669 completed, 157 unknown, 75 recruiting, 49 not yet recruiting. 524 Not applicable, 156 Phase 4, 111 Phase 2, 109 Phase 3, 47 Phase 1.
Follow Acute Pain: new trials by email Literature Review of Acute Pain trials Research Report on Acute Pain
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| VR-PAT and fNIRS to Identify CNS Biomarkers of Pain VR-PAT - Acute Pain, Pediatric ALL | Not applicable | Not yet recruiting | Nationwide Children's Hospital | 4 | 2027-07-01 | 2026-09-09 |
| Suzetrigine Versus Standard Analgesia After Skin Cancer Surgery Suzetrigine, Acetaminophen Plus Ibuprofen - Postoperative Pain, Acute Pain | Phase 4 | Not yet recruiting | University of Minnesota | 230 | 2027-04-01 | 2026-09-25 |
| Study of QL Analgesic Response and Extent Quadratus Lumborum with 1.5% Lidocaine - Acute Pain, Postoperative Pain | Phase 4 | Not yet recruiting | Duke University | 25 | 2027-01-01 | 2026-07-08 |
| Gender Affirming Mastectomy Analgesia Rial Paravertebral (single injection), Wide local infiltration - Gender Affirming Surgery, Mastectomy | Not applicable | Not yet recruiting | Nova Scotia Health Authority | 64 | 2027-01-01 | 2026-10-06 |
| Suzetrigine in Tonsillectomy for Opioid-sparing Pain Management Suzetrigine, Acetaminophen, oxycodone - Tonsillectomy, Pharyngoplasty | Phase 4 | Not yet recruiting | Stanford University | 58 | 2026-11-01 | 2026-09-16 |
| Human Experimental Models of Pain (HEMP) Placebo, Naproxen, Pregabalin - Acute Pain | Not applicable | Not yet recruiting | National Center for Complementary and Integrative Health (NCCIH) | 25 | 2026-10-28 | 2026-10-23 |
| Efficacy and Safety of DNN.63.18.040 for the Treatment of Moderate to Severe Pain Product DNN.63.18.040, Tramal® - Acute Pain | Phase 3 | Not yet recruiting | Ache Laboratorios Farmaceuticos S.A. | 370 | 2026-10-19 | 2026-10-19 |
| VR for Steroid Joint Injections - Feasibility VR-PAT - Acute Pain, Procedural Anxiety | Not applicable | Enrolling by invitation | Nationwide Children's Hospital | 10 | 2026-10-08 | 2026-10-20 |
| Two Bupivacaine Concentrations for Rectus Intercostal Fascial Plane Block After Laparoscopic Cholecystectomy Bupivacaine 0.25% - rectus intercostal fascial plane block, Bupivacaine 0.125% - rectus intercostal fascial plane block, Bupivacaine 0.25% - port-site infiltration - Postoperative Pain, Acute Pain | Not applicable | Not yet recruiting | Medipol University | 90 | 2026-10-05 | 2026-10-05 |
| Buprenorphine for the Management of Pain in Children With Sickle Cell Disease Buprenorphine Buccal Film [Belbuca] - Sickle Cell Disease (SCD), Sickle Cell Disease Vaso-occlusive Crisis | Phase 1 | Not yet recruiting | Natasha Archer | 25 | 2026-10-01 | 2026-09-02 |
| BLOCK-TRAUMA Study Polytrauma, Regional Anaesthesia | Completed | Ukrainian Society of Regional Anesthesia and Pain Therapy | 500 | 2026-10-01 | 2026-10-02 | |
| Comparison of Dexmedetomidine Versus Dexamethasone as Adjuvants to Bupivacaine in Ultrasound-Guided Erector Spinae Plane Block for Acute Pain Management in Patients With Traumatic Rib Fractures Dexmedetomidine with Bupivacaine in ESPB, Dexamethasone with Bupivacaine in ESPB - Rib Fractures, Acute Pain | Phase 2 / Phase 3 | Not yet recruiting | Assiut University | 100 | 2026-10-01 | 2026-09-18 |
| Suzetrigine for Postoperative Pain After Total Ankle Replacement Suzetrigine - Ankle Osteoarthritis, Postoperative Pain | Phase 4 | Not yet recruiting | Soheil Ashkani Esfahani | 28 | 2026-10-01 | 2026-09-30 |
| Examining Analgesic Synergy and Efficacy in Trauma Care Buprenorphine, Oxycodone - Opioid Use Disorder | Phase 4 | Not yet recruiting | Wake Forest University Health Sciences | 282 | 2026-10-01 | 2026-08-28 |
| Effect of Liposomal Bupivacaine on Rebound Pain After Peripheral Nerve Block in Orthopedic Surgery. liposomal bupivacaine, Normal Saline - Acute Pain, Orthopaedic Surgery | Phase 4 | Not yet recruiting | Shanghai Jiao Tong University Affiliated Sixth People's Hospital | 668 | 2026-10-01 | 2026-09-02 |
| Phoenixin and Pain in Pediatric Burn Patients Children, Acute Pain | Not yet recruiting | Ankara City Hospital Bilkent | 87 | 2026-10-01 | 2026-10-05 | |
