202 completed, 48 unknown, 10 recruiting, 10 withdrawn. 89 Phase 4, 72 Not applicable, 60 Phase 3, 41 Phase 2, 36 Phase 1.
Follow Tramadol: new trials by email Literature Review of Tramadol trials Research Report on Tramadol
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Suzetrigine for Opioid-Sparing Postoperative Analgesia Following Transvaginal Pelvic Reconstructive Surgery Suzetrigine, Opioid Analgesics (Tramadol or Oxycodone), Scheduled Acetaminophen and Ibuprofen - Pelvic Organ Prolapse (POP), Stress Urinary Incontinence (SUI) | Phase 4 | Not yet recruiting | University of California, Los Angeles | 120 | 2026-11-01 | 2026-09-15 |
| Efficacy and Safety of DNN.63.18.040 for the Treatment of Moderate to Severe Pain Product DNN.63.18.040, Tramal® - Acute Pain | Phase 3 | Not yet recruiting | Ache Laboratorios Farmaceuticos S.A. | 370 | 2026-10-19 | 2026-10-19 |
| Comparison of Two Postoperative Care Strategies After Breast Surgery Patient Education, Paracetamol, Dexketoprofen - Postoperative Pain, Pain Management | Not applicable | Recruiting | Moumtzidou Maria Aikaterini | 108 | 2026-10-19 | 2026-10-20 |
| Adaptive Platform Trial for Pain Management in Sickle Cell Vaso-Occlusive Crisis Group 02 Paracetamol + Morphine + Ketamine, Group 01 Control: Paracetamol + Morphine, Group 03 : Paracetamol + Morphine + Nefopam - Sickle Cell Disease, Vaso-occlusive Crisis | Phase 4 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 400 | 2026-10-01 | 2026-09-18 |
| Epidural Analgesia Versus Opioid-sparing Analgesia for Open Ventral Hernia Repair With Transversus Abdominis Release Bupivicaine, Fentanyl, Thoracic epidural analgesia - Ventral Hernia, Ventral Hernia Repair | Phase 4 | Recruiting | Northwestern University | 40 | 2026-09-25 | 2026-10-07 |
| Efficacy and Safety of Canadá Association in the Treatment of Chronic Pain Canadá, Canadá placebo, Dipyrone - Pain, Chronic | Phase 2 | Withdrawn | EMS | 2026-09-01 | 2023-09-08 | |
| Comparison of Low-Dose Intravenous Ketamine and Tramadol for Prevention of Post-Spinal Anaesthesia Shivering in Orthopedic Surgical Patients Tramadol, Ketamin - Post-spinal Anesthesia Shivering | Not applicable | Not yet recruiting | Shaheed Mohtarma Benazir Bhutto Institue of Trauma | 106 | 2026-08-21 | 2026-08-26 |
| Effects of Intraarticular Tramadol and Tramadol-Dexamethasone on Postoperative Pain After Knee Arthroscopy Saline, Tramadol, Tramadol + Dexamethasone - Knee Arthroscopy, Postoperative Pain | Phase 4 | Not yet recruiting | Arzu Esen Tekeli | 135 | 2026-07-15 | 2026-05-14 |
| Tapentadol vs Tramadol in Arthroscopic Rotator Cuff Repair Tramadol, Tapentadol - Arthroscopic Rotator Cuff Repair (ARCR), Postoperative Pain | Active not recruiting | University of Thessaly | 64 | 2026-07-01 | 2026-10-21 | |
| Superficial Plane Blocks for Analgesia After Laparoscopic Cholecystectomy Rectointercostal Plane Block, External Oblique-Rectus Abdominis Plane Block, Intravenous Patient-Controlled Analgesia With Tramadol - Postoperative Pain, Laparoscopic Cholecystectomy | Completed | Bursa Yuksek Ihtisas Training and Research Hospital | 90 | 2026-03-01 | 2026-09-22 | |
| Analgesic Efficacy and Obstetric Effects of Tramadol, Paracetamol and Placebo in Active Labor Tramadol Hydrochloride, Paracetamol (acetaminophen), Placebo (Saline Solution) - Labor Pain | Phase 4 | Recruiting | Universidad Nacional Autonoma de Honduras | 300 | 2026-02-15 | 2026-02-27 |
| Efficacy And Safety Of Tramadol And Oxycodone Versus Oxycodone Monotherapy For Pain Control After Primary Total Knee And Total Hip Arthroplasty Oxycodone, Tramadol and Oxycodone - Post Operative Pain | Phase 4 | Enrolling by invitation | Mayo Clinic | 560 | 2026-02-02 | 2026-03-18 |
| Effectiveness of Opioid vs Pregabalin Plus Naproxen Sodium in Pain Management of Oral Cancer Patients Tramadol, Pregabalin + Naproxen Sodium - Oral Cancer, Oral Cavity Cancer | Not applicable | Enrolling by invitation | Mayo Hospital Lahore | 98 | 2026-02-01 | 2026-05-26 |
