540 completed, 171 unknown, 74 terminated, 59 recruiting. 354 Not applicable, 342 Phase 4, 123 Phase 3, 89 Phase 2, 27 Phase 1.
Follow Ropivacaine: new trials by email Literature Review of Ropivacaine trials Research Report on Ropivacaine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Zynrelef Versus Adductor Canal Block ZYNRELEF 400Mg-12Mg Extended-Release Solution, Ultrasound-Guided Adductor Canal Block, Ropivacaine 0.5% Injectable Solution - Knee Osteoarthritis, Arthritis Knee | Phase 4 | Not yet recruiting | University of Miami | 120 | 2027-01-01 | 2026-06-12 |
| A Pilot Study Comparison of Programmed Intermittent Bolus Versus Continuous Infusion Ropivacaine (Epidural analgesia) intermittent bolus, Ropivacaine (Epidural analgesia) continuous infusion, Chloroprocaine intermittent bolus - Bladder Extrophy, Surgery in Children | Not applicable | Not yet recruiting | Giorgio Veneziano | 10 | 2026-11-01 | 2026-09-28 |
| Initiation Ropivacaine Dose for Labor Analgesia Via Double Dural Puncture Epidural Technique 0.1% Ropivacaine - Labor Pain | Not applicable | Not yet recruiting | General Hospital of Ningxia Medical University | 30 | 2026-11-01 | 2026-10-20 |
| TAP vs. ESP Blocks for Post-Cesarean Analgesia Ropivacaine, Ultrasound-guided Nerve Block, Ketoprofen and Paracetamol - Postoperative Pain After Cesarean Section | Not applicable | Not yet recruiting | Maternity Hospital - State Budgetary Institution of the Rostov Region, Taganrog | 162 | 2026-10-15 | 2026-10-06 |
| A Clinical Trial Evaluating the Efficacy and Safety of Local Infiltration of RF16001 for Injection for Analgesia After Total Hip Arthroplasty in China RF16001 for injection, Ropivacaine hydrochloride injection, 0.9% sodium chloride injection - Pain After Abdominal Surgery | Phase 3 | Enrolling by invitation | The Third Xiangya Hospital of Central South University | 300 | 2026-10-10 | 2026-10-14 |
| Effect of Preoperative Ultrasound-Guided Stellate Ganglion Block on Postoperative Delirium in Older Adults Undergoing Elective Peripheral Endovascular Intervention ropivacaine - Postoperative Delirium (POD), Peripheral Arterial Disease | Not applicable | Not yet recruiting | Assiut University | 168 | 2026-10-01 | 2026-09-29 |
| QLESP Block for Pain Control in Robotic Partial Nephrectomy ropivacaine (local infiltration), ropivacaine - Renal Cell Carcinoma (Kidney Cancer), Postoperative Pain | Not applicable | Recruiting | Huazhong University of Science and Technology | 120 | 2026-09-22 | 2026-09-25 |
| Intravenous Lidocaine Plus Port-Site Ropivacaine for Recovery After Laparoscopic Surgery Procedure/Standard care, ropivacaine, Lidocaine (intravenous infusion, perioperative) - Intravenous Lidocaine, Laparoscopic Surgery | Phase 3 | Recruiting | Centre Hospitalier Universitaire, Amiens | 182 | 2026-09-22 | 2026-10-16 |
| Serratus Anterior Plane Block for Recovery After Minimally Invasive CABG Ultrasound-guided Serratus Anterior Plane Block with Ropivacaine, Ultrasound-guided Serratus Anterior Plane Block with Normal Saline - Postoperative Pain Control, Coronary Artery Disease | Not applicable | Not yet recruiting | Chinese PLA General Hospital | 168 | 2026-09-17 | 2026-10-16 |
| Sphenopalatine Ganglion Block for Pain Relief After Pediatric Adenotonsillectomy Sphenopalatine ganglion block (Ropivacaine), Sham sphenopalatine ganglion block (Saline) - Postoperative Pain, Tonsillectomy | Phase 4 | Not yet recruiting | Vinícius C Quintão, MD, MSc, PhD | 145 | 2026-09-15 | 2026-08-28 |
| The Impact of Regional Motor-sparing Blocks on Early Rehabilitation Following Primary Hip or Knee Arthroplasty PENG Block with Ropivacaine, Sham PENG Block, Adductor Canal Block with Ropivacaine - Total Hip Arthroplasty (THA) or Total Knee Arthroplasty (TKA), Preoperative Adductor Canal Block (ACB) | Not applicable | Not yet recruiting | Poznan University of Physical Education | 220 | 2026-09-08 | 2026-09-22 |
| Pre-incisional Infiltration With Ropivacaine Plus Triamcinolone for Relieving Postoperative Pain After Thoracoscopic Surgery Pre-incisional infiltration with ropivacaine plus triamcinolone, Pre-incisional infiltration with ropivacaine alone - Video-assisted Thoracoscopic Surgery (VATS), Wedge Resection | Not applicable | Recruiting | Beijing Tiantan Hospital | 346 | 2026-09-01 | 2026-09-17 |
| Liposomal Bupivacaine vs Ropivacaine for Post-hemorrhoidectomy Analgesia Liposomal Bupivacaine (EXPAREL®)/Bupivacaine, Ropivacaine Hydrochloride - Resting Visual Analog Scale (VAS) Pain Score | Phase 4 | Not yet recruiting | Tongliao City People's Hospital | 140 | 2026-08-30 | 2026-08-31 |
