Chest Pain: Clinical Trials

669 completed, 291 unknown, 101 recruiting, 68 terminated. 417 Not applicable, 168 Phase 4, 117 Phase 3, 100 Phase 2, 27 Phase 1.

By phase and status

Phase	Trials	Status
Not applicable	417	Completed 213, Unknown 84, Recruiting 43, Active not recruiting 23, Not yet recruiting 23, Terminated 18, Withdrawn 10, Enrolling by invitation 2, Suspended 1
Phase 4	168	Completed 81, Unknown 48, Terminated 15, Withdrawn 14, Recruiting 6, Active not recruiting 2, Not yet recruiting 2
Phase 3	117	Completed 75, Unknown 23, Terminated 10, Recruiting 3, Enrolling by invitation 2, Not yet recruiting 2, Suspended 1, Withdrawn 1
Phase 2	100	Completed 60, Unknown 20, Terminated 9, Withdrawn 6, Recruiting 3, Enrolling by invitation 1, Suspended 1
Phase 1	27	Completed 13, Unknown 6, Terminated 3, Recruiting 2, Withdrawn 2, Suspended 1
Early Phase 1	4	Completed 2, Terminated 1, Unknown 1

Follow Chest Pain: new trials by email Literature Review of Chest Pain trials Research Report on Chest Pain