| A Phase 1 Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single Intravenous Doses of NH302 Injection in Healthy Participants NH302 injection, Placebo - Healthy Volunteers | Phase 1 | Not yet recruiting | The Third Xiangya Hospital of Central South University | 62 | 2026-09-30 | 2026-10-23 |
| A Study of Combogesic® IV (Intravenous) in Pediatric Patients With Acute Pain Combogesic® IV (fixed-dose combination containing acetaminophen 10 mg/ml + ibuprofen 3 mg/ml in 100 ml solution for infusion) - Acute Pain | Phase 3 | Recruiting | AFT Pharmaceuticals, Ltd. | 60 | 2026-09-14 | 2026-09-16 |
| Erector Spinae Plane vs Serratus Anterior Plane Catheter Infusions for Acute Pain Management in Patients With Traumatic Rib Fractures Erector spinae plane catheter, Serratus plane catheter - Traumatic Rib Fracture(s), Traumatic Rib Fracture | Not applicable | Recruiting | Sunnybrook Health Sciences Centre | 66 | 2026-09-09 | 2026-10-23 |
| Comparison of Paravertebral Versus Epidural Block for Post-thoracotomy Pain Control Continuous Thoracic Paravertebral Block, Continuous Thoracic Epidural Block - Postoperative Pain | Not applicable | Not yet recruiting | Hospital de Clinicas de Porto Alegre | 80 | 2026-09-01 | 2026-08-13 |
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Pain (197) · Pain, Postoperative (191) · Agnosia (152) · Chronic Pain (132) · Anxiety Disorders (55) · Emergencies (50) · Neuralgia (27) · Pain, Procedural (26) · Wounds and Injuries (22) · Low Back Pain (15) · Musculoskeletal Pain (14) · Burns (13) · Rib Fractures (13) · Back Pain (12)
Neurologic Manifestations (1058) · Pathological Conditions, Signs and Symptoms (1058) · Signs and Symptoms (1058) · Pain (861) · Pathologic Processes (270) · Nervous System Diseases (206) · Postoperative Complications (189) · Neurobehavioral Manifestations (159) · Perceptual Disorders (154) · Mental Disorders (86) · Wounds and Injuries (83) · Musculoskeletal Diseases (58) · Disease Attributes (57) · Behavior (55) · Neoplasms (36)
Ketamine (42) · Bupivacaine (41) · Acetaminophen (40) · Morphine (40) · Sodium Chloride (29) · Ibuprofen (22) · Lidocaine (21) · Saline Solution (21) · Tramadol (21) · Fentanyl (20) · Ropivacaine (18) · Hydromorphone (17) · Oxycodone (16) · Dexamethasone (15) · Dexmedetomidine (13)
Assiut University (17) · Montefiore Medical Center (14) · University of Minnesota (14) · The University of Hong Kong (13) · Aretaieion University Hospital (11) · Ataturk University (11) · Duke University (11) · Grünenthal GmbH (11) · Ondokuz Mayıs University (11) · University of Monastir (11) · Dokuz Eylul University (10) · Vertex Pharmaceuticals Incorporated (10) · Ankara Etlik City Hospital (9) · Stanford University (9) · Wake Forest University Health Sciences (9)
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Kassiani Theodoraki, PhD, DESA (6) · Stanley SC Wong, MBBS (5) · Franck Skobieranda, MD (4) · Raoul Daoust, MD MSc (4) · Sergey Motov, MD (4) · Andrew K Chang, MD (3) · Benjamin Friedman, MD (3) · Elliot V Hersh, DMD, MS, PhD (3) · Giuseppe Pascarella, MD (3) · He Huang, ph.D (3) · James C Eisenach, MD (3)
PMID 39316284, PMID 23403516, PMID 26827847, PMID 30063657, PMID 34145168, PMID 34165999, PMID 34196965, PMID 35143011, PMID 37530822, PMID 41719044, PMID 10801169, PMID 10813730, PMID 11013380, PMID 11033377, PMID 11068116, PMID 11331334, PMID 11576144, PMID 11586161, PMID 11589257, PMID 11808971, PMID 11837920, PMID 12538372, PMID 12576361, PMID 14694929, PMID 14749441, PMID 15216537, PMID 15310785, PMID 15504625, PMID 15560360, PMID 15571771, PMID 15572968, PMID 15576519, PMID 15733657, PMID 15813511, PMID 15896276, PMID 16148743, PMID 16275600, PMID 16303817, PMID 16331304, PMID 16558352, PMID 16625122, PMID 16869819, PMID 17006084, PMID 17509812, PMID 17592957, PMID 17678782, PMID 17916403, PMID 17933588, PMID 17961838, PMID 17977860
P01NS119159 (3), R01AG071585 (3), 2014 (2), 2016 (2), 2017 (2), 2019 (2), 2025 (2), R35GM159908 (2), 1UG3DE032621-01 (1), 1UL1TR003098 (1), 2009 (1), 2015 (1), 2018 (1), 2023 (1), 4UH3DE032621-02 (1)