496 completed, 143 unknown, 53 terminated, 49 recruiting. 276 Phase 4, 274 Not applicable, 108 Phase 3, 98 Phase 2, 52 Phase 1.
Follow Fentanyl: new trials by email Literature Review of Fentanyl trials Research Report on Fentanyl
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Does the Volume of Medication Affect the Success of Labor Epidural Analgesia administration of bupivacaine 7.5 mg and fentanyl 24 mcg every 40 minutes - Labor Pain and to Reduce Pain | Phase 4 | Not yet recruiting | Beth Israel Deaconess Medical Center | 70 | 2026-10-30 | 2026-10-05 |
| A Comparison of Pulsed Field Ablation (PFA) vs Cryoablation for Atrial Fibrillation Under Deep Sedation Catheter ablation, Deep sedation with midazolam and fentanyl or midazolam and remifentanil, Sedation with midazolam and fentanyl - Atrial Fibrillation (AF) | Not applicable | Recruiting | East Sussex Healthcare NHS Trust | 60 | 2026-10-19 | 2026-10-28 |
| Effect of a Low-Dose Ketamine-Dexmedetomidine-Based Opioid-Sparing Anesthesia Protocol on Postoperative Quality of Recovery After Percutaneous Nephrolithotomy Ketamine and Dexmedetomidine, Fentanyl - Nephrolithiasis, Postoperative Pain | Phase 4 | Not yet recruiting | Assiut University | 100 | 2026-10-01 | 2026-10-02 |
| Epidural Analgesia Versus Opioid-sparing Analgesia for Open Ventral Hernia Repair With Transversus Abdominis Release Bupivicaine, Fentanyl, Thoracic epidural analgesia - Ventral Hernia, Ventral Hernia Repair | Phase 4 | Recruiting | Northwestern University | 40 | 2026-09-25 | 2026-10-07 |
| Intraoperative Methadone for the Management of Postoperative Pain in Patients With Head and Neck Cancers Electronic Health Record Review, Fentanyl, Laryngoscopy - Head and Neck Carcinoma, Hypopharyngeal Carcinoma | Phase 4 | Recruiting | OHSU Knight Cancer Institute | 58 | 2026-09-22 | 2026-10-05 |
| External Oblique Intercostal Block With or Without Intravenous Lidocaine Infusion for Analgesia in Patients Undergoing Gastric Bypass Surgery Investigatore hypothesize that adding a perioperative lidocaine infusion (1.5 mg/kg loading + 1.5 mg/kg/h) to bilateral EOIB and low dose fentanyl loading reduces intraoperative fentanyl consumption., Bilateral EOIB + fentanyl 1 μg/kg loading + normal saline loading (equivalent volume) + normal saline infusion (equivalent rate). - Obese Patients | Not applicable | Recruiting | Menoufia University | 100 | 2026-09-15 | 2026-09-11 |
| Fentanyl Intranasal for Retinopathy of Prematurity Screening in Preterm Infants Fentanyl Citrate (Intranasal), Normal Saline (Placebo, Intranasal) - Neonatal Pain, Retinopathy of Prematurity (ROP) | Phase 1 / Phase 2 | Not yet recruiting | Marsha Campbell-Yeo | 58 | 2026-09-09 | 2026-06-30 |
| Remifentanil vs Fentanyl in Children 7-12 After Urologic Surgery: Emergence Delirium and Recovery Quality Opioids - Emergence Delirium, Emergence Agitation | Phase 4 | Not yet recruiting | Konya City Hospital | 88 | 2026-09-05 | 2026-10-06 |
| Fast-Track Anesthesia in Minimally Invasive Cardiac Surgery: Dexmedetomidine and Erector Spinae Plane Block vs Opioid-Based Anesthesia Dexmedetomidine, Ultrasound-Guided Bilateral Erector Spinae Plane Block (ESPB), Fentanyl - Cardiac Disease Minimally Invasive Cardiac Surgery Postoperative Pain | Not applicable | Not yet recruiting | Assiut University | 50 | 2026-09-01 | 2026-08-06 |
| Fentanyl and Rocuronium for Tracheal Intubation in Newborns Rocuronium Bromide 10 MG/ML, Fentanyl 1 mcg/kg IV, single dose, administered before non-emergent tracheal intubation. - Infant, Premature, Intubation, Intratracheal | Phase 4 | Not yet recruiting | UEA - Universidade Do Estado Do Amazonas | 102 | 2026-09-01 | 2026-07-01 |
| Dural Sac Area-Guided Spinal Anesthesia Dosing for TURP DSCSA-Guided Individualized Spinal Anesthesia Dosing, Bupivacaine, Fentanyl (FEN) - Intraoperative Hypotension, Spinal Aneshtesia | Not applicable | Enrolling by invitation | Istanbul University | 60 | 2026-08-27 | 2026-10-01 |
| Cervical Erector Spinae Plane Block in Proximal Humeral Fracture Surgery, A Motor-Sparing Block Cervical erector spinae plane block, General anesthesia - Cervical, Erector Spinae Plane Block | Not applicable | Recruiting | Menoufia University | 44 | 2026-08-01 | 2026-09-17 |
| Quadro-Iliac Plane Block for Pain Control After Posterior Spinal Instrumentation Surgery Fentanyl (IV), Meperidine, Paracetamol (acetaminophen) - Posterior Spinal Instrumentation Patients | Early Phase 1 | Not yet recruiting | Istanbul Medipol University Hospital | 60 | 2026-08-01 | 2026-08-28 |
