768 completed, 141 unknown, 88 terminated, 66 recruiting. 382 Phase 4, 245 Not applicable, 209 Phase 3, 203 Phase 2, 148 Phase 1.
Follow Acetaminophen: new trials by email Literature Review of Acetaminophen trials Research Report on Acetaminophen
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Suzetrigine Versus Standard Analgesia After Skin Cancer Surgery Suzetrigine, Acetaminophen Plus Ibuprofen - Postoperative Pain, Acute Pain | Phase 4 | Not yet recruiting | University of Minnesota | 230 | 2027-04-01 | 2026-09-25 |
| Office-Based Ureteroscopy Utilizing a Single Use Digital, Flexible Ureteroscope for Upper Tract Urothelial Carcinoma Analgesic Agent, Electronic Health Record Review, Lidocaine Topical - Renal Pelvis and Ureter Urothelial Carcinoma | Not applicable | Recruiting | University of Michigan Rogel Cancer Center | 10 | 2026-12-01 | 2026-10-15 |
| A Clinical Trial of MK-6916 in Participants With Pain After Bunion Removal Surgery (MK-6916-007) MK-6916, Hydrocodone/acetaminophen (HB/APAP), MK-6916 Placebo - Pain Management | Phase 2 | Not yet recruiting | Merck Sharp & Dohme LLC | 380 | 2026-11-23 | 2026-10-07 |
| A Clinical Trial of MK-6255 to Treat Endometrial and Ovarian Cancer (MK-6255-001) MK-6255, CD8 PET Tracer, Acetaminophen - Ovarian Neoplasms, Endometrial Neoplasms | Phase 1 | Not yet recruiting | Merck Sharp & Dohme LLC | 80 | 2026-11-13 | 2026-10-13 |
| Intravenous Paracetamol Versus Magnesium Sulfate for Control of Shivering Following Spinal Anesthesia in Cesarean Section Paracetamol, Magnesium Sulfate - Shivering, Post-Spinal Shivering | Phase 4 | Not yet recruiting | Assiut University | 90 | 2026-11-01 | 2026-10-02 |
| Optimizing the Paracetamol Dose for Prevention of Post-Spinal Shivering in Lower Limb Orthopedic Surgeries Paracetamol 2 g, Paracetamol 1 g, Normal Saline Placebo - Shivering, Postoperative Shivering | Phase 4 | Not yet recruiting | Assiut University | 150 | 2026-11-01 | 2026-10-02 |
| Comparing Pain Improvement for Intravenous Versus Oral Acetaminophen in Acute Pelvic Pain Acetaminophen 1000mg PO, IV Acetaminophen 1000mg, IV Placebo - Pelvic Pain | Phase 4 | Not yet recruiting | Montefiore Medical Center | 140 | 2026-11-01 | 2026-09-23 |
| Dexamethasone Plus Metoclopramide Versus Paracetamol/NSAIDs for Primary Headache Dexamethasone Plus Metoclopramide, Paracetamol/NSAIDs - Primary Headache | Phase 4 | Not yet recruiting | Pak Emirates Military Hospital | 94 | 2026-11-01 | 2026-05-22 |
| Suzetrigine in Tonsillectomy for Opioid-sparing Pain Management Suzetrigine, Acetaminophen, oxycodone - Tonsillectomy, Pharyngoplasty | Phase 4 | Not yet recruiting | Stanford University | 58 | 2026-11-01 | 2026-09-16 |
| Preoperative Celecoxib and Acetaminophen Versus Acetaminophen Alone for Pain Control After Pediatric Adenotonsillectomy Celecoxib, Acetaminophen, Dexamethasone - Adenotonsillectomy, Postoperative Pain | Phase 1 / Phase 2 | Not yet recruiting | NYU Langone Health | 500 | 2026-11-01 | 2026-10-13 |
| A Study Evaluating the Impact of a Painkiller Product on Quality-of-Life and Daily Functioning Paracetamol - Pain | Not yet recruiting | HALEON | 2100 | 2026-11-01 | 2026-11-02 | |
| Comparison of Two Postoperative Care Strategies After Breast Surgery Patient Education, Paracetamol, Dexketoprofen - Postoperative Pain, Pain Management | Not applicable | Recruiting | Moumtzidou Maria Aikaterini | 108 | 2026-10-19 | 2026-10-20 |
| TAP vs. ESP Blocks for Post-Cesarean Analgesia Ropivacaine, Ultrasound-guided Nerve Block, Ketoprofen and Paracetamol - Postoperative Pain After Cesarean Section | Not applicable | Not yet recruiting | Maternity Hospital - State Budgetary Institution of the Rostov Region, Taganrog | 162 | 2026-10-15 | 2026-10-06 |
