1583 completed, 402 unknown, 240 terminated, 139 recruiting. 2633 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 2633 | Completed 1583, Unknown 402, Terminated 240, Recruiting 139, Withdrawn 126, Not yet recruiting 93, Active not recruiting 32, Enrolling by invitation 11, Suspended 7 |
Follow Pain: new trials by email Literature Review of Pain trials Research Report on Pain
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Perioperative Esketamine Safety and Efficacy in Reducing Postoperative ENDometriosis PAIN (the ENDPAIN Trial): a Randomized Controlled Trial. Esketamine, Placebo - Endometriosis | Phase 4 | Not yet recruiting | Region Skane | 1000 | 2028-01-01 | 2026-10-19 |
| Suzetrigine Versus Standard Analgesia After Skin Cancer Surgery Suzetrigine, Acetaminophen Plus Ibuprofen - Postoperative Pain, Acute Pain | Phase 4 | Not yet recruiting | University of Minnesota | 230 | 2027-04-01 | 2026-09-25 |
| Examining Analgesic Synergy and Efficacy in Trauma Care Buprenorphine, Oxycodone - Opioid Use Disorder | Phase 4 | Not yet recruiting | Wake Forest University Health Sciences | 282 | 2027-03-01 | 2026-10-28 |
| Liposomal Bupivacaine vs Perineural Adjuvants in Adductor Canalf and iPACK Blocks in Total Knee Arthroplasty Liposomal Bupivacaine, Bupivacaine, Clonidine, Epinephrine, Buprenorphine and Dexamethasone (BPV-CEBD) Combination - Knee Arthroplasty, Total | Phase 4 | Not yet recruiting | Wake Forest University Health Sciences | 90 | 2027-02-01 | 2026-08-25 |
| Suzetrigine (Journavx) as Multimodal Therapy for Pain Management in Adults Undergoing Surgery for Hip Fracture Suzetrigine (Journavx) - Hip Fractures (ICD-10 72.01-72.2), Post Operative Analgesia | Phase 4 | Not yet recruiting | Beth Israel Deaconess Medical Center | 79 | 2027-01-05 | 2026-10-29 |
| Evaluation of the Efficacy of Sublingual Sufentanil (Prescribed as Rescue Analgesia for Acute Postoperative Pain) on the Quality of Health Recovery After Surgery: a Randomized, Controlled, Multicenter, Open-label Trial Against an Active Comparator (SUBLIME) Sublingual sufentanil 30 µg (one dose per hour, as needed), Morphine sulfate (10 mg every 4 hours as needed) - Postoperative Pain | Phase 4 | Not yet recruiting | University Hospital, Strasbourg, France | 1150 | 2027-01-01 | 2026-06-03 |
| Study of QL Analgesic Response and Extent Quadratus Lumborum with 1.5% Lidocaine - Acute Pain, Postoperative Pain | Phase 4 | Not yet recruiting | Duke University | 25 | 2027-01-01 | 2026-07-08 |
| Evaluation of the Efficacy and Acceptability of a Phytotherapy Combining Devil's Claw, Blackcurrant and Meadowsweet for the Management of Aromatase Inhibitor-induced Arthralgia in Patients Treated for Localized Breast Cancer in the Adjuvant Setting Phytotherapy Dietary Supplement (Harpagophytum, Meadowsweet, and Blackcurrant), Patient Experience Questionnaire - Hormone Therapy-induced Arthralgia, Phytotherapy | Phase 4 | Not yet recruiting | Hospices Civils de Lyon | 105 | 2027-01-01 | 2026-11-03 |
| Oral Tranexamic Acid After Total Knee Arthroplasty tranexamic acid Oral-Short Arm, tranexamic acid Oral-Long Arm, Control group placebo - Total Knee Arthroplasty | Phase 4 | Not yet recruiting | Rush University Medical Center | 351 | 2026-12-20 | 2026-10-22 |
