5681 completed, 1913 unknown, 1072 recruiting, 685 not yet recruiting. 4991 Not applicable, 1545 Phase 4, 798 Phase 3, 730 Phase 2, 235 Phase 1.
Follow Postoperative Complications: new trials by email Literature Review of Postoperative Complications trials Research Report on Postoperative Complications
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Tau Pathology in the Brain After Hip or Knee Replacement Surgery Hip or Knee Arthroplasty Under Spinal Anesthesia - Postoperative Cognitive Dysfunction, Alzheimer Disease | Recruiting | Uppsala University Hospital | 30 | 2029-04-01 | 2026-10-15 | |
| Postoperative Analgesia Using Ganglion Impar Block After Anal Surgery Ganglion impar block with Bupivacaine., Ganglion impar block with normal saline - Postoperative Pain | Not applicable | Not yet recruiting | University of Alexandria | 60 | 2028-07-01 | 2025-04-03 |
| Perioperative Esketamine Safety and Efficacy in Reducing Postoperative ENDometriosis PAIN (the ENDPAIN Trial): a Randomized Controlled Trial. Esketamine, Placebo - Endometriosis | Phase 4 | Not yet recruiting | Region Skane | 1000 | 2028-01-01 | 2026-10-19 |
| Psilocybin After Trauma Surgery for Pain Psilocybin (Usona Institute), Postoperative analgesia - Pain Management, Postoperative Pain | Phase 1 | Not yet recruiting | Trent Emerick | 70 | 2027-12-31 | 2026-08-06 |
| Vitamin B6 on Exercise Pressor Reflex on Leg Ischemia-reperfusion Vitamin B6 25 MG, Vitamin B6 50 MG, Vitamin B6 100 MG - Ischemia Reperfusion Injury, Peripheral Artery Disease | Early Phase 1 | Not yet recruiting | Milton S. Hershey Medical Center | 30 | 2027-12-01 | 2026-03-17 |
| ESP Blocks for Posterior Spinal Fusion ESP Block with Bupivacaine, ESP Block with Bupivacaine + Liposomal Bupivacaine - Postoperative Pain | Phase 4 | Not yet recruiting | Duke University | 75 | 2027-10-01 | 2026-08-27 |
| Efficacy of Different Disinfection Technologies in Molar Non-Surgical Retreatment GentleWave System, Conventional rotary instrumentation with passive ultrasonic irrigation - Apical Periodontitis | Not applicable | Not yet recruiting | University of Alabama at Birmingham | 60 | 2027-07-01 | 2026-04-08 |
| The IMPACT Study: Personalized Physical Therapy for Better Recovery and a Stronger Core After Hernia Surgery PT Group, Usual Care - Ventral Hernia, Ventral Incisional Hernia | Not applicable | Not yet recruiting | Thomas Jefferson University | 60 | 2027-07-01 | 2026-10-22 |
| ESP vs Subcostal TAP Block for Analgesia After Laparoscopic Cholecystectomy Erector Spinae Plane Block, Subcostal Transversus Abdominis Plane Block - Cholelithiasis, Postoperative Pain, Laparoscopic Cholecystectomy | Not applicable | Not yet recruiting | Gaziantep City Hospital | 100 | 2027-06-15 | 2026-06-22 |
| Effect of Betadine Vaginal Cleansing Before Cesarean Section to Reduce Postoperative Infectious Morbidity Povidone-iodine 5% solution - Cesarean Section, Surgical Site Infection | Not applicable | Not yet recruiting | Mohamed Mousa Mohamed Mousa | 600 | 2027-05-01 | 2026-07-20 |
| Early Intervention Juzo Compression Sleeve and Glove, Compression Sleeve Sensor - Breast Cancer, Breast Cancer Treatment Related Lymphedema | Not applicable | Not yet recruiting | Massachusetts General Hospital | 40 | 2027-05-01 | 2026-07-13 |
| Suzetrigine Versus Standard Analgesia After Skin Cancer Surgery Suzetrigine, Acetaminophen Plus Ibuprofen - Postoperative Pain, Acute Pain | Phase 4 | Not yet recruiting | University of Minnesota | 230 | 2027-04-01 | 2026-09-25 |
| Efficacy and Safety of TRA16 Administered Orally in Patients With Enteric Hyperoxaluria (EH). TRA16, Placebo - Enteric Hyperoxaluria | Phase 2 | Not yet recruiting | Wuhan Kangfude Urolithiasis Research Institute Co., Ltd. | 30 | 2027-03-01 | 2026-10-13 |
| Phase 3 Bunionectomy Study CPL-01, saline placebo - Postoperative Pain, Bunion | Phase 3 | Not yet recruiting | Cali Pharmaceuticals LLC | 112 | 2027-03-01 | 2026-10-21 |
| A Bowel Management Program (Retrograde Rectal Enema) for the Treatment of Low Anterior Resection Syndrome in Rectal Cancer Patients Dietary Fiber, Enema Administration, Loperamide Hydrochloride - Low Anterior Resection Syndrome, Rectal Carcinoma | Not applicable | Recruiting | Ohio State University Comprehensive Cancer Center | 80 | 2027-02-15 | 2026-10-06 |
