Musculoskeletal Diseases: Clinical Trials

15882 completed, 4512 unknown, 2777 recruiting, 1507 terminated. 12295 Not applicable, 3040 Phase 2, 2483 Phase 3, 1910 Phase 4, 1682 Phase 1.

By phase and status

Phase	Trials	Status
Not applicable	12295	Completed 6811, Unknown 2163, Recruiting 1275, Not yet recruiting 728, Terminated 446, Active not recruiting 436, Withdrawn 262, Enrolling by invitation 131, Suspended 43
Phase 2	3040	Completed 1775, Unknown 356, Terminated 342, Recruiting 217, Withdrawn 125, Active not recruiting 101, Not yet recruiting 87, Enrolling by invitation 28, Suspended 9
Phase 3	2483	Completed 1694, Unknown 258, Terminated 203, Recruiting 113, Active not recruiting 90, Withdrawn 63, Not yet recruiting 43, Enrolling by invitation 17, Suspended 2
Phase 4	1910	Completed 1139, Unknown 296, Terminated 160, Recruiting 125, Withdrawn 75, Not yet recruiting 62, Active not recruiting 44, Enrolling by invitation 8, Suspended 1
Phase 1	1682	Completed 1020, Unknown 200, Recruiting 157, Terminated 122, Withdrawn 59, Active not recruiting 54, Not yet recruiting 47, Enrolling by invitation 14, Suspended 9
Early Phase 1	214	Completed 79, Unknown 51, Recruiting 37, Not yet recruiting 17, Withdrawn 12, Active not recruiting 9, Terminated 6, Suspended 2, Enrolling by invitation 1

Follow Musculoskeletal Diseases: new trials by email Literature Review of Musculoskeletal Diseases trials Research Report on Musculoskeletal Diseases

