Postoperative Complications: Clinical Trials

5702 completed, 1911 unknown, 1080 recruiting, 693 not yet recruiting. 5012 Not applicable, 1551 Phase 4, 800 Phase 3, 730 Phase 2, 235 Phase 1.

By phase and status

Phase	Trials	Status
Not applicable	5012	Completed 2652, Unknown 922, Recruiting 600, Not yet recruiting 414, Terminated 161, Active not recruiting 115, Withdrawn 103, Enrolling by invitation 36, Suspended 9
Phase 4	1551	Completed 875, Unknown 267, Recruiting 108, Terminated 103, Not yet recruiting 91, Withdrawn 62, Active not recruiting 31, Enrolling by invitation 12, Suspended 2
Phase 3	800	Completed 469, Unknown 138, Recruiting 61, Terminated 52, Not yet recruiting 26, Active not recruiting 22, Withdrawn 22, Enrolling by invitation 5, Suspended 5
Phase 2	730	Completed 425, Unknown 125, Recruiting 57, Terminated 53, Not yet recruiting 29, Withdrawn 24, Active not recruiting 11, Enrolling by invitation 3, Suspended 3
Phase 1	235	Completed 129, Unknown 41, Terminated 16, Not yet recruiting 15, Recruiting 15, Active not recruiting 7, Withdrawn 7, Enrolling by invitation 3, Suspended 2
Early Phase 1	78	Completed 36, Unknown 20, Not yet recruiting 6, Withdrawn 6, Recruiting 5, Active not recruiting 2, Terminated 2, Enrolling by invitation 1

Follow Postoperative Complications: new trials by email Literature Review of Postoperative Complications trials Research Report on Postoperative Complications