| EXORA Block vs Epidural Analgesia in Gynecological Surgery Tramadol, exora block, epidural - Pain, Postoperative Pain | Not applicable | Active not recruiting | Bursa Yuksek Ihtisas Training and Research Hospital | 60 | 2025-12-26 | 2026-10-14 |
| Dexmedetomidine vs Tramadol for Anxiety, Pain, and Hemodynamics in Hemorrhoidectomy Dexmedetomidine, Tramadol, 0.9 % Normal Saline - Hemorrhoids, Perioperative Anxiety | Not applicable | Completed | Yuzuncu Yil University | 90 | 2025-11-17 | 2026-07-28 |
| Combined Intravenous Tramadol and Paracetamol Versus Intramuscular Pethidine for Pain Relief During the First Stage of Labor. Compare the Efficacy and Adverse Effects pethidine, Tramadol, Paracetamol 1 g - Pain Management, Birth | Not applicable | Recruiting | Zohar Nachum | 140 | 2025-11-01 | 2025-12-15 |
| Comparison of DW-1021 and Separate Doses of Pelubi CR and Zytram CR Under Fasting Conditions DW-1021, Pelubi CR + Zytram CR - Healthy Volunteer | Phase 1 | Recruiting | Haiphong University of Medicine and Pharmacy | 14 | 2025-09-20 | 2025-08-28 |
| KinesioTaping for Thoracic Drain Support Kinesiotaping, paracetamol tramadol - Primary Condition: Pain, Postoperative, Associated Conditions: Cardiac Surgical Procedures, Thoracic Surgery | Phase 2 / Phase 3 | Completed | Kastamonu University | 100 | 2025-08-15 | 2026-06-09 |
| The Effect of Bupivacaine Liposome Preemptive Analgesia on Postoperative Pain and Delirium in Elderly Patients Undergoing Hip Fracture Surgery Tramadol, bupivacaine liposome (ultrasound-guided high iliofascial space block) - Postoperative Delirium | Phase 4 | Not yet recruiting | Nanjing First Hospital, Nanjing Medical University | 40 | 2025-07-20 | 2025-07-15 |
| Efficacy of Peripheral Nerve Blocks in Total Knee Arthroplasty Opioid Analgesic (tramadol hydrochloride), Prophylactic analgesia (intravenous paracetamol), Rescue analgesia (intramuscular diclofenac sodium) - Postoperative Pain Following Knee Arthroplasty | Not applicable | Completed | Tokat Gaziosmanpasa University | 86 | 2025-06-08 | 2026-06-26 |
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Pain, Postoperative (68) · Pain (45) · Agnosia (33) · Acute Pain (21) · Chronic Pain (12) · Opioid-Related Disorders (8) · Osteoarthritis (7) · Low Back Pain (6) · Spinal Stenosis (4) · Wounds and Injuries (4) · Back Pain (3) · Breast Neoplasms (3) · Constipation (3) · Emergencies (3) · Fibromyalgia (3)
Cairo University (14) · Bursa Yuksek Ihtisas Training and Research Hospital (7) · Labopharm Inc. (7) · Assiut University (5) · Janssen Pharmaceutical K.K. (4) · Laboratorios Silanes S.A. de C.V. (4) · Al-Azhar University (3) · Ankara City Hospital Bilkent (3) · Avenue Therapeutics, Inc. (3) · Daewon Pharmaceutical Co., Ltd. (3) · EMS (3) · Federal University of São Paulo (3) · Grünenthal GmbH (3) · Janssen Korea, Ltd., Korea (3) · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (3)
United States (47) · Turkey (Türkiye) (33) · Egypt (23) · Pakistan (20) · China (14) · Mexico (10) · Spain (9) · Italy (8) · Brazil (7) · Denmark (7) · Greece (7) · Israel (7) · Poland (7) · France (6) · Hungary (6)
AbdelGany M Hassan (2) · AbdelGany MA Hassan, MRCOG, MD (2) · Eleni Arnaoutolglou, MD, PhD (2) · Eric C. Strain, MD (2) · Eva-Corina Caragounis, MD (2) · Hans Granhed, MD PhD (2) · Metaxia Bareka, MD, PhD (2)
PMID 39316284, PMID 21889833, PMID 31005596, PMID 10195537, PMID 12680529, PMID 15041620, PMID 15208882, PMID 15502049, PMID 15804720, PMID 16894407, PMID 17052637, PMID 17113683, PMID 17575561, PMID 17656294, PMID 18053120, PMID 18443635, PMID 18477077, PMID 18622068, PMID 19122548, PMID 19135997, PMID 19209273, PMID 19535182, PMID 20051587, PMID 20340056, PMID 20589494, PMID 21039357, PMID 21217614, PMID 21467190, PMID 21471025, PMID 21555171, PMID 21692235, PMID 22458917, PMID 22678319, PMID 22939099, PMID 22981094, PMID 23360885, PMID 23702435, PMID 23755929, PMID 23850410, PMID 23917460, PMID 24247230, PMID 24480836, PMID 25032676, PMID 25041873, PMID 25166484, PMID 25794212, PMID 26123824, PMID 26237001, PMID 26329661, PMID 26452678
R01DA018125 (3), 2014 (2), 2009 (1), 2016 (1), 2019 (1), 2023 (1), KL2TR000370 (1), R01DA027068 (1), R44DA027304 (1), UL1TR000371 (1)