430 completed, 111 unknown, 62 recruiting, 46 terminated. 320 Not applicable, 101 Phase 3, 77 Phase 2, 63 Phase 4, 27 Phase 1.
Follow this condition Literature Review of Headache trials Research Report on Headache
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Behavior Therapy vs Education for Persistent Headache After Mild TBI Headache reprocessing, Headache education - Post-Traumatic Headache | Not applicable | Not yet recruiting | VA Office of Research and Development | 60 | 2027-10-01 | 2025-12-26 |
| A Pivotal Clinical Study to Evaluate the MySalvia System for the Treatment of Resistant Migraine Neurostimulator - Resistant Migraine, Chronic Migraine Headache | Not applicable | Recruiting | Salvia BioElectronics | 150 | 2026-12-01 | 2026-08-28 |
| Sequential, Multiple Assignment, Double Randomized Preference, Migraine Behavioral Trial Migraine Behavioral Treatment - Migraine, Headache | Not applicable | Not yet recruiting | Mayo Clinic | 24 | 2026-12-01 | 2026-06-16 |
| MMA Infusion of Lidocaine for Treatment of Headache in Patients With Aneurysmal SAH Lidocaine hydrochloride, Isotonic saline - Headaches Associated With Subarachnoid Hemorrhage (SAH) | Phase 2 | Not yet recruiting | Copenhagen University Hospital, Rigshospitalet | 90 | 2026-12-01 | 2026-09-11 |
| Assessment of Head Awareness in Patients With Migraine in the Greek Population Migraine | Not yet recruiting | National and Kapodistrian University of Athens | 90 | 2026-11-01 | 2026-10-08 | |
| Validity and Reliability of the Greek WPAI:Migraine Migraine | Not yet recruiting | National and Kapodistrian University of Athens | 60 | 2026-11-01 | 2026-10-08 | |
| Validity and Reliability of the Greek Pain Catastrophizing Scale Migraine | Not yet recruiting | National and Kapodistrian University of Athens | 130 | 2026-11-01 | 2026-10-07 | |
| Headache and Hormone Use Among Transgender Population in Thailand: A Cross-Sectional Online Study gender-affirming hormone therapy, Gender-Affirming Surgery, HIV Pre-Exposure Prophylaxis - Headache, Migraine | Not yet recruiting | Chulalongkorn University | 500 | 2026-11-01 | 2026-09-14 | |
| Neuromodulation During the Prodrome to Prevent Disabling Migraine Attacks in Youth Active Remote Electrical Neuromodulation, Sham Remote Electrical Neuromodulation - Migraine, Migraine Headache | Not applicable | Not yet recruiting | University of Calgary | 30 | 2026-10-01 | 2026-08-19 |
| Zavegepant Intranasal Spray for the Acute Treatment of Episodic Cluster Headache Zavegepant 20 mg - Cluster Headache | Phase 2 | Not yet recruiting | The University of Texas Health Science Center, Houston | 40 | 2026-10-01 | 2026-10-02 |
| Migraine Characteristics and Associated Factors Observational assessment - Migraine | Not yet recruiting | Lokman Hekim University | 100 | 2026-10-01 | 2026-09-16 | |
| Headache Education and Awareness vs. Daily Mindfulness Strategies - Understanding Pain BREATHE with Headache (BREATHE-HA), Enhanced Standard-of-Care: Headache Education - Migraine, Migraine in Adolescence | Not applicable | Not yet recruiting | University of Colorado, Denver | 72 | 2026-10-01 | 2026-08-10 |
| Tear Biomarkers for Migraine Patients with migraine - Migraine | Not yet recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 400 | 2026-09-30 | 2026-07-10 | |
| Localized Injection of Lidocaine Via the Middle Meningeal Artery for Headache Treatment Lidocaine (drug), Saline - Refractory Migraine, Headache | Phase 2 | Recruiting | Daniel A Tonetti, MD | 80 | 2026-09-09 | 2026-10-01 |
| Comprehensive Approach to Lifestyle Modification in Chronic Migraine Comprehensive Lifestyle Intervention - Chronic Migraine, Headache | Not applicable | Not yet recruiting | Hacettepe University | 30 | 2026-09-01 | 2026-09-03 |
| Visual Instillation of Sphenopalatine-block Intervention for ONgoing Migraine Topical solution of 4% lidocaine, Saline 0.9% - Migraine, Facial Pain or Pressure | Phase 2 | Not yet recruiting | Association of Migraine Disorders | 74 | 2026-09-01 | 2026-08-14 |
