276 completed, 43 unknown, 35 terminated, 26 withdrawn. 132 Phase 4, 92 Phase 3, 81 Not applicable, 77 Phase 2, 31 Phase 1.
Follow Gabapentin: new trials by email Literature Review of Gabapentin trials Research Report on Gabapentin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Mechanistic Evaluation of Polypharmacy Effects for Pain Within-subject test of blinded study medications (Placebo, Hydromorphone, Gabapentin) - Chronic Lower Back Pain (CLBP) | Phase 1 / Phase 2 | Not yet recruiting | University of Maryland, Baltimore | 110 | 2027-01-15 | 2026-09-29 |
| Hormone thERapy Effects on BRAin-HEART Health During the Menopausal Transition Transdermal estradiol, Standard of care - non hormonal - Menopause, Perimenopause | Phase 4 | Not yet recruiting | McGill University Health Centre/Research Institute of the McGill University Health Centre | 100 | 2026-11-01 | 2026-07-29 |
| Gabapentin vs. Benzonatate vs. Standard of Care for Cough in ILD Gabapentin, Benzonatate 200 mg, Standard of care treatment for ILD - Interstitial Lung Disease | Phase 4 | Not yet recruiting | Post Graduate Institute of Medical Education and Research, Chandigarh | 177 | 2026-10-07 | 2026-10-08 |
| An Artificial Intelligence Driven Approach to Optimize Patient Selection for a Transitional Pain Service TPS-Select, Pharmacologic Pain Management, Interventional Pain Procedures - Postsurgical Pain Management, Postsurgical Pain, Chronic | Phase 3 | Not yet recruiting | University of California, San Francisco | 474 | 2026-10-01 | 2026-10-09 |
| Epidural Analgesia Versus Opioid-sparing Analgesia for Open Ventral Hernia Repair With Transversus Abdominis Release Bupivicaine, Fentanyl, Thoracic epidural analgesia - Ventral Hernia, Ventral Hernia Repair | Phase 4 | Recruiting | Northwestern University | 40 | 2026-09-25 | 2026-10-07 |
| Gabapentin and Pregabalin Effects on Inflammation and Cardiac Function in Peripheral Neuropathic Pain Gabapentin, Pregabalin - Peripheral Neuropathic Pain | Not yet recruiting | Giresun University | 75 | 2026-08-15 | 2026-08-10 | |
| Abuse Potential of Gabapentin Taken Orally Concomitantly With Oxycodone Hydrochloride in Healthy, Non-Drug-Dependent, Recreational Opioid Users Placebo, Oxycodone 20mg, gabapentin 600 mg - Healthy | Phase 4 | Recruiting | Viatris Inc. | 60 | 2026-08-03 | 2026-10-15 |
| Abuse Potential of Oral Gabapentin in Healthy, Non-Drug-Dependent Individuals With Recreational Sedative Drug Use Experience Alprazolam (Xanax), Placebo, Gabapentin (Neurontin® (Registered Trademark)) - Healthy Non-dependent, Recreational Sedative Users | Phase 4 | Completed | Viatris Inc. | 44 | 2026-06-18 | 2026-09-08 |
| Gabapentin and Oxcarbazepine for Chronic Neuropathic Pain in Children and Adolescents: A Clinical Effectiveness Study Gabapentin, Oxcarbazepine, Placebo - Pediatric Chronic Neuropathic Pain | Phase 3 | Withdrawn | Boston Children's Hospital | 2026-06-01 | 2026-10-08 | |
| Efficacy of Gabapentin Combined With Solifenacin for Non-neurogenic Overactive Bladder in Women solifenacin combined with gabapentin, solifenacin monotherapy - Overactive Bladder | Phase 3 | Not yet recruiting | Mansoura University | 60 | 2026-02-01 | 2026-02-24 |
| Efficacy of Methylprednisolone for Pain Control After ACL Repair Meloxicam 15 mg, Medrol 4 MG Oral Tablet Includes Medrol Dosepak, Gabapentin 300 mg - ACL Surgery, Pain Management | Phase 4 | Recruiting | St. Louis University | 90 | 2025-10-21 | 2025-10-24 |
| Analgesic Efficacy of Pre-operative Dose of Ketorolac and Gabapentin Ketorolac Tromethamine 30 MG/ML Prefilled Syringe, Gabapentin, Empty Medication Capsules - Pain, Postoperative, Osteoarthritis, Knee | Phase 2 / Phase 3 | Not yet recruiting | Assiut University | 86 | 2025-08-15 | 2025-08-01 |
| Comparison Between Oral Gabapentin Versus Diclofenac Sodium in Post-operative Analgesia Laparoscopic Cholecystectomy Gabapentin, Diclofenac Sodium - Cholecystitis, Chronic | Not applicable | Completed | Sohag University | 60 | 2025-07-14 | 2026-07-09 |
| Beneficial Side Effects of Topiramate in Obese Patients Undergoing Total Joint Arthroplasty Topamax, Gabapentin - Weight Loss, Pain, Postoperative | Early Phase 1 | Withdrawn | Stanford University | 2025-07-01 | 2025-04-11 | |
