1578 completed. 1578 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 1578 | Completed 1578 |
Follow Pain: new trials by email Literature Review of Pain trials Research Report on Pain
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Intraperitoneal Hydrocortisone for Postoperative Pain and CRP Following Caesarean Section hydrocortisone, Nornal Saline - Postoperative Pain, Caesarean Section | Phase 4 | Completed | Raditsya Mada Gautama, MD | 50 | 2026-06-25 | 2026-10-23 |
| Topical Lidocaine for Digital Nerve Block Pain Topical Lidocaine Spray, Placebo Spray - Finger Injuries, Procedural Pain | Phase 4 | Completed | Ankara City Hospital Bilkent | 240 | 2026-04-01 | 2026-09-22 |
| Ropivacaine Alone Versus Ropivacaine Plus Lidocaine With or Without Epinephrine for Supraclavicular Brachial Plexus Block in Upper Limb Orthopedic Surgery ropivacaine, lidocaine, lidocaine with epinephrine - Postoperative Pain, Upper Extremity Fracture | Phase 4 | Completed | Instituto Mexicano del Seguro Social | 138 | 2026-03-02 | 2026-10-30 |
| Spinal Morphine and Atropine Added to General Anaesthesia for Nausea and Pain After Abdominal Laparoscopy Intrathecal bupivacaine, morphine and atropine, General anaesthesia, Multimodal analgesia and antiemetic prophylaxis - Postoperative Nausea and Vomiting, Postoperative Pain | Phase 4 | Completed | Universitas Indonesia | 63 | 2026-02-02 | 2026-10-01 |
| Oral Methadone in Cardiac Surgery Methadone, oral, Methadone, intravenously - Pain, Postoperative, Anesthesia | Phase 4 | Completed | Mayo Clinic | 100 | 2026-01-13 | 2026-10-28 |
| Effect of Intraoperative Tetracycline on Postoperative Pain After Mandibular Molar Extraction Tetracycline, No Intrasocket Medicament - Postoperative Pain, Mandibular Molar Extraction | Phase 4 | Completed | CMH Lahore Medical College and Institute of Dentistry | 74 | 2026-01-10 | 2026-11-03 |
| Clinical Study of Equivalent Doses of Oxycodone or Tegileridine on Patients Undergoing Gynecological Laparoscopic Hysterectomy Tegileridine (tegileridine fumarate injection, IV), Oxycodone（Oxycodone Hydrochloride Injection，IV） - Total Laparoscopic Hysterectomy | Phase 4 | Completed | Xin Chen | 68 | 2025-12-17 | 2026-04-17 |
| Clinical Study on the Effect of Tegileridine on Postoperative Pain in Patients Undergoing Abdominal Surgery. Tegileridine (tegileridine fumarate injection, IV), 0.9% Normal Saline (0.9% Sodium Chloride) injection - Laparoscopic Surgery for Cholecystitis | Phase 4 | Completed | Xin Chen | 150 | 2025-11-30 | 2026-04-13 |
| A Study Of Opioid Avoidance In Surgery Through Integrating Suzetrigine Suzetrigine - Post Operative Pain | Phase 4 | Completed | Mayo Clinic | 100 | 2025-10-20 | 2026-05-01 |
| Paracervical Injection and Opioid Use After Vaginal Hysterectomy for Prolapse Bupivacaine-epinephrine, Normal saline - Opioid Use, Surgical Recovery | Phase 4 | Completed | University of North Carolina, Chapel Hill | 50 | 2025-10-20 | 2026-10-02 |
| Adjunctive Oral Probiotics in Endodontic Retreatment: Effects on Postoperative Pain and RANKL/OPG Levels Linex Adult®, Ca(OH)2 as intracanal medicament, Placebo - Chronic Apical Periodontitis | Phase 4 | Completed | Ain Shams University | 72 | 2025-10-04 | 2026-07-06 |
| Irrigation of Bupivacaine at the Surgical Bed for Postoperative Pain Relief After Laparoscopic Cholecystectomy for Acute Cholecystitis Bupivacaine 0.5%, Normal Saline 0.9% - Acute Cholecystitis, Postoperative Pain | Phase 4 | Completed | Ziauddin University | 64 | 2025-10-01 | 2026-10-01 |
| Preemptive IV Ibuprofen for Neurocognitive Recovery and Analgesic Needs After Inguinal Hernia Surgery Ibuprofen (400 mg x 4), Placebo (NaCl 0.9 % solution) - Inguinal Hernia Unilateral, Delayed Neurocognitive Recovery | Phase 4 | Completed | Mehmet Çiğdem | 76 | 2025-09-27 | 2026-03-03 |
| Liposomal Bupivacaine for Pain After Lumbar Fusion Liposomal bupivacaine (local infiltration), ropivacaine (local infiltration) - Postoperative Acute Pain, Lumbar Degenerative Diseases | Phase 4 | Completed | Min Li | 204 | 2025-09-20 | 2026-07-01 |
| Dexmedetomidine-esketamine-ropivacaine Versus Sufentanil-ropivacaine for Epidural Labor Analgesia sufentanil-ropivacaine combination, dexmedetomidine-esketamine-ropivacaine combination 1, dexmedetomidine-esketamine-ropivacaine combination 2 - Epidural Analgesia, Labor Pain | Phase 4 | Completed | Peking University First Hospital | 300 | 2025-09-05 | 2026-04-13 |