| Perioperative Colchicine for TKA Colchicine 1.8 mg (loading dose) + Dextrose Oral Placebo, Colchicine 1.8 mg + 0.6 mg, Dextrose Oral Placebo - Osteoarthritis of Knee, Recovery Following Primary Total Knee Arthroplasty | Phase 4 | Not yet recruiting | Geisinger Clinic | 75 | 2026-12-01 | 2026-09-03 |
| Efficacy of Topical Lidocaine Gel vs. Oral Duloxetine for Painful Diabetic Peripheral Neuropathy Topical Lidocaine 2% Gel, Duloxetine (60 MG) - Painful Diabetic Neuropathy (PDN), Diabetic Neuropathies | Phase 4 | Not yet recruiting | Wah Medical college , POF hospital | 80 | 2026-12-01 | 2026-09-02 |
| Effect of Low-Dose Esketamine Combined With Dexmedetomidine on the Incidence of Chronic Postsurgical Pain in Patients Undergoing Pancreatic Surgery Esketamine combined with dexmedetomidine, saline placebo - Chronic Pain, Postoperative | Phase 4 | Not yet recruiting | Tianjin Medical University Cancer Institute and Hospital | 450 | 2026-12-01 | 2026-10-22 |
| Role of Perineural Catheter in Pain Control and Opioid Consumption After Major Amputation of Lower Limb Bubpivacaine, Tramadol, Saline - Lower Limb Surgery, Pain | Phase 4 | Not yet recruiting | Aga Khan University | 96 | 2026-12-01 | 2026-11-02 |
| Exparel and Dexamethasone Liposomal Bupivacaine with Bupivacaine, Dexamethasone - Postoperative Pain, Shoulder Arthroscopic Surgeries | Phase 4 | Not yet recruiting | Duke University | 80 | 2026-11-01 | 2026-10-19 |
| Suzetrigine for Opioid-Sparing Postoperative Analgesia Following Transvaginal Pelvic Reconstructive Surgery Suzetrigine, Opioid Analgesics (Tramadol or Oxycodone), Scheduled Acetaminophen and Ibuprofen - Pelvic Organ Prolapse (POP), Stress Urinary Incontinence (SUI) | Phase 4 | Not yet recruiting | University of California, Los Angeles | 120 | 2026-11-01 | 2026-09-15 |
| Suzetrigine Added to Multimodal Analgesia for Women Undergoing Minimally Invasive Hysterectomy Suzetrigine - Postoperative Pain | Phase 4 | Not yet recruiting | Duke University | 123 | 2026-11-01 | 2026-09-23 |
| Suzetrigine Following Urogynecologic Surgery: Investigation of Postoperative Pain Management Suzetrigine, Placebo - Pelvic Organ Prolapse (POP), Postoperative Pain | Phase 4 | Not yet recruiting | Aditi Talkad | 48 | 2026-11-01 | 2026-10-02 |
| Comparing Pain Improvement for Intravenous Versus Oral Acetaminophen in Acute Pelvic Pain Acetaminophen 1000mg PO, IV Acetaminophen 1000mg, IV Placebo - Pelvic Pain | Phase 4 | Not yet recruiting | Montefiore Medical Center | 140 | 2026-11-01 | 2026-09-23 |
| Effect of Labetalol, Magnesium Sulfate, or Lidocaine on Opioid Consumption During Laparoscopic Cholecystectomy Labetalol, Magnesium Sulfate, Lidocaine - Postoperative Pain, Cholelithiasis | Phase 4 | Not yet recruiting | Assiut University | 90 | 2026-11-01 | 2026-10-08 |
| Pain Control During Hysterosalpingography: A Three-Arm Randomized Trial Indomethacin 100Mg Suppository, Lidocaine %2 ampoule - Hysterosalpingography-Related Pain | Phase 4 | Not yet recruiting | Balikesir University | 180 | 2026-11-01 | 2026-10-15 |
Showing 20 of 2633. Sign in to see all of them.