| Comparison of Pregabalin Versus Gabapentin as Pre-emptive Analgesic Gabapentin, Pregabalin - Orthopedic Surgery | Not applicable | Completed | Muhammad Aamir Latif | 142 | 2025-07-01 | 2026-02-05 |
| High-dose Prophylactic Gabapentin (HOPE) vs. Placebo to Prevent Opioid Use for Oral Mucositis Pain During Concurrent Chemoradiation for Head and Neck Cancer Gabapentin, Placebo, Chemotheraphy - Head and Neck Squamous Cell Carcinoma, Stage I Head and Neck Cutaneous Squamous Cell Carcinoma AJCC v8 | Phase 3 | Recruiting | Alliance for Clinical Trials in Oncology | 228 | 2025-06-05 | 2026-10-02 |
| Enhanced Recovery After Surgery (ERAS) in Live Donor Kidney Transplant Recipients pre-operative carbohydrate drink, Acetaminophen, Gabapentin - Postoperative Pain | Phase 4 | Enrolling by invitation | Baylor Research Institute | 60 | 2025-05-05 | 2026-10-15 |
| Effectiveness of Warm Acupuncture in Patients with Postherpetic Neuralgia Warm acupuncture and Gabapentin, Gabapentin - Postherpetic Neuralgia ( PHN ) | Not applicable | Not yet recruiting | University of Medicine and Pharmacy at Ho Chi Minh City | 36 | 2025-04-01 | 2025-03-25 |
| Pain Management Protocol in Abdominal Surgeries in City of Erbil Gabapentin (Neurontin® (Registered Trademark)) - Pain Management, Analgesia, Postoperative | Not applicable | Active not recruiting | Haroon Muhammad Khalil | 136 | 2025-03-02 | 2025-06-13 |
| The Effect of Oral Gabapentin on Emergence Agitation and Delirium in Adult Patients After Nasal Surgery. Gabapentin 600 mg capsules, Gabapentin 400 mg capsules, Placebo - Emergence Agitation | Phase 3 | Not yet recruiting | Cairo University | 63 | 2025-03-01 | 2025-03-21 |
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Pain, Postoperative (64) · Pain (47) · Agnosia (25) · Neuralgia (18) · Sleep Initiation and Maintenance Disorders (16) · Hot Flashes (14) · Alcoholism (11) · Chronic Pain (11) · Diabetic Neuropathies (9) · Opioid-Related Disorders (9) · Restless Legs Syndrome (9) · Anxiety Disorders (8) · Epilepsy (8) · Neuralgia, Postherpetic (8) · Breast Neoplasms (7)
Pfizer's Upjohn has merged with Mylan to form Viatris Inc. (19) · Medical University of South Carolina (8) · Tanta University (8) · Actavis Inc. (6) · Ain Shams University (6) · Mayo Clinic (6) · Alliance for Clinical Trials in Oncology (5) · Henry Ford Health System (5) · New York State Psychiatric Institute (5) · University of Arkansas (5) · Cairo University (4) · Depomed (4) · Hvidovre University Hospital (4) · Indiana University (4) · Massachusetts General Hospital (4)
United States (213) · Egypt (36) · Canada (24) · Denmark (9) · China (7) · France (7) · Pakistan (7) · Brazil (6) · India (5) · South Korea (5) · Germany (4) · Iran (4) · Japan (4) · Thailand (4) · Venezuela (4)
Francisco Unda, PhD (4) · Toufic R Jildeh, MD (4) · Alison Oliveto, PhD (3) · Jose CA Carvalho, MD (3) · Steven Caras, MD (3) · Alison Oliveto, Ph.D. (2) · Anurag Singh (2) · Charles L. Loprinzi, MD (2) · Doralina Anghelescu, MD (2) · James C Eisenach, MD (2) · James D. Carlson,, Pharm. D. (2) · James D. Carlson,, Pharm.D, (2) · James J Prisciandaro, PhD (2)
PMID 24190578, PMID 25317090, PMID 31169568, PMID 10568846, PMID 10598635, PMID 10863041, PMID 12460250, PMID 12670812, PMID 12804680, PMID 12933409, PMID 15275765, PMID 15453912, PMID 16139656, PMID 16300039, PMID 16415311, PMID 16679671, PMID 16816054, PMID 16914695, PMID 17058231, PMID 17146104, PMID 17438255, PMID 17513656, PMID 17853395, PMID 17960408, PMID 18040817, PMID 18166705, PMID 18582931, PMID 18614026, PMID 18716003, PMID 18819759, PMID 18823363, PMID 19129205, PMID 19135997, PMID 19195785, PMID 19209273, PMID 19480225, PMID 19535182, PMID 19560604, PMID 19593171, PMID 19628433, PMID 19672167, PMID 19935070, PMID 20081039, PMID 20112079, PMID 20124884, PMID 20418301, PMID 20552926, PMID 20817595, PMID 20851058, PMID 21454917
2014 (4), R01DA010017 (3), 2018 (1), K23DA021209 (1), K23MH113008 (1), KL2TR000370 (1), P01GM113852 (1), P30CA015704 (1), P30CA068485 (1), P50DA018197 (1), R01AA009568 (1), R01AA016117 (1), R01AA025365 (1), R01AA030460 (1), R01AA030568 (1)