Diabetic Neuropathies: Clinical Trials

809 completed, 251 unknown, 144 recruiting, 120 terminated. 722 Not applicable, 246 Phase 2, 147 Phase 3, 111 Phase 1, 97 Phase 4.

By phase and status

Phase	Trials	Status
Not applicable	722	Completed 368, Unknown 115, Recruiting 87, Terminated 52, Not yet recruiting 43, Active not recruiting 27, Withdrawn 22, Enrolling by invitation 6, Suspended 2
Phase 2	246	Completed 147, Unknown 35, Terminated 28, Recruiting 16, Withdrawn 10, Not yet recruiting 6, Active not recruiting 4
Phase 3	147	Completed 90, Terminated 23, Unknown 22, Recruiting 5, Not yet recruiting 3, Withdrawn 3, Active not recruiting 1
Phase 1	111	Completed 53, Unknown 28, Terminated 8, Active not recruiting 6, Recruiting 6, Not yet recruiting 4, Withdrawn 4, Enrolling by invitation 1, Suspended 1
Phase 4	97	Completed 61, Unknown 13, Terminated 9, Recruiting 5, Withdrawn 5, Not yet recruiting 3, Active not recruiting 1
Early Phase 1	12	Unknown 6, Completed 3, Not yet recruiting 1, Recruiting 1, Withdrawn 1

Follow Diabetic Neuropathies: new trials by email Literature Review of Diabetic Neuropathies trials Research Report on Diabetic Neuropathies