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Study of AQUACEL™ Ag Surgical Cover Dressing Following Total Knee Replacement Aquacel Ag dressing - Osteoarthritis	Not applicable	Withdrawn	Golden Jubilee National Hospital		2050-01-01	2019-07-31
Patients Understanding of PROM Graphs survey 1, survey 2 - Orthopedic Disorder	Not applicable	Withdrawn	Stanford University		2040-05-15	2025-04-09
Personalizing Veteran Pain Care: Adapting Coaching Interventions to Support Maintenance of Self-Care Coaching - Chronic Pain, Musculoskeletal Pain	Phase 1	Not yet recruiting	VA Office of Research and Development	30	2029-01-01	2026-03-06
Cannabichromene Safety in Rheumatoid Arthritis Cannabichromene - Arthritis, Rheumatoid	Phase 1 / Phase 2	Withdrawn	Crystal Lederhos Smith		2028-07-15	2026-09-23
Smartphone App for Adolescents With Idiopathic Scoliosis DinSkoliose smartphone application - Adolescence Idiopathic Scoliosis, AIS	Not applicable	Not yet recruiting	Oslo Metropolitan University	30	2028-04-01	2026-07-07
Effectiveness of Non-surgical Management in Rotator Cuff Calcific Tendinopathy (THE EFFECT TRIAL) Exercise Therapy, Extracorporeal Shockwave Therapy, Ultrasound-Guided Percutaneous Irrigation - Rotator Cuff Tendinosis, Rotator Cuff Injuries	Not applicable	Suspended	University of Valencia	116	2028-01-01	2026-06-26
Autogenous Mesenchymal Stem Cell Culture-Derived Signalling Molecules as Enhancers of Bone Formation in Bone Grafting Maxillary sinus floor elevation grafting with synthetic bone substitute. - Bone Loss, Osteoclastic, Bone Loss, Alveolar	Phase 1	Not yet recruiting	Pontificia Universidade Católica do Rio Grande do Sul	20	2027-12-15	2026-09-21
An Open-label Study of GC012F in Rheumatoid Arthritis. LD and GC012F CAR-T Cell Injection, GC012F CAR-T Cell Injection - Rheumatoid Arthritis	Early Phase 1	Withdrawn	Institute of Hematology & Blood Diseases Hospital, China		2027-12-01	2026-06-10
Evaluating the Effect of Adipose Tissue Processed With the SyntrFuge™ System for Knee Osteoarthritis SyntrFuge System, Triamcinolone Injection - Knee Osteoarthritis	Not applicable	Not yet recruiting	Syntr Health Technologies, Inc.	180	2027-12-01	2026-08-20
Neoadjuvant Pimicotinib Combined With Surgery Versus Upfront Surgery for Diffuse Tenosynovial Giant Cell Tumor Pimicotinib, Tumor resection surgery - Tenosynovial Giant Cell Tumor, Diffuse	Phase 2	Not yet recruiting	Second Affiliated Hospital, Zhejiang University, School of Medicine	84	2027-10-01	2026-07-16
A Study to Determine the Safety and Efficacy of TG-C in Subjects With Symptomatic Early Hip Osteoarthritis TG-C, Placebo Control - Degenerative Osteoarthritis	Phase 2	Not yet recruiting	Kolon TissueGene, Inc.	255	2027-10-01	2026-08-20
Testosterone Therapy With or Without Finasteride After Spinal Cord Injury: TRT-SCI Trial testosterone cypionate, finasteride, placebo injection - Spinal Cord Injury, Spinal Cord Injuries	Phase 2 / Phase 3	Not yet recruiting	VA Office of Research and Development	300	2027-10-01	2026-08-04
Clinical Outcomes of Focused Shockwave Therapy Without Adjunct Rehabilitation Compared to Standard Physical Rehabilitation in Patients With Grade I-III Knee Osteoarthritis: A Single-Blind Randomized Study Physical Rehab, Focused Shockwave Therapy - Knee Osteoarthristis	Not applicable	Not yet recruiting	Pulse Wave USA	60	2027-09-25	2026-05-05
Does MI Have a Therapeutic Role in Arthroscopic Rotator Cuff Repair? Motor Imagery, Physical Therapy - Rotator Cuff Tears, Motor Imagery	Not applicable	Suspended	Alanya Alaaddin Keykubat University	36	2027-09-15	2026-10-28
Clinical Trial of a MEK Inhibitor for RASopathy-Associated Severe Infantile Hypertrophic Cardiomyopathy: Baby MERIT Trametinib - HCM, Noonan Syndrome and Other Rasopathy	Phase 3	Not yet recruiting	Carelon Research	25	2027-08-01	2026-09-14
Feasibility and Acceptability of OLP-EXP in Chronic Pain OLP-EXP, OLP, EXP - Temporomandibular Disorders (TMD)	Not applicable	Not yet recruiting	University of Maryland, Baltimore	57	2027-07-01	2026-08-25
Efficacy and Safety of GNSC-001 Intra-articular Injection for Knee Osteoarthritis Gene Therapy GNSC-001, Placebo - Knee Arthritis Osteoarthritis, Knee Arthritis, Osteoarthritis	Phase 2 / Phase 3	Not yet recruiting	Genascence Corporation	240	2027-07-01	2026-09-21
Combination Immunotherapy Targeting Sarcomas Multiple sarcoma-specific CAR-T cells and sarcoma vaccines - Sarcoma, Osteoid Sarcoma	Phase 1 / Phase 2	Not yet recruiting	Shenzhen Geno-Immune Medical Institute	20	2027-07-01	2026-08-26
The AgRP and GH/IGF-1 Axis in Children Growth Hormone Deficiency		Not yet recruiting	Columbia University	156	2027-06-10	2026-09-25
Safety and Efficacy Evaluation of 4th Generation Safety-engineered CAR T Cells Targeting Sarcomas Sarcoma-specific CAR-T cells - Sarcoma, Osteoid Sarcoma	Phase 1 / Phase 2	Not yet recruiting	Shenzhen Geno-Immune Medical Institute	20	2027-06-01	2026-08-26

Showing 20 of 28110. Sign in to see all of them.

