Osteoarthritis, Knee: Clinical Trials

1796 completed, 596 unknown, 300 recruiting, 162 not yet recruiting. 1824 Not applicable, 349 Phase 2, 257 Phase 3, 227 Phase 4, 171 Phase 1.

By phase and status

Phase	Trials	Status
Not applicable	1824	Completed 1011, Unknown 340, Recruiting 188, Not yet recruiting 110, Active not recruiting 76, Terminated 53, Withdrawn 34, Enrolling by invitation 8, Suspended 4
Phase 2	349	Completed 207, Unknown 57, Terminated 24, Withdrawn 21, Recruiting 17, Not yet recruiting 10, Active not recruiting 9, Enrolling by invitation 2, Suspended 2
Phase 3	257	Completed 167, Unknown 33, Recruiting 13, Active not recruiting 12, Withdrawn 11, Not yet recruiting 10, Terminated 9, Enrolling by invitation 2
Phase 4	227	Completed 126, Unknown 57, Terminated 16, Not yet recruiting 8, Recruiting 8, Withdrawn 7, Active not recruiting 5
Phase 1	171	Completed 95, Unknown 42, Withdrawn 10, Active not recruiting 9, Recruiting 7, Not yet recruiting 4, Terminated 3, Enrolling by invitation 1
Early Phase 1	25	Unknown 9, Completed 7, Not yet recruiting 3, Recruiting 3, Withdrawn 2, Active not recruiting 1

Follow Osteoarthritis, Knee: new trials by email Literature Review of Osteoarthritis, Knee trials Research Report on Osteoarthritis, Knee