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
AI-based Decision Support in Acute Chest Pain AIDE-CP available - Myocardial Infarction, Chest Pain	Not applicable	Not yet recruiting	Region Skane	4500	2027-01-18	2026-10-07
ER-VISION-AI Study Generative Pre-trained Transformer (GPT)-assisted multimodal visual language model (VLM) diagnostic support, Conventional emergency department diagnostic evaluation - Chest Pain, Dyspnea	Not applicable	Not yet recruiting	Ewha Womans University Mokdong Hospital	1000	2027-01-01	2026-07-27
Clinical Evidence With Biomarker Confirmation for PPMI in PCI Clinical Trials Study Biomarker testing - Peri-procedural Myocardial Infarction, Heart Failure Hospitalization		Not yet recruiting	Baim Institute for Clinical Research	1000	2026-12-01	2026-09-30
Diagnosis of Women With ANOCA Angina With No Obstructive Coronary Artery Disease		Not yet recruiting	NHS Greater Glasgow and Clyde	400	2026-11-27	2026-09-03
Drug-Coated Balloon Only Strategy After Recanalization of Chronic Total Coronary Occlusions Paclitaxel-coated balloon (AGENT Paclitaxel-Coated PTCA Balloon Catheter), Serial intravascular ultrasound and protocol-mandated nine-month angiographic reassessment - Angina (Stable), Coronary Occlusion	Not applicable	Not yet recruiting	University of Sao Paulo General Hospital	38	2026-11-01	2026-09-14
AI-ECG Detection of Occlusion Myocardial Infarction at Emergency Department Triage (TRIACS) Acute Coronary Syndromes, Chest Pain		Not yet recruiting	University Medical Centre Maribor	1000	2026-10-19	2026-10-20
Hybrid Exercise Program for Heart Disease: Effect on Health and Quality of Life Hybrid Endurance Strength Training, Usual Care - Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD))	Not applicable	Not yet recruiting	University of Malaya	84	2026-10-01	2026-04-17
Coronary Sinus Reducer Objective Impact on SymptoMs, Ischaemia and miCrovascular Resistance in Non-obstructive Hypertrophic CardioMyopathy Coronary sinus reducer, Placebo procedure - Hypertrophic Cardiomyopathy	Not applicable	Not yet recruiting	Imperial College London	50	2026-10-01	2026-10-08
Exercise Therapy for Women With ANOCA Resistance based exercise - Angina Patients With Non-obstructive Coronary Artery Disease	Not applicable	Not yet recruiting	NHS Greater Glasgow and Clyde	76	2026-09-14	2026-07-29
Silent Deployment and Prospective Evaluation of Zhunxin Agent for Emergency Chest Pain Assessment Chest Pain Center, Chest Pain		Not yet recruiting	Peking University Health Science Center	10000	2026-09-09	2026-09-21
"Discovery2" Study of Using MCG at Emergency Departments Magnetocardiography - Acute Coronary Syndromes (ACS), Coronary Artery Disease (CAD)		Not yet recruiting	SB Technology, Inc.	200	2026-09-01	2026-09-16
Rapid or Ultra-rapid Diagnosis of Myocardial Infarction Using High-Sensitivity Cardiac Troponin on Hospital Presentation 0/3-hour high-sensitivity cardiac troponin algorithm, 0/1-hour high-sensitivity cardiac troponin algorithm - Coronary Syndrome, Acute, Myocardial Infarction	Not applicable	Not yet recruiting	Herlev and Gentofte Hospital	28000	2026-09-01	2026-08-06
BRIDGE Trial: Embedding Consumer-grade mHealth Technologies Into Cardiac Rehabilitation CBCR, BRIDGE mHealth intervention - Acute Myocardial Infarction (AMI), Percutaneous Coronary Intervention (PCI)	Not applicable	Not yet recruiting	University of Illinois at Chicago	30	2026-09-01	2026-08-03
Contactless Ultrasound Data Acquisition in Emergency Departments to Discriminate the Origin of Dyspnea and Chest Pain All patients from both groups will be imaged with airborne ultrasound device - Dyspnea, Chest Pain		Not yet recruiting	Austral Diagnostics	2500	2026-09-01	2026-06-17
Percutaneous Cryoablation of Intercostal Nerves for the Treatment of Rib Fractures Percutaneous Cryoablation of Intercostal Nerves, Multi-modal pain regimen - Trauma, Rib Fractures	Not applicable	Not yet recruiting	Loma Linda University	30	2026-09-01	2026-02-09
Sodium Hyaluronate for Myofascial Thoracic Pain Sodium Hyaluronate Injection, Saline Injections - Thoracic Pain, Back Pain	Not applicable	Not yet recruiting	EPC Education s.r.o.	100	2026-08-31	2026-08-20
Quality of Life After Transcatheter Aortic Valve Implantation Aortic Stenosis, Heart Failure		Active not recruiting	Aalborg University Hospital	200	2026-08-26	2026-09-01
Early Triple Lipid-Lowering Therapy With Bempedoic Acid After Acute Coronary Syndrome bempedoic acid, Ezetimibe, High-Intensity Statin Therapy - Acute Coronary Syndromes, Dyslipidemia	Phase 4	Recruiting	Taipei Medical University Hospital	400	2026-08-26	2026-09-17
Identification of Lesion Characteristics in Coronary Plaques Using Multimodality Intravascular Imaging and Novel Photon-counting CT in Stable Angina observational study - Coronary Artery Disease (CAD), Stable Angina Pectoris		Recruiting	Queen Mary University of London	70	2026-08-19	2026-10-07
SMARTwatch for the Diagnosis of ST-segment Elevation Myocardial Infarction in Patients With Chest Pain ECG smartwatch recording - STEMI - ST-segment Elevation Myocardial Infarction, Chest Pain		Recruiting	Hospital General Universitario Santa Lucia	100	2026-08-14	2026-08-26

Showing 20 of 1277. Sign in to see all of them.

Narrower conditions

Angina Pectoris (452)  ·  Coronary Artery Disease (373)  ·  Angina, Stable (337)  ·  Angina, Unstable (328)  ·  Myocardial Infarction (244)  ·  Acute Coronary Syndrome (238)  ·  Myocardial Ischemia (161)  ·  Coronary Disease (117)  ·  Non-ST Elevated Myocardial Infarction (106)  ·  Cardiovascular Diseases (88)  ·  ST Elevation Myocardial Infarction (80)  ·  Heart Failure (63)  ·  Heart Diseases (60)  ·  Atherosclerosis (47)

