829 completed, 230 unknown, 86 terminated, 80 recruiting. 553 Not applicable, 383 Phase 4, 180 Phase 2, 179 Phase 3, 95 Phase 1.
Follow Lidocaine: new trials by email Literature Review of Lidocaine trials Research Report on Lidocaine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Focused Versus Multi-Target Trigger Point Injection for Chronic Myofascial Neck Pain Lidocaine 1% Trigger Point Injection - Myofacial Pain Syndrome, Chronic Neck Pain | Not applicable | Not yet recruiting | Mardin Artuklu University | 100 | 2027-04-01 | 2026-10-20 |
| Study of QL Analgesic Response and Extent Quadratus Lumborum with 1.5% Lidocaine - Acute Pain, Postoperative Pain | Phase 4 | Not yet recruiting | Duke University | 25 | 2027-01-01 | 2026-07-08 |
| Office-Based Ureteroscopy Utilizing a Single Use Digital, Flexible Ureteroscope for Upper Tract Urothelial Carcinoma Analgesic Agent, Electronic Health Record Review, Lidocaine Topical - Renal Pelvis and Ureter Urothelial Carcinoma | Not applicable | Recruiting | University of Michigan Rogel Cancer Center | 10 | 2026-12-01 | 2026-10-15 |
| Efficacy of Topical Lidocaine Gel vs. Oral Duloxetine for Painful Diabetic Peripheral Neuropathy Topical Lidocaine 2% Gel, Duloxetine (60 MG) - Painful Diabetic Neuropathy (PDN), Diabetic Neuropathies | Phase 4 | Not yet recruiting | Wah Medical college , POF hospital | 80 | 2026-12-01 | 2026-09-02 |
| MMA Infusion of Lidocaine for Treatment of Headache in Patients With Aneurysmal SAH Lidocaine hydrochloride, Isotonic saline - Headaches Associated With Subarachnoid Hemorrhage (SAH) | Phase 2 | Not yet recruiting | Copenhagen University Hospital, Rigshospitalet | 90 | 2026-12-01 | 2026-09-11 |
| Effect of Nebulized Lignocaine on Emergence Agitation After Sevoflurane Anesthesia in Pediatric Patients Undergoing Tonsillectomy Lidocaine, 0.9% Normal Saline - Emergence Agitation, Emergence Delirium | Phase 3 | Not yet recruiting | Assiut University | 60 | 2026-11-01 | 2026-10-13 |
| Lidocaine Infusions for Pain in Patients With Malignant Bowel Obstruction Lidocaine - Malignant Bowel Obstruction, Cancer Pain | Not yet recruiting | Fundación Santa Fe de Bogota | 50 | 2026-11-01 | 2026-10-02 | |
| Effect of Labetalol, Magnesium Sulfate, or Lidocaine on Opioid Consumption During Laparoscopic Cholecystectomy Labetalol, Magnesium Sulfate, Lidocaine - Postoperative Pain, Cholelithiasis | Phase 4 | Not yet recruiting | Assiut University | 90 | 2026-11-01 | 2026-10-08 |
| Evaluation of the Effect of Adding Sodium Bicarbonate to Lidocaine in the Treatment of Myofascial Pain Syndrome Lidocaine 2 %, Lidocaine + Sodium Bicarbonate - Myofacial Pain, Myofacial Pain Syndrome | Not applicable | Recruiting | Cairo University | 30 | 2026-11-01 | 2026-10-21 |
| Alcohol Neurolysis and Capsaicin for Postamputation Pain (PAP) Injection of alcohol near neuroma, Lidocaine 2% injection, Injection of capsaicin 150 mcg per mL if relief with lidocaine 2% - Postamputation Pain | Not applicable | Not yet recruiting | Northwestern University | 120 | 2026-10-31 | 2026-08-18 |
| The Impact of Perioperative Lidocaine Infusions on Enhanced Recovery After Non-Cardiac Surgery Lidocaine HCl 0.8% in D5W, Dextrose 5% in water - Pain, Post Operative Analgesia | Phase 4 | Not yet recruiting | Vanderbilt University Medical Center | 2290 | 2026-10-31 | 2026-10-15 |
| The Ultrasound-Guided Dextrose Prolotherapy in Ehlers-Danlos Syndrome Patients Dextrose 50% Intravenous Solution, Lidocaine 1% Injectable Solution - Ehlers-Danlos Syndrome, Low Back Pain | Phase 3 | Withdrawn | Tulane University | 2026-10-05 | 2026-10-08 | |
| The Effect of Perioperative Intravenous Lidocaine Infusion on Post-amputation Pain in Amputee Patients Lidocaine Hydrochloride, Injectable, 0.9% normal saline - Amputation | Not applicable | Not yet recruiting | West China Hospital | 200 | 2026-10-01 | 2026-08-25 |