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
On the Move: Center and Home-Based Exercise to Enhance Mobility in Diabetic Foot Ulcer Recovery 12-week exercise regimen, 12-week standard of care - Diabetic Foot Ulcer	Not applicable	Not yet recruiting	University of Maryland, Baltimore	60	2027-06-01	2026-10-07
Placental Cells for Diabetic Foot Ulcers Placenta Stem Cells - Diabetic Foot Ulcer	Phase 1	Not yet recruiting	Wake Forest University Health Sciences	12	2027-03-01	2026-10-23
Subcutaneous Dexpanthenol Administration and Wound Epithelialization Dexpanthenol, Standard Wound Care - Chronic Wounds, Diabetic Foot Ulcer	Not applicable	Not yet recruiting	Dilara CANBAY OZDEMIR	40	2026-12-02	2026-10-22
Efficacy of Topical Lidocaine Gel vs. Oral Duloxetine for Painful Diabetic Peripheral Neuropathy Topical Lidocaine 2% Gel, Duloxetine (60 MG) - Painful Diabetic Neuropathy (PDN), Diabetic Neuropathies	Phase 4	Not yet recruiting	Wah Medical college , POF hospital	80	2026-12-01	2026-09-02
Clinical Efficacy of Modified Simiao Yongan Decoction and Endovascular Therapy for Diabetic Foot Ulcers Modified Simiao Yongan Decoction, Endovascular Therapy and Standard Care - Diabetic Foot Ulcer, Damp-Heat Toxins Accumulation Syndrome	Not applicable	Not yet recruiting	Chengdu University of Traditional Chinese Medicine	120	2026-12-01	2026-09-08
18F-FDG PET/CT for Diagnosis of Diabetic Foot Osteomyelitis 18F-FDG PET/CT - Diabetic Foot Infections		Not yet recruiting	Jewish General Hospital	150	2026-11-01	2026-09-18
Modality Choice Before and After Failure for the Treatment of Painful Diabetic Neuropathy Cognitive Behavioral Therapy (CBT), Oral Medication, Topical Medication - Painful Diabetic Neuropathy (PDN), Diabetic Nephropathies	Phase 4	Not yet recruiting	University of Michigan	600	2026-11-01	2026-10-21
Perineural Botulinum Toxin Injection Versus Oral Duloxetine in Relief of Foot Pain in Painful Peripheral Diabetic Neuropathy Botulinum Toxin Type A, Duloxetine, Oral Placebo Tablet - Diabetic Peripheral Neuropathy, Painful Diabetic Neuropathy	Phase 2	Not yet recruiting	Assiut University	56	2026-11-01	2026-10-20
Comparison of Negative Pressure Wound Therapy Versus Moist Wound Dressing in Diabetic Foot Ulcer Patients Negative Pressure Wound Therapy, Moist Wound Dressing - Diabetic Foot Ulcer	Not applicable	Not yet recruiting	Abbas Institute of Medical Sciences	60	2026-11-01	2026-10-28
Tibial Nerve Mobilization Versus Multisensory Exercises in Patients With Diabetic Foot Ulcer Tibial Nerve Mobilization, Multisensory exercises - Diabetic Foot	Not applicable	Not yet recruiting	University of Lahore	38	2026-11-01	2026-11-10
Comparative Effects of tDCS and tACS on Pain, Dexterity, and Strength in Diabetic Peripheral Neuropathy Transcranial Direct Current Stimulation (tDCS), Transcranial Alternating Current Stimulation (tACS) - Diabetic Peripheral Neuropathy (DPN)	Not applicable	Active not recruiting	University of Management and Technology Lahore	46	2026-10-22	2026-11-03
Systemic Biochemical Signature and Functional Quality Index of Calcaneal Bone Marrow Aspirate in Adults Undergoing Foot or Ankle Surgery Diabetic Foot Ulcer, Wound Healing		Recruiting	Universidade Sao Francisco	40	2026-10-21	2026-10-22
Seltoplasmid Plus Revascularization for Diabetic Infrapopliteal Chronic Limb-Threatening Ischemia Lower-Extremity Revascularization, Donaperminogene Seltoplasmid - Chronic Limb-Threatening Ischemia, Diabetic Foot Ulcer	Phase 4	Not yet recruiting	First Affiliated Hospital of Wenzhou Medical University	180	2026-10-20	2026-09-18
DiaFootCare to Promote Self-Care of Diabetic Foot Ulcers in Oman DiaFootCare Mobile Application, Usual Diabetic Foot Care - Diabetic Foot Ulcer (DFU), Diabetes Mellitus	Not applicable	Recruiting	Oman Ministry of Health	108	2026-10-13	2026-11-02
a Prospective, Multicenter, Randomized Controlled Trial, With a Non-randomized Sentinel Cohort, Evaluating the Efficacy of Bioxheal, a Single-layer Placental-derived Biologic in Nonhealing Diabetic Foot Ulcers Standard of Care, BIOxHEAL (human amniotic membrane allograft) - Diabetic Foot Ulcer, Amniotic Membrane Placental Allograft	Phase 3	Recruiting	Applied Biologics, LLC	253	2026-10-08	2026-10-16
Activity Reduction vs Advice for Plantar Hotspots in Diabetes Individualized Objectively Monitored Activity Reduction, Standard Activity-Reduction Advice - Diabetic Foot, Diabetic Peripheral Neuropathy	Not applicable	Not yet recruiting	Shifa International Hospital	100	2026-10-01	2026-09-25
Evaluating the Effect of Adipose Tissue Processed With the SyntrFuge™ System in the Healing of Diabetic Foot Ulcers Syntrfuge Microfragmented Fat, Standard of Care - Diabetic Foot Ulcer	Not applicable	Not yet recruiting	Syntr Health Technologies, Inc.	62	2026-09-30	2026-08-21
Nutritional Status in Adults With Diabetic Foot Ulcers Protein supplementation and nutrition education - Diabetic Foot Ulcers (DFU), Nutrition Assessment		Not yet recruiting	Hvidovre University Hospital	30	2026-09-21	2026-09-18
Effect of Digital-Supported Foot Care Education in Individuals With Type 2 Diabetes Digital-Supported Foot Care Education - Type 2 Diabetes Mellitus (T2DM)	Not applicable	Not yet recruiting	Siirt University	90	2026-09-20	2026-09-10
Beneficial Effects of Supplementation With CRONILIEF™ (Palmitoylethanolamide Phospholipids) in Diabetic Subjects With Neuropathic Pain. Cronilief™ (300 mg), Placebo - Neuropathic Pain Management, Diabetic Neuropathies, Painful	Not applicable	Not yet recruiting	Azienda di Servizi alla Persona di Pavia	70	2026-09-15	2026-02-17

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Narrower conditions

Diabetic Foot (1032)  ·  Diabetes Mellitus (305)  ·  Foot Ulcer (111)  ·  Diabetes Mellitus, Type 2 (96)  ·  Varicose Ulcer (74)  ·  Pain (70)  ·  Diabetes Complications (69)  ·  Neuralgia (65)  ·  Ulcer (62)  ·  Wounds and Injuries (54)  ·  Pressure Ulcer (53)  ·  Leg Ulcer (41)  ·  Peripheral Nervous System Diseases (41)  ·  Peripheral Arterial Disease (33)

