Botulinum Toxins, Type A: Clinical Trials

593 completed, 135 unknown, 66 terminated, 47 recruiting. 260 Phase 3, 232 Phase 2, 176 Phase 4, 145 Not applicable, 79 Phase 1.

By phase and status

Phase	Trials	Status
Phase 3	260	Completed 184, Unknown 31, Terminated 17, Recruiting 12, Active not recruiting 8, Not yet recruiting 4, Withdrawn 4
Phase 2	232	Completed 140, Unknown 37, Terminated 21, Recruiting 13, Withdrawn 10, Not yet recruiting 8, Active not recruiting 3
Phase 4	176	Completed 110, Unknown 23, Terminated 15, Not yet recruiting 10, Recruiting 10, Active not recruiting 4, Withdrawn 4
Not applicable	145	Completed 82, Unknown 28, Recruiting 13, Terminated 9, Not yet recruiting 8, Withdrawn 3, Active not recruiting 2
Phase 1	79	Completed 58, Unknown 9, Terminated 6, Withdrawn 3, Recruiting 2, Not yet recruiting 1
Early Phase 1	24	Completed 10, Unknown 6, Active not recruiting 2, Enrolling by invitation 1, Not yet recruiting 1, Recruiting 1, Suspended 1, Terminated 1, Withdrawn 1

Follow Botulinum Toxins, Type A: new trials by email Literature Review of Botulinum Toxins, Type A trials Research Report on Botulinum Toxins, Type A

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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
A Randomized Trial of Botulinum Toxin A vs Strabismus Surgery for Esotropia >10 to ≤30PD Botulinum toxin A, bilateral medial rectus recession - Esotropia	Phase 3	Not yet recruiting	Jaeb Center for Health Research	244	2027-01-01	2026-04-06
Efficacy of Botulinum Toxin A Versus Nanofat in the Treatment of Androgenetic Alopecia: A Comparative Clinical Trial Botulinum Toxin Type A, Autologous Nanofat Injection - Androgenetic Alopecia	Phase 2 / Phase 3	Not yet recruiting	Sherief Ayman Hussein Shaamash	40	2026-12-01	2026-10-07
Neoadjuvant Intraprostatic OnabotulinumtoxinA Before Radical Prostatectomy for High-Risk Localized Prostate Cancer OnabotulinumtoxinA (BOTOX®), Normal Saline Placebo - Prostate Cancer	Phase 1 / Phase 2	Not yet recruiting	The Methodist Hospital Research Institute	30	2026-11-01	2026-09-02
Perineural Botulinum Toxin Injection Versus Oral Duloxetine in Relief of Foot Pain in Painful Peripheral Diabetic Neuropathy Botulinum Toxin Type A, Duloxetine, Oral Placebo Tablet - Diabetic Peripheral Neuropathy, Painful Diabetic Neuropathy	Phase 2	Not yet recruiting	Assiut University	56	2026-11-01	2026-10-20
Botulinum Toxin-A for Bruxism Using Digital Occlusal Analysis Botulinum Toxin-A injection, Placebo (saline injection) - Bruxism	Early Phase 1	Not yet recruiting	Bilecik Seyh Edebali Universitesi	36	2026-10-20	2026-10-02
Botulinum Toxin Type A Versus Triamcinolone for Facial Myalgia Botulinum Toxin A (Botox ), Triamcinolone Acetonide - Myofascial Pain Syndrome (MPS)	Phase 4	Not yet recruiting	Riyadh Elm University	56	2026-10-11	2026-10-09
A Study to Assess the Safety and Efficacy of Co-Reconstituted TrenibotulinumtoxinE and OnabotulinumtoxinA in Adult Participants With Moderate to Severe Upper Facial Lines TrenibotulinumtoxinE and OnabotulinumtoxinA, Placebo, OnabotulinumtoxinA - Upper Facial Lines, Glabellar Lines	Phase 2	Recruiting	AbbVie	300	2026-10-07	2026-10-13
Effectiveness of Greater Occipital Nerve and Supratrochlear Nerve Pulsed Radiofrequency Versus Botulinum Toxin Type A Injection in Chronic Migraine Ultrasound-guided pulsed radiofrequency (PRF), OnabotulinumtoxinA - Chronic Migraine Headache	Phase 4	Not yet recruiting	Assiut University	70	2026-10-01	2026-09-22
Comparison of the Effectiveness of Greater Occipital Nerve and Supratrochlear Nerve Pulsed Radiofrequency Versus Botulinum Toxin Type A Injection in Chronic Migraine OnabotulinumtoxinA, Ultrasound-guided pulsed radiofrequency (PRF) of the greater occipital nerve (GON) and supratrochlear nerve - Chronic Migraine	Phase 4	Not yet recruiting	Assiut University	70	2026-10-01	2026-09-23
MRI Study of OnabotulinumtoxinA (OnabotA) Effect on Jaw Muscle Pain Onabotulinumtoxin A, Placebo - Masticatory Myofascial Pain Syndrome	Phase 2	Not yet recruiting	Weill Medical College of Cornell University	120	2026-10-01	2026-10-16
Comparative Evaluation of Intraneuroma and Perineuroma Botulinum Toxin Type A Injection Techniques for Chronic Neuroma Pain After Combat-Related Amputation Botulinum toxin type A injection - Chronic Pain, Neuroma	Not applicable	Completed	Ukrainian Society of Regional Anesthesia and Pain Therapy	100	2026-10-01	2026-10-06
Botulinum Toxin Blockade of Neuronal Signals to Immune Cells as a Novel Treatment for Hidradenitis Suppurativa Botulinum Toxin A (Allergan, Inc, Irvine CA), Placebo - Hidradenitis Suppurativa (HS)	Phase 2	Not yet recruiting	University of Massachusetts, Worcester	40	2026-10-01	2026-09-10
DaxibotulinumtoxinA for Blepharospasm Botulinum Neurotoxin Type A - Blepharospasm of Both Eyelids, Blepharospasm of Left Eyelid	Phase 2	Recruiting	University of Pennsylvania	20	2026-09-24	2026-09-29
Impact of Dysport on PMFF Donor Scar Abobotulinumtoxin-A, Control- Saline injection - Skin Cancer Excision Site, Basal Cell Carcinoma	Phase 4	Not yet recruiting	Vanderbilt University Medical Center	50	2026-09-14	2026-08-26
Study to Assess Participant Satisfaction After Jawline and Neck Treatment OnabotulinumtoxinA, SKINVIVE, VOLUX - Jawline and Neck Appearance	Phase 4	Recruiting	AbbVie	100	2026-09-09	2026-10-08
Clinical Evaluation of Botulinum Toxin a in the Management of Temporomandibular Myofascial Pain Botulinum Toxin Type A (BoNT-A), 0.9% Normal Saline (Placebo) - Temporomandibular Disorder	Phase 2	Recruiting	Riphah International University	118	2026-08-15	2026-09-29
Arthrocentesis Versus Botulinum Toxin Injection in Patients With Temporomandibular Joint Disorders: A Randomized Controlled Trial Arthrocentesis, Botulinum Toxin-A - Temporomandibular Joint Disorders, Temporomandibular Joint Dysfunction Syndrome	Not applicable	Not yet recruiting	Mudher MB Alsunbuli	66	2026-08-15	2026-07-30
Botulinum Toxin Type A for Wound Healing After Laparoscopic Colectomy Botulinum toxin type A (Botox®, Allergan) - Surgical Wound Healing, Botulinum Toxin, Type A	Not applicable	Recruiting	Pham Ngoc Thach University of Medicine	60	2026-08-10	2026-08-31
A Study to Evaluate Sequential Administration of Injections of AGN-151586 Followed by BOTOX in Adult Participants for Treatment of Glabellar Lines AGN-151586, BOTOX - Glabellar Lines	Phase 1	Recruiting	AbbVie	120	2026-08-10	2026-09-09
Botox Injections in Non-Cranial Nerve VII Innervated Muscles for Facial Synkinesis Botulinum Toxin Type A Injection [Botox] - Synkinesis	Phase 4	Not yet recruiting	Vanderbilt University Medical Center	50	2026-07-01	2026-04-15