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Tau Pathology in the Brain After Hip or Knee Replacement Surgery Hip or Knee Arthroplasty Under Spinal Anesthesia - Postoperative Cognitive Dysfunction, Alzheimer Disease		Recruiting	Uppsala University Hospital	30	2029-04-01	2026-10-15
Postoperative Analgesia Using Ganglion Impar Block After Anal Surgery Ganglion impar block with Bupivacaine., Ganglion impar block with normal saline - Postoperative Pain	Not applicable	Not yet recruiting	University of Alexandria	60	2028-07-01	2025-04-03
Perioperative Esketamine Safety and Efficacy in Reducing Postoperative ENDometriosis PAIN (the ENDPAIN Trial): a Randomized Controlled Trial. Esketamine, Placebo - Endometriosis	Phase 4	Not yet recruiting	Region Skane	1000	2028-01-01	2026-10-19
Psilocybin After Trauma Surgery for Pain Psilocybin (Usona Institute), Postoperative analgesia - Pain Management, Postoperative Pain	Phase 1	Not yet recruiting	Trent Emerick	70	2027-12-31	2026-08-06
Vitamin B6 on Exercise Pressor Reflex on Leg Ischemia-reperfusion Vitamin B6 25 MG, Vitamin B6 50 MG, Vitamin B6 100 MG - Ischemia Reperfusion Injury, Peripheral Artery Disease	Early Phase 1	Not yet recruiting	Milton S. Hershey Medical Center	30	2027-12-01	2026-03-17
VibraCool Device to Reduce Pain and Opioid Use After Anterior Cruciate Ligament Reconstruction (ACLR) VibraCool mechanical stimulation and neuromodulatory therapeutic device, Cryocompression (Game Ready, Bregs) device, Standard ice packs - ACL, Opioid Use	Not applicable	Not yet recruiting	Columbia University	130	2027-11-01	2026-10-28
SUTURE TYPE AND RECURRENCE RISK AFTER INCISIONAL HERNIA REPAIR Suturing of hernia defect with non-absorbable suture, Suturing of hernia defect with slowly absorbable suture - Ventral Incisional Hernia	Not applicable	Not yet recruiting	Ersta Diakoni	980	2027-09-01	2026-10-23
Efficacy of Different Disinfection Technologies in Molar Non-Surgical Retreatment GentleWave System, Conventional rotary instrumentation with passive ultrasonic irrigation - Apical Periodontitis	Not applicable	Not yet recruiting	University of Alabama at Birmingham	60	2027-07-01	2026-04-08
The IMPACT Study: Personalized Physical Therapy for Better Recovery and a Stronger Core After Hernia Surgery PT Group, Usual Care - Ventral Hernia, Ventral Incisional Hernia	Not applicable	Not yet recruiting	Thomas Jefferson University	60	2027-07-01	2026-10-22
Prospective Observational Multimodal Neuromonitoring During High-Risk Adult Surgery Postoperative Cognitive Complications, Delirium		Not yet recruiting	University of Texas Southwestern Medical Center	300	2027-07-01	2026-10-23
Prospective Observational Multimodal Neuromonitoring in Adult NSICU Patients Subarachnoid Hemorrhage, Aneurysmal, Brain Injuries, Traumatic		Not yet recruiting	University of Texas Southwestern Medical Center	300	2027-07-01	2026-10-23
ESP vs Subcostal TAP Block for Analgesia After Laparoscopic Cholecystectomy Erector Spinae Plane Block, Subcostal Transversus Abdominis Plane Block - Cholelithiasis, Postoperative Pain, Laparoscopic Cholecystectomy	Not applicable	Not yet recruiting	Gaziantep City Hospital	100	2027-06-15	2026-06-22
Effect of Betadine Vaginal Cleansing Before Cesarean Section to Reduce Postoperative Infectious Morbidity Povidone-iodine 5% solution - Cesarean Section, Surgical Site Infection	Not applicable	Not yet recruiting	Mohamed Mousa Mohamed Mousa	600	2027-05-01	2026-07-20
Early Intervention Juzo Compression Sleeve and Glove, Compression Sleeve Sensor - Breast Cancer, Breast Cancer Treatment Related Lymphedema	Not applicable	Not yet recruiting	Massachusetts General Hospital	40	2027-05-01	2026-07-13
Suzetrigine Versus Standard Analgesia After Skin Cancer Surgery Suzetrigine, Acetaminophen Plus Ibuprofen - Postoperative Pain, Acute Pain	Phase 4	Not yet recruiting	University of Minnesota	230	2027-04-01	2026-09-25
Efficacy and Safety of TRA16 Administered Orally in Patients With Enteric Hyperoxaluria (EH). TRA16, Placebo - Enteric Hyperoxaluria	Phase 2	Not yet recruiting	Wuhan Kangfude Urolithiasis Research Institute Co., Ltd.	30	2027-03-01	2026-10-13
Phase 3 Bunionectomy Study CPL-01, saline placebo - Postoperative Pain, Bunion	Phase 3	Not yet recruiting	Cali Pharmaceuticals LLC	112	2027-03-01	2026-10-21
A Bowel Management Program (Retrograde Rectal Enema) for the Treatment of Low Anterior Resection Syndrome in Rectal Cancer Patients Dietary Fiber, Enema Administration, Loperamide Hydrochloride - Low Anterior Resection Syndrome, Rectal Carcinoma	Not applicable	Recruiting	Ohio State University Comprehensive Cancer Center	80	2027-02-15	2026-10-06
Opioid Reduction and Enhanced Recovery in Orthopaedic Surgery (OREOS)-Knee Standard care, Multicomponent opioid reduction and pain management pathway - Knee Arthroplasty, Total, Partial Knee Arthroplasty	Not applicable	Not yet recruiting	McMaster University	170	2027-02-01	2026-10-26
Use of a Vibration Tool for Postoperative Pain Control in Distal Radius Fractures Vibration tool - Distal Radius Fracture, Radius Fracture Distal	Not applicable	Not yet recruiting	Northwestern University	100	2027-01-01	2026-07-10

Showing 20 of 10429. Sign in to see all of them.

