Rheumatic Diseases: Clinical Trials

6391 completed, 1685 unknown, 972 recruiting, 644 terminated. 4312 Not applicable, 1426 Phase 2, 1194 Phase 3, 898 Phase 4, 822 Phase 1.

By phase and status

Phase	Trials	Status
Not applicable	4312	Completed 2402, Unknown 742, Recruiting 432, Not yet recruiting 228, Active not recruiting 192, Terminated 167, Withdrawn 93, Enrolling by invitation 39, Suspended 17
Phase 2	1426	Completed 910, Unknown 151, Terminated 148, Recruiting 86, Withdrawn 57, Not yet recruiting 36, Active not recruiting 27, Enrolling by invitation 7, Suspended 4
Phase 3	1194	Completed 861, Unknown 108, Terminated 87, Recruiting 54, Active not recruiting 34, Withdrawn 25, Not yet recruiting 18, Enrolling by invitation 6, Suspended 1
Phase 4	898	Completed 541, Unknown 149, Terminated 83, Recruiting 54, Not yet recruiting 30, Withdrawn 29, Active not recruiting 10, Enrolling by invitation 2
Phase 1	822	Completed 523, Unknown 100, Recruiting 75, Terminated 44, Withdrawn 33, Active not recruiting 23, Not yet recruiting 19, Enrolling by invitation 3, Suspended 2
Early Phase 1	86	Completed 27, Unknown 20, Recruiting 17, Not yet recruiting 10, Withdrawn 5, Active not recruiting 3, Suspended 2, Enrolling by invitation 1, Terminated 1

Follow Rheumatic Diseases: new trials by email Literature Review of Rheumatic Diseases trials Research Report on Rheumatic Diseases

