Sodium Chloride: Clinical Trials

2031 completed, 530 unknown, 300 terminated, 290 recruiting. 893 Not applicable, 886 Phase 2, 851 Phase 4, 609 Phase 3, 503 Phase 1.

By phase and status

Phase	Trials	Status
Not applicable	893	Completed 515, Unknown 165, Recruiting 74, Terminated 43, Not yet recruiting 39, Withdrawn 38, Active not recruiting 15, Enrolling by invitation 4
Phase 2	886	Completed 455, Unknown 120, Terminated 95, Recruiting 89, Withdrawn 46, Active not recruiting 38, Not yet recruiting 37, Enrolling by invitation 4, Suspended 2
Phase 4	851	Completed 497, Unknown 142, Terminated 75, Recruiting 57, Withdrawn 37, Not yet recruiting 28, Active not recruiting 9, Enrolling by invitation 3, Suspended 3
Phase 3	609	Completed 338, Unknown 79, Terminated 66, Recruiting 53, Not yet recruiting 30, Withdrawn 17, Active not recruiting 16, Enrolling by invitation 7, Suspended 3
Phase 1	503	Completed 305, Unknown 61, Terminated 34, Recruiting 33, Withdrawn 27, Active not recruiting 24, Not yet recruiting 13, Suspended 4, Enrolling by invitation 2
Early Phase 1	94	Completed 53, Unknown 15, Recruiting 10, Terminated 7, Withdrawn 4, Not yet recruiting 3, Active not recruiting 1, Enrolling by invitation 1

Follow Sodium Chloride: new trials by email Literature Review of Sodium Chloride trials Research Report on Sodium Chloride

