5519 completed, 2198 unknown, 1009 recruiting, 539 terminated. 3376 Not applicable, 1369 Phase 4, 873 Phase 3, 779 Phase 2, 297 Phase 1.
Follow Myocardial Ischemia: new trials by email Literature Review of Myocardial Ischemia trials Research Report on Myocardial Ischemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Fibroblast Growth Factor-1 (FGF-1) for the Treatment of Coronary Heart Disease Human Recombinant Fibroblast Growth Factor-1 (FGF 1-141) - low dose, Human Recombinant Fibroblast Growth Factor-1 (FGF1-141) - high dose, Placebo - Coronary Disease, Coronary Heart Disease | Phase 2 | Not yet recruiting | Venturis Therapeutics, Inc. | 150 | 2027-09-01 | 2026-08-19 |
| Rapid Engagement for Solutions to Population and Outcomes Through Networked Dialogue for Coronary Heart Disease Polygenic risk score - Coronary Heart Disease | Not yet recruiting | Medical College of Wisconsin | 200 | 2027-06-01 | 2026-05-04 | |
| Heart tEam Decision-making Assisted by Revaz AI Trial Revaz AI - Coronary Artery Disease | Not applicable | Not yet recruiting | University of Calgary | 712 | 2027-04-01 | 2026-09-24 |
| OPTIA-AF Trial: Rhythm-Guided Antithrombotic Strategy After AF Ablation Oral anticoagulation, Single antiplatelet therapy - Atrial Fibrillation (AF), Coronary Artery Disease | Phase 4 | Not yet recruiting | Ewha Womans University Mokdong Hospital | 2 | 2027-03-01 | 2026-03-27 |
| Spontaneous Coronary Artery Dissection - AntipLatelet Therapy Intensity in Guided coNservative Management (SCAD-ALIGN) Trial Acetylsalicylic acid ASA, ASA plus Clopidogrel - SCAD, ACS (Acute Coronary Syndrome) | Phase 4 | Not yet recruiting | Universitätsklinikum Hamburg-Eppendorf | 3518 | 2027-03-01 | 2026-10-16 |
| A Trial Assessing the Effectiveness of Evolocumab in Reducing the Plaque Burden in Participants With Subclinical Atheroma Evolocumab, Routine Lipid Management, Autoinjector - Coronary Artery Disease, Hypercholesterolemia | Phase 4 | Not yet recruiting | Amgen | 308 | 2027-01-31 | 2026-09-21 |
| AI-based Decision Support in Acute Chest Pain AIDE-CP available - Myocardial Infarction, Chest Pain | Not applicable | Not yet recruiting | Region Skane | 4500 | 2027-01-18 | 2026-10-07 |
| Utilizing Carbon Dioxide for Assessing Coronary Blood Flow in Subjects With Coronary Artery Disease RespirAct - Coronary Artery Disease | Not applicable | Not yet recruiting | Indiana University | 30 | 2027-01-10 | 2026-05-26 |
| Nursing Intervention for Adaptation After Myocardial Revascularization Nursing Intervention Program, Usual Care - Coronary Artery Disease, Myocardial Revascularization | Not applicable | Not yet recruiting | Universidad de la Sabana | 40 | 2027-01-01 | 2026-05-08 |
| Norwegian Danish Spontaneous Coronary Artery Dissection Exercise Study High intensity interval training (HIIT) - Spontaneous Coronary Artery Dissection, Myocardial Infarction (MI) | Not applicable | Enrolling by invitation | Oslo University Hospital | 120 | 2027-01-01 | 2026-08-25 |
| Photobiomodulation in Coronary Artery Bypass Grafting With No-Touch vs Conventional Saphenous Vein Harvesting. Photobiomodulation Therapy, Sham Laser irradiation, Conventional Saphenous Vein Harvesting - Coronary Artery Disease, Coronary Artery Bypass Graft (CABG) | Not applicable | Not yet recruiting | Federal University of São Paulo | 292 | 2027-01-01 | 2026-10-07 |
| Intraoperative Ultrasound Assessment of Coronary Artery and Bypass Graft Blood Flow During CABG Intraoperative Ultrasound Blood Flow Measurement - Coronary Artery Disease | Not yet recruiting | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | 190 | 2027-01-01 | 2026-08-11 | |
| French Observatory on the Management of Cardiogenic Shock 2 Cardiogenic Shock | Not yet recruiting | French Cardiology Society | 1000 | 2027-01-01 | 2026-10-09 | |
| wCAR-Austria: A Women-Specific Score to Assess Cardiovascular Risk in Women Aged 40 to 65 Arm 1: wCAR-CARE - Precision Prevention (Arm A), Guideline-directed standard of care - Cardiovascular Diseases (CVD), Coronary Artery Disease | Not applicable | Not yet recruiting | Women's Heart Austria | 800 | 2027-01-01 | 2026-09-30 |
| Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD) Endothelial cell collection - Obesity and Obesity-related Medical Conditions, Diabetes | Recruiting | Bettina Mittendorfer | 100 | 2027-01-01 | 2026-05-07 | |
| A Study of Microcirculatory Function in Type 2 Myocardial Infarction (T2MI) Coronary angiogram with coronary reactivity testing (CRT) - Myocardial Infarction, Coronary Microvascular Disease | Not yet recruiting | Mayo Clinic | 52 | 2027-01-01 | 2026-08-31 | |