Narrower conditions

Pain, Postoperative (5427)  ·  Emergence Delirium (735)  ·  Surgical Wound Infection (725)  ·  Postoperative Nausea and Vomiting (632)  ·  Pain (618)  ·  Agnosia (595)  ·  Postoperative Cognitive Complications (257)  ·  Reperfusion Injury (242)  ·  Anastomotic Leak (231)  ·  Acute Pain (197)  ·  Chronic Pain (192)  ·  Incisional Hernia (188)  ·  Breast Neoplasms (177)  ·  Phantom Limb (159)

Broader conditions

Pathological Conditions, Signs and Symptoms (10427)  ·  Pathologic Processes (10414)  ·  Signs and Symptoms (7219)  ·  Neurologic Manifestations (6558)  ·  Pain (5151)  ·  Nervous System Diseases (1907)  ·  Neurobehavioral Manifestations (1527)  ·  Mental Disorders (1199)  ·  Neurocognitive Disorders (947)  ·  Infections (830)  ·  Digestive System Diseases (818)  ·  Neoplasms (784)  ·  Confusion (775)  ·  Neoplasms by Site (748)

Interventions

Bupivacaine (477)  ·  Saline Solution (341)  ·  Sodium Chloride (336)  ·  Dexmedetomidine (269)  ·  Ropivacaine (261)  ·  Dexamethasone (259)  ·  Acetaminophen (236)  ·  Morphine (189)  ·  Ketamine (143)  ·  Lidocaine (140)  ·  Propofol (117)  ·  Fentanyl (109)  ·  Ibuprofen (103)  ·  Control Groups (95)  ·  Sevoflurane (94)

Sponsors

Cairo University (164)  ·  Assiut University (155)  ·  Ain Shams University (124)  ·  Seoul National University Hospital (65)  ·  Tanta University (57)  ·  Mayo Clinic (49)  ·  Ankara City Hospital Bilkent (44)  ·  Cukurova University (43)  ·  Mansoura University (42)  ·  The Cleveland Clinic (42)  ·  Beijing Tiantan Hospital (41)  ·  Peking University First Hospital (40)  ·  Yonsei University (40)  ·  Ataturk University (39)  ·  Istanbul University (39)

Countries

United States (2016)  ·  Turkey (Türkiye) (1438)  ·  China (781)  ·  Egypt (778)  ·  Canada (361)  ·  Denmark (332)  ·  France (327)  ·  Italy (322)  ·  Spain (290)  ·  South Korea (272)  ·  Germany (250)  ·  Belgium (197)  ·  Pakistan (187)  ·  United Kingdom (186)  ·  Switzerland (181)

Top investigators

Dong-Xin Wang, MD, PhD (27)  ·  Claudia Spies, MD, Prof. (10)  ·  Brian M Ilfeld, M.D., M.S. (9)  ·  Musa Zengin, MD (8)  ·  Brian M Ilfeld, MD, MS (7)  ·  David Prior (7)  ·  Fang Luo, M.D. (7)  ·  Hala S Abdel-Ghaffar, MD (7)  ·  Nicolai Goettel, MD (7)  ·  Saleh K Saleh, MD (7)

Results publications

PMID 27501016, PMID 41159585, PMID 36748942, PMID 22900785, PMID 40260835, PMID 30063657, PMID 32580252, PMID 32871021, PMID 15114210, PMID 15273542, PMID 26225500, PMID 32335895, PMID 34002866, PMID 34854473, PMID 10219875, PMID 23121612, PMID 23471754, PMID 23992774, PMID 24012235, PMID 24535604, PMID 25032676, PMID 30737315, PMID 38148266, PMID 38345071, PMID 9525362, PMID 10485781, PMID 11756886, PMID 12873949, PMID 15733628, PMID 16698416, PMID 17678782, PMID 17981197, PMID 18156878, PMID 18443635, PMID 18577850, PMID 20601860, PMID 22762316, PMID 23360885, PMID 23392233, PMID 23411725, PMID 24121608, PMID 25535538, PMID 25565885, PMID 26241763, PMID 26275092, PMID 26827847, PMID 27755488, PMID 28576285, PMID 28641875, PMID 29492863

NIH funding

2019 (23), 2014 (22), 2017 (18), 2025 (18), 2009 (14), 2016 (12), 2018 (11), 2023 (11), 2015 (10), 2008 (9), 2005 (5), 2004 (4), K23AT011569 (2), K24DA053564 (2), R01DA044245 (2)