789 completed, 190 unknown, 139 recruiting, 69 not yet recruiting. 593 Not applicable, 105 Phase 4, 47 Phase 3, 39 Phase 2, 15 Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Emergency and Urgent Care Indicators in Piedmont Emergency Departments | Not yet recruiting | Mario Negri Institute for Pharmacological Research | 650000 | 2027-07-01 | 2026-10-09 | |
| ED PLWD/Care Partner Text Messaging CAPTURE Text Message Care Transition Support - Dementia, Caregiver | Not applicable | Not yet recruiting | Yale University | 80 | 2027-03-01 | 2026-02-23 |
| Preventing Harmful Alcohol Use Among Trauma Patients in Cameroon Cameroon-Adapted SBIRT, Usual Care - Alcohol Use Disorder, Alcohol-Related Injury | Not applicable | Not yet recruiting | University of Buea | 690 | 2027-03-01 | 2026-06-30 |
| Increasing Lung Cancer Screening Among Emergency Department Patients - LCS R01 Basic Referral, Facilitated Referral, Text Messaging - Smoking History, Current Smoker | Not applicable | Not yet recruiting | University of Rochester | 1036 | 2027-03-01 | 2026-05-05 |
| Comparison of Sepsis Prediction Algorithms Epic Sepsis Model Version - 1, Epic Sepsis Model Version - 2, Emory Sepsis Model - Sepsis | Not yet recruiting | Emory University | 1200 | 2027-03-01 | 2026-10-26 | |
| Identification of Depressive and Anxiety Symptoms Among a Sample of Emergency Department Patients Using Artificial Intelligence (AI) Technology Biometrics (or AI Biomaker) - Artificial Intelligence (AI) | Not applicable | Not yet recruiting | University Hospitals Cleveland Medical Center | 30 | 2027-02-01 | 2026-09-15 |
| Hypnosis Antalgia Emergency Stitching hypnotic guidance - Pain Management | Not applicable | Not yet recruiting | University Hospital, Angers | 134 | 2027-02-01 | 2026-10-14 |
| AI-based Decision Support in Acute Chest Pain AIDE-CP available - Myocardial Infarction, Chest Pain | Not applicable | Not yet recruiting | Region Skane | 4500 | 2027-01-18 | 2026-10-07 |
| ER-VISION-AI Study Generative Pre-trained Transformer (GPT)-assisted multimodal visual language model (VLM) diagnostic support, Conventional emergency department diagnostic evaluation - Chest Pain, Dyspnea | Not applicable | Not yet recruiting | Ewha Womans University Mokdong Hospital | 1000 | 2027-01-01 | 2026-07-27 |
| Efficacy of High-Dose Continuous Intravenous Magnesium Sulfate Infusion vs Standard Intravenous Magnesium Sulfate Therapy in Status Asthmaticus in the ED ้High-dose Magnesium sulphate, standard-dose Magnesium Sulfate - Asthma Exacerbation, Emergency Department | Not applicable | Not yet recruiting | Thammasat University | 72 | 2026-11-01 | 2026-08-31 |
| Emergency Department-Initiated Team-Based Care for Severe Hypertension Emergency Department-Initiated Team-Based Care, Usual Care - Severe Hypertension, Hypertension | Not applicable | Not yet recruiting | Henry Ford Health System | 700 | 2026-10-30 | 2026-08-20 |
| Impact of an Emergency Advanced Practice Nurse on Complications After Home Discharge of Oxygen-Dependent Patients Managed in the Emergency Department: A Quantitative and Qualitative Study APN-physician team management of the Oxy-Urg pathway, Usual care: physician-alone management of the Oxy-Urg pathway - Acute Respiratory Conditions Requiring Oxygen Therapy, Advanced Practice Nursing | Not applicable | Not yet recruiting | University Hospital, Strasbourg, France | 170 | 2026-10-30 | 2026-08-24 |
| An Evaluation Study of Nursing Assistants' Performance of Electrocardiograms in Emergency Departments as Part of a Delegation of Medical Procedures electrocardiogram by nursing assistant, electrocardiogram - ECG | Not applicable | Not yet recruiting | University Hospital, Angers | 2450 | 2026-10-24 | 2026-08-19 |
| AI-ECG Detection of Occlusion Myocardial Infarction at Emergency Department Triage (TRIACS) Acute Coronary Syndromes, Chest Pain | Not yet recruiting | University Medical Centre Maribor | 1000 | 2026-10-19 | 2026-10-20 | |
| Morphine or Ketamine for Analgesia Ketamine hydrochloride, Morphine sulphate - Abdominal Pain, Isolated Extremity Fracture | Phase 3 | Recruiting | Columbia University | 1010 | 2026-10-17 | 2026-10-20 |
