315 completed, 75 unknown, 36 recruiting, 35 terminated. 178 Not applicable, 167 Phase 4, 84 Phase 2, 56 Phase 3, 40 Phase 1.
Follow Epinephrine: new trials by email Literature Review of Epinephrine trials Research Report on Epinephrine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Liposomal Bupivacaine vs Perineural Adjuvants in Adductor Canalf and iPACK Blocks in Total Knee Arthroplasty Liposomal Bupivacaine, Bupivacaine, Clonidine, Epinephrine, Buprenorphine and Dexamethasone (BPV-CEBD) Combination - Knee Arthroplasty, Total | Phase 4 | Not yet recruiting | Wake Forest University Health Sciences | 90 | 2027-02-01 | 2026-08-25 |
| Intralesional Chemotherapy (IC): Cisplatin + Epinephrine Cisplatin, Epinephrine injection, Laryngeal Biopsy - Laryngeal Squamous Cell Carcinoma | Phase 2 | Recruiting | University of Miami | 20 | 2026-12-01 | 2026-08-26 |
| A Clinical Trial of MK-2010 Alone and With Other Treatments in Participants With Advanced Solid Tumors (MK-2010-002) MK-2010, Pembrolizumab, 5-Fluorouracil - Malignant Neoplam, Advanced Solid Tumors | Phase 2 | Not yet recruiting | Merck Sharp & Dohme LLC | 480 | 2026-10-27 | 2026-10-08 |
| A Clinical Trial of MK-2010 With Sacituzumab Tirumotecan (Sac-TMT) in Participants With Solid Tumors (MK-2010) MK-2010, Sacituzumab tirumotecan, Histamine H1 Receptor Antagonist - Advanced Solid Tumors, Malignant Neoplasm | Phase 2 | Recruiting | Merck Sharp & Dohme LLC | 200 | 2026-10-07 | 2026-10-15 |
| ESP Blocks in Breast Free Flaps Bupivacaine with Epinephrine and Dexamethasone - Breast Reconstruction, Free Flap Reconstruction | Phase 1 | Recruiting | Carilion Clinic | 60 | 2026-10-01 | 2026-10-23 |
| REctus Sheath Trial 1.0% lidocaine with epinephrine (1:100,000) - Acute Pain, Postoperative Pain, Acute | Phase 2 | Not yet recruiting | Duke University | 25 | 2026-09-01 | 2026-06-17 |
| Different Local Anesthesia Techniques for Mandibular Primary Molar Pulpectomy Computer-Controlled Local Anesthesia, Conventional Inferior Alveolar Nerve Block, Articaine hydrochloride with epinephrine 1:100,000 - Dental Anxiety, Pain | Not applicable | Not yet recruiting | Recep Tayyip Erdogan University Training and Research Hospital | 38 | 2026-08-12 | 2026-08-12 |
| Pre-emptive Local Anesthesia and Sevoflurane Consumption in Pediatric Dental Anesthesia Pre-emptive Local Anesthesia, Articaine With Epinephrine, Sevoflurane - Sevoflurane Consumption | Not applicable | Not yet recruiting | TC Erciyes University | 80 | 2026-08-01 | 2026-05-27 |
| Chest Tube-Delivered Bupivacaine to Decrease Postoperative Pain After Cardiac Surgery 0.5% Bupivacaine without epinephrine, 10cc injection of normal saline (0.9%) - Coronary Artery Bypass Graft (CABG), Chest Tubes | Early Phase 1 | Not yet recruiting | University of Calgary | 60 | 2026-06-15 | 2026-06-11 |
| Pre-emptive Local Anesthesia and Emergence Behavior After Pediatric Dental General Anesthesia Pre-emptive Local Anesthesia, Articaine Hydrochloride With Epinephrine - Emergence Delirium, Pediatric Dental General Anesthesia | Not applicable | Not yet recruiting | seher orbay yasli | 80 | 2026-06-01 | 2026-06-09 |
| Effect of Push-Dose Adrenaline on Peri-intubation Hypotension During Rapid Sequence Intubation in the Emergency Department Adrenaline, 0.9 % sodium chloride - Peri-intubation Hypotension | Phase 4 | Not yet recruiting | Marmara University Pendik Training and Research Hospital | 128 | 2026-06-01 | 2026-06-10 |
| Impact of Low Dose Epinephrine in the Management of Out-of-hospital Cardiac Arrest on Neurological Outcome Epinephrine 0.5 mg intravenous bolus, Epinephrine 1 mg intravenous bolus - Out-of-hospital Cardiac Arrest (OHCA) | Phase 3 | Not yet recruiting | Central Hospital, Nancy, France | 4336 | 2026-06-01 | 2026-03-02 |
| Vasopressor Agents in Pulmonary Hypertension Crisis Norepinephrine, Dopamine, Epinephrine - Pulmonary Arterial Hypertension (PAH), Chronic Thromboembolic Pulmonary Hypertension (CTEPH) | Not applicable | Not yet recruiting | China National Center for Cardiovascular Diseases | 75 | 2026-06-01 | 2026-06-25 |
| Cervicothoracic Sympathetic Block Evaluation for Post COVID Condition 5 mL of 0.25% bupivacaine with epinephrine (1:200,000), Placebo (Saline) Control - Autonomic Dysfunction | Phase 4 | Recruiting | University Health Network, Toronto | 78 | 2026-05-19 | 2026-10-09 |
