Peripheral Nervous System Diseases: Clinical Trials

2460 completed, 714 unknown, 648 recruiting, 306 terminated. 2054 Not applicable, 769 Phase 2, 394 Phase 3, 336 Phase 1, 240 Phase 4.

By phase and status

Phase	Trials	Status
Not applicable	2054	Completed 1043, Unknown 332, Recruiting 294, Not yet recruiting 147, Terminated 85, Withdrawn 60, Active not recruiting 59, Enrolling by invitation 26, Suspended 8
Phase 2	769	Completed 409, Terminated 112, Unknown 71, Recruiting 68, Withdrawn 40, Active not recruiting 31, Not yet recruiting 29, Suspended 5, Enrolling by invitation 4
Phase 3	394	Completed 234, Unknown 59, Terminated 39, Recruiting 31, Withdrawn 12, Not yet recruiting 10, Active not recruiting 7, Enrolling by invitation 2
Phase 1	336	Completed 187, Recruiting 50, Terminated 29, Unknown 21, Active not recruiting 19, Withdrawn 13, Not yet recruiting 11, Enrolling by invitation 4, Suspended 2
Phase 4	240	Completed 146, Unknown 32, Terminated 20, Recruiting 17, Not yet recruiting 10, Active not recruiting 7, Withdrawn 6, Enrolling by invitation 2
Early Phase 1	42	Completed 14, Recruiting 10, Unknown 10, Terminated 3, Withdrawn 2, Active not recruiting 1, Not yet recruiting 1, Suspended 1

Follow Peripheral Nervous System Diseases: new trials by email Literature Review of Peripheral Nervous System Diseases trials Research Report on Peripheral Nervous System Diseases