Broader conditions

Neurologic Manifestations (1276)  ·  Pathological Conditions, Signs and Symptoms (1276)  ·  Signs and Symptoms (1274)  ·  Pain (1265)  ·  Vascular Diseases (1110)  ·  Heart Diseases (1065)  ·  Cardiovascular Diseases (1051)  ·  Myocardial Ischemia (951)  ·  Angina Pectoris (535)  ·  Pathologic Processes (450)  ·  Arterial Occlusive Diseases (404)  ·  Arteriosclerosis (399)  ·  Coronary Disease (345)  ·  Necrosis (343)

Interventions

Percutaneous Coronary Intervention (34)  ·  Clopidogrel (33)  ·  Aspirin (24)  ·  Ticagrelor (24)  ·  Ranolazine (23)  ·  Atorvastatin (18)  ·  Standard of Care (12)  ·  Drug-Eluting Stents (11)  ·  Nitroglycerin (11)  ·  Heparin (9)  ·  Prasugrel Hydrochloride (9)  ·  Exercise Test (7)  ·  Hydroxymethylglutaryl-CoA Reductase Inhibitors (7)  ·  Sodium Chloride (7)  ·  Abciximab (6)

Sponsors

Seoul National University Hospital (16)  ·  University College, London (16)  ·  National Heart, Lung, and Blood Institute (NHLBI) (15)  ·  Imperial College London (12)  ·  CardioDx (11)  ·  Wake Forest University Health Sciences (11)  ·  Samsung Medical Center (10)  ·  Massachusetts General Hospital (9)  ·  Mayo Clinic (9)  ·  University of Edinburgh (9)  ·  Aarhus University Hospital Skejby (8)  ·  Assistance Publique - Hôpitaux de Paris (8)  ·  AstraZeneca (8)  ·  Copenhagen University Hospital, Rigshospitalet (8)  ·  Qilu Hospital of Shandong University (8)

Countries

United States (308)  ·  United Kingdom (118)  ·  China (95)  ·  South Korea (78)  ·  Italy (74)  ·  Netherlands (74)  ·  Germany (70)  ·  Canada (59)  ·  Denmark (56)  ·  France (56)  ·  Belgium (44)  ·  Spain (44)  ·  Poland (37)  ·  Sweden (36)  ·  Russia (33)

Top investigators

Bon-Kwon Koo, MD, PhD (6)  ·  Jun Li, MD (6)  ·  Alexander Ehlgen, MD, PhD (5)  ·  Harry Hemingway, FRCP (5)  ·  Antonio Colombo, MD (4)  ·  Gilbert Raff, MD (4)  ·  Jeffrey M Levsky, MD, PhD (4)  ·  Joo Myung Lee, MD, MPH, PhD (4)  ·  Michael Zapien, MS (4)  ·  Yong Huo, MD (4)  ·  Adnan Kastrati, MD (3)  ·  Braim Rahel, Dr. (3)  ·  Christian Mueller, MD (3)  ·  Emily Herrett, MSc (3)

Results publications

PMID 40590244, PMID 22536282, PMID 23762142, PMID 27777598, PMID 35641327, PMID 37131096, PMID 37619976, PMID 37745109, PMID 17825712, PMID 23737852, PMID 25254054, PMID 31242362, PMID 35224730, PMID 39788470, PMID 41913985, PMID 20579539, PMID 21079055, PMID 22212857, PMID 22483327, PMID 22795280, PMID 24529158, PMID 24884807, PMID 24998674, PMID 25119856, PMID 25828395, PMID 28487318, PMID 28923845, PMID 30169752, PMID 30538057, PMID 31535314, PMID 31648761, PMID 31829173, PMID 31843947, PMID 32654558, PMID 32890442, PMID 33766254, PMID 34237166, PMID 34251454, PMID 34649504, PMID 34717627, PMID 35470686, PMID 35589164, PMID 37675090, PMID 38018702, PMID 38598970, PMID 39198005, PMID 39217607, PMID 39959922, PMID 40687396, PMID 40887988

NIH funding

2014 (4), 2016 (3), 2023 (3), 2008 (2), 2018 (2), 1RC1LM010424-01 (1), 1RC2HL101458-01 (1), 2005 (1), 2015 (1), 2019 (1), 2025 (1), K23AT009715 (1), K23HL004444 (1), K23HL119620 (1), K76AG088428 (1)