14355 completed, 5306 unknown, 3269 recruiting, 1642 terminated. 10345 Not applicable, 2570 Phase 4, 2063 Phase 2, 2007 Phase 3, 873 Phase 1.
Follow Heart Diseases: new trials by email Literature Review of Heart Diseases trials Research Report on Heart Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Impact of Iron Supplementation on Right Ventricular Function and Exercise Performance in Hypoxia Ferrous sulfate 325mg - Right Ventricular Dysfunction, Hypoxia | Early Phase 1 | Not yet recruiting | University of Colorado, Denver | 5 | 2028-03-01 | 2026-04-29 |
| Real-world Study to Describe the Effectiveness and Safety Outcomes of Jardiance in Chinese Patients With Heart Failure and Preserved Ejection Fraction Heart Failure, Preserved Ejection Fraction | Not yet recruiting | Boehringer Ingelheim | 3000 | 2028-01-31 | 2026-09-16 | |
| Standalone Thoracoscopic Left Atrial Appendage Closure Versus Medical Therapy in Atrial Fibrillation Video-assisted thoracoscopic closure of the left atrial appendage using a closure device and discontinuation of treatment if the patient is treated with OAC - ATRIAL APPENDAGE CLOSURE for ATRIAL FIBRILLATION, Oral Anticoagulation | Not applicable | Not yet recruiting | Region Skane | 936 | 2028-01-01 | 2026-07-15 |
| Timing for Computed Tomography and Post-Resuscitation Care on Short-Term Outcomes in Out-of-Hospital Cardiac Arrest Out of Hospital Cardiac Arrest, Computed Tomography | Not yet recruiting | National Taiwan University Hospital | 5000 | 2027-12-31 | 2025-11-19 | |
| Study to Evaluate the effIcacy and Safety of Abelacimab in High-risk Patients With Atrial Fibrillation Who Have Been Deemed Unsuitable for Oral Anticoagulation Abelacimab - Atrial Fibrillation (AF) | Phase 3 | Not yet recruiting | Novartis Pharmaceuticals | 2500 | 2027-12-30 | 2026-07-31 |
| Fibroblast Growth Factor-1 (FGF-1) for the Treatment of Coronary Heart Disease Human Recombinant Fibroblast Growth Factor-1 (FGF 1-141) - low dose, Human Recombinant Fibroblast Growth Factor-1 (FGF1-141) - high dose, Placebo - Coronary Disease, Coronary Heart Disease | Phase 2 | Not yet recruiting | Venturis Therapeutics, Inc. | 150 | 2027-09-01 | 2026-08-19 |
| Conscious Sedation Study CLAAS® System - Atrial Fibrillation | Not applicable | Not yet recruiting | Conformal Medical, Inc | 300 | 2027-08-01 | 2026-03-20 |
| Clinical Trial of a MEK Inhibitor for RASopathy-Associated Severe Infantile Hypertrophic Cardiomyopathy: Baby MERIT Trametinib - HCM, Noonan Syndrome and Other Rasopathy | Phase 3 | Not yet recruiting | Carelon Research | 25 | 2027-08-01 | 2026-09-14 |
| Categorizing Patient Risk for Tricuspid Regurgitation (TR) Intervention With Admittance Pulmonary Artery Catheter System (APACS) Right Heart Catheterization - Tricuspid Regurgitation (TR) | Not yet recruiting | Feldman Cardiology, PLLC | 8 | 2027-07-10 | 2026-03-30 | |
| Aficamten and Patient-Reported Outcomes in Real-World nHCM receiving aficamten - Hypertrophic Cardiomyopathy (HCM) | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 100 | 2027-06-01 | 2026-09-29 | |
| Understanding the Metabolic and Functional Derangement of Primary Mitral Regurgitation: a Feasibility Study Using Carbon 11(C-11) Acetate Cardiac Positron Emission Tomography Magnetic Resonance Imaging (PET-MRI) [11C] acetate - Mitral Valve Regurgitation | Early Phase 1 | Withdrawn | University of Alabama at Birmingham | 2027-06-01 | 2025-01-24 | |
| Rapid Engagement for Solutions to Population and Outcomes Through Networked Dialogue for Coronary Heart Disease Polygenic risk score - Coronary Heart Disease | Not yet recruiting | Medical College of Wisconsin | 200 | 2027-06-01 | 2026-05-04 | |
| Registry on Luma Vision's VERAFEYE System (ENLIgHT) VERAFEYE System - Atrial Fibrillation, Left Atrial Appendage Closure | Not yet recruiting | LUMA Vision Ltd. | 50 | 2027-05-15 | 2026-09-15 | |
| The Variation in Electrode Configuration for Termination of Out-of-Hospital Rhythms That Are Shockable in Cardiac Arrest Trial defibrillator electrode pads - Cardiac Arrest (CA) | Not applicable | Not yet recruiting | Oregon Health and Science University | 1500 | 2027-04-01 | 2026-09-14 |
