217 completed, 19 unknown, 17 terminated, 10 withdrawn. 66 Phase 1, 66 Phase 3, 66 Phase 4, 53 Phase 2, 34 Not applicable.
Follow Naproxen: new trials by email Literature Review of Naproxen trials Research Report on Naproxen
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Human Experimental Models of Pain (HEMP) Placebo, Naproxen, Pregabalin - Acute Pain | Not applicable | Not yet recruiting | National Center for Complementary and Integrative Health (NCCIH) | 25 | 2026-11-04 | 2026-10-30 |
| Naproxen Versus Placebo as Adjunct Treatment of Cellulitis enteric-coated naproxen, Cephalexin Tablets, Placebo - Cellulitis, Skin Disease, Infectious | Phase 3 | Not yet recruiting | Ottawa Hospital Research Institute | 884 | 2026-11-01 | 2026-10-20 |
| Safety and Tolerability of Metformin and Naproxen for Cancer Prevention in Fanconi Anemia Metformin, Naproxen Sodium - Fanconi Anemia, Head and Neck Cancer | Phase 1 | Recruiting | Rockefeller University | 80 | 2026-10-14 | 2026-10-28 |
| An Artificial Intelligence Driven Approach to Optimize Patient Selection for a Transitional Pain Service TPS-Select, Pharmacologic Pain Management, Interventional Pain Procedures - Postsurgical Pain Management, Postsurgical Pain, Chronic | Phase 3 | Not yet recruiting | University of California, San Francisco | 474 | 2026-10-01 | 2026-10-09 |
| Effectiveness of Opioid vs Pregabalin Plus Naproxen Sodium in Pain Management of Oral Cancer Patients Tramadol, Pregabalin + Naproxen Sodium - Oral Cancer, Oral Cavity Cancer | Not applicable | Enrolling by invitation | Mayo Hospital Lahore | 98 | 2026-02-01 | 2026-05-26 |
| A Study to Evaluate the Pharmacokinetics and Food-effect of IN-M00002 Tablet in Healthy Adult Volunteers Tegoprazan, Naproxen, IN-M00002 - Healthy Volunteer | Phase 1 | Not yet recruiting | HK inno.N Corporation | 74 | 2025-12-27 | 2025-12-11 |
| G-CSF-Related Bone Pain and Supportive Care Strategies in Patients With Solid Tumors Filgrastim (G-CSF), Naproxen, Loratadine - Solid Tumors, Chemotherapy-induced Neutropenia | Completed | Ankara Etlik City Hospital | 190 | 2025-09-27 | 2026-10-09 | |
| Multimodal Pain Management After Wide Awake Local Anesthesia No Tourniquet Orthopedic Hand Surgery: A Randomized Control Trial Oxycodone 5mg taken first, Acetaminophen, Naproxen Tablets, 500 mg - Pain Management | Not applicable | Not yet recruiting | University of Puerto Rico | 100 | 2025-05-01 | 2025-04-08 |
| Use of the Combination of Sumatriptan and Naproxen in the Acute Treatment of Migraine: Real World Evidence Study combination of sumatriptan 85 mg and naproxen 500 mg - Migraine | Not yet recruiting | IRCCS San Raffaele Roma | 300 | 2025-04-10 | 2025-03-11 | |
| NSAID Use for Treating Dysmenorrhea and Preventing Chronic Pelvic Pain (NSAID HEAL) Naproxen Sodium 550mg, Placebo, Extended Release Acetaminophen (650 mg) - Dysmenorrhea, Chronic Pelvic Pain | Phase 4 | Recruiting | Endeavor Health | 600 | 2025-04-07 | 2025-08-07 |
| Non Steroidal Anti-inflammatory Drugs in the Prevention of Bone Pain Flares After Palliative Radiotherapy Naproxen (Proxen S), Placebo, Esomeprazole 20mg once daily - Bone Pain Flare, Bone Metastasis | Phase 2 | Not yet recruiting | American University of Beirut Medical Center | 385 | 2025-04-01 | 2025-04-04 |
| Comparing Trypsin-Chymotrypsin and Naproxen Sodium for Post-endodontic Treatment Pain Trypsin-Chymotrypsin, Naproxen Sodium 550mg - Effect of Drug | Phase 4 | Recruiting | Dow University of Health Sciences | 100 | 2024-08-16 | 2024-11-04 |
| Reducing Opioid Use After Upper Extremity Surgery: Testing Lower Prescriptions and Pill Quantity Naproxen, Acetaminophen, oxycodone - Opioid Abuse (Disorder), Opioid Analgesia | Phase 4 | Enrolling by invitation | AdventHealth | 300 | 2024-08-01 | 2026-10-08 |