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Ketamine and Midazolam Infusions for CRPS: Feasibility Study Ketamine, Midazolam, Normal Saline - Complex Regional Pain Syndromes	Phase 2	Withdrawn	Stanford University		2099-01-01	2024-11-22
Hypersound Treatment for Chronic Neuropathic and Radicular Pain Hypersound RF-PNS system, Sham Hypersound - Chronic Neuropathic Pain, Radiculopathy	Not applicable	Not yet recruiting	Hypersound Medical Inc	71	2027-06-01	2026-09-21
Phase I/IIa Trial of scAAV1.tMCK.NTF3 for Treatment of CMT1A scAAV1.tMCK.NTF3 - Charcot-Marie-Tooth Neuropathy Type 1A	Phase 1 / Phase 2	Withdrawn	Nationwide Children's Hospital		2027-04-01	2026-07-29
Safety and Efficacy Study on AFA-281 for the Treatment of Low Back Pain AFA-281 - Lumbosacral Radiculopathy	Phase 2	Not yet recruiting	Afasci Inc	408	2027-04-01	2025-06-26
Graded Motor Imagery in Carpal Tunnel Syndrome Graded Motor Imagery (GMI), Progressive Neurodynamic Exercise, Nighttime Resting Splint - Carpal Tunnel Syndrome (CTS)	Not applicable	Not yet recruiting	Artvin Coruh University	46	2027-03-01	2026-09-02
Corticosteroid Lumbar Epidural Analgesia for Radicular Pain 2 SP-102, Placebo, Dexamethasone Sodium Phosphate 10 MG/ML - Lumbosacral Radicular Pain	Phase 3	Not yet recruiting	Semnur Pharmaceuticals, Inc.	755	2027-02-01	2026-09-09
Randomized Evaluation of Lumbar Injection Effectiveness and Function Triojection® System, Selective Nerve Root Block (SNRB) - Lumbar Radiculopathy, Lumbar Disc Herniation	Not applicable	Not yet recruiting	SpinaFX Medical Inc.	300	2027-01-15	2026-10-07
Comparison of Efficacy of Caudal Versus Transforaminal Epidural Steroid Injections in Unilateral S1 Nerve Root Pain: A Randomized Controlled Trial Caudal Epidural Steroid Injection (CEI), Transforaminal Epidural Steroid Injection (TFI) - Unilateral S1 Nerve Root Pain	Not applicable	Not yet recruiting	University of Health Sciences Lahore	120	2027-01-05	2026-10-16
BreEStim in Managing Neuropathic Pain After Spinal Cord Injury (SCI) Active BreEStim Treatment, Sham BreEStim Treatment, The TENS Treatment - Pain Management	Not applicable	Not yet recruiting	The University of Texas Health Science Center, Houston	66	2027-01-04	2026-10-14
Assessing the Efficacy of Repeat, Monthly Treatments of Alexandrite Laser for NF1-associated Cutaneous Neurofibromas (cNFs) GentleMax Pro (with skin cooling), GentleMax Pro (without skin cooling) - Neurofibromatosis 1 (NF1), Neurofibromatosis Type I	Not applicable	Suspended	Massachusetts General Hospital	10	2027-01-01	2026-06-04
Efficacy of Mirdametinib Alone or Combination With Radiotherapy for Germline and Sporadic NF1-Altered High-Grade Glioma mirdametinib with radiation, mirdametinib - Neurofibromatosis 1 (NF1)	Phase 2	Not yet recruiting	University of Alabama at Birmingham	55	2027-01-01	2026-10-05
Ketamine HCl Prolonged Release Oral Tablets for CRPS 80mg/day Ketamine HCl Prolonged Release, 160mg/day Ketamine HCl Prolonged Release - Complex Regional Pain Syndromes	Phase 2	Suspended	University of Southern California	65	2027-01-01	2026-07-27
Efficacy of Botulinum Toxin Versus Placebo on Pain and Health Related Quality of Life of Patients With Piriformis Muscle Syndrome Botulinum Toxin - A injections, Placebo - Piriformis Muscle Syndrome	Phase 2	Not yet recruiting	Centre Hospitalier Universitaire de Nīmes	108	2027-01-01	2026-10-21
Simultaneous Engagement of Networks for Alleviating Pain (SENAP) PFM-guided cortical stimulation - Neuropathic Pain, Postherpetic Neuralgia	Phase 1	Not yet recruiting	University of Minnesota	20	2027-01-01	2026-11-03
Selective Nerve Root Block Versus Sham to Reduce Surgery for Lumbar Disc Herniation Selective Nerve Root Block, Sham Procedure - Lumbar Disc Herniation, Lumbar Radiculopathy	Not applicable	Not yet recruiting	Karolinska Institutet	262	2027-01-01	2026-10-27
Combination of Avutometinib and Defactinib for Treatment of Relapsed, Refractory, Metastatic, or Unresectable Malignant Peripheral Nerve Sheath Tumor avutometinib capsule + defactinib tablet - MPNST (Malignant Peripheral Nerve Sheath Tumor)	Phase 2	Not yet recruiting	Girish Dhall, MD	25	2027-01-01	2026-10-28
Pediatric Electrocutaneous Analgesia for Children Experiencing Neuropathic Pain Scrambler Therapy MC-5A Device - Neuropathic Pain, Chronic Pain	Not applicable	Not yet recruiting	Johns Hopkins University	70	2027-01-01	2026-10-30
Trial of Self-Applied Transcutaneous Auricular Vagus Nerve Stimulation for Chemotherapy-Induced Peripheral Neuropathy Sparrow Link (taVNS) - Chemotherapy Induced Peripheral Neuropathy (CIPN)	Not applicable	Not yet recruiting	University of Miami	55	2027-01-01	2026-11-09
Aspirin and PAClitaxel in Head & Neck Squamous Cell Carcinoma Aspirin, Paclitaxel - Head and Neck (HNSCC), Head and Neck Squamous Cell Carcinoma (HNSCC) - Recurrent/Metastatic (R/M)	Phase 2	Not yet recruiting	Washington University School of Medicine	40	2026-12-31	2026-10-28
Assessment of Safety and Effectiveness of Spatial StimelMD (SSMD) in Subjects With Upper Limb Neuromotor Impairments SSMD, Functional Electrical Stimulation (FES) - Stroke, TBI	Not applicable	Not yet recruiting	Motion Informatics LTD	120	2026-12-30	2026-02-11

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Narrower conditions

Neuralgia (986)  ·  Carpal Tunnel Syndrome (581)  ·  Diabetic Neuropathies (524)  ·  Radiculopathy (438)  ·  Pain (406)  ·  Chronic Pain (255)  ·  Complex Regional Pain Syndromes (203)  ·  Neuralgia, Postherpetic (195)  ·  Diabetes Mellitus (189)  ·  Amyloid Neuropathies, Familial (186)  ·  Hereditary Sensory and Autonomic Neuropathies (175)  ·  Neurofibromatosis 1 (174)  ·  Sciatica (144)  ·  Low Back Pain (143)