| QLESP Block Versus PENG+LFCN Block for Total Hip Arthroplasty QLESP Block, PENG+LFCN Block, ropivacaine - Pain Management, Arthroplasty Total Hip Replacement | Not applicable | Recruiting | Huazhong University of Science and Technology | 136 | 2026-08-19 | 2026-09-29 |
| Thoracic Epidural Analgesia for Acute Pancreatitis With Early Organ Dysfunction Thoracic Epidural Analgesia With Ropivacaine, conventional analgesia - Organ Dysfunction, Organ Support | Not applicable | Not yet recruiting | First People's Hospital of Chenzhou | 150 | 2026-08-01 | 2026-07-21 |
| ACB and iPACK Blocks With Intravenous Dexamethasone and Perineural Dexmedetomidine in Total Knee Arthroplasty Ropivacaine 0.2% Injectable Solution, Dexamethasone, Dexmedetomidine - Knee Osteoarthritis | Not applicable | Not yet recruiting | Poznan University of Medical Sciences | 120 | 2026-07-01 | 2026-06-30 |
| Effect of Liposomal Bupivacaine TAPB Combined With Oxycodone PCIA on Postoperative Gastrointestinal Recovery in Patients Undergoing Major Abdominal Surgery ropivacaine hydrochloride, Liposomal bupivacaine (LB), Sufentanil citrate - Postoperative Pain, Postoperative Ileus | Not applicable | Recruiting | Tianjin First Central Hospital | 132 | 2026-06-16 | 2026-06-25 |
| Lumbar Paravertebral Block vs Erector Spinae Plane Block in Elderly Patients Undergoing Lumbar Spine Surgery Ropivacaine 0.2% Injectable Solution - Spine Disease | Not applicable | Not yet recruiting | Poznan University of Medical Sciences | 120 | 2026-06-01 | 2026-05-26 |
| Transversus Abdominis Plane and Rectus Sheath Block for Robotic Colectomy Ropivacaine, Saline - Rectus Sheath Block, Transversus Abdominis Plane Block | Phase 4 | Not yet recruiting | Tri-Service General Hospital (TSGH) | 90 | 2026-06-01 | 2026-06-03 |
| Pre-incisional Infiltration With Ropivacaine Plus Triamcinolone for Relieving Postoperative Pain After Laparoscopic Surgery Pre-incisional infiltration with ropivacaine plus triamcinolone, Pre-incisional infiltration with ropivacaine alone - Laparoscopic Surgery, Laparoscopic Cholecystectomy | Not applicable | Recruiting | Beijing Tiantan Hospital | 150 | 2026-06-01 | 2026-06-17 |
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Pain, Postoperative (253) · Pain (104) · Agnosia (89) · Osteoarthritis, Knee (30) · Osteoarthritis, Hip (21) · Hip Fractures (19) · Acute Pain (18) · Breast Neoplasms (16) · Labor Pain (15) · Osteoarthritis (14) · Anterior Cruciate Ligament Injuries (10) · Chronic Pain (10) · Hernia, Inguinal (10) · Bites and Stings (9) · Rotator Cuff Injuries (9)
Poznan University of Medical Sciences (29) · Beijing Tiantan Hospital (17) · Zealand University Hospital (16) · Mayo Clinic (11) · Yonsei University (11) · Duke University (10) · Huazhong University of Science and Technology (8) · University of Florida (8) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (7) · University of California, San Francisco (7) · Asklepieion Voulas General Hospital (6) · Boston Children's Hospital (6) · Chuncheon Sacred Heart Hospital (6) · Northwestern University (6) · San Gerardo Hospital (6)
United States (231) · China (123) · France (69) · Denmark (63) · Canada (50) · Poland (42) · South Korea (36) · Italy (26) · Greece (23) · Belgium (14) · Sweden (13) · Switzerland (13) · Brazil (11) · Malaysia (9) · Israel (8)
Malgorzata Reysner, M.D. Ph.D. (7) · Malgorzata Reysner, MD PhD (6) · Pablo M Ingelmo, MD (5) · Daniel I Sessler, MD (4) · Guolin Wang, MD (4) · Antoun Nader, MD (3) · Bryant Tran, MD (3) · Fang Luo (3) · Fang Luo, M.D. (3) · Giorgio Veneziano, MD (3) · Kassiani Theodoraki, PhD, DESA (3) · Kenneth Cummings, MD (3) · Malgorzata Domagalska, Ph.D. (3)
PMID 33238043, PMID 17180268, PMID 18633034, PMID 26225500, PMID 17413915, PMID 18347861, PMID 19376789, PMID 19903919, PMID 20889939, PMID 21377888, PMID 21519308, PMID 21670611, PMID 23161360, PMID 24764186, PMID 25032676, PMID 25774458, PMID 31153628, PMID 40772525, PMID 10486687, PMID 10598635, PMID 10794256, PMID 10910857, PMID 10916593, PMID 11020770, PMID 11090729, PMID 11380742, PMID 11433201, PMID 11444448, PMID 11756886, PMID 12355695, PMID 12452227, PMID 12492792, PMID 12548273, PMID 12560416, PMID 12567343, PMID 12841551, PMID 12855309, PMID 12873949, PMID 12934742, PMID 15488058, PMID 1550287, PMID 15515303, PMID 1559888, PMID 15755432, PMID 16036192, PMID 16153272, PMID 16508385, PMID 16521220, PMID 16698416, PMID 16703434
2014 (6), 2015 (6), 2019 (5), 2016 (4), 2018 (3), 2008 (2), 2009 (2), 2017 (2), 2025 (2), UL1TR000135 (2), P30CA014089 (1), U01NS124613 (1)