Nervous System Diseases: Clinical Trials

40039 completed, 11915 unknown, 9921 recruiting, 4400 terminated. 33973 Not applicable, 9570 Phase 2, 5915 Phase 3, 5536 Phase 1, 3810 Phase 4.

By phase and status

Phase	Trials	Status
Not applicable	33973	Completed 17519, Unknown 5564, Recruiting 4799, Not yet recruiting 2201, Terminated 1415, Active not recruiting 1085, Withdrawn 828, Enrolling by invitation 438, Suspended 124
Phase 2	9570	Completed 5171, Terminated 1065, Unknown 1026, Recruiting 982, Active not recruiting 429, Withdrawn 418, Not yet recruiting 364, Enrolling by invitation 67, Suspended 48
Phase 3	5915	Completed 3504, Terminated 648, Unknown 580, Recruiting 541, Active not recruiting 225, Not yet recruiting 194, Withdrawn 174, Enrolling by invitation 31, Suspended 18
Phase 1	5536	Completed 3190, Recruiting 581, Terminated 491, Unknown 491, Active not recruiting 268, Withdrawn 226, Not yet recruiting 222, Enrolling by invitation 36, Suspended 31
Phase 4	3810	Completed 2168, Unknown 619, Terminated 322, Recruiting 280, Not yet recruiting 168, Withdrawn 154, Active not recruiting 76, Enrolling by invitation 19, Suspended 4
Early Phase 1	833	Completed 333, Recruiting 138, Unknown 114, Not yet recruiting 74, Terminated 66, Withdrawn 49, Active not recruiting 38, Enrolling by invitation 12, Suspended 9

Follow Nervous System Diseases: new trials by email Literature Review of Nervous System Diseases trials Research Report on Nervous System Diseases

