457 completed, 89 unknown, 54 terminated, 34 recruiting. 210 Phase 4, 151 Not applicable, 122 Phase 3, 113 Phase 2, 87 Phase 1.
Follow Ibuprofen: new trials by email Literature Review of Ibuprofen trials Research Report on Ibuprofen
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Suzetrigine Versus Standard Analgesia After Skin Cancer Surgery Suzetrigine, Acetaminophen Plus Ibuprofen - Postoperative Pain, Acute Pain | Phase 4 | Not yet recruiting | University of Minnesota | 230 | 2027-04-01 | 2026-09-25 |
| Pollution, Isotonic Nasal Wash, NSAID Evaluation Wood Smoke (Lodgepole Pine) exposure, Filtered Air exposure, Placebo Pill - This Study Will Evaluate the Effects of Woodsmoke Exposures and Advil in Healthy Adults | Phase 4 | Not yet recruiting | University of British Columbia | 20 | 2026-12-01 | 2026-11-09 |
| Effects of Hypoxia or Caffeine on 4km Time-trial Morning Cycling. Caffeine (300mg), Placebo (caffeine, paracetamol, cephalexin, or ibuprofen), Control - Caffeine, Hypoxia | Phase 4 | Recruiting | Liverpool John Moores University | 20 | 2026-11-15 | 2026-11-13 |
| Suzetrigine for Opioid-Sparing Postoperative Analgesia Following Transvaginal Pelvic Reconstructive Surgery Suzetrigine, Opioid Analgesics (Tramadol or Oxycodone), Scheduled Acetaminophen and Ibuprofen - Pelvic Organ Prolapse (POP), Stress Urinary Incontinence (SUI) | Phase 4 | Not yet recruiting | University of California, Los Angeles | 120 | 2026-11-01 | 2026-09-15 |
| Effect of Nonsteroidal Anti-Inflammatory Drug Restriction on the Efficacy of Platelet-Rich Plasma in Knee Osteoarthritis Leukocyte-Rich Platelet-Rich Plasma, ibuprofen, Acetaminophen - Osteoarthritis, Knee | Not applicable | Not yet recruiting | Federal University of São Paulo | 90 | 2026-10-01 | 2026-08-14 |
| A Study of Combogesic® 325 in Adolescent Patients With Moderate to Severe Postoperative Pain Associated With Orthopedic Surgery Combogesic® tablets, Acetaminophen 500mg, Placebo - Post Operative Pain, Acute | Phase 3 | Not yet recruiting | AFT Pharmaceuticals, Ltd. | 180 | 2026-10-01 | 2026-07-01 |
| Post-op Analgesia of Nail Unit Procedures Suzetrigine, Oxycodone/Acetaminophen, Acetaminophen - Nail Diseases | Phase 4 | Not yet recruiting | University of Miami | 45 | 2026-10-01 | 2026-10-01 |
| Efficacy of Non-opioid Drugs in Addition to Opioid Therapy for Cancer Pain Management Metamizole, Ibuprofen, Placebo - Cancer Pain, Cancer Palliative Care | Phase 3 | Not yet recruiting | University Hospital, Basel, Switzerland | 318 | 2026-10-01 | 2026-08-19 |
| Pain Control During ESWL Using Non-Opioid Analgesics Ibuprofen (Brufen®), Paracetamol (drug), Tenoxicam - Urolithiasis, Kidney Stones | Phase 4 | Not yet recruiting | University of Gaziantep | 160 | 2026-10-01 | 2026-08-12 |
| An Artificial Intelligence Driven Approach to Optimize Patient Selection for a Transitional Pain Service TPS-Select, Pharmacologic Pain Management, Interventional Pain Procedures - Postsurgical Pain Management, Postsurgical Pain, Chronic | Phase 3 | Not yet recruiting | University of California, San Francisco | 474 | 2026-10-01 | 2026-10-09 |
| A Study of Combogesic® IV (Intravenous) in Pediatric Patients With Acute Pain Combogesic® IV (fixed-dose combination containing acetaminophen 10 mg/ml + ibuprofen 3 mg/ml in 100 ml solution for infusion) - Acute Pain | Phase 3 | Recruiting | AFT Pharmaceuticals, Ltd. | 60 | 2026-09-14 | 2026-09-16 |
| Post-Vasectomy Pain Study Acetaminophen, ibuprofen, oxycodone - Vasectomy, NSAIDs | Phase 1 | Recruiting | Columbia University | 200 | 2026-09-10 | 2026-09-24 |
| Paracetamol and Ibuprofen With or Without Famotidine for Calcific Tendinitis of the Shoulder Paracetamol + Ibuprofen + Famotidine, Paracetamol + Ibuprofen - Calcific Tendinitis | Not applicable | Not yet recruiting | University Hospital Dubrava | 200 | 2026-09-01 | 2026-04-20 |
| Impact of Preemptive Analgesia on Postoperative Pain in Orthognathic Surgery Acetaminophen, ibuprofen - Post Operative Pain, Orthognathic Surgery | Phase 4 | Recruiting | University of Puerto Rico | 72 | 2026-09-01 | 2026-09-01 |