| Modified Jailed Balloon Technique vs Jailed Wire Technique in Coronary Bifurcation Intervention jailed wire technique, Modified jailed balloon technique - Coronary Artery Disease | Not applicable | Not yet recruiting | Assiut University | 140 | 2027-01-01 | 2026-10-14 |
| Rapid Inflation/Deflation Compared With Prolonged High-Pressure Balloon Inflation Prolonged inflation, Rapid inflation - Coronary Artery Disease, Coronary Stent Occlusion | Not applicable | Not yet recruiting | Central Arkansas Veterans Healthcare System | 40 | 2027-01-01 | 2026-10-21 |
| PCI With GDMT Versus GDMT Alone for Patients With Ischemic Cardiomyopathy and Reduced LVEF Percutaneous coronary intervention, Guideline-directed medical therapy - Heart Failure With Reduced Ejection Fraction, Coronary Artery Disease | Not applicable | Not yet recruiting | Nanjing First Hospital, Nanjing Medical University | 1154 | 2026-12-30 | 2026-05-28 |
| PREventive Invasive Strategy for Obstructive Coronary Artery Disease With Vulnerable Plaque Evaluated by CoroNary Computed Tomography Angiography-2 Initial Invasive Strategy, Initial Conservative Strategy - Coronary Artery Disease | Not applicable | Not yet recruiting | Duk-Woo Park, MD | 2500 | 2026-12-30 | 2026-10-21 |
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Coronary Artery Disease (4729) · Myocardial Infarction (1960) · Coronary Disease (1498) · Acute Coronary Syndrome (1460) · Cardiovascular Diseases (969) · ST Elevation Myocardial Infarction (826) · Heart Diseases (618) · Heart Failure (509) · Angina Pectoris (452) · Atherosclerosis (445) · Diabetes Mellitus (381) · Stroke (366) · Angina, Stable (337) · Angina, Unstable (328)
Vascular Diseases (10292) · Heart Diseases (9794) · Cardiovascular Diseases (9443) · Arterial Occlusive Diseases (4884) · Arteriosclerosis (4863) · Pathological Conditions, Signs and Symptoms (4663) · Coronary Disease (4661) · Pathologic Processes (3755) · Necrosis (2997) · Infarction (2973) · Ischemia (2960) · Signs and Symptoms (1378) · Neurologic Manifestations (1199) · Pain (1123)
Clopidogrel (339) · Percutaneous Coronary Intervention (268) · Ticagrelor (241) · Aspirin (229) · Atorvastatin (141) · Prasugrel Hydrochloride (126) · Rosuvastatin Calcium (93) · Exercise (74) · Coronary Artery Bypass (71) · Drug-Eluting Stents (69) · Standard of Care (69) · Ezetimibe (65) · Sodium Chloride (62) · Blood Specimen Collection (56) · Rivaroxaban (54)
National Heart, Lung, and Blood Institute (NHLBI) (245) · Assiut University (98) · Yonsei University (93) · Abbott Medical Devices (87) · China National Center for Cardiovascular Diseases (87) · Seoul National University Hospital (76) · AstraZeneca (74) · Seung-Jung Park (70) · Assistance Publique - Hôpitaux de Paris (67) · Samsung Medical Center (66) · Beijing Anzhen Hospital (65) · Ottawa Heart Institute Research Corporation (65) · Deutsches Herzzentrum Muenchen (55) · University of Edinburgh (55) · Boston Scientific Corporation (53)
United States (2024) · China (1180) · Germany (727) · United Kingdom (642) · Italy (640) · South Korea (621) · Canada (610) · France (603) · Netherlands (496) · Spain (455) · Denmark (378) · Poland (327) · Belgium (322) · Switzerland (321) · Brazil (290)
Seung-Jung Park, MD, PhD (31) · Adnan Kastrati, MD (29) · Bon-Kwon Koo, MD, PhD (26) · Ron Waksman, MD (18) · Joo Myung Lee, MD, MPH, PhD (16) · Antonio Colombo, MD (13) · Gregg W Stone, MD (13) · Harry Hemingway, FRCP (13) · Joo-Yong Hahn, MD, PhD (13) · Shigeru Saito, MD (13) · Dominick J Angiolillo, MD, PhD (12)
PMID 35224730, PMID 19717846, PMID 40875095, PMID 25940520, PMID 28886621, PMID 34932836, PMID 41114449, PMID 17982182, PMID 21670242, PMID 24746650, PMID 34741536, PMID 37131096, PMID 19228612, PMID 19463432, PMID 19737719, PMID 19923168, PMID 20142198, PMID 23468513, PMID 23523454, PMID 23636237, PMID 26347918, PMID 29098321, PMID 30165437, PMID 31561250, PMID 36398903, PMID 36526898, PMID 40014670, PMID 40590244, PMID 41044734, PMID 17296825, PMID 18307999, PMID 18765162, PMID 18783301, PMID 20129555, PMID 21873419, PMID 22017936, PMID 22115661, PMID 22536282, PMID 22922414, PMID 22995877, PMID 23232250, PMID 23762142, PMID 24510638, PMID 25173339, PMID 26089177, PMID 26320110, PMID 26354543, PMID 26794722, PMID 26823484, PMID 26825231
2018 (19), 2019 (15), 2023 (15), 2014 (13), 2025 (13), 2016 (12), 2017 (12), 2015 (10), 2009 (9), 2008 (6), 2005 (5), U01HL088942 (4), P30AG064198 (3), R01AG031750 (3), R01HL092954 (3)