| Comparison of Anesthetic Efficacy OF 2% Lidocaine Inferior Alveolar Nerve (IANB) Block Versus Primary Buccal Infilteration With 4% Articaine in Symptomatic Irreversible Pulpitis(SIP) IN Mandibular First Molars INTERVENTION 1: 2% Lignocaine 1:80,000 epinephrine, INTERVENTION 2 : 4%Articaine 1:100,000 epinephrine - Anesthetic Efficacy | Not applicable | Recruiting | Armed Forces Institute of Dentistry, Pakistan | 330 | 2026-03-20 | 2026-10-27 |
| Effect of Adding a Low-Dose Epinephrine Bolus Prior to Infusion on Maternal Hemodynamic Stability During Cesarean Section Epinephrine (Adrenaline) bolus then infusion, Epinephrine (Adrenaline) infusion - Hemodynamic (MAP) Stability | Phase 3 | Completed | Cairo University | 80 | 2026-03-18 | 2026-08-28 |
| Articaine Versus Lidocaine for Supplemental Buccal Infiltration in Lower First Molars With Irreversible Pulpitis Articaine 4% with epinephrine 1:100,000, Lidocaine 2% with Epinephrine 1:100,000 - Irreversible Pulpitis, Failed Inferior Alveolar Nerve Block | Phase 4 | Completed | Rehman Medical Institute - RMI | 50 | 2026-03-03 | 2026-10-09 |
| Buffered Versus Conventional Local Anesthesia for Pain and Anxiety Reduction in School-Aged Children With Pulpitis Buffered Lidocaine with Epinephrine, idocaine with Epinephrine (Conventional) - Pulpitis | Not applicable | Recruiting | Universidad Autonoma de San Luis Potosí | 60 | 2026-03-02 | 2026-06-10 |
| Management of Epistaxis Comparing Nasal Packing Versus Greater Palatine Foramen Block Greater Palatine Foramen Block with 2% xylocaine with adrenaline, Anterior Nasal Packing - Epistaxis Nosebleed, Greater Palatine Foramen | Not applicable | Not yet recruiting | Sheikh Zayed Federal Postgraduate Medical Institute | 40 | 2026-03-01 | 2026-02-24 |
| Comparison of Milrinone and Epinephrine on TAPSE Epinephrine, Milrinone Injection - Cardiac Anaesthesia, Cardiopulmonary Bypass | Not applicable | Recruiting | Mansoura University | 102 | 2026-03-01 | 2026-10-13 |
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Pain, Postoperative (70) · Pain (46) · Agnosia (38) · Heart Arrest (13) · Osteoarthritis, Knee (13) · Hemorrhage (12) · Osteoarthritis (12) · Anaphylaxis (11) · Hypotension (10) · Bronchiolitis (9) · Asthma (7) · Shock, Septic (7) · Acute Pain (6) · Cataract (5) · Diabetes Insipidus (5)
Assiut University (8) · Cairo University (8) · Amphastar Pharmaceuticals, Inc. (7) · Chinese University of Hong Kong (7) · Wake Forest University Health Sciences (7) · Mayo Clinic (5) · Pacira Pharmaceuticals, Inc (5) · Seoul National University Hospital (5) · Boston Children's Hospital (4) · Dow University of Health Sciences (4) · Indiana University (4) · Minia University (4) · Nasus Pharma (4) · National Cancer Institute (NCI) (4) · Netherlands Institute for Pigment Disorders (4)
United States (173) · Canada (35) · Egypt (35) · Pakistan (16) · South Korea (16) · Turkey (Türkiye) (15) · China (13) · France (13) · Brazil (12) · Norway (11) · Denmark (10) · Thailand (9) · Israel (8) · Spain (8) · Hong Kong (7)
Albert Wolkerstorfer, MD, PhD (4) · Manoj K Karmakar, MD (3) · Menno A. De Rie, MD, PhD (3) · Won Ho Kim, M.D. (3) · Anton Bermont, MD (2) · Craig Birch, MD (2) · Daniel Katz, MD (2) · Daryl S Henshaw, MD (2) · Eric Bellissant, MD, PhD (2) · Itamara LI Neves, PhD (2) · Justin Haller, MD (2) · Kevin Finkel, MD (2) · Kira Minkis, MD, PhD (2) · Mi Geum Lee, MD, PhD (2)
PMID 22900785, PMID 22227789, PMID 22285545, PMID 22579125, PMID 26447431, PMID 28186223, PMID 31959019, PMID 33929377, PMID 34990764, PMID 8666460, PMID 9846537, PMID 10212363, PMID 10371570, PMID 10422923, PMID 10488571, PMID 1053919, PMID 10709851, PMID 10717828, PMID 10895619, PMID 10916328, PMID 11061773, PMID 11133630, PMID 11139785, PMID 11199555, PMID 11321382, PMID 11409642, PMID 1157366, PMID 11692118, PMID 1170757, PMID 11738322, PMID 11875603, PMID 12116514, PMID 12298311, PMID 12411815, PMID 12436828, PMID 12675760, PMID 12685620, PMID 12723166, PMID 12767443, PMID 12873775, PMID 12873949, PMID 12934209, PMID 13263433, PMID 1437073, PMID 14446037, PMID 1452871, PMID 14894244, PMID 15051743, PMID 1517644, PMID 15190533
2014 (5), UL1TR000135 (3), 2023 (2), 2008 (1), 2009 (1), 2015 (1), 2016 (1), 2017 (1), 2018 (1), 2019 (1), 2025 (1), K23HL148312 (1), R01AR063091 (1), R01DK040484 (1), R01DK069803 (1)