-10-06 |
| Dexmedetomidine for Invasive Ventilation In the NEOnate Dexmedetomidine Injectable Solution, Glucose 5% Injectable Solution - Invasive Ventilation, Infant Pain | Phase 2 / Phase 3 | Not yet recruiting | Centre Hospitalier Intercommunal Creteil | 246 | 2027-01-01 | 2026-08-26 |
| Safety of F14 Following Total Knee Replacement F14 (sustained release celecoxib) - Analgesia | Phase 2 / Phase 3 | Suspended | Arthritis Innovation Corporation | 100 | 2027-01-01 | 2026-06-05 |
| CBD Supplementation in Brazilian Jiu-Jitsu Athletes CBD Isolate 100mg BID, Placebo - Pro and Anti Inflamatory Cytokines, Pain | Phase 2 / Phase 3 | Not yet recruiting | Associação Pan-Americana Multidisciplinar de Endocanabinologia | 100 | 2027-01-01 | 2026-07-27 |
| Efficacy of Botulinum Toxin Versus Placebo on Pain and Health Related Quality of Life of Patients With Piriformis Muscle Syndrome Botulinum Toxin - A injections, Placebo - Piriformis Muscle Syndrome | Phase 2 | Not yet recruiting | Centre Hospitalier Universitaire de Nīmes | 108 | 2027-01-01 | 2026-10-21 |
| Visual Instillation of Sphenopalatine-block Intervention for ONgoing Migraine Topical solution of 4% lidocaine, Saline 0.9% - Migraine, Facial Pain or Pressure | Phase 2 | Not yet recruiting | Association of Migraine Disorders | 74 | 2027-01-01 | 2026-11-09 |
| Efficacy of Intravenous Oxytocin to Speed Recovery After THA intravenous administration of oxytocin, Placebo - Total Hip Arthroplasty | Phase 2 | Enrolling by invitation | Wake Forest University Health Sciences | 80 | 2026-12-01 | 2026-10-23 |
| Allopregnanolone in Chronic Complex Traumatic Brain Injury Placebo, Allopregnanolone - Traumatic Brain Injury (TBI) | Phase 2 | Not yet recruiting | VA Office of Research and Development | 132 | 2026-12-01 | 2026-10-19 |
| Investigating Novel Interventions for Low Back Pain in US Military Veterans: A Randomized Controlled Adaptive Phase II Trial Pregnenolone, DHEA, Placebo - Chronic Low Back Pain | Phase 2 | Not yet recruiting | VA Office of Research and Development | 108 | 2026-12-01 | 2026-09-08 |
| 3D1002 in Combination With Oxycodone Hydrochloride Sustained-release Tablets in Patients With Moderate to Severe Cancer Pain 3D1002 (50 mg)(Phase IIa), 3D1002 (100 mg)(Phase IIa), 3D1002 (150 mg)(Phase IIa) - Cancer Pain | Phase 2 | Not yet recruiting | 3D Medicines | 177 | 2026-12-01 | 2026-03-11 |
| Ketamine-Assisted Psychotherapy for Treatment-Resistant Depression Ketamine hydrochloride injection - Treatment Resistant Depression (TRD), Chronic Pain | Phase 2 | Not yet recruiting | University of Rochester | 25 | 2026-12-01 | 2026-09-24 |
| MMA Infusion of Lidocaine for Treatment of Headache in Patients With Aneurysmal SAH Lidocaine hydrochloride, Isotonic saline - Headaches Associated With Subarachnoid Hemorrhage (SAH) | Phase 2 | Not yet recruiting | Copenhagen University Hospital, Rigshospitalet | 90 | 2026-12-01 | 2026-09-11 |
| Periganglionic Resiniferatoxin for the Treatment of Intractable Pain Due to Cancer-induced Bone Pain Resiniferatoxin - Intractable Pain, Palliative Care | Phase 1 / Phase 2 | Not yet recruiting | National Institute of Neurological Disorders and Stroke (NINDS) | 30 | 2026-11-27 | 2026-10-29 |
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Pain, Postoperative (398) · Chronic Pain (187) · Neuralgia (174) · Agnosia (124) · Acute Pain (111) · Low Back Pain (110) · Headache (77) · Osteoarthritis (69) · Neuralgia, Postherpetic (68) · Angina Pectoris (51) · Migraine Disorders (51) · Neoplasms (51) · Osteoarthritis, Knee (51) · Abdominal Pain (47)
Neurologic Manifestations (2050) · Pathological Conditions, Signs and Symptoms (2050) · Signs and Symptoms (2049) · Nervous System Diseases (611) · Pathologic Processes (579) · Postoperative Complications (406) · Neuromuscular Diseases (344) · Musculoskeletal Diseases (283) · Peripheral Nervous System Diseases (257) · Joint Diseases (162) · Neurobehavioral Manifestations (140) · Mental Disorders (134) · Rheumatic Diseases (133) · Cardiovascular Diseases (131)
Bupivacaine (98) · Lidocaine (70) · Saline Solution (69) · Morphine (67) · Acetaminophen (58) · Sodium Chloride (56) · Ketamine (43) · Pregabalin (39) · Dexmedetomidine (37) · Ibuprofen (36) · Ropivacaine (31) · Fentanyl (30) · Dexamethasone (27) · Dronabinol (23) · Botulinum Toxins, Type A (22)
Assiut University (49) · Pfizer (26) · Wake Forest University Health Sciences (19) · Mayo Clinic (17) · National Institute of Dental and Craniofacial Research (NIDCR) (17) · Pacira Pharmaceuticals, Inc (17) · University Hospital, Clermont-Ferrand (17) · Cairo University (16) · Montefiore Medical Center (14) · University of Florida (13) · AstraZeneca (12) · GlaxoSmithKline (12) · Johns Hopkins University (12) · VA Office of Research and Development (12) · Heron Therapeutics (11)
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David Prior (6) · Hala S Abdel-Ghaffar, MD (5) · James C Eisenach, MD (5) · James C. Eisenach, M.D. (5) · Adeel Riaz, MD (4) · Bror Jonzon (4)
PMID 22900785, PMID 36729473, PMID 37523477, PMID 17825712, PMID 17877825, PMID 21079055, PMID 22212857, PMID 22510183, PMID 22792007, PMID 22795280, PMID 26112278, PMID 26554876, PMID 27720917, PMID 27747583, PMID 27893109, PMID 28159728, PMID 30737315, PMID 32871021, PMID 33675631, PMID 34532852, PMID 37530822, PMID 10353500, PMID 10506634, PMID 10613619, PMID 10772585, PMID 11027905, PMID 11145807, PMID 11323325, PMID 11387363, PMID 11402097, PMID 11554951, PMID 11576800, PMID 11853818, PMID 12145072, PMID 12148679, PMID 12221344, PMID 12384756, PMID 12779107, PMID 12807853, PMID 12873949, PMID 12897484, PMID 12907905, PMID 1349061, PMID 14665993, PMID 14701781, PMID 15030944, PMID 15115710, PMID 1517644, PMID 15230906, PMID 15234492
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