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Study of AQUACEL™ Ag Surgical Cover Dressing Following Total Knee Replacement Aquacel Ag dressing - Osteoarthritis	Not applicable	Withdrawn	Golden Jubilee National Hospital		2050-01-01	2019-07-31
Cannabichromene Safety in Rheumatoid Arthritis Cannabichromene - Arthritis, Rheumatoid	Phase 1 / Phase 2	Withdrawn	Crystal Lederhos Smith		2028-07-15	2026-09-23
An Open-label Study of GC012F in Rheumatoid Arthritis. LD and GC012F CAR-T Cell Injection, GC012F CAR-T Cell Injection - Rheumatoid Arthritis	Early Phase 1	Withdrawn	Institute of Hematology & Blood Diseases Hospital, China		2027-12-01	2026-06-10
Evaluating the Effect of Adipose Tissue Processed With the SyntrFuge™ System for Knee Osteoarthritis SyntrFuge System, Triamcinolone Injection - Knee Osteoarthritis	Not applicable	Not yet recruiting	Syntr Health Technologies, Inc.	180	2027-12-01	2026-08-20
Clinical Outcomes of Focused Shockwave Therapy Without Adjunct Rehabilitation Compared to Standard Physical Rehabilitation in Patients With Grade I-III Knee Osteoarthritis: A Single-Blind Randomized Study Physical Rehab, Focused Shockwave Therapy - Knee Osteoarthristis	Not applicable	Not yet recruiting	Pulse Wave USA	60	2027-09-25	2026-05-05
Efficacy and Safety of GNSC-001 Intra-articular Injection for Knee Osteoarthritis Gene Therapy GNSC-001, Placebo - Knee Arthritis Osteoarthritis, Knee Arthritis, Osteoarthritis	Phase 2 / Phase 3	Not yet recruiting	Genascence Corporation	240	2027-07-01	2026-09-21
Feasibility and Preliminary Effects of an Asynchronous Microlearning Intervention on Fibromyalgia Knowledge Among Primary Health Care Workers Written Educational Material on Fibromyalgia, Asynchronous Microlearning Intervention on Fibromyalgia - Fibromyalgia, Fibromyalgia (FM)	Not applicable	Not yet recruiting	Instituto Neurociencia Del Dolor	68	2027-06-01	2026-10-13
Duloxetine and aeRobic Exercise to Improve Function in VEterans With Knee Osteoarthritis (DRIVE) Exercise, Duloxetine, Placebo - Knee Osteoarthritis, Pain	Phase 2	Not yet recruiting	VA Office of Research and Development	102	2027-03-01	2026-06-16
Undenatured Type II Collagen for Knee Osteoarthritis Pain Placebo, Nuvicol II, Nuvicol SII - Osteoarthritis, Knee	Not applicable	Recruiting	Universidad Católica San Antonio de Murcia	120	2027-03-01	2026-10-22
Comparing Pain Science Education to Biomedical Education for People With Knee Osteoarthritis: A Randomized Controlled Trial Pain Science Education, Biomedical Education - Knee Arthritis Osteoarthritis	Not applicable	Not yet recruiting	McMaster University	82	2027-02-01	2026-09-16
Improving Management and Secondary Prevention Through Azithromycin Comparative Trial in Rheumatic Heart Disease in Nigeria)- IMPACT-RHD Nigeria Benzathine Penicillin, Azithromycin (Azithro) - Rheumatic Fever, Valvular Heart Diseases	Not applicable	Not yet recruiting	Ladoke Akintola University of Technology, Ogbomoso, Nigeria	474	2027-01-05	2026-06-04
AI and Computer Vision-Assisted Telerehabilitation in Fibromyalgia: The FibroIA 2.0 Trial AI Combined (mobility and resistance training), AI mobility - Fibromyalgia, Fibromyalgia (FM)	Not applicable	Not yet recruiting	Instituto Neurociencia Del Dolor	66	2027-01-04	2026-07-01
Treatment of Fibromyalgia and PTSD With Live and Inactive Vagus Nerve Stimulation With PEPC tAN plus PEPC, sham plus PEPC - Fibromyalgia (FM), Posttraumatic Stress Disorder (PTSD)	Not applicable	Not yet recruiting	VA Office of Research and Development	180	2027-01-01	2026-09-29
HTO and Tranexamic Acid Study Tranexamic Acid, Routine medial opening wedge high tibial osteotomy - Osteoarthritis, Knee	Phase 3	Not yet recruiting	Western University, Canada	200	2027-01-01	2026-09-17
FIBROmyalgia: Somatic Tracking and Exercise Program Study Group exercising, Somatic tracking, General activity recommendaitons - Fibromyalgia (FM), Fibromyalgia	Not applicable	Not yet recruiting	University of Tromso	200	2027-01-01	2025-05-13
Zynrelef Versus Adductor Canal Block ZYNRELEF 400Mg-12Mg Extended-Release Solution, Ultrasound-Guided Adductor Canal Block, Ropivacaine 0.5% Injectable Solution - Knee Osteoarthritis, Arthritis Knee	Phase 4	Not yet recruiting	University of Miami	120	2027-01-01	2026-06-12
Patient-Reported Outcomes Dashboard With Goal Setting to Support Shared Decision-Making in Inflammatory Arthritis Patient-Reported Outcomes Dashboard With Goal Setting - Arthritis, Psoriatic (PsA), Arthritis, Rheumatoid (RA)	Not applicable	Not yet recruiting	Northwestern University	160	2027-01-01	2026-10-15
Pilot and Feasibility Study of Anti-CD14 for the Treatment of Knee Osteoarthritis Atibuclimab, saline placebo - Knee Osteoarthritis (Knee OA)	Phase 1	Not yet recruiting	VA Office of Research and Development	40	2027-01-01	2026-07-15
Penn SICCA Follow-up Study Dry Eye, Sjogren's Syndrome		Not yet recruiting	University of Pennsylvania	220	2027-01-01	2026-03-02
Heart Rate Variability Guided Physical Activity and Exercise Prescription in Individuals With Knee Osteoarthritis HRV-guided home exercise prescription, Traditional Home Exercise - Knee Osteoarthritis	Not applicable	Not yet recruiting	The Hong Kong Polytechnic University	240	2027-01-01	2026-02-12

Showing 20 of 10935. Sign in to see all of them.