| Study on the Effect of Electronic Moxibustion on Non-Specific Low Back Pain in Young Adults Electronic Moxibustion, ibuprofen or celecoxib analgesics - Electronic Moxibustion, Low Back Pain | Not applicable | Not yet recruiting | Nanfang Hospital, Southern Medical University | 90 | 2026-09-01 | 2026-10-05 |
| Curcumin Versus Ibuprofen for Exercise-Induced Muscle Damage in Physically Active Women Curcumin, Ibuprofen, Placebo - Exercise-Induced Muscle Damage, Delayed Onset Muscle Soreness (DOMS) | Not applicable | Completed | University of Valladolid | 36 | 2026-08-22 | 2026-09-23 |
| Role of Alprazolam in Management of Post Endodontic Pain After Single Visit Root Canal Treatment. To Compare Mean Pain Score Between Two Group of Participants Undergoing Post Operative Pain Management After Single Visit Root Canal Treatment: NSAIDs Alone and a Combination of NSAIDs and Alprazolam. Brufen and alprazolam, Brufen - Pain | Not applicable | Recruiting | Armed Forces Post Graduate Medical Institute (AFPGMI), Rawalpindi | 110 | 2026-07-30 | 2026-07-28 |
| Non-antibiotic Management in Acute Uncomplicated Diverticulitis Symptomatic treatment (ibuprofen and acetaminophen), Amoxicillin-clavulanate, Ciprofloxacin plus metronidazole - Acute Uncomplicated Diverticulitis | Phase 4 | Withdrawn | Montefiore Medical Center | 2026-07-01 | 2026-08-31 | |
| Comparison of Acupressure, Ibuprofen, and Chewing Gum for the Management of Post-Archwire Orthodontic Pain Acupressure, Ibuprofen 400 mg (if necessary), Chewing Gum - Malocclusion | Not applicable | Not yet recruiting | Bahria University | 105 | 2026-07-01 | 2026-06-11 |
| A Phase IV Randomized Trial of Maxigesic® Versus Standard Analgesia After Radical Gastrectomy Acetaminophen (Newaminophen Premix), Maxigesic IV (acetaminophen/ibuprofen) - Stomach Neoplasms, Pain | Phase 4 | Not yet recruiting | Yonsei University | 160 | 2026-07-01 | 2026-07-07 |
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Pain (112) · Pain, Postoperative (99) · Agnosia (55) · Ductus Arteriosus, Patent (34) · Fever (23) · Acute Pain (22) · Low Back Pain (20) · Osteoarthritis (16) · Emergencies (14) · Inflammation (14) · Premature Birth (13) · Toothache (13) · Migraine Disorders (11) · Osteoarthritis, Knee (11) · Headache (10)
Pfizer (21) · Cairo University (11) · Cumberland Pharmaceuticals (11) · Boehringer Ingelheim (9) · Montefiore Medical Center (8) · Heron Therapeutics (7) · AFT Pharmaceuticals, Ltd. (6) · Bayer (6) · Dr. Reddy's Laboratories Limited (6) · Organon and Co (6) · Pamukkale University (6) · Ain Shams University (5) · Albany Medical College (5) · Ankara City Hospital Bilkent (5) · Aziende Chimiche Riunite Angelini Francesco S.p.A (5)
United States (274) · Turkey (Türkiye) (38) · Canada (33) · United Kingdom (27) · Egypt (20) · Germany (18) · Spain (17) · South Korea (16) · Brazil (15) · Israel (14) · Italy (14) · China (12) · Pakistan (12) · Denmark (11) · Switzerland (11)
Milko Radicioni, MD (3) · Amr M Elnaghy, PhD (2) · Art P Wheeler, M.D. (2) · Benjamin Friedman, MD (2) · Benoit Girard, MD (2) · Bryce Weber, MD FRCSC (2) · Cathy Hammerman, MD (2)
PMID 23360885, PMID 25349008, PMID 25526232, PMID 26165391, PMID 32797734, PMID 35553047, PMID 36519620, PMID 39698942, PMID 10606379, PMID 10613619, PMID 10662747, PMID 10846153, PMID 11735667, PMID 11884154, PMID 11904109, PMID 11914403, PMID 11927799, PMID 12119802, PMID 12148679, PMID 12151246, PMID 12723749, PMID 12807523, PMID 12832331, PMID 12918862, PMID 12973155, PMID 15066944, PMID 1509971, PMID 15230906, PMID 1542147, PMID 15710782, PMID 15738343, PMID 15784928, PMID 15951714, PMID 16416713, PMID 16436853, PMID 16448572, PMID 16632326, PMID 16848101, PMID 16862046, PMID 16885182, PMID 16967609, PMID 17185058, PMID 17397460, PMID 17413924, PMID 17437870, PMID 17515447, PMID 17515448, PMID 17564958, PMID 17920504, PMID 17955107
2015 (6), 2014 (5), 2016 (5), 2018 (3), 2019 (2), 2023 (2), 2004 (1), 2017 (1), 2025 (1), K07CA168886 (1), K23DK146181 (1), P30CA033572 (1), P30CA068485 (1), R01AG018857 (1), R01AG024010 (1)