| Comparing Esketamine and Remazolam With Propofol for Breathing Safety in Pediatric Gastroscopy Fentanyl and Propofol, Esketamine and remimazolam - Adverse Respiratory Events, Hypoxemia | Phase 4 | Not yet recruiting | Second Affiliated Hospital of Wenzhou Medical University | 120 | 2026-08-01 | 2026-08-06 |
| Intraperitoneal Ketamine Versus Fentanyl as Adjuvants to Bupivacaine in Laparoscopic Cholecystectomy Fentanyl, Ketamine - Postoperative Pain | Phase 4 | Not yet recruiting | Assiut University | 84 | 2026-08-01 | 2026-06-26 |
| The Analgesic Efficacy of Dexmedetomidine Versus Fentanyl as an Adjuvant to Bupivacaine in Ultrasound Guided Peripheral Nerve Blocks as a Solo Anesthetic Technique in High Risk Patients Undergoing Unilateral Above Knee Amputation . Dexmedetomidine, Fentanyl (as Citrate) - Analgesia Assessment, Above Knee Amputation | Not applicable | Recruiting | Kasr El Aini Hospital | 64 | 2026-07-01 | 2026-07-13 |
| The ED95 of Ciprofol for Laryngeal Mask Airway Insertion With Fentanyl in Children: A Biased-Coin Dose-Finding Trial Ciprofol, Fentanyl - Pediatric, Anesthesia Induction | Phase 4 | Recruiting | Huazhong University of Science and Technology | 180 | 2026-06-15 | 2026-07-13 |
| Biceps Femoris Short Head (BiFeS) Block and Adductor Canal Block for Postoperative Analgesia Following Total Knee Arthroplasty Procedure: Biceps Femoris Short Head Block, Procedure: Spinal Anesthesia - Postoperative Pain Following Knee Arthroplasty, Total Knee Arthroplasty | Not applicable | Recruiting | Ömer Kayar | 60 | 2026-06-02 | 2026-06-12 |
| Conscious Sedation Versus General Anesthesia for Pulsed Field Ablation in Paroxysmal Atrial Fibrillation Local Anesthesia With Conscious Sedation, General Anesthesia, VARIPULSE Pulsed Field Ablation System - Paroxysmal Atrial Fibrillation | Not applicable | Recruiting | China National Center for Cardiovascular Diseases | 390 | 2026-06-01 | 2026-10-26 |
| A Phase 2 Safety, Tolerability, PK, and Efficacy Study of CS-1103 Following Fentanyl Challenge With Naloxone Blockade Naloxone Hydrochloride, Fentanyl, Sterile Saline - Fentanyl Overdose, Fentanyl Poisoning | Phase 2 | Completed | Clear Scientific, Inc. | 16 | 2026-05-28 | 2026-11-10 |
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Pain (110) · Pain, Postoperative (89) · Agnosia (84) · Labor Pain (27) · Chronic Pain (23) · Neoplasms (21) · Acute Pain (20) · Breakthrough Pain (13) · Respiratory Insufficiency (13) · Emergence Delirium (12) · Cancer Pain (10) · Opioid-Related Disorders (9) · Delirium (8) · Hip Fractures (8) · Anxiety Disorders (7)
Assiut University (26) · Ain Shams University (22) · Cairo University (20) · Kasr El Aini Hospital (12) · Mansoura University (11) · Tanta University (11) · Yonsei University (10) · Duke University (9) · Zagazig University (9) · INSYS Therapeutics Inc (8) · Johns Hopkins University (8) · Janssen Pharmaceutical K.K. (7) · Al-Azhar University (6) · Benha University (6) · M.D. Anderson Cancer Center (6)
United States (216) · Egypt (133) · Canada (42) · Turkey (Türkiye) (37) · China (32) · South Korea (26) · Greece (18) · Italy (17) · Israel (14) · Thailand (12) · Denmark (11) · Germany (11) · Brazil (10) · Norway (9) · France (8)
Denis E O'Donnell, MD, FRCPC (3) · Giovanni DeCastro (3) · Jose CA Carvalho, MD (3) · Amy R Deipolyi, M.D., Ph.D. (2) · Ayman A Yousef, MD (2) · Dorian Williams, M.D. (2) · Giorgio Danelli, MD (2) · Jose CA Carvalho, MD PhD (2) · Julia C Finkel, MD (2)
PMID 33238043, PMID 22045879, PMID 24238862, PMID 25068412, PMID 26359327, PMID 38666154, PMID 10195546, PMID 10211042, PMID 10215686, PMID 10353500, PMID 10364865, PMID 10389815, PMID 10414444, PMID 10460554, PMID 10472223, PMID 10475291, PMID 10490157, PMID 10792142, PMID 10793585, PMID 10825328, PMID 10866915, PMID 10960384, PMID 11426893, PMID 11495870, PMID 11555797, PMID 11591092, PMID 11727145, PMID 11812698, PMID 11873026, PMID 11878707, PMID 12031757, PMID 12088814, PMID 12095019, PMID 12127688, PMID 12160502, PMID 12351295, PMID 12487041, PMID 12626983, PMID 12773983, PMID 12847519, PMID 12873949, PMID 1326621, PMID 13679931, PMID 14566537, PMID 14570648, PMID 14693585, PMID 14693611, PMID 14754697, PMID 15059702, PMID 15064269
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