Broader conditions

Endocrine System Diseases (1502)  ·  Diabetes Complications (1438)  ·  Diabetes Mellitus (1202)  ·  Cardiovascular Diseases (1044)  ·  Vascular Diseases (1038)  ·  Skin and Connective Tissue Diseases (1036)  ·  Skin Diseases (1030)  ·  Diabetic Angiopathies (1028)  ·  Skin Ulcer (1015)  ·  Leg Ulcer (992)  ·  Foot Ulcer (922)  ·  Nervous System Diseases (541)  ·  Neuromuscular Diseases (538)  ·  Peripheral Nervous System Diseases (497)

Interventions

Standard of Care (94)  ·  Pregabalin (24)  ·  Duloxetine Hydrochloride (16)  ·  Bandages (15)  ·  Control Groups (13)  ·  Negative-Pressure Wound Therapy (12)  ·  Sodium Chloride (12)  ·  Exercise (11)  ·  Saline Solution (11)  ·  Thioctic Acid (10)  ·  Gabapentin (9)  ·  Debridement (8)  ·  Educational Status (8)  ·  2-(acetylamino)-3-methoxy-N-(phenylmethyl)-, (2R)- (7)  ·  Collagenases (7)

Sponsors

Riphah International University (24)  ·  University of Texas Southwestern Medical Center (16)  ·  Cairo University (14)  ·  Universidad Complutense de Madrid (14)  ·  Integra LifeSciences Corporation (13)  ·  Assiut University (12)  ·  Eli Lilly and Company (12)  ·  Anterogen Co., Ltd. (10)  ·  Pfizer's Upjohn has merged with Mylan to form Viatris Inc. (10)  ·  Healthpoint (9)  ·  MiMedx Group, Inc. (9)  ·  Molnlycke Health Care AB (9)  ·  Pfizer (9)  ·  Smith & Nephew, Inc. (9)  ·  UCB Pharma (9)

Countries

United States (502)  ·  United Kingdom (81)  ·  Germany (70)  ·  Turkey (Türkiye) (70)  ·  France (64)  ·  China (62)  ·  Canada (58)  ·  Egypt (57)  ·  Pakistan (57)  ·  Denmark (55)  ·  Spain (48)  ·  Italy (44)  ·  Sweden (31)  ·  Israel (28)  ·  Poland (28)

Top investigators

Herbert B Slade, MD (7)  ·  David Armstrong, DPM, MD, PhD (6)  ·  Lawrence Lavery, DPM MPH (5)  ·  Chandan K Sen, PhD (4)  ·  Lawrence Lavery, DPM (4)  ·  Windy Cole, DPM (4)  ·  Aziz Shaibani, MD (3)  ·  Charles M Zelen, DPM (3)

Results publications

PMID 20876709, PMID 24767584, PMID 27611736, PMID 28614678, PMID 30084288, PMID 30206821, PMID 30521533, PMID 31802967, PMID 16291066, PMID 22717465, PMID 23958264, PMID 26738255, PMID 27269974, PMID 28326159, PMID 31876991, PMID 34187716, PMID 35534614, PMID 35587172, PMID 10693087, PMID 10720604, PMID 11319655, PMID 11926784, PMID 12589096, PMID 15353531, PMID 15793206, PMID 16291063, PMID 16389125, PMID 16758177, PMID 17277315, PMID 18612117, PMID 18619874, PMID 18990064, PMID 19383872, PMID 20032779, PMID 20332511, PMID 20336198, PMID 20655123, PMID 20818193, PMID 21540423, PMID 21636159, PMID 21775755, PMID 22417277, PMID 22883509, PMID 23159553, PMID 23222938, PMID 23613782, PMID 24657294, PMID 24822048, PMID 24843743, PMID 25018648

NIH funding

2018 (5), 2019 (4), 2005 (3), 2008 (3), 2015 (3), 2016 (3), 2023 (3), U24DK122927 (3), 2004 (2), R01NS057594 (2), 1DP3DK104386-01 (1), 2009 (1), I01RX000130 (1), K01HD091449 (1), K23DK081021 (1)