| Whole-Body Point-of-Care Ultrasound in Older Adults Presenting to the Emergency Department After a Fall Whole-body point-of-care ultrasound (POCUS) - Accidental Falls, Aged | Recruiting | Kocaeli City Hospital | 105 | 2026-10-12 | 2026-10-21 | |
| Atomized Intranasal Ketorolac at 30 mg Versus 20 mg for the Treatment of Acute Pain in the Emergency Department 20mg intranasal ketorolac, 30mg Intranasal Ketorolac - Pain, Ketorolac | Phase 3 | Not yet recruiting | Tehran University of Medical Sciences | 100 | 2026-10-10 | 2026-09-16 |
| Ketadex Versus Ketofol for Adult Procedural Sedation in the Emergency Department. Ketamine (1 mg/kg), propofol, Dexmedetomidine - Procedural Sedation | Phase 4 | Not yet recruiting | Sultan Qaboos University | 100 | 2026-10-10 | 2026-10-15 |
| Advancing Scalable Alcohol Brief Interventions in the ED: A Trial of Conversational AI With Digital Reinforcements MICA, TRAC - Alcohol Misuse | Not applicable | Recruiting | Stanford University | 750 | 2026-10-08 | 2026-10-15 |
| Decision Support Tool to Integrate PrEP Into Emergency Departments Decision support tool, PrEP Delivery - HIV | Phase 1 | Not yet recruiting | George Washington University | 120 | 2026-10-01 | 2026-10-08 |
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Pain (69) · Acute Pain (50) · Sepsis (49) · Agnosia (47) · Wounds and Injuries (46) · Chest Pain (37) · Acute Coronary Syndrome (31) · COVID-19 (31) · Asthma (29) · Anxiety Disorders (26) · Disease (24) · Frailty (22) · Migraine Disorders (22) · Shock (22)
Disease Attributes (1319) · Pathological Conditions, Signs and Symptoms (1319) · Pathologic Processes (1317) · Signs and Symptoms (328) · Neurologic Manifestations (271) · Nervous System Diseases (161) · Pain (146) · Respiratory Tract Diseases (145) · Cardiovascular Diseases (142) · Infections (138) · Behavior (122) · Vascular Diseases (102) · Lung Diseases (99) · Mental Disorders (90) · Heart Diseases (87)
Saline Solution (24) · Acetaminophen (22) · Ketamine (21) · Standard of Care (20) · Hydromorphone (16) · Morphine (16) · Ibuprofen (13) · Sodium Chloride (12) · dexketoprofen trometamol (11) · Midazolam (10) · Emergency Service, Hospital (9) · Ketorolac (8) · Propofol (8) · Control Groups (7) · Dexamethasone (7)
Assistance Publique - Hôpitaux de Paris (29) · Montefiore Medical Center (15) · University Hospital, Toulouse (13) · Hospices Civils de Lyon (11) · The University of Hong Kong (11) · University Hospital, Montpellier (11) · University Hospital, Clermont-Ferrand (10) · University of Alberta (10) · Wake Forest University Health Sciences (10) · Johns Hopkins University (9) · Pamukkale University (9) · University Hospital, Grenoble (9) · University Hospital, Strasbourg, France (9) · Yale University (9) · Akdeniz University (8)
United States (385) · France (223) · Turkey (Türkiye) (106) · Canada (96) · Italy (46) · Denmark (37) · Switzerland (36) · United Kingdom (36) · Germany (30) · Spain (25) · Netherlands (21) · Belgium (20) · China (18) · South Korea (18) · Hong Kong (17)
Mustapha Sebbane, MD, PhD (5) · Xavier Bobbia, MD (5) · Amir Goren, PhD (4) · Christian Backer Mogensen (4) · Ho Cheung William Li, PhD (4) · Andrew K Chang, MD (3) · Colin A Graham, MD (3) · Daniel S Tsze, MD, MPH (3) · Edwin D Boudreaux, PhD (3) · Ewoud ter Avest, MD, PhD (3) · James R Miner, MD (3) · Jocelyn Gravel, MD (3) · Johan N Siebert, MD (3) · Mustafa Serinken, MD (3)
PMID 34593497, PMID 33884617, PMID 22238693, PMID 24119887, PMID 25737484, PMID 28487318, PMID 28923845, PMID 31242362, PMID 33238043, PMID 33397050, PMID 33766254, PMID 34734879, PMID 35330427, PMID 39053972, PMID 10036346, PMID 1015603, PMID 10522957, PMID 10577399, PMID 10613941, PMID 10700684, PMID 10781906, PMID 10801169, PMID 10818378, PMID 10834680, PMID 10891633, PMID 10894454, PMID 10963540, PMID 11012954, PMID 11043992, PMID 11190989, PMID 11265032, PMID 11331167, PMID 11331334, PMID 11374619, PMID 11428801, PMID 11445789, PMID 11459715, PMID 11472277, PMID 11555797, PMID 12096376, PMID 12355007, PMID 12411815, PMID 12487041, PMID 12502975, PMID 12548273, PMID 12560416, PMID 12615585, PMID 12637593, PMID 12646670, PMID 12919984
2016 (4), 2023 (4), 2019 (2), P50MH129701 (2), R21AG075230 (2), 2009 (1), 2018 (1), 2025 (1), 5UH3AT009844 (1), K23AA022989 (1), K23DA039974 (1), K23HD096060 (1), K23HD098299 (1), K23HD109469 (1), K23HL074250 (1)