134 completed, 47 unknown, 33 recruiting, 25 not yet recruiting. 124 Not applicable, 41 Phase 3, 35 Phase 2, 29 Phase 4, 15 Phase 1.
Follow Cancer Pain: new trials by email Literature Review of Cancer Pain trials Research Report on Cancer Pain
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Healing Gardens: Leveraging Serious Games to Deliver Accessible Pain-CBT and Pharmacologic Support for Patients With Advanced Cancer Managing Pain Healing Gardens content development/refinement activities, Healing Gardens serious game - Advanced Cancer, Cancer Pain | Not applicable | Not yet recruiting | Dana-Farber Cancer Institute | 46 | 2027-02-13 | 2026-09-17 |
| Quad Shot Versus Split Course Radiotherapy in Incurable Head and Neck Cancer Quad Shot Radiotherapy, Split Course Radiotherapy - Head and Neck Neoplasms, Squamous Cell Carcinoma of Head and Neck | Not applicable | Not yet recruiting | Instituto Nacional de Cancerologia, Columbia | 40 | 2027-01-01 | 2026-10-02 |
| 3D1002 in Combination With Oxycodone Hydrochloride Sustained-release Tablets in Patients With Moderate to Severe Cancer Pain 3D1002 (50 mg)(Phase IIa), 3D1002 (100 mg)(Phase IIa), 3D1002 (150 mg)(Phase IIa) - Cancer Pain | Phase 2 | Not yet recruiting | 3D Medicines | 177 | 2026-12-01 | 2026-03-11 |
| Periganglionic Resiniferatoxin for the Treatment of Intractable Pain Due to Cancer-induced Bone Pain Resiniferatoxin - Intractable Pain, Palliative Care | Phase 1 / Phase 2 | Not yet recruiting | National Institute of Neurological Disorders and Stroke (NINDS) | 30 | 2026-11-27 | 2026-10-26 |
| Lidocaine Infusions for Pain in Patients With Malignant Bowel Obstruction Lidocaine - Malignant Bowel Obstruction, Cancer Pain | Not yet recruiting | Fundación Santa Fe de Bogota | 50 | 2026-11-01 | 2026-10-02 | |
| Cancer Pain 101: A Digital, Asynchronous Intervention of Pain Management in Advanced Cancer Cancer Pain 101 - Cancer, Pain | Not applicable | Not yet recruiting | University of Alabama at Birmingham | 45 | 2026-11-01 | 2026-10-20 |
| Real-world Study of the Effectiveness and Tolerability of Outpatient Titration of OxyContin for the Moderate and Severe Pain in Cancer Patients Cancer Pain | Not yet recruiting | Mundipharma (China) Pharmaceutical Co. Ltd | 378 | 2026-10-01 | 2026-10-13 | |
| Efficacy of Non-opioid Drugs in Addition to Opioid Therapy for Cancer Pain Management Metamizole, Ibuprofen, Placebo - Cancer Pain, Cancer Palliative Care | Phase 3 | Not yet recruiting | University Hospital, Basel, Switzerland | 318 | 2026-10-01 | 2026-08-19 |
| Outcomes of Fluoroscopy-Guided Transdiscal Splanchnic Nerve Neurolysis for Upper Abdominal Cancer Pain. Chemical Neurolysis - Upper Abdominal Cancer Pain, Pancreatic Cancer | Not applicable | Not yet recruiting | Sahiwal medical college sahiwal | 40 | 2026-09-20 | 2026-09-17 |
| Single Fraction and Multifraction Arc-Based Radiotherapy for Painful Bone Metastases Single-Fraction Radiotherapy (8Gy x 1#), Multifraction Radiotherapy (20 Gy in 5 #) - Bone Metastases of a Malignant Tumor, Cancer Pain | Not applicable | Not yet recruiting | Oman Ministry of Health | 70 | 2026-09-01 | 2026-08-19 |
| Efficacy of Spinal Cord Stimulation in Chemotherapy-Induced Peripheral Neuropathy Spinal cord stimulation (FAST mode), Sham Spinal Cord Stimulation - Neuropathic Pain, Chemotherapy-induced Peripheral Neuropathy (CIPN) | Not applicable | Not yet recruiting | Assistance Publique Hopitaux De Marseille | 68 | 2026-09-01 | 2026-05-12 |
| Evaluation of the Effects of Traditional and E-Learning Methods in Cancer Pain Care Education on Learning Outcomes and Institutional Costs e-learning, traditional group - Cancer Pain, Nursing Students | Not applicable | Not yet recruiting | Bilecik Seyh Edebali Universitesi | 100 | 2026-09-01 | 2026-08-05 |
| Hydromorphone With Electroacupuncture and Ear Acupoint Pressing for Refractory Cancer Pain Hydromorphone Hydrochloride Extended-Release Tablets, Electroacupuncture, Ear Acupoint Pressing Beans - Refractory Cancer Pain, Cancer Pain | Early Phase 1 | Recruiting | Qinghai Red Cross Hospital | 30 | 2026-08-05 | 2026-08-14 |
| Intrathecal Therapy Versus Standard Care for Severe Cancer Pain Intrathecal Drug Delivery, Comprehensive Medical Management - Intrathecal Drug Delivery, Refractory Cancer Pain | Not applicable | Recruiting | Universitair Ziekenhuis Brussel | 72 | 2026-07-01 | 2026-07-09 |
