136 completed, 42 recruiting, 19 unknown, 17 terminated. 86 Phase 2, 80 Phase 1, 33 Early Phase 1, 31 Not applicable, 26 Phase 3.
Follow Dronabinol: new trials by email Literature Review of Dronabinol trials Research Report on Dronabinol
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Behavioral Pharmacology of THC and Beta-Myrcene Placebo, THC, Beta-Myrcene - Cannabis Use | Phase 1 | Not yet recruiting | Johns Hopkins University | 32 | 2027-07-01 | 2026-07-31 |
| Effects of Cannabidiol (CBD) on a Fixed Dose of Delta-9-tetrahydrocannabinol (THC) 0mg THC + 0mg CBD Brownie, 10mg THC + 0mg CBD Brownie, 10mg THC + 10mg CBD Brownie - Cannabis Intoxication | Phase 1 | Not yet recruiting | Johns Hopkins University | 70 | 2027-02-01 | 2026-10-15 |
| Research Investigating Drug Effects-2 (RiDE-2) Placebo Oral Capsule, THC - Cannabis Use, Substance Use Disorder (SUD) | Early Phase 1 | Not yet recruiting | University of Illinois at Chicago | 144 | 2027-01-04 | 2026-10-22 |
| Lung Health and Breath Biomarkers: Acute Effects of Inhaled Cannabis Cannabis (THC), Tobacco Cigarette - Cannabis Use, Tobacco | Early Phase 1 | Not yet recruiting | Hannah Harris | 12 | 2026-11-01 | 2026-10-06 |
| A Study Of Synthetic THC And Sleep Dronabinol, Placebo - Obstructive Sleep Apnea | Phase 2 / Phase 3 | Not yet recruiting | Mayo Clinic | 72 | 2026-11-01 | 2026-09-18 |
| Synthetic THC And Blood Pressure Dronabinol, Placebo - Blood Pressure | Phase 2 / Phase 3 | Not yet recruiting | Mayo Clinic | 50 | 2026-10-01 | 2026-09-11 |
| Dronabinol and Epidiolex to Manage Uncontrolled Residual Symptoms of Buprenorphine Initiation Trial Dronabinol Capsules, Epidiolex 100 mg/mL Oral Solution, Placebo Dronabinol - Opioid Use Disorder | Phase 3 | Not yet recruiting | Montefiore Medical Center | 40 | 2026-10-01 | 2026-06-09 |
| Endocannabinoids in Reward Dronabinol, Placebo - Cannabis Use Disorder | Phase 2 | Recruiting | Medical University of South Carolina | 78 | 2026-10-01 | 2026-10-05 |
| Effects of Various Cannabis Strains on Perceptual, Subjective and Objective Use Outcomes Cannabis, 0 mg THC (placebo) - Cannabis Intoxication | Phase 1 | Recruiting | Johns Hopkins University | 70 | 2026-09-15 | 2026-09-18 |
| Acute Effects of Cannabis on Cognition and Affect THC 20mg, Placebo - Cannabis Use | Phase 1 | Recruiting | Washington State University | 92 | 2026-09-11 | 2026-10-29 |
| Wayne State Warriors Marijuana Clinical Research Program: Cannabinoid Adjunct to Prolonged Exposure & Recovery Cannabidiol (CBD) only, Placebo only, Delta-9-tetrahydrocannabinol (THC) only - PTSD, Post Traumatic Stress Disorder | Phase 1 / Phase 2 | Not yet recruiting | Leslie Lundahl | 280 | 2026-09-01 | 2026-08-26 |
| Evaluation of Oral THC and CBD in Men and Women Placebo, THC, CBD - Drug Abuse, Intoxication by Drug | Phase 1 | Recruiting | University of California, Los Angeles | 22 | 2026-08-13 | 2026-09-08 |
| DReAMzz- Dronabinol and Acetazolamide Medication for Sleep Apnea (ZZ). Dose Confirmation Crossover Study for IHL-42X in Subjects With Obstructive Sleep Apnea. IHL-42X: 2.5 mg dronabinol + 125 mg acetazolamide, IHL-42X: 5 mg dronabinol + 125 mg acetazolamide, IHL-42X: 7.5 mg dronabinol + 125 mg acetazolamide - Obstructive Sleep Apnea (OSA) | Phase 2 | Recruiting | Incannex Healthcare Ltd | 120 | 2026-07-21 | 2026-10-13 |
| Challenging the Endocannabinoid System in Sleep Restricted Healthy Volunteers to Modulate Physiological Arousal (CANISLEEP) Study THC, CBD, THC + CBD - Healthy Volunteer | Not applicable | Recruiting | King's College London | 60 | 2026-06-02 | 2026-06-18 |
| The Pharmacokinetics of a Hemp-Based Topical Product CBD, THC - Cannabis | Phase 1 | Recruiting | Johns Hopkins University | 20 | 2026-05-26 | 2026-09-03 |