| A Clinical Trial of MK-1045 in People With B-cell Cancer (MK-1045-006) MK-1045, Acetaminophen (or similar antipyretic), Diphenhydramine (or similar antihistamine) - Chronic Lymphocytic Leukaemia, Small Lymphocytic Lymphoma | Phase 2 | Recruiting | Merck Sharp & Dohme LLC | 60 | 2026-10-14 | 2026-11-04 |
| A Clinical Trial of MK-2010 With Sacituzumab Tirumotecan (Sac-TMT) in Participants With Solid Tumors (MK-2010) MK-2010, Sacituzumab tirumotecan, Histamine H1 Receptor Antagonist - Advanced Solid Tumors, Malignant Neoplasm | Phase 2 | Recruiting | Merck Sharp & Dohme LLC | 200 | 2026-10-07 | 2026-10-15 |
| Pain After Strabismus Surgery Tylenol - Strabismus | Phase 2 | Suspended | Ann & Robert H Lurie Children's Hospital of Chicago | 80 | 2026-10-01 | 2026-07-30 |
| Intravenous Metoclopramide Versus Intravenous Acetaminophen for Acute Concussion Treatment Metoclopramide 10mg, Acetaminophen - Concussion Post Syndrome, Head Trauma Injury | Phase 4 | Not yet recruiting | Montefiore Medical Center | 200 | 2026-10-01 | 2026-10-01 |
| Effect of Nonsteroidal Anti-Inflammatory Drug Restriction on the Efficacy of Platelet-Rich Plasma in Knee Osteoarthritis Leukocyte-Rich Platelet-Rich Plasma, ibuprofen, Acetaminophen - Osteoarthritis, Knee | Not applicable | Not yet recruiting | Federal University of São Paulo | 90 | 2026-10-01 | 2026-08-14 |
| A Study of Combogesic® 325 in Adolescent Patients With Moderate to Severe Postoperative Pain Associated With Orthopedic Surgery Combogesic® tablets, Acetaminophen 500mg, Placebo - Post Operative Pain, Acute | Phase 3 | Not yet recruiting | AFT Pharmaceuticals, Ltd. | 180 | 2026-10-01 | 2026-07-01 |
| Post-op Analgesia of Nail Unit Procedures Suzetrigine, Oxycodone/Acetaminophen, Acetaminophen - Nail Diseases | Phase 4 | Not yet recruiting | University of Miami | 45 | 2026-10-01 | 2026-10-01 |
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Pain, Postoperative (228) · Pain (177) · Agnosia (101) · Fever (43) · Acute Pain (40) · Ductus Arteriosus, Patent (26) · Obesity (23) · Emergencies (22) · Low Back Pain (19) · Osteoarthritis (19) · Osteoarthritis, Knee (19) · Overweight (18) · Migraine Disorders (17) · Headache (15) · Toothache (14)
GlaxoSmithKline (24) · Merck Sharp & Dohme LLC (18) · National Cancer Institute (NCI) (16) · Montefiore Medical Center (14) · Pamukkale University (13) · Cairo University (12) · Stanford University (12) · University Hospital, Clermont-Ferrand (12) · Mallinckrodt (11) · Ain Shams University (10) · National Institute of Allergy and Infectious Diseases (NIAID) (10) · Assiut University (9) · Bayer (9) · Hoffmann-La Roche (8) · Pfizer (8)
United States (499) · Turkey (Türkiye) (64) · Canada (60) · France (52) · Egypt (48) · Italy (40) · Spain (36) · United Kingdom (33) · Israel (32) · Denmark (30) · Poland (29) · Brazil (26) · China (25) · South Korea (24) · Germany (16)
Toufic R Jildeh, MD (4) · Kennon Heard, MD (3)
PMID 11756886, PMID 15791113, PMID 21353105, PMID 22524979, PMID 23360885, PMID 23471754, PMID 24012235, PMID 24535604, PMID 25032676, PMID 33693991, PMID 36519620, PMID 37678236, PMID 10486687, PMID 10794256, PMID 11112243, PMID 11331334, PMID 11472277, PMID 12355695, PMID 12567343, PMID 15310785, PMID 16135345, PMID 16703549, PMID 17175134, PMID 18662331, PMID 19453963, PMID 19647342, PMID 20548058, PMID 21114616, PMID 21519308, PMID 22186009, PMID 22412772, PMID 22520687, PMID 23972577, PMID 24404359, PMID 25582785, PMID 25744676, PMID 25774458, PMID 26304646, PMID 26603732, PMID 26603742, PMID 26993881, PMID 28322750, PMID 29310498, PMID 29369450, PMID 29723634, PMID 33078388, PMID 33238043, PMID 35622074, PMID 1015603, PMID 10352050
2023 (15), 2019 (9), 2025 (7), 2014 (6), 2016 (5), 2015 (4), 2017 (3), 2018 (3), 2009 (2), 2008 (1), K23AG033100 (1), K23DK146181 (1), K23GM147350 (1), KL2RR025754-04 (1), P01AR043584 (1)