Narrower conditions

Arthritis, Rheumatoid (3278)  ·  Osteoarthritis, Knee (3209)  ·  Osteoarthritis (2690)  ·  Fibromyalgia (1230)  ·  Pain (727)  ·  Osteoarthritis, Hip (634)  ·  Arthritis (483)  ·  Motor Activity (370)  ·  Arthritis, Juvenile (356)  ·  Chronic Pain (346)  ·  Sjogren's Syndrome (318)  ·  Gout (307)  ·  Joint Diseases (223)  ·  Arthritis, Psoriatic (193)

Broader conditions

Musculoskeletal Diseases (10807)  ·  Joint Diseases (9401)  ·  Arthritis (9121)  ·  Skin and Connective Tissue Diseases (4207)  ·  Connective Tissue Diseases (4151)  ·  Immune System Diseases (3956)  ·  Autoimmune Diseases (3808)  ·  Osteoarthritis (2931)  ·  Pathological Conditions, Signs and Symptoms (2197)  ·  Nervous System Diseases (1641)  ·  Signs and Symptoms (1592)  ·  Muscular Diseases (1443)  ·  Neurologic Manifestations (1395)  ·  Neuromuscular Diseases (1376)

Interventions

Methotrexate (314)  ·  Exercise (220)  ·  tocilizumab (193)  ·  Adalimumab (171)  ·  Etanercept (154)  ·  Sodium Chloride (133)  ·  Arthroplasty, Replacement, Knee (127)  ·  Abatacept (100)  ·  Rituximab (96)  ·  Infliximab (93)  ·  Hyaluronic Acid (92)  ·  tofacitinib (83)  ·  Arthroplasty, Replacement, Hip (82)  ·  Saline Solution (78)  ·  Celecoxib (71)

Sponsors

Hoffmann-La Roche (199)  ·  Pfizer (181)  ·  Zimmer Biomet (124)  ·  Bristol-Myers Squibb (96)  ·  Assiut University (87)  ·  Amgen (81)  ·  Riphah International University (80)  ·  Novartis Pharmaceuticals (73)  ·  Eli Lilly and Company (67)  ·  Assistance Publique - Hôpitaux de Paris (64)  ·  Istituto Ortopedico Rizzoli (60)  ·  GlaxoSmithKline (58)  ·  AbbVie (56)  ·  Cairo University (53)  ·  AstraZeneca (50)

Countries

United States (3113)  ·  France (775)  ·  Turkey (Türkiye) (729)  ·  Canada (719)  ·  Spain (654)  ·  United Kingdom (651)  ·  Germany (641)  ·  China (566)  ·  Poland (507)  ·  Italy (493)  ·  South Korea (378)  ·  Denmark (366)  ·  Brazil (356)  ·  Belgium (340)  ·  Australia (315)

Results publications

PMID 36600185, PMID 36601090, PMID 36931693, PMID 36526796, PMID 32816215, PMID 33127856, PMID 34870800, PMID 28143815, PMID 39192350, PMID 25047021, PMID 27338778, PMID 38958913, PMID 29244149, PMID 30649524, PMID 37453736, PMID 26275429, PMID 30936738, PMID 33263165, PMID 34706874, PMID 37460782, PMID 29463520, PMID 34041702, PMID 31610021, PMID 36205910, PMID 37747626, PMID 20461783, PMID 28941219, PMID 30177460, PMID 35577477, PMID 36715850, PMID 36754548, PMID 36814062, PMID 37308218, PMID 37945286, PMID 37982966, PMID 40875187, PMID 41766528, PMID 21055873, PMID 22491018, PMID 26554876, PMID 27889300, PMID 29949132, PMID 30219772, PMID 30842122, PMID 33057725, PMID 33059710, PMID 33115760, PMID 34921355, PMID 36125701, PMID 36269595

NIH funding

2009 (49), 2015 (41), 2016 (35), 2014 (34), 2023 (31), 2017 (28), 2008 (27), 2025 (26), 2018 (25), 2019 (21), 2005 (12), 2004 (6), P60AR047782 (3), R01AT004623 (3), K23AG029978 (2)