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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Ketamine and Midazolam Infusions for CRPS: Feasibility Study Ketamine, Midazolam, Normal Saline - Complex Regional Pain Syndromes	Phase 2	Withdrawn	Stanford University		2099-01-01	2024-11-22
Mixed Exercise Training and Novel Multi-Nutrient Supplementation in Young Adults Multi-nutrient supplement, Exercise - Sarcopenia	Not applicable	Withdrawn	McMaster University		2030-01-20	2024-01-30
Comparison of Vigorous Versus Low Intensity Cool Room Treadmill Training in People with Multiple Sclerosis Body-weight supported treadmill training in a room cooled to 16°C - Multiple Sclerosis, Neurological Rehabilitation	Not applicable	Withdrawn	Memorial University of Newfoundland		2030-01-01	2024-11-27
Patient-centered Assessment of the Effects of Powered Exoskeleton Use in People With Spinal Cord Injury Rehabilitation - Spinal Cord Injuries	Not applicable	Suspended	Istituto Nazionale Assicurazione contro gli Infortuni sul Lavoro	18	2030-01-01	2026-03-27
Buddhist Awareness Training Program and Qigong Psychosocial Interventions for People With Insomnia Psychosocial intervention - Insomnia, Randomised Controlled Trial	Not applicable	Suspended	College of Professional and Continuing Education Limited	86	2030-01-01	2026-03-19
Observational Study to Assess Migraine Prediction Tool Daily questionnaire - Migraine		Suspended	Theranica	200	2030-01-01	2024-11-22
Tau Pathology in the Brain After Hip or Knee Replacement Surgery Hip or Knee Arthroplasty Under Spinal Anesthesia - Postoperative Cognitive Dysfunction, Alzheimer Disease		Recruiting	Uppsala University Hospital	30	2029-04-01	2026-10-15
Post-surgical Delirium in Patients Undergoing Radical Cystectomy. Radical cystectomy. - Delirium, Radical Cystectomy		Not yet recruiting	University of Alexandria	100	2028-11-25	2025-04-03
Post-surgical Delirium in Patients Undergoing Open Heart Surgery. Open heart surgery - Delirium, Open Heart Surgery		Not yet recruiting	University of Alexandria	300	2028-10-01	2025-04-03
A Multiple Dose Study to Investigate Safety, Tolerability and Pharmacokinetics of TBN Tetramethylpyrazine nitrone (TBN) tablet / Placebo - Healthy	Phase 1	Not yet recruiting	Guangzhou Magpie Pharmaceuticals Co., Ltd.	16	2028-09-01	2026-09-11
PAP Systems External Clinical Studies (ECS) PAP System A (with Amalfi) then PAP System B (with CLA11), PAP System B (with CLA11) then PAP System A (with Amalfi) - Obstructive Sleep Apnea	Not applicable	Not yet recruiting	ResMed	30	2028-08-01	2026-04-24
A Study Using Brain Stimulation and Behavioral Therapy to Increase Extent of Resection in Low-Grade Gliomas RNS System Implantation - Glioma, Glioma Intracranial	Not applicable	Not yet recruiting	Medical College of Wisconsin	3	2028-08-01	2026-10-13
The Effect of Sympathetic Modulation on Cerebral Vasospasm Secondary to Aneurysmal Subarachnoid Hemorrhage Vectris trial leads and stimulation, Sham - Vasospasm, Cerebral, Aneurysmal Subarachnoid Hemorrhage	Not applicable	Suspended	University of Alabama at Birmingham	25	2028-07-31	2026-09-24
Terazosin And Metabolic Energetics in Parkinson's Disease Terazosin 5 MG, Placebo - Parkinson's Disease (PD)	Phase 2	Suspended	Ergun Y. Uc	120	2028-07-01	2026-10-09
Device for Bladder Control for Men With SCI Noninvasive electrical stimulation device to improve bladder control - Neurogenic Bladder	Phase 1 / Phase 2	Not yet recruiting	VA Office of Research and Development	12	2028-06-01	2026-06-25
Efficacy of iPSC-Derived Motor Neuron Cells (XS228) in Subacute Spinal Cord Injury: A Phase II Randomized Controlled Trial Allogeneic Human Induced Pluripotent Stem Cell (iPSC)-Derived Motor Neuron Progenitor Cells, Placebo - Spinal Cord Injury, Safety	Phase 2	Not yet recruiting	XellSmart Bio-Pharmaceutical (Suzhou) Co., Ltd.	60	2028-05-25	2025-11-25
Phase 1/2 Study Evaluating the Safety, PK/PD, and Clinical Activity of Oral JBI-778 in Patients With Brain Metastases, Leptomeningeal Disease, or Recurrent High Grade Glioma JBI-778 - Brain Metastases From Solid Tumors, Leptomeningeal Disease	Phase 1 / Phase 2	Not yet recruiting	Jubilant Therapeutics Inc.	113	2028-04-01	2026-08-07
Smartphone App for Adolescents With Idiopathic Scoliosis DinSkoliose smartphone application - Adolescence Idiopathic Scoliosis, AIS	Not applicable	Not yet recruiting	Oslo Metropolitan University	30	2028-04-01	2026-07-07
RCT: Trazodone vs Quetiapine vs Placebo for Treating ICU Delirium (TraQ) Trazodone, Quetiapine, Placebo - Delirium, Morality	Phase 4	Withdrawn	University of Southern California		2028-03-01	2026-05-04
EMBRACE Study: Enduring Migraine Benefit From Responsive Artery Coil Embolization TEMMA Endovascular Treatment - Migraine Disorders, Refractory Migraine	Not applicable	Withdrawn	Cortex Neurovascular		2028-03-01	2026-10-27

Showing 20 of 76510. Sign in to see all of them.