| EMBRACE-OBS: Single-Site Observational Registry of Patient-Reported Outcomes Following MMA Embolization for Migraine Middle Meningeal Artery Embolization - Migraine Disorders, Chronic Migraine Headache | Recruiting | Cortex Neurovascular | 50 | 2026-09-01 | 2026-09-23 | |
| Tirzepatide in Idiopathic Intracranial Hypertension Trial Tirzepatide, Tirzepatide Placebo - Idiopathic Intracranial Hypertension (IIH) | Phase 4 | Recruiting | Duke University | 60 | 2026-08-25 | 2026-09-15 |
| CORRELATION BETWEEN FORWARD HEAD POSTURE, CERVICAL MUSCLES ENDURANCE, AND PROPRIOCEPTIVE FUCTIONS IN CERVICOGENIC HEADACHE AMONG LATE ADOLESCENT STUDENTS. Cervicogenic Headache | Not yet recruiting | Delta University for Science and Technology | 100 | 2026-08-10 | 2026-08-13 | |
| EFFECT OF ANODAL TRANSCRANIAL DIRECT CURRENT STIMULATION (tDCS) OF PRIMARY MOTOR CORTEX ON HEADACHE FREQUENCY IN PATIENTS WITH CHRONIC MIGRAINE Transcranial Direct Current stimulation - Chronic Migraine Headache, Chronic Migraine, Headache | Phase 3 | Not yet recruiting | Dr. Ram Manohar Lohia Hospital | 32 | 2026-08-01 | 2026-08-04 |
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Migraine Disorders (316) · Pain (69) · Headache Disorders (45) · Post-Traumatic Headache (41) · Neck Pain (36) · Tension-Type Headache (27) · Migraine with Aura (22) · Migraine without Aura (22) · Chronic Pain (19) · Anxiety Disorders (17) · Brain Concussion (17) · Cluster Headache (17) · Epilepsy (17) · Brain Injuries, Traumatic (16)
Pathological Conditions, Signs and Symptoms (740) · Signs and Symptoms (740) · Neurologic Manifestations (737) · Pain (672) · Nervous System Diseases (506) · Central Nervous System Diseases (462) · Brain Diseases (460) · Headache Disorders (363) · Headache Disorders, Primary (332) · Pathologic Processes (68) · Musculoskeletal Diseases (59) · Respiratory Tract Diseases (53) · Headache Disorders, Secondary (51) · Wounds and Injuries (50) · Muscular Diseases (47)
Sodium Chloride (25) · Lidocaine (22) · Topiramate (19) · Saline Solution (17) · erenumab (17) · Acetaminophen (15) · Sumatriptan (14) · Metoclopramide (12) · galcanezumab (12) · Bupivacaine (11) · Ibuprofen (10) · Dry Needling (9) · Exercise (9) · Manipulation, Osteopathic (9) · Botulinum Toxins, Type A (8)
Danish Headache Center (40) · Eli Lilly and Company (15) · Amgen (9) · Assiut University (9) · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (8) · Pfizer (7) · Children's Hospital Medical Center, Cincinnati (6) · Mayo Clinic (6) · Montefiore Medical Center (6) · Novartis Pharmaceuticals (6) · Riphah International University (6) · Seattle Children's Hospital (6) · University of Florence (6) · Bnai Zion Medical Center (5) · Boston Scientific Corporation (5)
United States (317) · Denmark (63) · Turkey (Türkiye) (62) · Canada (38) · Spain (36) · Germany (33) · Italy (32) · France (28) · Belgium (27) · United Kingdom (24) · Egypt (19) · Israel (17) · Poland (17) · Netherlands (14) · Czechia (13)
Jes Olesen, Professor (4) · Alit Stark Inbar, PhD (3) · Ana Beatriz Gago Veiga (3) · Hakan Ashina, MD (3)
PMID 31482569, PMID 31952501, PMID 32576229, PMID 34264500, PMID 35076090, PMID 35978286, PMID 30462830, PMID 30594122, PMID 33069214, PMID 33143451, PMID 33544305, PMID 33549036, PMID 33950375, PMID 34928306, PMID 19546766, PMID 20353434, PMID 21521204, PMID 21711255, PMID 23567060, PMID 23771276, PMID 24579886, PMID 25338927, PMID 25526232, PMID 26852024, PMID 29368949, PMID 30152015, PMID 30942898, PMID 31253091, PMID 34049484, PMID 34145431, PMID 35639525, PMID 38581615, PMID 39198005, PMID 42129417, PMID 8656545, PMID 10412281, PMID 10772585, PMID 11098098, PMID 11168599, PMID 11279917, PMID 11279969, PMID 11282668, PMID 11294956, PMID 11535479, PMID 11554951, PMID 11739822, PMID 12405429, PMID 12455560, PMID 12598264, PMID 12764341
2018 (5), 2015 (4), 2023 (3), 2008 (2), 2014 (2), 2017 (2), 2019 (2), K01NS124911 (2), 1IK2RX001136-01A2 (1), 2004 (1), 2005 (1), 2009 (1), 2016 (1), K23AT013838 (1), K23NS102521 (1)