| To Evaluate the Efficacy, Safety, and Tolerability of Dronabinol Oral Solution for Agitation in Patients With Alzheimer's Disease Dronabinol Oral Solution, Placebo Control - Agitation in Dementia | Phase 2 / Phase 3 | Not yet recruiting | Benuvia Therapeutics Inc. | 140 | 2026-05-01 | 2026-02-25 |
| Sex Differences in Neurobehavioral Response to THC Dronabinol, Placebo - Cannabis Use Disorder | Phase 2 | Terminated | Medical University of South Carolina | 5 | 2026-04-27 | 2026-10-06 |
| Pregnenolone as a Treatment for Cannabis Intoxication Cannabis, Pregnenolone 250 mg, Pregnenolone 500 mg - Cannabis Intoxication | Phase 2 | Recruiting | Johns Hopkins University | 20 | 2026-04-24 | 2026-09-29 |
| Dronabinol As an Adjunct for Reducing Pain (DARP)-Texas Children's Hospital Dronabinol Capsules, Placebo - Endometriosis, Endometriosis Related Pain | Phase 2 | Withdrawn | Baylor College of Medicine | 2026-04-01 | 2026-03-13 | |
| Exploring The Effect Of Cannabidiol On Cannabis Tolerance Using A Novel Vaporiser Device In Heavy Users (Stage 1) delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) - Cannabis Intoxication | Not applicable | Not yet recruiting | King's College London | 10 | 2026-03-01 | 2026-03-13 |
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Marijuana Abuse (86) · Pain (19) · Substance-Related Disorders (12) · Psychotic Disorders (10) · Chronic Pain (9) · Schizophrenia (8) · Stress Disorders, Post-Traumatic (8) · Vomiting (8) · Nausea (7) · Sleep Apnea, Obstructive (6) · Fibromyalgia (5) · Multiple Sclerosis (5) · Alzheimer Disease (4) · HIV Infections (4) · Neoplasms (4)
Yale University (27) · Johns Hopkins University (20) · New York State Psychiatric Institute (10) · University of California, San Diego (9) · University of Chicago (8) · National Institute on Drug Abuse (NIDA) (6) · Radboud University Medical Center (6) · Wayne State University (6) · Hadassah Medical Organization (5) · Central Institute of Mental Health, Mannheim (4) · Centre for Addiction and Mental Health (4) · King's College London (4) · University of California, Los Angeles (4) · University of Illinois at Chicago (4) · INSYS Therapeutics Inc (3)
United States (162) · Canada (16) · Germany (11) · Netherlands (10) · Israel (9) · United Kingdom (6) · Australia (4) · Austria (3) · Switzerland (3) · Brazil (2) · Denmark (2) · New Zealand (2) · Spain (2) · Belgium (1) · Colombia (1)
Ryan Vandrey, PhD (6) · Margaret Haney, Ph.D. (4) · Godfrey Pearlson, M.D (3) · Mohini Ranganathan, MD (3) · Tory Spindle, PhD (3) · Carlos A Zamarripa, PhD (2) · Christine A. Rabinak, PhD (2) · David Crowley, MD (2) · Deepak D'Souza, M.D. (2) · Diana Martinez, MD (2) · Dustin Lee, PhD (2) · Elisa Pabon (2) · Harriet de Wit, PhD (2) · Harry van Goor, MD PhD (2)
PMID 34532852, PMID 27720917, PMID 28642081, PMID 19896326, PMID 21176784, PMID 21343383, PMID 21590520, PMID 21671456, PMID 21803011, PMID 21869692, PMID 22066583, PMID 22288893, PMID 22921474, PMID 23188041, PMID 23220273, PMID 23831756, PMID 25220020, PMID 25725933, PMID 26283236, PMID 26513587, PMID 26858214, PMID 27159993, PMID 27436749, PMID 29121334, PMID 29457671, PMID 29689485, PMID 29870396, PMID 29884456, PMID 30659041, PMID 30872375, PMID 30949710, PMID 31187152, PMID 31668830, PMID 32178232, PMID 32459420, PMID 33304282, PMID 33386756, PMID 33660625, PMID 33730032, PMID 34582562, PMID 34629131, PMID 34825898, PMID 34999737, PMID 35032682, PMID 35141873, PMID 35319274, PMID 36308640, PMID 36493386, PMID 36642667, PMID 36730769
P50DA009236 (3), R01DA043475 (3), 2025 (2), R01DA025044 (2), R01DA058624 (2), R01DK079866 (2), UL1RR024150 (2), 2019 (1), K01DA043652 (1), K01DA049219 (1), K12DA031794 (1), K23DA048132 (1), K23HL151884 (1), P01DA032507 (1), P30CA033572 (1)