Pain, Postoperative (1047) · Agnosia (222) · Acute Pain (156) · Chronic Pain (118) · Low Back Pain (101) · Neuralgia (69) · Headache (63) · Angina Pectoris (58) · Angina, Unstable (56) · Angina, Stable (52) · Postoperative Nausea and Vomiting (46) · Coronary Artery Disease (45) · Back Pain (42) · Labor Pain (42)
Neurologic Manifestations (2633) · Pathological Conditions, Signs and Symptoms (2633) · Signs and Symptoms (2633) · Pathologic Processes (1231) · Postoperative Complications (1057) · Nervous System Diseases (495) · Neurobehavioral Manifestations (247) · Musculoskeletal Diseases (238) · Perceptual Disorders (230) · Cardiovascular Diseases (189) · Vascular Diseases (188) · Heart Diseases (165) · Myocardial Ischemia (153) · Chest Pain (150)
Bupivacaine (231) · Acetaminophen (206) · Sodium Chloride (184) · Ropivacaine (155) · Lidocaine (142) · Morphine (134) · Saline Solution (132) · Dexamethasone (120) · Fentanyl (107) · Ketamine (106) · Ibuprofen (104) · Oxycodone (81) · Dexmedetomidine (78) · Pregabalin (58) · Gabapentin (57)
Duke University (35) · University of California, San Diego (32) · Montefiore Medical Center (29) · Northwestern University (24) · Cairo University (21) · Antonios Likourezos (18) · Mayo Clinic (18) · Pfizer (18) · The University of Texas Health Science Center, Houston (18) · Mahidol University (17) · Beijing Tiantan Hospital (16) · Hvidovre University Hospital (16) · Wake Forest University Health Sciences (16) · Ain Shams University (15) · Cukurova University (15)
United States (953) · China (131) · Denmark (120) · Canada (115) · Turkey (Türkiye) (114) · Egypt (73) · South Korea (73) · France (69) · Brazil (64) · Italy (62) · Germany (54) · Spain (52) · United Kingdom (52) · Finland (45) · Poland (43)
Sergey Motov, MD (12) · Brian M Ilfeld, M.D., M.S. (11) · Sirilak Suksompong, MD (8) · Dong-Xin Wang, MD, PhD (7) · Fang Luo, M.D. (7) · Jun Li, MD (6) · Pamela Flood, MD (6) · XiaoFeng Shen, MD (6) · Brian M Ilfeld, MD, MS (5) · Stanley SC Wong, MBBS (5)
PMID 22536282, PMID 23762142, PMID 27777598, PMID 22048651, PMID 23737852, PMID 25254054, PMID 33238043, PMID 36269595, PMID 10411041, PMID 11020772, PMID 11331334, PMID 15041597, PMID 17464603, PMID 18987053, PMID 19478674, PMID 19524353, PMID 20418301, PMID 22067185, PMID 23121612, PMID 23334883, PMID 23567060, PMID 23706726, PMID 23850410, PMID 23972577, PMID 24127709, PMID 24216403, PMID 25822923, PMID 26184397, PMID 27782769, PMID 31663286, PMID 31829173, PMID 31937091, PMID 32175985, PMID 33990439, PMID 34433773, PMID 35553047, PMID 35641327, PMID 36063082, PMID 37619976, PMID 37745109, PMID 38598970, PMID 39959922, PMID 1015603, PMID 10195475, PMID 10214567, PMID 10534584, PMID 10702460, PMID 10776835, PMID 10813730, PMID 10927999
2017 (13), 2014 (12), 2008 (8), 2009 (8), 2019 (8), 2015 (7), 2018 (6), 2023 (6), 2005 (5), 2016 (5), 2025 (3), U01AR045444 (3), 2004 (2), P01HD033988 (2), R01AT007987 (2)