932 completed, 254 unknown, 118 recruiting, 97 terminated. 589 Not applicable, 524 Phase 4, 191 Phase 2, 184 Phase 3, 80 Phase 1.
Follow Bupivacaine: new trials by email Literature Review of Bupivacaine trials Research Report on Bupivacaine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Postoperative Analgesia Using Ganglion Impar Block After Anal Surgery Ganglion impar block with Bupivacaine., Ganglion impar block with normal saline - Postoperative Pain | Not applicable | Not yet recruiting | University of Alexandria | 60 | 2028-07-01 | 2025-04-03 |
| Neostigmine as an Adjuvant in Tranversus Abdominis Plane (TAP) Block in Cesarean Section Under Spinal Anesthesia Bupivacaine-Neostigmine, Bupivacaine - Analgesia | Not applicable | Not yet recruiting | Mansoura University | 58 | 2027-12-01 | 2026-02-17 |
| ESP Blocks for Posterior Spinal Fusion ESP Block with Bupivacaine, ESP Block with Bupivacaine + Liposomal Bupivacaine - Postoperative Pain | Phase 4 | Not yet recruiting | Duke University | 75 | 2027-10-01 | 2026-08-27 |
| Comparison of Hemodynamic Effects of Bupivacaine in Spinal Anesthesia Spinal Anesthesia (bupivacaine) - Hemondynamic Changes in Spinal Anesthesia | Phase 2 | Not yet recruiting | Liaquat National Hospital & Medical College | 100 | 2027-04-01 | 2026-06-01 |
| Liposomal Bupivacaine vs Perineural Adjuvants in Adductor Canalf and iPACK Blocks in Total Knee Arthroplasty Liposomal Bupivacaine, Bupivacaine, Clonidine, Epinephrine, Buprenorphine and Dexamethasone (BPV-CEBD) Combination - Knee Arthroplasty, Total | Phase 4 | Not yet recruiting | Wake Forest University Health Sciences | 90 | 2027-02-01 | 2026-08-25 |
| Intraoperative Placement of Vancomycin-impregnated Calcium Sulfate Beads Conjugated With Analgesics to Improve Spine Surgery Outcomes Vancomycin (local, via calcium sulfate beads), Morphine (local, via calcium sulfate beads), Bupivacaine (local, via calcium sulfate beads) - Spine Surgery, Postoperative Pain Management | Phase 2 | Not yet recruiting | Ganesh M. Shankar | 100 | 2027-01-01 | 2026-04-16 |
| Efficacy of Gastrocnemius Plane Block for Foot and Ankle Surgery GPB Group : This group will receive ultrasound-guided Gastrocnemius plane block with 30 mL bupivacaine (0.25%), SAB - Gastrocnemius, Ankle Surgery | Not applicable | Recruiting | Cairo University | 40 | 2026-11-01 | 2026-10-16 |
| Exparel and Dexamethasone Liposomal Bupivacaine with Bupivacaine, Dexamethasone - Postoperative Pain, Shoulder Arthroscopic Surgeries | Phase 4 | Not yet recruiting | Duke University | 80 | 2026-11-01 | 2026-10-19 |
| Low-Volume Pericapsular Nerve Group (PENG) Block With Dexamethasone vs Standard-Volume PENG Block After Total Hip Arthroplasty Pericapsular nerve group (PENG) block, Bupivacaine, Dexamethasone - Pain, Postoperative, Muscle Weakness | Phase 4 | Recruiting | Ain Shams University | 60 | 2026-10-15 | 2026-10-16 |
| Two Bupivacaine Concentrations for Rectus Intercostal Fascial Plane Block After Laparoscopic Cholecystectomy Bupivacaine 0.25% - rectus intercostal fascial plane block, Bupivacaine 0.125% - rectus intercostal fascial plane block, Bupivacaine 0.25% - port-site infiltration - Postoperative Pain, Acute Pain | Not applicable | Not yet recruiting | Medipol University | 90 | 2026-10-05 | 2026-10-05 |
| US-Guided Saphenous Block in Knee OA Intra-articular corticosteroid injection, Ultrasound-Guided High-Volume Saphenous Nerve Block, Home-Based Exercise Program - Knee Osteoarthritis, Osteoarthritis, Knee | Not applicable | Not yet recruiting | Gaziler Physical Medicine and Rehabilitation Education and Research Hospital | 60 | 2026-10-02 | 2026-10-09 |
| Ultrasound-Guided Ilioinguinal-Iliohypogastric Nerve Block Following Spinal Anesthesia Comparing Dexmedetomidine Versus Nalbuphine as Adjuvants to Bupivacaine in Unilateral Inguinal Hernia Repair Bupivacaine, Nalbuphine, Dexmedetomidine - Inguinal Hernia, Postoperative Pain | Phase 4 | Not yet recruiting | Assiut University | 102 | 2026-10-01 | 2026-09-23 |
| Comparison of Dexmedetomidine Versus Dexamethasone as Adjuvants to Bupivacaine in Ultrasound-Guided Erector Spinae Plane Block for Acute Pain Management in Patients With Traumatic Rib Fractures Dexmedetomidine with Bupivacaine in ESPB, Dexamethasone with Bupivacaine in ESPB - Rib Fractures, Acute Pain | Phase 2 / Phase 3 | Not yet recruiting | Assiut University | 100 | 2026-10-01 | 2026-09-18 |
