568 completed, 165 unknown, 98 recruiting, 98 terminated. 304 Phase 4, 242 Phase 2, 226 Not applicable, 166 Phase 3, 130 Phase 1.
Follow Ketamine: new trials by email Literature Review of Ketamine trials Research Report on Ketamine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Ketamine and Midazolam Infusions for CRPS: Feasibility Study Ketamine, Midazolam, Normal Saline - Complex Regional Pain Syndromes | Phase 2 | Withdrawn | Stanford University | 2099-01-01 | 2024-11-22 | |
| Department of Defense PTSD Adaptive Platform Trial - Intervention D - SLS-002 Intervention D SLS-002, Intervention D Placebo - Post Traumatic Stress Disorder | Phase 2 | Suspended | Global Coalition for Adaptive Research | 200 | 2028-05-01 | 2026-05-20 |
| Nebulized Ketamine for Severe Asthma Attacks in Children Ketamine (1 mg/kg), Placebo - Asthma Acute, Exacerbation of Allergic Asthma | Phase 2 | Not yet recruiting | Sultan Qaboos University | 60 | 2027-01-01 | 2026-07-27 |
| Prospective Study of Induction Medications Used in the Trauma RSI Ketamine, Etomidate, Propofol - Trauma, Rapid Sequence Intubation | Withdrawn | University of Southern California | 2027-01-01 | 2026-05-04 | ||
| Ketamine-Assisted Psychotherapy for Treatment-Resistant Depression Ketamine hydrochloride injection - Treatment Resistant Depression (TRD), Chronic Pain | Phase 2 | Not yet recruiting | University of Rochester | 25 | 2026-12-01 | 2026-09-24 |
| Head and Neck Cancer Patients With Oral Mucositis Treated With Ketamine Oral Rinse Placebo, Ketamine Topical - Head and Neck Cancer | Phase 2 | Not yet recruiting | University of Oklahoma | 62 | 2026-12-01 | 2026-10-16 |
| Electrophysiologic Mechanisms of Ketamine Antidepressant Response Ketamine - Epilepsy, Depressive Symptoms | Phase 2 | Not yet recruiting | Emory University | 37 | 2026-12-01 | 2026-08-17 |
| Efficacy of Intravenous Midazolam-Ketamine Combination Versus Placebo for Prevention of Post-Spinal Shivering in Elective Cesarean Section Midazolam and Ketamine, 0.9% Sodium Chloride - Shivering, Post-Spinal Shivering | Phase 4 | Not yet recruiting | Assiut University | 120 | 2026-11-01 | 2026-10-02 |
| Effect of Ketamine-Propofol Total Intravenous Anesthesia Versus Sevoflurane-Based Anesthesia on Postoperative Vomiting in Children Undergoing Strabismus Surgery Ketamine and Propofol, Sevoflurane - Postoperative Vomiting, Postoperative Nausea and Vomiting | Phase 4 | Not yet recruiting | Assiut University | 50 | 2026-11-01 | 2026-10-13 |
| Morphine or Ketamine for Analgesia Ketamine hydrochloride, Morphine sulphate - Abdominal Pain, Isolated Extremity Fracture | Phase 3 | Recruiting | Columbia University | 1010 | 2026-10-17 | 2026-10-20 |
| Ketadex Versus Ketofol for Adult Procedural Sedation in the Emergency Department. Ketamine (1 mg/kg), propofol, Dexmedetomidine - Procedural Sedation | Phase 4 | Not yet recruiting | Sultan Qaboos University | 100 | 2026-10-10 | 2026-10-15 |
| Effect of a Low-Dose Ketamine-Dexmedetomidine-Based Opioid-Sparing Anesthesia Protocol on Postoperative Quality of Recovery After Percutaneous Nephrolithotomy Ketamine and Dexmedetomidine, Fentanyl - Nephrolithiasis, Postoperative Pain | Phase 4 | Not yet recruiting | Assiut University | 100 | 2026-10-01 | 2026-10-02 |
| Outcomes Registry After Ketamine Infusions for Chronic Pain: A Longitudinal Evaluation Ketamine (Ketalar) - Chronic Pain, Ketamine | Not yet recruiting | Stanford University | 800 | 2026-10-01 | 2026-09-15 | |
| Oral and Sublingual Ketamine 75 mg of oral ketamine, Sublingual ketamine 75 mg - Major Depression Severe | Phase 1 | Not yet recruiting | Western University, Canada | 10 | 2026-10-01 | 2026-07-06 |
| A Study Comparing Oral Ketamine With Oral Midazolam for the Treatment of Major Depressive Episodes Oral ketamine, Oral midazolam - Major Depressive Episode | Phase 3 | Not yet recruiting | Jawaharlal Institute of Postgraduate Medical Education & Research | 220 | 2026-10-01 | 2026-10-01 |