Narrower conditions

Arthritis, Rheumatoid (3281)  ·  Osteoarthritis, Knee (3217)  ·  Osteoarthritis (2694)  ·  Osteoporosis (1554)  ·  Pain (1322)  ·  Fibromyalgia (1231)  ·  Arthritis (841)  ·  Motor Activity (825)  ·  Shoulder Pain (683)  ·  Bone Diseases, Metabolic (659)  ·  Osteoarthritis, Hip (634)  ·  Muscle Spasticity (621)  ·  Arthritis, Psoriatic (592)  ·  Temporomandibular Joint Disorders (588)

Broader conditions

Joint Diseases (13819)  ·  Rheumatic Diseases (10700)  ·  Arthritis (10169)  ·  Pathological Conditions, Signs and Symptoms (7972)  ·  Bone Diseases (7929)  ·  Muscular Diseases (6345)  ·  Nervous System Diseases (6021)  ·  Signs and Symptoms (5908)  ·  Skin and Connective Tissue Diseases (5611)  ·  Neurologic Manifestations (5432)  ·  Connective Tissue Diseases (4795)  ·  Immune System Diseases (4359)  ·  Autoimmune Diseases (4024)  ·  Neuromuscular Diseases (3444)

Interventions

Exercise (555)  ·  Methotrexate (361)  ·  Sodium Chloride (280)  ·  Adalimumab (239)  ·  Etanercept (228)  ·  Physical Therapy Modalities (224)  ·  tocilizumab (205)  ·  Saline Solution (195)  ·  Control Groups (152)  ·  Resistance Training (147)  ·  Denosumab (143)  ·  Dry Needling (138)  ·  Arthroplasty, Replacement, Knee (137)  ·  Infliximab (136)  ·  Surveys and Questionnaires (134)

Sponsors

Cairo University (382)  ·  Riphah International University (305)  ·  Pfizer (278)  ·  Hoffmann-La Roche (240)  ·  Assiut University (214)  ·  Novartis Pharmaceuticals (195)  ·  Assistance Publique - Hôpitaux de Paris (190)  ·  Zimmer Biomet (174)  ·  Amgen (164)  ·  Hacettepe University (151)  ·  Istituto Ortopedico Rizzoli (142)  ·  Eli Lilly and Company (139)  ·  National Taiwan University Hospital (127)  ·  University of Aarhus (111)  ·  Bristol-Myers Squibb (109)

Countries

United States (7801)  ·  Turkey (Türkiye) (2494)  ·  France (2043)  ·  Spain (1682)  ·  Canada (1678)  ·  United Kingdom (1494)  ·  Germany (1394)  ·  Italy (1365)  ·  China (1330)  ·  Egypt (981)  ·  Poland (972)  ·  Denmark (941)  ·  Belgium (819)  ·  Brazil (790)  ·  South Korea (776)

Results publications

PMID 36931693, PMID 36526796, PMID 32816215, PMID 34870800, PMID 36600185, PMID 36601090, PMID 33127856, PMID 28143815, PMID 39192350, PMID 25047021, PMID 27338778, PMID 38958913, PMID 38979716, PMID 29244149, PMID 30649524, PMID 37453736, PMID 37982966, PMID 40194794, PMID 40875187, PMID 41807031, PMID 26275429, PMID 30936738, PMID 33263165, PMID 34706874, PMID 36754548, PMID 37460782, PMID 37945286, PMID 29463520, PMID 34041702, PMID 34590307, PMID 36814062, PMID 31203228, PMID 31610021, PMID 34921355, PMID 36205910, PMID 37316690, PMID 37747626, PMID 38446397, PMID 39151033, PMID 20461783, PMID 24482784, PMID 28941219, PMID 30177460, PMID 35577477, PMID 36715850, PMID 37308218, PMID 41766528, PMID 41965705, PMID 42386286, PMID 18035553

NIH funding

2015 (90), 2023 (85), 2016 (80), 2009 (72), 2014 (69), 2018 (63), 2019 (62), 2017 (61), 2025 (53), 2008 (46), 2005 (26), 2004 (16), K12HD043494 (7), R01AI047040 (7), R01AI054843 (6)