Broader conditions

Nervous System Diseases (4777)  ·  Neuromuscular Diseases (4768)  ·  Pathological Conditions, Signs and Symptoms (2295)  ·  Signs and Symptoms (1938)  ·  Neurologic Manifestations (1891)  ·  Pain (1358)  ·  Mononeuropathies (925)  ·  Wounds and Injuries (870)  ·  Congenital, Hereditary, and Neonatal Diseases and Abnormalities (820)  ·  Genetic Diseases, Inborn (767)  ·  Neurodegenerative Diseases (765)  ·  Heredodegenerative Disorders, Nervous System (721)  ·  Nerve Compression Syndromes (721)  ·  Endocrine System Diseases (676)

Interventions

Pregabalin (110)  ·  Lidocaine (74)  ·  Exercise (51)  ·  Saline Solution (51)  ·  Gabapentin (44)  ·  Acupuncture Therapy (42)  ·  Physical Therapy Modalities (41)  ·  Sodium Chloride (39)  ·  Transcutaneous Electric Nerve Stimulation (38)  ·  Duloxetine Hydrochloride (32)  ·  Dexamethasone (31)  ·  Surveys and Questionnaires (31)  ·  Transcranial Direct Current Stimulation (31)  ·  Capsaicin (30)  ·  Transcranial Magnetic Stimulation (29)

Sponsors

Riphah International University (114)  ·  Cairo University (81)  ·  National Cancer Institute (NCI) (47)  ·  Assiut University (45)  ·  Pfizer's Upjohn has merged with Mylan to form Viatris Inc. (40)  ·  Pfizer (36)  ·  AstraZeneca (33)  ·  University Hospital, Clermont-Ferrand (31)  ·  Mayo Clinic (30)  ·  Assistance Publique - Hôpitaux de Paris (29)  ·  Johns Hopkins University (28)  ·  Stanford University (28)  ·  Marmara University (26)  ·  Massachusetts General Hospital (26)  ·  Washington University School of Medicine (24)

Countries

United States (1494)  ·  Turkey (Türkiye) (400)  ·  France (393)  ·  Canada (246)  ·  Germany (245)  ·  United Kingdom (232)  ·  Egypt (229)  ·  China (209)  ·  Pakistan (209)  ·  Spain (193)  ·  Italy (187)  ·  Denmark (168)  ·  Netherlands (140)  ·  Belgium (121)  ·  Taiwan (118)

Top investigators

Yung-Tsan Wu, MD (15)  ·  Brigitte C Widemann, M.D. (13)  ·  Amal Fawzy, Ph.d (12)  ·  Steven P Cohen, MD (8)

Results publications

PMID 34854473, PMID 27611736, PMID 23024624, PMID 25794202, PMID 42578463, PMID 19465371, PMID 24405257, PMID 27448285, PMID 28778254, PMID 30084288, PMID 30206821, PMID 30521533, PMID 30936738, PMID 31802967, PMID 10846153, PMID 11884154, PMID 12151246, PMID 12723749, PMID 12918862, PMID 12973155, PMID 15784928, PMID 16448572, PMID 16848101, PMID 16862046, PMID 16967609, PMID 17413924, PMID 18003941, PMID 18209131, PMID 18316238, PMID 18482862, PMID 18495734, PMID 18809959, PMID 1894754, PMID 19119380, PMID 19119381, PMID 19251067, PMID 19345936, PMID 19487826, PMID 19782873, PMID 20052961, PMID 20091520, PMID 20876709, PMID 20961685, PMID 21075037, PMID 21216272, PMID 21561527, PMID 21623291, PMID 22317661, PMID 22341379, PMID 22588743

NIH funding

2018 (16), 2017 (15), 2025 (14), 2016 (12), 2023 (12), 2009 (11), 2019 (11), 2014 (9), 2015 (8), 2008 (6), 2005 (5), U10CA180886 (5), U54NS065712 (4), 2004 (3), P30CA008748 (3)