| Adaptive Platform Trial for Pain Management in Sickle Cell Vaso-Occlusive Crisis Group 02 Paracetamol + Morphine + Ketamine, Group 01 Control: Paracetamol + Morphine, Group 03 : Paracetamol + Morphine + Nefopam - Sickle Cell Disease, Vaso-occlusive Crisis | Phase 4 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 400 | 2026-10-01 | 2026-09-18 |
| An Artificial Intelligence Driven Approach to Optimize Patient Selection for a Transitional Pain Service TPS-Select, Pharmacologic Pain Management, Interventional Pain Procedures - Postsurgical Pain Management, Postsurgical Pain, Chronic | Phase 3 | Not yet recruiting | University of California, San Francisco | 474 | 2026-10-01 | 2026-10-09 |
| Dexametedomidine Ketamine Infusion Versus Dexametedomidine Propofol Infusion in Non-compliant Agitated Patients on Continuous Positive Airway Pressure (CPAP) Mask Ventilation in the Intensive Care Unit Group DK will receive dexmedetomidine (0.2-1.4 μg/kg/hour) and ketamine (0.5 mg/kg/hr)., Group KP will receive dexmedetomidine (0.2-1.4 μg/kg/hour) and propofol (2-4 mg/kg/hr).( - CPAP Ventilation, Sedation | Not applicable | Not yet recruiting | Ain Shams University | 100 | 2026-10-01 | 2026-10-22 |
| Effects of Low-Dose Ketamine Added to Propofol Sedation During Colonoscopy Propofol group, Propofol + Ketamine - Colonoscopy Procedures, Sedation | Not applicable | Not yet recruiting | Ankara Etlik City Hospital | 100 | 2026-09-14 | 2026-09-09 |
| Intramuscular Ketamine for Suicidal Patients in the Evanston Hospital Emergency Department for Suicidal Distress Ketamine (0.5 mg/kg) - Suicidal, Suicidal Ideation | Not applicable | Enrolling by invitation | Endeavor Health | 8 | 2026-09-10 | 2026-09-09 |
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Depression (126) · Pain (114) · Pain, Postoperative (110) · Depressive Disorder, Major (108) · Agnosia (71) · Depressive Disorder, Treatment-Resistant (53) · Acute Pain (42) · Chronic Pain (40) · Suicidal Ideation (35) · Bipolar Disorder (32) · Stress Disorders, Post-Traumatic (32) · Depressive Disorder (29) · Suicide (24) · Anxiety Disorders (21) · Emergencies (21)
Assiut University (38) · Yale University (26) · Ain Shams University (24) · Cairo University (15) · Massachusetts General Hospital (15) · New York State Psychiatric Institute (15) · Mayo Clinic (14) · Zagazig University (12) · Assistance Publique - Hôpitaux de Paris (11) · Icahn School of Medicine at Mount Sinai (11) · Tel-Aviv Sourasky Medical Center (11) · Washington University School of Medicine (11) · Antonios Likourezos (10) · Stanford University (10) · Tanta University (9)
United States (445) · Egypt (129) · Canada (55) · Turkey (Türkiye) (46) · France (40) · Israel (25) · Brazil (23) · China (19) · South Korea (15) · United Kingdom (14) · Pakistan (12) · Belgium (10) · Austria (8) · Denmark (8) · Germany (8)
Sergey Motov, MD (7) · James W Murrough, MD (5) · Adriana Feder, MD (3) · Carlos A Zarate, M.D. (3) · Chadi Abdallah, MD (3) · Cristina Cusin, M.D. (3) · Fang Tan (3) · James Murrough, MD, PhD (3) · Jonathan Gamble, MD (3) · Naveen Poonai, MD (3) · Nirvana Elshalakany, Professor (3) · Scott Irwin, MD, PhD (3)
PMID 39428602, PMID 10686270, PMID 23982301, PMID 25271445, PMID 16894061, PMID 17074942, PMID 19422355, PMID 19545857, PMID 19897179, PMID 20673547, PMID 20679587, PMID 22297150, PMID 22840761, PMID 23432384, PMID 24268616, PMID 24821196, PMID 25010396, PMID 27028832, PMID 27056608, PMID 27656788, PMID 29282469, PMID 29748628, PMID 30232735, PMID 34510411, PMID 34623633, PMID 35141873, PMID 38767196, PMID 40879542, PMID 42171126, PMID 10439740, PMID 10691234, PMID 10702460, PMID 10863041, PMID 10910487, PMID 10910490, PMID 10966311, PMID 11027905, PMID 11032280, PMID 11425500, PMID 11535479, PMID 11576800, PMID 11772567, PMID 12088953, PMID 12472704, PMID 12598264, PMID 12764341, PMID 12813115, PMID 12826855, PMID 12873568, PMID 12873949
2014 (5), 2019 (5), 2016 (4), 2017 (4), 2023 (4), 2025 (3), 2009 (2), 2018 (2), R01MH134538 (2), 2015 (1), 271201100006I-0-27100007-1 (1), 2KL2TR001870 (1), 5KL2TR002379 (1), 5KL2TR002379-08 (1), IK2CX002646-01A2 (1)