| Intravenous Lidocaine Plus Port-Site Ropivacaine for Recovery After Laparoscopic Surgery Procedure/Standard care, ropivacaine, Lidocaine (intravenous infusion, perioperative) - Intravenous Lidocaine, Laparoscopic Surgery | Phase 3 | Recruiting | Centre Hospitalier Universitaire, Amiens | 182 | 2026-09-22 | 2026-10-16 |
| Assessing the Efficacy of a High-Dose Lidocaine-Tetracaine Cream for the Treatment of Peripheral Neuropathic Pain Lidocaine (23%) + Tetracaine (7%), Placebo cream application - Neuropathic Chronic Pain | Phase 1 / Phase 2 | Not yet recruiting | Pontificia Universidad Catolica de Chile | 30 | 2026-09-20 | 2026-08-25 |
| Dexmedetomidine Versus Lidocaine for Optic Nerve Sheath Diameter During Craniotomy Intubation Dexmedetomidine, Lidocaine, Normal Saline - Endotracheal Intubation | Phase 4 | Not yet recruiting | Benha University | 90 | 2026-09-20 | 2026-09-15 |
| Ultrasound-Guided Platelet-Rich Plasma Versus Local Anesthetic Injection for Chronic Neuroma Pain After Combat-Related Amputation Platelet-Rich Plasma (PRP) Injections, Local Anesthetic Injection - Neuroma, Phantom Limb Pain After Amputation | Not applicable | Completed | Ukrainian Society of Regional Anesthesia and Pain Therapy | 100 | 2026-09-15 | 2026-10-07 |
| Localized Injection of Lidocaine Via the Middle Meningeal Artery for Headache Treatment Lidocaine (drug), Saline - Refractory Migraine, Headache | Phase 2 | Recruiting | Daniel A Tonetti, MD | 80 | 2026-09-09 | 2026-10-01 |
| Intravenous Lidocaine for Postoperative Fatigue After Laparoscopic TAPP Inguinal Hernia Repair Lidocaine, 0.9 % sodium chloride - Postoperative Fatigue Syndrome, Inguinal Hernia Unilateral | Not applicable | Not yet recruiting | Hakan Emirkadı | 80 | 2026-09-02 | 2026-09-04 |
| Efficacy of Temocillin Compared to Standard of Care in the Treatment of Neisseria Gonorrhoeae Infections Temocillin (NEGABAN®) 2 g intravenous with lidocaine (3ml), Rectal swab for ESBL-E and microbiota (Eswab), Temocillin (NEGABAN®) 2 g intramuscular single dose with lidocaine (3ml) - Neisseria Gonorrhoeae (Ng) Infections | Phase 3 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 360 | 2026-09-01 | 2026-06-22 |
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Pain (223) · Pain, Postoperative (119) · Agnosia (84) · Neuralgia (29) · Chronic Pain (22) · Headache (22) · Acute Pain (21) · Migraine Disorders (17) · Carpal Tunnel Syndrome (16) · Bursitis (14) · Myofascial Pain Syndromes (14) · Osteoarthritis, Knee (14) · Postoperative Nausea and Vomiting (14) · Breast Neoplasms (13) · Colorectal Neoplasms (12)
Assiut University (32) · Ain Shams University (25) · Cairo University (23) · Mayo Clinic (16) · Northwestern University (15) · ZARS Pharma Inc. (12) · Duke University (11) · Ankara City Hospital Bilkent (10) · Copka Sonpashan (10) · Scilex Pharmaceuticals, Inc. (9) · Tanta University (9) · The University of Texas Health Science Center, Houston (9) · Washington University School of Medicine (9) · McGill University Health Centre/Research Institute of the McGill University Health Centre (8) · Vanderbilt University Medical Center (8)
United States (420) · Egypt (137) · Canada (83) · Turkey (Türkiye) (70) · China (55) · France (49) · Brazil (39) · South Korea (34) · Pakistan (29) · Denmark (25) · Taiwan (25) · Israel (17) · Belgium (16) · United Kingdom (16) · India (14)
Nieto Luis, Master (16) · Nieto Luis (5) · Chunling Jiang, PhD (4) · Albert Wolkerstorfer, MD, PhD (3) · Daniel I Sessler, MD (3) · Konstantinos Kalimeris, Assoc Prof of Anesthesiology (3) · Manoj K Karmakar, MD (3) · Phillip LaStella, MD (3) · Thomas Pieber, Prof. (3) · Anna Taddio, PhD (2) · Asish Subedi, MD (2) · Brian Mendelson, MD (2)
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