| Continuous Epidural With Dexmedetomidine Adjuvant in Gynecologic Laparotomy Dexmedetomidine & Bupivacaine., Bupivacain - Post Operative Pain, Acute, Chronic Post Surgical Pain | Phase 4 | Completed | Udayana University | 62 | 2025-08-21 | 2026-03-25 |
| EFFECT OF ZOLPIDEM ON SLEEP QUALITY AND OPIOID CONSUMPTION FOLLOWING PRIMARY TOTAL KNEE ARTHROPLASTY: A PROSPECTIVE, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL Zolpidem 10 mg tablets, Avocado-soybean unsaponifiables 300 mg - Postoperative Pain Management in Total Knee Arthroplasty | Phase 4 | Completed | Sanatorio Allende | 54 | 2025-08-05 | 2026-09-03 |
| Comparison of Pain Relief Duration With Dexmedetomidine Versus Fentanyl Added to Spinal Anesthesia in Patients Undergoing Lower Limb Orthopedic Surgery Dexmedetomidine & Bupivacaine., fentanyl and bupivacaine - Postoperative Pain | Phase 4 | Completed | Allama Iqbal Teaching Hospital | 60 | 2025-08-01 | 2026-08-18 |
| Vitamin E Plus Mefenamic Acid Versus Mefenamic Acid Alone for Treating Primary Dysmenorrhea in Women Mefenamic acid, Vitamin E capsule - Dysmenorrhea Primary, Vitamin E | Phase 4 | Completed | Nishtar Medical University | 60 | 2025-07-15 | 2026-03-12 |
| Reducing Pain With Methadone and Ketamine in Liver Transplant Methadone, ketamine, Hydromorphone - Liver Transplantation | Phase 4 | Completed | Lahey Clinic | 50 | 2025-06-30 | 2026-08-11 |
Showing 20 of 1578. Sign in to see all of them.
Pain, Postoperative (597) · Agnosia (127) · Acute Pain (89) · Chronic Pain (73) · Low Back Pain (59) · Neuralgia (47) · Headache (41) · Angina Pectoris (30) · Postoperative Nausea and Vomiting (30) · Angina, Unstable (28) · Migraine Disorders (28) · Osteoarthritis (26) · Back Pain (25) · Emergencies (25)
Neurologic Manifestations (1578) · Pathological Conditions, Signs and Symptoms (1578) · Signs and Symptoms (1578) · Pathologic Processes (704) · Postoperative Complications (600) · Nervous System Diseases (294) · Musculoskeletal Diseases (149) · Neurobehavioral Manifestations (138) · Perceptual Disorders (130) · Cardiovascular Diseases (92) · Vascular Diseases (92) · Neuromuscular Diseases (87) · Joint Diseases (86) · Heart Diseases (79)
Bupivacaine (142) · Acetaminophen (124) · Sodium Chloride (113) · Ropivacaine (96) · Lidocaine (91) · Morphine (88) · Saline Solution (81) · Ketamine (65) · Dexamethasone (64) · Fentanyl (62) · Ibuprofen (59) · Dexmedetomidine (45) · Oxycodone (44) · Epinephrine (35) · Gabapentin (34)
Montefiore Medical Center (22) · Duke University (20) · University of California, San Diego (17) · Hvidovre University Hospital (14) · Mahidol University (13) · Mayo Clinic (13) · Northwestern University (13) · Ain Shams University (12) · Cukurova University (12) · Hospital for Special Surgery, New York (12) · Oregon Health and Science University (12) · Antonios Likourezos (10) · Copenhagen University Hospital, Rigshospitalet (10) · Pfizer's Upjohn has merged with Mylan to form Viatris Inc. (10) · The University of Texas Health Science Center, Houston (10)
United States (541) · Denmark (98) · Turkey (Türkiye) (84) · China (64) · Canada (61) · Egypt (52) · Brazil (49) · France (48) · South Korea (43) · Germany (39) · Spain (39) · Italy (35) · Poland (35) · Norway (34) · United Kingdom (33)
Brian M Ilfeld, M.D., M.S. (8) · Sergey Motov, MD (7) · XiaoFeng Shen, MD (6) · Pamela Flood, MD (5) · Fang Luo, M.D. (4) · Sirilak Suksompong, MD (4) · Adnan Kastrati, MD (3) · Brian M Ilfeld, MD, MS (3) · Glenn S Murphy, MD (3)
PMID 22048651, PMID 36269595, PMID 10411041, PMID 11020772, PMID 15041597, PMID 18987053, PMID 19478674, PMID 19524353, PMID 20418301, PMID 22067185, PMID 23334883, PMID 23567060, PMID 23706726, PMID 23972577, PMID 24127709, PMID 26184397, PMID 31937091, PMID 32175985, PMID 33238043, PMID 33990439, PMID 34433773, PMID 35553047, PMID 35641327, PMID 36063082, PMID 37619976, PMID 37745109, PMID 38598970, PMID 39959922, PMID 10195475, PMID 10702460, PMID 10776835, PMID 10813730, PMID 10927999, PMID 11013380, PMID 11020770, PMID 11033377, PMID 11034732, PMID 11056756, PMID 11068116, PMID 11098714, PMID 11331334, PMID 11535479, PMID 11589257, PMID 11808971, PMID 11895532, PMID 12067003, PMID 12098173, PMID 12453928, PMID 12538184, PMID 12538372
2014 (10), 2017 (10), 2009 (7), 2019 (6), 2015 (5), 2018 (4), 2005 (3), 2016 (3), U01AR045444 (3), 2004 (2), 2008 (2), P01HD033988 (2), R01AT007987 (2), 1RC1DK086182 (1), 1RC1HD063312-01 (1)