340 completed, 78 terminated, 62 unknown, 31 recruiting. 218 Phase 2, 106 Phase 1, 101 Phase 3, 97 Phase 4, 46 Not applicable.
Follow this drug Literature Review of Celecoxib trials Research Report on Celecoxib
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Timed Aspirin Chronobiome Study Aspirin 81 mg, Celecoxib 200mg capsule - Healthy | Early Phase 1 | Not yet recruiting | University of Pennsylvania | 60 | 2027-12-01 | 2026-05-29 |
| Stony Brook Medicine Anti-Inflammatory Trial Celecoxib, Minocycline - Major Depressive Disorder | Phase 4 | Not yet recruiting | Stony Brook University | 42 | 2027-06-01 | 2026-04-23 |
| Evaluation of Superiority of Valsartan+Celecoxib+Metformin Over Metformin Alone in Type 2 Diabetes Patients Metformin, Val, Cel and Met XR Low, Val, Cel and Met XR High - Type 2 Diabetes, High Blood Pressure | Phase 1 / Phase 2 | Withdrawn | ARKAY Therapeutics | 2026-12-10 | 2026-07-16 | |
| Preoperative Celecoxib and Acetaminophen Versus Acetaminophen Alone for Pain Control After Pediatric Adenotonsillectomy Celecoxib, Acetaminophen, Dexamethasone - Adenotonsillectomy, Postoperative Pain | Phase 1 / Phase 2 | Not yet recruiting | NYU Langone Health | 500 | 2026-11-01 | 2026-10-13 |
| Intensive Locoregional Chemoimmunotherapy, Intradermal Autologous Alpha-DC1 Vaccines, and Systemic Pembrolizumab for Advanced-Stage Ovarian Cancer Paclitaxel, Cisplatin, Bioferon - Ovarian Cancer | Phase 2 | Not yet recruiting | Kalinski, Pawel, MD, PhD | 28 | 2026-10-01 | 2026-10-13 |
| An Artificial Intelligence Driven Approach to Optimize Patient Selection for a Transitional Pain Service TPS-Select, Pharmacologic Pain Management, Interventional Pain Procedures - Postsurgical Pain Management, Postsurgical Pain, Chronic | Phase 3 | Not yet recruiting | University of California, San Francisco | 474 | 2026-10-01 | 2026-10-09 |
| A Trial in Healthy Participants to Assess Drug Interaction Potential of BGB-43395 BGB-43395, Midazolam, Celecoxib - Healthy Adult Participants | Phase 1 | Recruiting | BeOne Medicines | 24 | 2026-09-25 | 2026-10-08 |
| A Multicenter, Prospective, Randomized, Open-label Phase Ib/II Study of Celecoxib Plus Pembrolizumab and Gemcitabine/Cisplatin Versus Pembrolizumab and Gemcitabine/Cisplatin in Patients With CK5/6-High Unresectable Locally Advanced or Metastatic Intrahepatic Cholangiocarcinoma Celecoxib + Pembrolizumab + Gemcitabine/Cisplatin, Pembrolizumab + Gemcitabine/Cisplatin - Intrahepatic Cholangiocarcinoma (Icc) | Phase 1 / Phase 2 | Not yet recruiting | Shanghai 6th People's Hospital | 112 | 2026-09-15 | 2026-08-28 |
| TriGlytza®-01 Versus Metformin in Overweight and Obese Adults With Type 2 Diabetes and Inadequate Glycaemic Control Despite Metformin Therapy Metformin XR, Celecoxib, Valsartan - Type 2 Diabetes (T2DM) | Phase 2 | Not yet recruiting | Myopharm Limited | 48 | 2026-09-01 | 2026-07-08 |
| Efficacy and Safety of Oral Antiviral Therapy for Idiopathic Trigeminal Neuralgia Intervention：Drug: Carbamazepine, Intervention：Drug: Carbamazepine + Acyclovir, Intervention：Drug: Carbamazepine + Celecoxib - Idiopathic Trigeminal Neuralgia | Not applicable | Not yet recruiting | Beijing Tiantan Hospital | 165 | 2026-08-31 | 2026-06-29 |
| Ivosidenib Plus mFOLFOXIRI and Celecoxib for BRAF-targeted Therapy-refractory BRAF V600E-mutant Colorectal Cancer Patients Ivonescimab +mFOLFOXIRI +celecoxib - Colorectal Cancer | Phase 2 | Recruiting | Sun Yat-sen University | 45 | 2026-08-10 | 2026-09-09 |
| SARS-CoV-2 and Herpesvirus Inhibition for Ending Long COVID Dysfunction Valacyclovir, Celecoxib, Paxlovid - Post-acute Sequelae of COVID-19, Long COVID | Phase 2 | Not yet recruiting | Icahn School of Medicine at Mount Sinai | 150 | 2026-06-01 | 2026-05-19 |
| Efficacy and Safety of TRD205 Tablets for Postoperative Analgesia in Unilateral Total Hip Arthroplasty (Phase IIb) TRD205 Tablets, oral; 400 mg initial dose, then 200 mg q12h for 3 doses; total 4 doses, TRD205 Tablets, oral; 800 mg initial dose, then 400 mg q12h; total 4 doses, TRD205 Tablets, oral; 1200 mg initial dose, then 600 mg q12h; total 4 doses - Postoperative Analgesia After Unilateral Hip Arthroplasty | Phase 2 | Recruiting | Beijing Tide Pharmaceutical Co., Ltd | 200 | 2026-03-18 | 2026-04-22 |