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Evaluating the Effect of Adipose Tissue Processed With the SyntrFuge™ System for Knee Osteoarthritis SyntrFuge System, Triamcinolone Injection - Knee Osteoarthritis	Not applicable	Not yet recruiting	Syntr Health Technologies, Inc.	180	2027-12-01	2026-08-20
Clinical Outcomes of Focused Shockwave Therapy Without Adjunct Rehabilitation Compared to Standard Physical Rehabilitation in Patients With Grade I-III Knee Osteoarthritis: A Single-Blind Randomized Study Physical Rehab, Focused Shockwave Therapy - Knee Osteoarthristis	Not applicable	Not yet recruiting	Pulse Wave USA	60	2027-09-25	2026-05-05
Platelet-Rich Plasma, Hyaluronic Acid, or Their Combination for Knee Osteoarthritis in Athletes Leukocyte-Poor Platelet-Rich Plasma, Cross-Linked Hyaluronic Acid - Knee Osteoarthritis	Not applicable	Not yet recruiting	University of Sao Paulo General Hospital	300	2027-04-01	2026-10-28
Duloxetine and aeRobic Exercise to Improve Function in VEterans With Knee Osteoarthritis (DRIVE) Exercise, Duloxetine, Placebo - Knee Osteoarthritis, Pain	Phase 2	Not yet recruiting	VA Office of Research and Development	102	2027-03-01	2026-06-16
Undenatured Type II Collagen for Knee Osteoarthritis Pain Placebo, Nuvicol II, Nuvicol SII - Osteoarthritis, Knee	Not applicable	Recruiting	Universidad Católica San Antonio de Murcia	120	2027-03-01	2026-10-22
Comparing Pain Science Education to Biomedical Education for People With Knee Osteoarthritis: A Randomized Controlled Trial Pain Science Education, Biomedical Education - Knee Arthritis Osteoarthritis	Not applicable	Not yet recruiting	McMaster University	82	2027-02-01	2026-09-16
HTO and Tranexamic Acid Study Tranexamic Acid, Routine medial opening wedge high tibial osteotomy - Osteoarthritis, Knee	Phase 3	Not yet recruiting	Western University, Canada	200	2027-01-01	2026-09-17
Zynrelef Versus Adductor Canal Block ZYNRELEF 400Mg-12Mg Extended-Release Solution, Ultrasound-Guided Adductor Canal Block, Ropivacaine 0.5% Injectable Solution - Knee Osteoarthritis, Arthritis Knee	Phase 4	Not yet recruiting	University of Miami	120	2027-01-01	2026-06-12
Pilot and Feasibility Study of Anti-CD14 for the Treatment of Knee Osteoarthritis Atibuclimab, saline placebo - Knee Osteoarthritis (Knee OA)	Phase 1	Not yet recruiting	VA Office of Research and Development	40	2027-01-01	2026-07-15
Heart Rate Variability Guided Physical Activity and Exercise Prescription in Individuals With Knee Osteoarthritis HRV-guided home exercise prescription, Traditional Home Exercise - Knee Osteoarthritis	Not applicable	Not yet recruiting	The Hong Kong Polytechnic University	240	2027-01-01	2026-02-12
Mechanical Alignment Versus Kinematic Alignment Total Knee Arthroplasty Total knee arthroplasty - Knee Osteoarthritis	Not applicable	Not yet recruiting	Loyola University	96	2027-01-01	2026-08-27
IMAGES: Identifying Metabolic Imaging Association With Genicular Artery Embolization Success Embolization - Knee Osteoarthritis, Knee Discomfort	Not applicable	Not yet recruiting	Lucas R. Cusumano, MD	25	2026-12-30	2026-09-21
Efficacy of Autologous Adipose Derived Stromal Vascular Fraction for Musculoskeletal Conditions stromal vascular fraction injection in the osteoarthritic knee - Knee Osteoarthritis	Not applicable	Not yet recruiting	Dubai Health Authority	300	2026-12-30	2025-08-26
Perioperative Colchicine for TKA Colchicine 1.8 mg (loading dose) + Dextrose Oral Placebo, Colchicine 1.8 mg + 0.6 mg, Dextrose Oral Placebo - Osteoarthritis of Knee, Recovery Following Primary Total Knee Arthroplasty	Phase 4	Not yet recruiting	Geisinger Clinic	75	2026-12-01	2026-09-03
Clinical Evaluation of TrHCROSS® for Different Joints TrHCROSS®, Monovisc - Joint Osteoarthritis, Knee Osteoarthristis	Not applicable	Not yet recruiting	i+Med S.Coop.	150	2026-12-01	2026-10-13
GENIVS Block Versus Adductor Canal Block After Total Knee Arthroplasty GENIVS block, Adductor Canal Block (ACB) Only - Arthroplasty, Replacement, Knee, Pain, Postoperative	Not applicable	Not yet recruiting	Bakirkoy Dr. Sadi Konuk Research and Training Hospital	74	2026-12-01	2026-10-28
Clinical Importance of Occult Suprapatellar Effusion in Knee Osteoarthritis Static and Dynamic Suprapatellar Ultrasonography - Knee Osteoarthritis		Not yet recruiting	Mardin Artuklu University	105	2026-11-30	2026-10-20
Bipolar Versus Cooled Radiofrequency Ablation for Gonarthrosis Bipolar Radiofrequency Ablation, Cooled Radiofrequency Ablation - Gonarthrosis	Not applicable	Not yet recruiting	Saglik Bilimleri Universitesi	80	2026-11-20	2026-10-19
The ACT-ON: A Geriatric 5-Ms-Guided Physical Therapy Intervention for Knee Osteo-Arthritis in Older Adults. Geriatric 5Ms framework, Exercises PT - Rehabilitation, Excercise	Not applicable	Not yet recruiting	King Saud University	40	2026-11-15	2026-08-31
Whole-body Vibration Training on the Elderly With Combined Bilateral Knee Osteoarthritis Whole-body vibration training - Knee OA, Sarcopenic Obesity	Not applicable	Enrolling by invitation	Beni-Suef University	30	2026-11-15	2026-10-02

Showing 20 of 3219. Sign in to see all of them.