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Ketamine and Midazolam Infusions for CRPS: Feasibility Study Ketamine, Midazolam, Normal Saline - Complex Regional Pain Syndromes	Phase 2	Withdrawn	Stanford University		2099-01-01	2024-11-22
Aspirin in Acute Pneumonia in the Elderly: a Multicenter, Double-blind, Randomized, Placebo-controlled Trial. Acetylsalicylic acid/Aspirin (100 mg), Placebo acetylsalicylic acid (100 mg) / 0.9% sodium chloride - Acute Pneumonia, Elderly Person	Phase 3	Not yet recruiting	Centre Hospitalier Universitaire Dijon	600	2028-07-01	2026-09-24
Sodium Lactate in Severe TBI Sodium Lactate, placebo - Traumatic Brain Injury	Phase 2	Not yet recruiting	University of California, Los Angeles	264	2028-01-10	2026-01-16
Echinocandin Added to Standard Treatment for Severe Pneumocystis Pneumonia Echinocandins, Placebo (0.9% Sodium chloride) infusion - Pneumocystis Jirovecii Pneumonia	Phase 3	Not yet recruiting	McGill University Health Centre/Research Institute of the McGill University Health Centre	416	2027-04-01	2026-10-28
Naloxone for Opioid Associated Out of Hospital Cardiac Arrest Naloxone 2 MG, Saline 2ml - Heart Arrest, Out-Of-Hospital, Opioid Overdose	Phase 2	Not yet recruiting	University of California, San Francisco	98	2027-03-01	2026-09-11
Interest of a Targeted Therapy for the Treatment of a Severe Form of Hypersensitivity to Drug (DRESS Syndrome) Benralizumab 30 MG/ML [Fasenra], Placebo Comparator: Placebo-Control Arm 0.9% Sodium Chloride - DRESS Syndrome	Phase 2	Not yet recruiting	University Hospital, Lille	96	2027-01-06	2026-05-15
Phase I Study of VLPDEN-02 Dengue Vaccine in Healthy Adults VLPDEN-02 1.0 µg (0.25 µg of each VLP) + ALFQ adjuvant, VLPDEN-02 10 µg (2.5 µg of each VLP) + ALFQ adjuvant, VLPDEN-02 100 µg (25 µg of each VLP) + ALFQ adjuvant - Randomised Clinical Trial, Double Blind	Phase 1	Not yet recruiting	VLP Therapeutics	42	2027-01-04	2026-09-21
SHIELD-T1D: Shingrix and GLP-1 Agonist for Beta-Cell Preservation in Recent-Onset Type 1 Diabetes. Recombinant Zoster Vaccine (Shingrix; RZV), Semaglutide (Ozempic®), Placebo (saline injection) - Type 1 Diabetes Mellitus	Phase 2	Not yet recruiting	Ministry of Health, Saudi Arabia	240	2027-01-01	2026-05-29
Early Neutralizing Antibodies in Infants Living With HIV to Enhance Their Life Broadly neutralizing antibody (bNAb) ePGT121v1-LS, Saline (0.9% NaCl) - HIV -1 Infection	Phase 1 / Phase 2	Not yet recruiting	Hospital Universitario 12 de Octubre	87	2027-01-01	2026-08-20
Early Neutralizing Antibodies in Infants Living With HIV to Enhance Their Life (2) Broadly neutralizing antibody (bNAb) ePGT121v1-LS, Saline (0.9% NaCl), Broadly neutralizing antibody (bNAb) VRC07-523-LS - HIV -1 Infection	Phase 1 / Phase 2	Not yet recruiting	Hospital Universitario 12 de Octubre	73	2027-01-01	2026-08-20
Phase 1 Study to Evaluate RG002C0106 Injection in Healthy Participants RG002C0106, 0.9% sodium chloride injection - Safety Issues	Phase 1	Not yet recruiting	Rigerna Therapeutics Co., Ltd.; Rigerna Therapeutics (Beijing) Co., Ltd.	30	2026-12-10	2026-10-28
Efficacy of Intravenous Oxytocin to Speed Recovery After THA intravenous administration of oxytocin, Placebo - Total Hip Arthroplasty	Phase 2	Enrolling by invitation	Wake Forest University Health Sciences	80	2026-12-01	2026-10-23
A Study to Evaluate the Maintenance of Efficacy and Long-term Safety of CBL-514 Injection for Reducing Subcutaneous Fat (Stage 1) CBL-514 Injection, 0.9 % sodium chloride - Subcutaneous Fat	Phase 3	Not yet recruiting	Caliway Biopharmaceuticals Co., Ltd.	300	2026-12-01	2026-10-19
CD19-B Cell Depletion in PAIS-ME/CFS Patients Inebilizumab, Placebo - Post-acute Infectious Syndrome (PAIS), Post-COVID 19 Condition (PCC or Long COVID)	Phase 2	Not yet recruiting	Charite University, Berlin, Germany	38	2026-12-01	2026-07-24
XVIE to Treat Androgenetic Alopecia (AGA) Decellularized allogeneic human amniotic fluid, Sodium chloride 0.9% injectable solution - Androgenetic Alopecia	Phase 1 / Phase 2	Not yet recruiting	Restore Biologics Holdings, Inc. dba Xtressé	30	2026-12-01	2026-08-12
Mild-Intensity Whole Body Hyperthermia (WBH) for Major Depressive Disorder Tocilizumab, Placebo, Whole-Body Hyperthermia - Major Depressive Disorder	Phase 2	Suspended	Massachusetts General Hospital	35	2026-12-01	2025-11-13
MMA Infusion of Lidocaine for Treatment of Headache in Patients With Aneurysmal SAH Lidocaine hydrochloride, Isotonic saline - Headaches Associated With Subarachnoid Hemorrhage (SAH)	Phase 2	Not yet recruiting	Copenhagen University Hospital, Rigshospitalet	90	2026-12-01	2026-09-11
Postsurgical Analgesia After Unilateral Bunionectomy AMT-143, Saline (NaCl 0,9 %) (placebo) - Bunionectomy, Bunion	Phase 2	Not yet recruiting	AmacaThera Inc.	60	2026-12-01	2026-10-22
Role of Perineural Catheter in Pain Control and Opioid Consumption After Major Amputation of Lower Limb Bubpivacaine, Tramadol, Saline - Lower Limb Surgery, Pain	Phase 4	Not yet recruiting	Aga Khan University	96	2026-12-01	2026-11-02
Effect of an Intraoperative Polynucleotide Injection on Scar Quality After Thyroidectomy Polynucleotide (PN-HPT), Sterile 0.9% Sodium Chloride - Postoperative Surgical Scar, Scar	Not applicable	Not yet recruiting	Dr. Lutfi Kirdar Kartal Training and Research Hospital	80	2026-11-20	2026-09-23

Showing 20 of 3561. Sign in to see all of them.