| Use of a Vibration Tool for Postoperative Pain Control in Distal Radius Fractures Vibration tool - Distal Radius Fracture, Radius Fracture Distal | Not applicable | Not yet recruiting | Northwestern University | 100 | 2027-01-01 | 2026-07-10 |
| Safety of F14 Following Total Knee Replacement F14 (sustained release celecoxib) - Analgesia | Phase 2 / Phase 3 | Suspended | Arthritis Innovation Corporation | 100 | 2027-01-01 | 2026-06-05 |
| Evaluation of the Efficacy of Sublingual Sufentanil (Prescribed as Rescue Analgesia for Acute Postoperative Pain) on the Quality of Health Recovery After Surgery: a Randomized, Controlled, Multicenter, Open-label Trial Against an Active Comparator (SUBLIME) Sublingual sufentanil 30 µg (one dose per hour, as needed), Morphine sulfate (10 mg every 4 hours as needed) - Postoperative Pain | Phase 4 | Not yet recruiting | University Hospital, Strasbourg, France | 1150 | 2027-01-01 | 2026-06-03 |
| A Predictive Model for Postoperative Analgesic Requirements After Abdominal Surgery Intravenous Morphine Patient-Controlled Analgesia - Postoperative Pain, Postoperative Analgesia | Not yet recruiting | Chaw Sook Hui | 65 | 2027-01-01 | 2026-09-03 | |
| Study of QL Analgesic Response and Extent Quadratus Lumborum with 1.5% Lidocaine - Acute Pain, Postoperative Pain | Phase 4 | Not yet recruiting | Duke University | 25 | 2027-01-01 | 2026-07-08 |
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Pain, Postoperative (5413) · Emergence Delirium (730) · Surgical Wound Infection (723) · Postoperative Nausea and Vomiting (631) · Pain (616) · Agnosia (595) · Postoperative Cognitive Complications (256) · Reperfusion Injury (242) · Anastomotic Leak (230) · Acute Pain (197) · Chronic Pain (192) · Incisional Hernia (186) · Breast Neoplasms (176) · Phantom Limb (159)
Pathological Conditions, Signs and Symptoms (10394) · Pathologic Processes (10381) · Signs and Symptoms (7196) · Neurologic Manifestations (6536) · Pain (5139) · Nervous System Diseases (1899) · Neurobehavioral Manifestations (1521) · Mental Disorders (1191) · Neurocognitive Disorders (941) · Infections (827) · Digestive System Diseases (815) · Neoplasms (780) · Confusion (770) · Neoplasms by Site (744)
Bupivacaine (476) · Saline Solution (338) · Sodium Chloride (336) · Dexmedetomidine (269) · Ropivacaine (261) · Dexamethasone (258) · Acetaminophen (236) · Morphine (189) · Ketamine (143) · Lidocaine (140) · Propofol (116) · Fentanyl (109) · Ibuprofen (103) · Control Groups (95) · Sevoflurane (94)
Cairo University (164) · Assiut University (154) · Ain Shams University (124) · Seoul National University Hospital (65) · Tanta University (56) · Mayo Clinic (49) · Ankara City Hospital Bilkent (44) · Cukurova University (43) · Mansoura University (42) · The Cleveland Clinic (42) · Beijing Tiantan Hospital (41) · Peking University First Hospital (40) · Yonsei University (40) · Ataturk University (39) · Istanbul University (39)
United States (2015) · Turkey (Türkiye) (1429) · China (777) · Egypt (772) · Canada (361) · Denmark (331) · France (325) · Italy (322) · Spain (290) · South Korea (271) · Germany (250) · Belgium (197) · Pakistan (187) · United Kingdom (186) · Switzerland (181)
Dong-Xin Wang, MD, PhD (27) · Claudia Spies, MD, Prof. (10) · Brian M Ilfeld, M.D., M.S. (9) · Musa Zengin, MD (8) · Brian M Ilfeld, MD, MS (7) · David Prior (7) · Fang Luo, M.D. (7) · Hala S Abdel-Ghaffar, MD (7) · Nicolai Goettel, MD (7) · Saleh K Saleh, MD (7)
PMID 27501016, PMID 41159585, PMID 36748942, PMID 22900785, PMID 40260835, PMID 30063657, PMID 32580252, PMID 32871021, PMID 15114210, PMID 15273542, PMID 26225500, PMID 32335895, PMID 34002866, PMID 34854473, PMID 10219875, PMID 23121612, PMID 23471754, PMID 23992774, PMID 24012235, PMID 24535604, PMID 25032676, PMID 30737315, PMID 38148266, PMID 38345071, PMID 9525362, PMID 10485781, PMID 11756886, PMID 12873949, PMID 15733628, PMID 16698416, PMID 17678782, PMID 17981197, PMID 18156878, PMID 18443635, PMID 18577850, PMID 20601860, PMID 22762316, PMID 23360885, PMID 23392233, PMID 23411725, PMID 24121608, PMID 25535538, PMID 25565885, PMID 26241763, PMID 26275092, PMID 26827847, PMID 27755488, PMID 28576285, PMID 28641875, PMID 29492863
2019 (23), 2014 (22), 2017 (18), 2025 (17), 2009 (14), 2016 (12), 2018 (11), 2023 (11), 2015 (10), 2008 (9), 2005 (5), 2004 (4), K23AT011569 (2), K24DA053564 (2), R01DA044245 (2)