| A Study to Learn About Whether BAYH006689 Causes Skin Irritation When Applied as a Topical Gel in Healthy Participants Naproxen (BAYH006689), Placebo Gel, A solution of 0.9% Saline - Pain, Healthy Volunteers | Phase 1 | Completed | Bayer | 42 | 2024-07-23 | 2024-09-19 |
| NSAIDS Following Elective Lumbar Spine Fusion Ketorolac, Naproxen, Standard Postoperative Pain Management - NSAID (Non-Steroidal Anti-Inflammatory Drug), Lumbar Spine Fusion | Phase 3 | Enrolling by invitation | Rothman Institute Orthopaedics | 428 | 2024-07-08 | 2026-08-04 |
| Pain Control After Lumbar Spine Fusion Naproxen 500 Mg, Ketorolac, OxyCODONE 5 mg Oral Tablet - Spine Fusion, NSAID (Non-Steroidal Anti-Inflammatory Drug) | Phase 4 | Unknown | Rothman Institute Orthopaedics | 428 | 2024-06-28 | 2024-07-03 |
| A Study to Learn About Whether BAY H006689 Causes an Allergic Reaction When Applied as a Topical Gel in Healthy Participants Naproxen (BAYH006689), Placebo Gel, A solution of 0.9% Saline - Pain, Healthy Volunteers | Phase 1 | Completed | Bayer | 236 | 2024-06-05 | 2024-08-14 |
| PK,PD and DDI of Epaminurad and Naproxen in Healthy Volunteers Epaminurad, Naproxen, Epaminurad, Epaminurad placebo - Healthy | Phase 1 | Completed | JW Pharmaceutical | 57 | 2024-06-03 | 2026-04-16 |
| Valacyclovir Monotherapy in Pain Management of Acute Periapical Abscesses After Emergency Chamber Opening Valacyclovir 500 mg, Naproxen Sodium 550mg - Acute Apical Abscess | Phase 4 | Unknown | Dow University of Health Sciences | 82 | 2024-03-27 | 2024-04-10 |
| Non-Steroidal Anti-Inflammatory Drug (NSAID) Response and Central Sensitization of Pain in Women With Dysmenorrhea Sodium Naproxen, Placebo - Dysmenorrhea, Menstrual Pain | Phase 4 | Completed | Mclean Hospital | 70 | 2024-03-25 | 2026-09-22 |
Showing 20 of 283. Sign in to see all of them.
Osteoarthritis (36) · Pain (35) · Migraine Disorders (31) · Osteoarthritis, Knee (23) · Pain, Postoperative (18) · Arthritis (12) · Agnosia (9) · Arthritis, Rheumatoid (9) · Toothache (9) · Dysmenorrhea (8) · Headache (8) · Low Back Pain (8) · Acute Pain (7) · Gout (7) · Stomach Ulcer (7)
Bayer (22) · Pfizer (17) · GlaxoSmithKline (14) · POZEN (10) · AstraZeneca (7) · NicOx (7) · Montefiore Medical Center (6) · Northwestern University (6) · Cady, Roger, M.D. (5) · Dr. Reddy's Laboratories Limited (4) · Merck Sharp & Dohme LLC (4) · Pfizer's Upjohn has merged with Mylan to form Viatris Inc. (4) · Primus Pharmaceuticals (4) · Rothman Institute Orthopaedics (4) · Boehringer Ingelheim (3)
United States (162) · Canada (18) · United Kingdom (12) · South Korea (10) · Brazil (9) · Turkey (Türkiye) (8) · Germany (7) · Sweden (7) · Russia (6) · Denmark (5) · Pakistan (5) · Australia (4) · Belgium (4) · France (4) · India (4)
Roger K Cady, MD (5) · Apkar V Apkarian, PhD (3) · David Taylor (3) · Everardus Orlemans, PhD (3) · Apkar Apkarian, PhD (2) · Bror Jonzon (2) · Dr. Umesh Dhakate, MBBS (2) · Eva-Corina Caragounis, MD (2) · Garret A FitzGerald, MD (2)
PMID 17405970, PMID 19546766, PMID 20353434, PMID 20855373, PMID 21521204, PMID 24579886, PMID 25274899, PMID 25996289, PMID 30936738, PMID 34433773, PMID 37460782, PMID 12783912, PMID 17111043, PMID 17460158, PMID 17916545, PMID 18378608, PMID 18474729, PMID 18990046, PMID 19486178, PMID 19539115, PMID 19555810, PMID 19961603, PMID 20175977, PMID 20202489, PMID 20643821, PMID 20722026, PMID 20804454, PMID 21052881, PMID 21248083, PMID 21319944, PMID 21592098, PMID 21955195, PMID 22278334, PMID 22585767, PMID 23364320, PMID 23406052, PMID 23628600, PMID 23696633, PMID 23740231, PMID 24020994, PMID 24108307, PMID 24127200, PMID 24756302, PMID 24756514, PMID 24781936, PMID 25022541, PMID 25115882, PMID 25297013, PMID 25370510, PMID 25370513
2014 (5), 2009 (3), 2017 (2), 2018 (2), R01AT007987 (2), R01DE022746 (2), 1RC3AR059535-01 (1), 2004 (1), 2008 (1), 2015 (1), 2016 (1), 2019 (1), 2023 (1), KL2TR000370 (1), KL2TR003168 (1)