Narrower conditions

Stroke (7815)  ·  Parkinson Disease (4483)  ·  Alzheimer Disease (3881)  ·  Multiple Sclerosis (3154)  ·  Agnosia (2964)  ·  Sleep Initiation and Maintenance Disorders (2673)  ·  Ischemic Stroke (2559)  ·  Brain Neoplasms (2367)  ·  Dementia (2257)  ·  Sleep Apnea, Obstructive (2162)  ·  Pain (2025)  ·  Cognitive Dysfunction (1978)  ·  Spinal Cord Injuries (1941)  ·  Cerebral Palsy (1836)  ·  Epilepsy (1810)

Broader conditions

Central Nervous System Diseases (41327)  ·  Brain Diseases (36857)  ·  Pathological Conditions, Signs and Symptoms (30971)  ·  Signs and Symptoms (25362)  ·  Neurologic Manifestations (23930)  ·  Mental Disorders (15591)  ·  Cardiovascular Diseases (14516)  ·  Vascular Diseases (14092)  ·  Cerebrovascular Disorders (12412)  ·  Neurodegenerative Diseases (11938)  ·  Neuromuscular Diseases (9573)  ·  Pathologic Processes (9481)  ·  Neurobehavioral Manifestations (9157)  ·  Neurocognitive Disorders (8254)

Interventions

Exercise (794)  ·  Transcranial Direct Current Stimulation (636)  ·  Sodium Chloride (514)  ·  Saline Solution (503)  ·  Transcranial Magnetic Stimulation (410)  ·  Blood Specimen Collection (403)  ·  Control Groups (402)  ·  Dexmedetomidine (384)  ·  Standard of Care (371)  ·  Cognitive Behavioral Therapy (366)  ·  Surveys and Questionnaires (356)  ·  Magnetic Resonance Spectroscopy (298)  ·  Physical Therapy Modalities (280)  ·  Therapeutics (274)  ·  Lidocaine (268)

Sponsors

Riphah International University (617)  ·  Assistance Publique - Hôpitaux de Paris (588)  ·  VA Office of Research and Development (523)  ·  National Institute of Neurological Disorders and Stroke (NINDS) (482)  ·  Cairo University (453)  ·  Assiut University (424)  ·  Mayo Clinic (386)  ·  Johns Hopkins University (363)  ·  National Taiwan University Hospital (361)  ·  Massachusetts General Hospital (349)  ·  Hospices Civils de Lyon (326)  ·  GlaxoSmithKline (322)  ·  Novartis Pharmaceuticals (321)  ·  Beijing Tiantan Hospital (320)  ·  Pfizer (320)

Countries

United States (26502)  ·  France (6425)  ·  China (5246)  ·  Canada (4499)  ·  Turkey (Türkiye) (4252)  ·  United Kingdom (3827)  ·  Germany (3664)  ·  Italy (3622)  ·  Spain (3427)  ·  Belgium (1996)  ·  Taiwan (1829)  ·  Netherlands (1825)  ·  Denmark (1697)  ·  Switzerland (1670)  ·  Egypt (1628)

Results publications

PMID 36602886, PMID 38588457, PMID 33175411, PMID 34813082, PMID 41170811, PMID 37870112, PMID 2748771, PMID 34196963, PMID 31867054, PMID 39498781, PMID 33189083, PMID 30312372, PMID 34184251, PMID 40603145, PMID 12807523, PMID 34854473, PMID 35857365, PMID 36700520, PMID 18190818, PMID 31401903, PMID 35305920, PMID 37467180, PMID 11914403, PMID 15817019, PMID 20392703, PMID 20451898, PMID 34022170, PMID 34487721, PMID 40680102, PMID 16731270, PMID 21899409, PMID 33238043, PMID 34081125, PMID 34515113, PMID 36398903, PMID 39800465, PMID 15670960, PMID 22108357, PMID 22900785, PMID 2375765, PMID 25671797, PMID 26898852, PMID 26899665, PMID 27611736, PMID 31072380, PMID 31356217, PMID 31420846, PMID 32905623, PMID 33825230, PMID 34695300

NIH funding

2023 (242), 2019 (194), 2018 (186), 2025 (184), 2017 (172), 2014 (165), 2016 (159), 2015 (157), 2009 (112), 2008 (82), 2005 (44), 2004 (43), U10EY011751 (26), U10CA180886 (23), U54AG063546 (23)