| RAD ONC FREEDOM Oncology Pain Radiosurgery - Cancer Pain | Not applicable | Recruiting | Jonsson Comprehensive Cancer Center | 19 | 2026-06-09 | 2026-07-08 |
| Effects of Opioid Drugs on Sleep and Emotion in Patients With Moderate to Severe Cancer Pain No intervention - Moderate to Severe Cancer Pain | Recruiting | First Affiliated Hospital of Zhejiang University | 200 | 2026-04-15 | 2026-06-01 | |
| Dexmedetomidine for Refractory Pain in Palliative Cancer Patients Cancer, Palliative Care, Patient Care | Recruiting | St. Olavs Hospital | 30 | 2026-04-10 | 2026-10-21 | |
| Enhancing Pain Management Among Patients Diagnosed With Stage III and Stage IV of Breast Cancer: The Power of Immersive and Non-Immersive Virtual Reality-Driven Interactive Guided Imagery Immersive Virtual reality guided imagery, VR (VR-Control) - Cancer Pain, Virtual Reality Immersion | Not applicable | Not yet recruiting | Middle East University | 90 | 2026-03-20 | 2026-03-27 |
| Intermittent Erector Spinae Plane Block Via Subcutaneous Port for Cancer Pain Erector Spinae Plane Block - Cancer Pain, Erector Spinae Plane Block | Not applicable | Recruiting | Hanoi Medical University | 180 | 2026-03-01 | 2026-09-17 |
| MRI Evaluation of Spinal Cord Edema After CT-Guided Percutaneous Cordotomy in Cancer Pain Patients CT-guided Percutaneous Cervical Cordotomy - Cancer Pain, Intractable Pain | Not yet recruiting | Mersin University | 15 | 2026-03-01 | 2026-02-10 |
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Neoplasms (86) · Pain (82) · Chronic Pain (22) · Agnosia (19) · Breast Neoplasms (13) · Pain, Intractable (12) · Pancreatic Neoplasms (11) · Neuralgia (10) · Neoplasm Metastasis (9) · Lung Neoplasms (8) · Anxiety Disorders (7) · Breakthrough Pain (7) · Head and Neck Neoplasms (7) · Prostatic Neoplasms (6)
Neurologic Manifestations (288) · Pathological Conditions, Signs and Symptoms (288) · Signs and Symptoms (287) · Pain (206) · Neoplasms by Site (44) · Neoplasms (43) · Nervous System Diseases (31) · Digestive System Diseases (21) · Neurobehavioral Manifestations (19) · Perceptual Disorders (19) · Digestive System Neoplasms (18) · Mental Disorders (17) · Pathologic Processes (14) · Breast Diseases (13) · Neoplasms by Histologic Type (13)
Morphine (16) · Oxycodone (14) · Fentanyl (10) · Methadone (7) · Lidocaine (6) · Acetaminophen (5) · nabiximols (5) · Acupuncture Therapy (4) · Ethanol (4) · Hydromorphone (4) · resiniferatoxin (4) · Buprenorphine (3) · Transcutaneous Electric Nerve Stimulation (3) · 6'-fluoro-4',9'-dihydro-N,N-dimethyl-4-phenylspiro(cyclohexane-1,1'(3'H)-pyrano(3,4-b)indol)-4-amine (2) · Analgesics, Opioid (2)
Fujian Cancer Hospital (6) · Janssen Korea, Ltd., Korea (6) · M.D. Anderson Cancer Center (6) · InSightec (4) · Medstar Health Research Institute (4) · Memorial Sloan Kettering Cancer Center (4) · Taiwan Mundipharma Pharmaceuticals Ltd. (4) · Jazz Pharmaceuticals (3) · Kyowa Kirin Co., Ltd. (3) · Mario Negri Institute for Pharmacological Research (3) · Mundipharma (China) Pharmaceutical Co. Ltd (3) · Mundipharma Korea Ltd (3) · National Cancer Institute, Egypt (3) · National Taiwan University Hospital (3) · Pfizer (3)
United States (74) · China (29) · Italy (18) · Taiwan (17) · United Kingdom (17) · France (15) · South Korea (14) · Poland (13) · Spain (12) · Brazil (11) · Germany (11) · Canada (10) · Hungary (10) · Romania (9) · Turkey (Türkiye) (9)
Jun Mao, MD, MSCE (3) · Desiree Azizoddin, PsyD (2) · Eduardo Bruera, MD (2) · Gao-Jun Teng, MD (2) · John D Heiss, M.D. (2) · Ka Wing Ma, MBBS, MS (2)
PMID 10964347, PMID 15310785, PMID 16036506, PMID 19912069, PMID 26582720, PMID 36452492, PMID 42142332, PMID 10506634, PMID 10577695, PMID 10813730, PMID 11013380, PMID 11027905, PMID 11033377, PMID 11068116, PMID 11331334, PMID 11387363, PMID 11576800, PMID 11683656, PMID 12555009, PMID 1349061, PMID 14694929, PMID 14701781, PMID 15813511, PMID 15928300, PMID 16012423, PMID 16051965, PMID 16260054, PMID 16869819, PMID 17081915, PMID 17355955, PMID 17509812, PMID 17916403, PMID 18838491, PMID 18843665, PMID 19167840, PMID 19260241, PMID 19343373, PMID 19421788, PMID 20083373, PMID 20220181, PMID 20332509, PMID 20562730, PMID 20813492, PMID 20818875, PMID 20822038, PMID 21074335, PMID 21394458, PMID 21489705, PMID 21672306, PMID 21763099
2008 (3), 2009 (3), 2023 (2), 2025 (1), 3UG1CA189824-06S1 (1), K08CA263317 (1), P30CA068485 (1), R01CA116423 (1), R01CA124481 (1), R01CA252211 (1), R01DA054513 (1), R21CA263838 (1), R21CA299799 (1), R34CA308746 (1), R43CA302795 (1)