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Conditions studied

Muscle Spasticity (73)  ·  Urinary Bladder, Overactive (61)  ·  Stroke (48)  ·  Cerebral Palsy (41)  ·  Migraine Disorders (31)  ·  Torticollis (30)  ·  Urinary Incontinence (29)  ·  Pain (22)  ·  Hyperhidrosis (14)  ·  Spinal Cord Injuries (14)  ·  Bruxism (13)  ·  Urinary Incontinence, Urge (13)  ·  Blepharospasm (12)  ·  Neuralgia (12)  ·  Temporomandibular Joint Disorders (12)

Sponsors

Allergan (95)  ·  Ipsen (47)  ·  Medy-Tox (27)  ·  AbbVie (22)  ·  Merz Pharmaceuticals GmbH (21)  ·  Revance Therapeutics, Inc. (19)  ·  Cairo University (16)  ·  Hugel (12)  ·  Buddhist Tzu Chi General Hospital (9)  ·  Norwegian University of Science and Technology (9)  ·  Assiut University (8)  ·  Daewoong Pharmaceutical Co. LTD. (8)  ·  GlaxoSmithKline (8)  ·  Mayo Clinic (8)  ·  Northwestern University (8)

Countries

United States (341)  ·  Canada (98)  ·  South Korea (83)  ·  France (75)  ·  Germany (67)  ·  Egypt (50)  ·  Poland (50)  ·  United Kingdom (50)  ·  Czechia (39)  ·  Turkey (Türkiye) (39)  ·  Spain (38)  ·  Russia (36)  ·  Taiwan (36)  ·  China (35)  ·  Italy (35)

Top investigators

Hann-Chorng Kuo, M.D. (8)  ·  Murad Alam, MD (5)  ·  Mandar Jog, MD (4)  ·  Doris M Hexsel, MD (3)  ·  Ian R Carroll (3)  ·  Nigar Dursun, MD (3)  ·  Pong Ya-Ping, MD (3)  ·  Rui Avelar, MD (3)

Results publications

PMID 36136523, PMID 38470985, PMID 18844269, PMID 20359934, PMID 20487038, PMID 21368663, PMID 21791356, PMID 21883197, PMID 23098762, PMID 23740337, PMID 24754838, PMID 25080874, PMID 25288099, PMID 25324317, PMID 25500317, PMID 26231052, PMID 29093068, PMID 29141611, PMID 29781237, PMID 31112399, PMID 31609882, PMID 31791824, PMID 32108436, PMID 32665528, PMID 32734597, PMID 32741133, PMID 33026630, PMID 33026631, PMID 33206382, PMID 33620895, PMID 33955921, PMID 35400537, PMID 36206385, PMID 39475143, PMID 40968493, PMID 10395629, PMID 10534247, PMID 10896696, PMID 10906647, PMID 10925088, PMID 11176403, PMID 11743295, PMID 11857671, PMID 12145388, PMID 12893330, PMID 12894267, PMID 12907905, PMID 12963779, PMID 12973229, PMID 1356988

NIH funding

2014 (10), 2004 (5), 2015 (5), 2018 (5), 2009 (4), 2023 (4), 2005 (3), 2016 (3), 2017 (3), 2019 (2), 2008 (1), 2025 (1), K08AR080844 (1), R15HD071397 (1), R21HD048972 (1)