| Comparing Three Epidural Steroid Injection Approaches for Lumbar Radicular Pain High-Volume Parasagittal Interlaminar Epidural Steroid Injection, Low-Volume Parasagittal Interlaminar Epidural Steroid Injection, Transforaminal epidural steroid injection - Lumbar Disc Herniation, Lumbosacral Radiculopathy | Phase 4 | Not yet recruiting | Benha University | 99 | 2026-10-01 | 2026-09-14 |
| Effect of Post-Radiofrequency Corticosteroid Injection on the Incidence of Post-Neurotomy Neuritis Dexamethasone, Normal Saline, Bupivacaine - Facet Joint Pain, Arthropathy | Phase 2 | Enrolling by invitation | Siriraj Hospital | 126 | 2026-10-01 | 2026-09-28 |
| Combination Versus Alone Liposomal Bupivacaine Blocks in Minimally Invasive Thoracic Surgery-1 Arm 1 "LipoB-I": Liposomal Bupivacaine via Multi-Level Intercostal Nerve Block, Arm 2 "LipoB-S": Liposomal Bupivacaine via Serratus Anterior Plane Block, Arm 3 "LipoB-C": Liposomal Bupivacaine Administered via Combination Block - Lung Cancer (Diagnosis) | Not applicable | Not yet recruiting | University of Texas Southwestern Medical Center | 300 | 2026-10-01 | 2026-08-26 |
| Dexmedetomidine Versus Ketamine in TAP Block for Postoperative Analgesia After Total Abdominal Hysterectomy TAP block using Dexmedetomidine & Bupivacaine, TAP block using Ketamine Hydrochloride and Bupivacaine - Postoperative Pain, Total Abdominal Hysterectomy | Phase 4 | Not yet recruiting | Bangladesh Medical University | 64 | 2026-10-01 | 2026-10-01 |
| Dexmedetomidine as an Adjuvant to Greater Auricular Nerve Block in Middle Ear Surgeries Bupivacaine, Dexmedetomidine, Normal saline - Postoperative Pain, Middle Ear Surgery | Phase 2 | Recruiting | Minia University | 40 | 2026-09-25 | 2026-10-16 |
| Ultrasound-Guided Platelet-Rich Plasma Versus Local Anesthetic Injection for Chronic Neuroma Pain After Combat-Related Amputation Platelet-Rich Plasma (PRP) Injections, Local Anesthetic Injection - Neuroma, Phantom Limb Pain After Amputation | Not applicable | Completed | Ukrainian Society of Regional Anesthesia and Pain Therapy | 100 | 2026-09-15 | 2026-10-07 |
| Magnesium Sulfate With Standard Combined Costoclavicular-Suprascapular Block for Pain Relief After Shoulder Arthroscopy. Bupivacaine, Magnesium sulfate (MgSO4), Normal Saline (NS) - Shoulder Arthroscopy, Postoperative Pain | Not applicable | Not yet recruiting | Assiut University | 84 | 2026-09-01 | 2026-09-01 |
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Pain, Postoperative (456) · Agnosia (178) · Pain (148) · Acute Pain (41) · Breast Neoplasms (26) · Hernia, Inguinal (26) · Labor Pain (23) · Hip Fractures (22) · Osteoarthritis, Knee (17) · Hypotension (16) · Migraine Disorders (16) · Osteoarthritis (16) · Chronic Pain (13) · Postoperative Nausea and Vomiting (13) · Shoulder Pain (13)
Assiut University (82) · Ain Shams University (56) · Cairo University (50) · Pacira Pharmaceuticals, Inc (27) · Ataturk University (26) · Tanta University (22) · Istanbul University (20) · Hospital for Special Surgery, New York (18) · Northwestern University (18) · Icahn School of Medicine at Mount Sinai (16) · Mayo Clinic (16) · Zagazig University (15) · Mahidol University (14) · Mansoura University (14) · Heron Therapeutics (13)
United States (536) · Egypt (320) · Turkey (Türkiye) (167) · Canada (74) · Pakistan (36) · China (26) · Denmark (23) · Thailand (21) · South Korea (19) · Israel (15) · Poland (15) · Brazil (13) · United Kingdom (13) · Belgium (10) · Ireland (9)
Ahmed Mukhtar, Professor (6) · Antoun Nader, MD (6) · Jose CA Carvalho, MD (6) · Hala S Abdel-Ghaffar, MD (4) · Sameh M El-Sherbiny, MD (4) · Adeel Riaz, MD (3) · Ali Shariat, MD (3) · Ashraf S Habib, MD (3) · Christina Jeng, MD (3) · Daniel I Sessler, MD (3) · David H Kim, MD (3) · Jose CA Carvalho, MD PhD (3) · Kay Warnott, RN, ACNP (3) · Mohamed A Hamed, MD (3) · Yar Yeap, MD (3)
PMID 22900785, PMID 33238043, PMID 33372953, PMID 34261807, PMID 15321413, PMID 1539813, PMID 16443140, PMID 18173431, PMID 19447599, PMID 19672175, PMID 20011857, PMID 20455872, PMID 21203878, PMID 21307769, PMID 21334503, PMID 21334504, PMID 22108086, PMID 22227789, PMID 22326199, PMID 22813360, PMID 23135692, PMID 23262963, PMID 23411725, PMID 23969793, PMID 23997449, PMID 24034832, PMID 24946047, PMID 25032676, PMID 25146109, PMID 25201313, PMID 25376971, PMID 25821536, PMID 25912739, PMID 25936783, PMID 26056753, PMID 26507422, PMID 26692415, PMID 26694495, PMID 27574464, PMID 27629425, PMID 27870737, PMID 32303180, PMID 34284613, PMID 36369781, PMID 8267196, PMID 10319823, PMID 10422923, PMID 10486687, PMID 10702460, PMID 10794256
2023 (3), 2014 (2), 2015 (2), 2016 (2), 2018 (2), UL1TR000135 (2), 2009 (1), 2019 (1), 2025 (1), P30CA015083 (1), P30CA077598 (1), R33AT012283 (1)