Conditions studied

Pain, Postoperative (225)  ·  Pain (145)  ·  COVID-19 (87)  ·  Agnosia (78)  ·  Osteoarthritis, Knee (68)  ·  Obesity (66)  ·  Osteoarthritis (56)  ·  Postoperative Nausea and Vomiting (47)  ·  Diabetes Mellitus (43)  ·  Acute Kidney Injury (39)  ·  Diabetes Mellitus, Type 2 (37)  ·  Inflammation (36)  ·  Hemorrhage (34)  ·  Sepsis (34)  ·  Breast Neoplasms (33)

Sponsors

Assiut University (43)  ·  Cairo University (39)  ·  Copenhagen University Hospital, Rigshospitalet (36)  ·  Poznan University of Medical Sciences (30)  ·  University of Aarhus (26)  ·  GlaxoSmithKline (23)  ·  Northwestern University (22)  ·  Ain Shams University (21)  ·  Mayo Clinic (21)  ·  National Institute of Allergy and Infectious Diseases (NIAID) (21)  ·  Tanta University (21)  ·  University Hospital, Gentofte, Copenhagen (21)  ·  Yonsei University (21)  ·  Danish Headache Center (20)  ·  Pfizer (20)

Countries

United States (1160)  ·  Denmark (278)  ·  China (277)  ·  Canada (196)  ·  Egypt (188)  ·  United Kingdom (135)  ·  Turkey (Türkiye) (129)  ·  Germany (113)  ·  France (106)  ·  Australia (89)  ·  South Korea (89)  ·  Netherlands (80)  ·  Poland (79)  ·  Belgium (75)  ·  Spain (72)

Top investigators

Adrian Vella, MD (6)  ·  Anne Sheu (6)  ·  Viktoria Lindberg-Larsen, MD (6)  ·  David H Barad, MD, MS (4)  ·  Filip K Knop, MD, PhD (4)  ·  Guolin Wang, MD (4)  ·  Jian-Xin Zhou, MD (4)  ·  Norbert Gleicher, MD (4)

Results publications

PMID 29515037, PMID 39903535, PMID 32031570, PMID 32171076, PMID 37319354, PMID 20554319, PMID 23121612, PMID 32681472, PMID 33238043, PMID 34002866, PMID 35164991, PMID 39162220, PMID 39356039, PMID 39428602, PMID 42159953, PMID 12873949, PMID 15150204, PMID 17180268, PMID 17413463, PMID 18633034, PMID 18844269, PMID 19376789, PMID 19404806, PMID 20487038, PMID 20818886, PMID 20920772, PMID 21883197, PMID 22900785, PMID 23053510, PMID 23312695, PMID 24026316, PMID 24216403, PMID 25080874, PMID 25157725, PMID 25500317, PMID 25534356, PMID 26452709, PMID 27187300, PMID 28284978, PMID 28286967, PMID 28302179, PMID 29156068, PMID 29485925, PMID 31112399, PMID 32492040, PMID 32941801, PMID 33026630, PMID 33026631, PMID 33196806, PMID 33407156

NIH funding

2014 (21), 2017 (21), 2019 (20), 2015 (18), 2016 (17), 2023 (14), 2018 (11), 2008 (9), 2009 (9), 2025 (8), 2004 (4), R01DK126206 (3), UL1RR024150 (3), 5UM1AI148684-03 (2), 5UM1AI148684-04 (2)