| Heart tEam Decision-making Assisted by Revaz AI Trial Revaz AI - Coronary Artery Disease | Not applicable | Not yet recruiting | University of Calgary | 712 | 2027-04-01 | 2026-09-24 |
| TORCH-LATAM-003: Regional Advanced-Therapy Pathways for Congenital Heart Disease TORCH Congenital Advanced Therapies Pathway (TORCH-CATP) - Congenital Heart Disease, Advanced Heart Failure | Not applicable | Not yet recruiting | CardioVision International Tech, S.A.S. de C.V. | 360 | 2027-03-30 | 2026-10-13 |
| The Effectiveness of Patch-Based Screening for Pre-Symptomatic Atrial Fibrillation to Improve Patient Outcome Zio XT® Patch - Atrial Fibrillation | Not applicable | Not yet recruiting | VA Office of Research and Development | 24060 | 2027-03-08 | 2026-06-30 |
| OPTIA-AF Trial: Rhythm-Guided Antithrombotic Strategy After AF Ablation Oral anticoagulation, Single antiplatelet therapy - Atrial Fibrillation (AF), Coronary Artery Disease | Phase 4 | Not yet recruiting | Ewha Womans University Mokdong Hospital | 2 | 2027-03-01 | 2026-03-27 |
| WSO BEAT STROKE Initiative Educational and implementation Neurocardiology tool, No educational or implementation tool will be provided - Stroke, PFO - Patent Foramen Ovale | Not applicable | Not yet recruiting | Luciano A. Sposato | 2400 | 2027-03-01 | 2026-09-18 |
| Lattice vs Pentaspline Comparative Evaluation in Persistent AF Pulmonary vein isolation - Persistent Atrial Fibrillation | Not applicable | Not yet recruiting | Mitera Hospital | 250 | 2027-03-01 | 2026-09-15 |
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Heart Failure (5584) · Coronary Artery Disease (4729) · Atrial Fibrillation (3821) · Myocardial Infarction (1960) · Cardiovascular Diseases (1914) · Coronary Disease (1498) · Acute Coronary Syndrome (1460) · Myocardial Ischemia (1094) · Arrhythmias, Cardiac (1048) · Heart Defects, Congenital (988) · Aortic Valve Stenosis (986) · Heart Arrest (898) · ST Elevation Myocardial Infarction (826) · Stroke (802)
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Clopidogrel (380) · Aspirin (290) · Percutaneous Coronary Intervention (273) · Ticagrelor (250) · Exercise (232) · Catheter Ablation (194) · Standard of Care (191) · Echocardiography (187) · Blood Specimen Collection (174) · Atorvastatin (171) · Rivaroxaban (170) · Sodium Chloride (169) · Transcatheter Aortic Valve Replacement (162) · Warfarin (140) · Saline Solution (139)
National Heart, Lung, and Blood Institute (NHLBI) (557) · Abbott Medical Devices (378) · Boston Scientific Corporation (233) · Assiut University (229) · Mayo Clinic (216) · Medtronic Cardiac Rhythm and Heart Failure (208) · Assistance Publique - Hôpitaux de Paris (207) · Yonsei University (186) · China National Center for Cardiovascular Diseases (157) · AstraZeneca (141) · Seoul National University Hospital (140) · Duke University (134) · National Taiwan University Hospital (130) · Ottawa Heart Institute Research Corporation (123) · Beijing Anzhen Hospital (118)
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Vivek Reddy, MD (34) · Andrea Natale, MD (32) · Seung-Jung Park, MD, PhD (31) · Adnan Kastrati, MD (30) · Bon-Kwon Koo, MD, PhD (26) · Dhanunjaya Lakkireddy, MD (23)
PMID 35224730, PMID 32860505, PMID 19717846, PMID 20961243, PMID 40875095, PMID 31081589, PMID 34447992, PMID 36700520, PMID 41114449, PMID 25940520, PMID 28886621, PMID 31535829, PMID 33962483, PMID 34932836, PMID 17982182, PMID 21670242, PMID 23636237, PMID 24746650, PMID 26354543, PMID 31698933, PMID 34022170, PMID 34693515, PMID 34741536, PMID 36398903, PMID 37131096, PMID 37366061, PMID 18035553, PMID 18424759, PMID 18557726, PMID 19066739, PMID 19228612, PMID 19463432, PMID 19737719, PMID 19923168, PMID 20142198, PMID 20236866, PMID 21639811, PMID 22236222, PMID 23468513, PMID 23523454, PMID 25173339, PMID 26320110, PMID 26347918, PMID 27042964, PMID 27206819, PMID 29098321, PMID 29555836, PMID 30165437, PMID 31561250, PMID 31690104
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