| A Phase Ib Study to Evaluate the Efficacy and Safety of HRS-2129 in Patients With Knee Osteoarthritis HRS-2129 Tablet, Celecoxib capsule, Celecoxib Capsule Placebo - Moderate Pain in Knee Osteoarthritis, Severe Pain in Knee Osteoarthritis | Phase 1 | Completed | Shandong Suncadia Medicine Co., Ltd. | 202 | 2026-03-10 | 2026-09-21 |
| Celecoxib, Durvalumab and Tremelimumab for the Treatment of Patients With Advanced or Metastatic Liver Cancer Celecoxib, Durvalumab, Tremelimumab - Advanced Hepatocellular Carcinoma, Metastatic Hepatocellular Carcinoma | Phase 2 | Recruiting | Emory University | 39 | 2026-01-02 | 2026-01-28 |
| Celecoxib in Parkinson Disease as Adjuvant Therapy Levodopa Carbidopa, Celecoxib 200mg - Parkinson Disease | Phase 1 / Phase 2 | Recruiting | Tanta University | 80 | 2025-11-20 | 2025-12-05 |
| Pilot Study of IT Topotecan and Maintenance Chemotherapy for HR-EBTs in Children < 6 Years, Post Consolidation Cytarabine IT, hydrocortisone, Cisplatin - CNS Embryonal Tumor, CNS, Medulloblastoma | Early Phase 1 | Recruiting | C17 Council | 15 | 2025-09-23 | 2026-07-14 |
| A Phase I Study of KLA318-2 Nanocrystal Injection KLA318-2 Nanocrystal Injection, Celebrex Capsule - Healthy Participants | Phase 1 | Recruiting | Hunan Kelun Pharmaceutical Co., Ltd. | 48 | 2025-09-01 | 2026-05-26 |
| Long-course Chemoradiotherapy or Short-course Radiotherapy Combined With CAPOX, PD-1antibody, and COX-2 Inhibitor for MSS Locally Advanced Rectal Cancer (SERRAC) Long-course radiotherapy, Oxaliplatin, Capecitabine - Locally Advanced Rectal Cancer, Neoadjuvant Therapy | Phase 2 | Recruiting | Fudan University | 138 | 2025-08-28 | 2025-09-02 |
| Methotrexate, Erlotinib, and Celecoxib for the Treatment of Recurrent/Metastatic Head and Neck Cancer in a Rural Midwest United States Population Celecoxib, Erlotinib Hydrochloride, Imaging Procedure - Metastatic Oral Cavity Carcinoma, Recurrent Oral Cavity Carcinoma | Phase 2 | Recruiting | Mayo Clinic | 25 | 2025-08-07 | 2026-10-01 |
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Osteoarthritis, Knee (36) · Colorectal Neoplasms (35) · Pain, Postoperative (33) · Osteoarthritis (29) · Breast Neoplasms (26) · Carcinoma, Non-Small-Cell Lung (26) · Pain (26) · Lung Neoplasms (24) · Colonic Neoplasms (18) · Head and Neck Neoplasms (16) · Rectal Neoplasms (14) · Acute Pain (11) · Agnosia (11) · Inflammation (11) · Prostatic Neoplasms (11)
Pfizer's Upjohn has merged with Mylan to form Viatris Inc. (34) · National Cancer Institute (NCI) (21) · Pfizer (14) · Cairo University (10) · M.D. Anderson Cancer Center (10) · Roswell Park Cancer Institute (8) · Sun Yat-sen University (8) · Dana-Farber Cancer Institute (7) · Eli Lilly and Company (7) · Northwestern University (6) · Seoul National University Hospital (6) · University of Alabama at Birmingham (6) · Alliance for Clinical Trials in Oncology (5) · Emory University (5) · Henry Ford Health System (5)
United States (293) · China (43) · Canada (36) · South Korea (33) · Egypt (19) · Germany (18) · United Kingdom (17) · Belgium (14) · Spain (14) · Taiwan (14) · France (13) · Mexico (11) · Brazil (10) · Israel (10) · Italy (10)
David S Schrump, M.D. (7) · Toufic R Jildeh, MD (4) · Carol J Fabian, MD (3) · Francis K Chan, MD (3) · Shirish M. Gadgeel, MD (3) · A. Bapsi Chakravarthy, MD (2) · AbdelGany M Hassan (2) · Alice Pentland (2) · Alison Edelman, MD, MPH (2) · Athanassios Argiris, MD (2) · Basil Kasimis, MD (2)
PMID 18378608, PMID 39316284, PMID 16943394, PMID 17707751, PMID 21524238, PMID 22386831, PMID 26235613, PMID 26313454, PMID 34606846, PMID 10662747, PMID 11904109, PMID 11927685, PMID 11927799, PMID 12119802, PMID 12122152, PMID 12181243, PMID 12237259, PMID 12793996, PMID 12832331, PMID 1417117, PMID 14679827, PMID 14710506, PMID 15066944, PMID 15153776, PMID 15498811, PMID 15563538, PMID 15710782, PMID 15738343, PMID 15863167, PMID 16096702, PMID 16282886, PMID 16495392, PMID 16522694, PMID 16740761, PMID 16943400, PMID 16943401, PMID 17030548, PMID 17084549, PMID 17111043, PMID 17405999, PMID 17460158, PMID 17482376, PMID 17499604, PMID 17515447, PMID 17515448, PMID 17916545, PMID 18037095, PMID 18053191, PMID 18065406, PMID 18281656
P30CA006516 (4), P30CA022453 (4), P30CA068485 (4), P01CA234212 (3), P30CA016672 (3), U10CA031946 (3), 2004 (2), P01CA132714 (2), P30CA006973 (2), P30CA033572 (2), R01MH058156 (2), U10CA037429 (2), 2014 (1), 2015 (1), 2016 (1)