Narrower conditions

Osteoarthritis (691)  ·  Pain (258)  ·  Osteoarthritis, Hip (162)  ·  Motor Activity (141)  ·  Arthritis (89)  ·  Chronic Pain (67)  ·  Joint Diseases (59)  ·  Pain, Postoperative (53)  ·  Obesity (40)  ·  Agnosia (38)  ·  Musculoskeletal Diseases (38)  ·  Knee Injuries (37)  ·  Arthritis, Rheumatoid (33)  ·  Inflammation (25)

Broader conditions

Rheumatic Diseases (3200)  ·  Musculoskeletal Diseases (3181)  ·  Joint Diseases (3160)  ·  Arthritis (3130)  ·  Osteoarthritis (2528)  ·  Pathological Conditions, Signs and Symptoms (581)  ·  Signs and Symptoms (518)  ·  Neurologic Manifestations (463)  ·  Behavior (179)  ·  Pain (155)  ·  Pathologic Processes (138)  ·  Nervous System Diseases (99)  ·  Nutritional and Metabolic Diseases (72)  ·  Wounds and Injuries (72)  ·  Skin and Connective Tissue Diseases (62)

Interventions

Exercise (100)  ·  Arthroplasty, Replacement, Knee (82)  ·  Sodium Chloride (68)  ·  Hyaluronic Acid (66)  ·  Saline Solution (37)  ·  Celecoxib (36)  ·  Resistance Training (35)  ·  Physical Therapy Modalities (34)  ·  Adrenal Cortex Hormones (31)  ·  Ropivacaine (30)  ·  Exercise Therapy (29)  ·  Transcutaneous Electric Nerve Stimulation (25)  ·  Naproxen (23)  ·  Triamcinolone (23)  ·  Triamcinolone Acetonide (21)

Sponsors

Riphah International University (73)  ·  Istituto Ortopedico Rizzoli (31)  ·  Cairo University (25)  ·  Zimmer Biomet (22)  ·  Assiut University (19)  ·  Chinese University of Hong Kong (19)  ·  University of North Carolina, Chapel Hill (19)  ·  Thammasat University (17)  ·  University of British Columbia (17)  ·  VA Office of Research and Development (17)  ·  Pacira Pharmaceuticals, Inc (16)  ·  University of Sao Paulo General Hospital (16)  ·  Hospital for Special Surgery, New York (15)  ·  London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (15)  ·  Pfizer (15)

Countries

United States (780)  ·  Turkey (Türkiye) (265)  ·  Canada (166)  ·  China (132)  ·  Pakistan (130)  ·  France (122)  ·  Denmark (114)  ·  United Kingdom (109)  ·  Italy (104)  ·  Spain (100)  ·  South Korea (95)  ·  Taiwan (87)  ·  Egypt (82)  ·  Brazil (78)  ·  Poland (76)

Top investigators

Jianhao Lin, MD (10)  ·  James C Eisenach, MD (7)  ·  Neil A Segal, MD, MS (7)  ·  Neil Bodick, MD (6)  ·  Ru-Lan Hsieh, MD (6)  ·  Howard Levy, MD (5)  ·  Kelli D Allen, PhD (5)  ·  Muhammad Kashif (5)

Results publications

PMID 21055873, PMID 15039276, PMID 17403800, PMID 19734131, PMID 21174485, PMID 21518322, PMID 23340531, PMID 23559821, PMID 23973136, PMID 24985410, PMID 26403468, PMID 35232805, PMID 35960482, PMID 35980115, PMID 36269595, PMID 36301512, PMID 36474952, PMID 37470295, PMID 37652258, PMID 38343426, PMID 38650049, PMID 39004211, PMID 39495154, PMID 15611487, PMID 17076974, PMID 17266764, PMID 20699159, PMID 22200383, PMID 22220431, PMID 22227789, PMID 22961435, PMID 23325966, PMID 23709304, PMID 24353047, PMID 24916058, PMID 25035839, PMID 25822648, PMID 25925602, PMID 26304646, PMID 26889617, PMID 27250845, PMID 27455842, PMID 27681448, PMID 28146403, PMID 28566193, PMID 29035179, PMID 29156068, PMID 29369450, PMID 29723634, PMID 29780263

NIH funding

2009 (6), 2016 (5), 2017 (5), 2023 (5), 2018 (3), 2019 (3), 2008 (2), 2014 (2), 2015 (2), K23AG030945 (2), P60AR047785 (2), 1P2CHD086851-01 (1), 1UG3AR077360-01 (1), 1UG3AR077748-01 (1), 1UM1AR062800-01 (1)