Midazolam: Clinical Trials

743 completed, 129 unknown, 62 terminated, 59 recruiting. 440 Phase 1, 237 Phase 4, 199 Not applicable, 108 Phase 2, 97 Phase 3.

By phase and status

Phase	Trials	Status
Phase 1	440	Completed 369, Terminated 23, Recruiting 22, Not yet recruiting 8, Unknown 7, Active not recruiting 6, Withdrawn 4, Suspended 1
Phase 4	237	Completed 136, Unknown 54, Terminated 17, Withdrawn 10, Not yet recruiting 7, Recruiting 6, Enrolling by invitation 3, Active not recruiting 2, Suspended 2
Not applicable	199	Completed 120, Unknown 36, Recruiting 13, Not yet recruiting 10, Withdrawn 10, Terminated 7, Active not recruiting 1, Enrolling by invitation 1, Suspended 1
Phase 2	108	Completed 60, Terminated 10, Unknown 10, Recruiting 8, Active not recruiting 7, Withdrawn 7, Not yet recruiting 5, Suspended 1
Phase 3	97	Completed 47, Unknown 18, Recruiting 12, Not yet recruiting 8, Terminated 5, Active not recruiting 3, Withdrawn 3, Enrolling by invitation 1
Early Phase 1	23	Completed 15, Unknown 3, Terminated 2, Active not recruiting 1, Enrolling by invitation 1, Recruiting 1

Follow Midazolam: new trials by email Literature Review of Midazolam trials Research Report on Midazolam

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Ketamine and Midazolam Infusions for CRPS: Feasibility Study Ketamine, Midazolam, Normal Saline - Complex Regional Pain Syndromes	Phase 2	Withdrawn	Stanford University		2099-01-01	2024-11-22
Intravenous Ketamine for Acute Suicidal Crisis and Psychiatric Hospital Length of Stay Esketamine, Midazolam (Intravenous) - Suicidal Ideation, Suicidal Behavior	Phase 2	Not yet recruiting	University of Sao Paulo	106	2027-04-30	2026-10-22
Effect of Midazolam Given at Induction on Recall of Propofol Injection Pain Midazolam, Lidocaine Hydrochloride 2%, Propofol 1% - Propofol Injection Pain, Postoperative Recall of Pain	Phase 4	Not yet recruiting	Atlas University	150	2026-12-01	2026-11-03
A Clinical Trial of MK-6916 With Midazolam and Rosuvastatin in Healthy Participants (MK-6916-012) Midazolam, Rosuvastatin, MK-6916 - Healthy	Phase 1	Not yet recruiting	Merck Sharp & Dohme LLC	18	2026-11-30	2026-10-07
Impact on Delirium of the Use of DEXmedetomidine as First-line Sedation in PEDIAtric Intensive Care Dexmedetomidine, Midazolam - Delirium in the Intensive Care Unit	Phase 3	Not yet recruiting	University Hospital, Tours	266	2026-11-15	2026-09-28
Lactium Versus Midazolam Premedication on Postoperative Negative Behavioral Changes Lactium, Midazolam, Flavored oral solution - Lactium, Midazolam	Phase 2 / Phase 3	Not yet recruiting	Tanta University	180	2026-11-15	2026-11-10
Efficacy of Intravenous Midazolam-Ketamine Combination Versus Placebo for Prevention of Post-Spinal Shivering in Elective Cesarean Section Midazolam and Ketamine, 0.9% Sodium Chloride - Shivering, Post-Spinal Shivering	Phase 4	Not yet recruiting	Assiut University	120	2026-11-01	2026-10-02
DDI Study of ECC0509 With Metformin, Midazolam, and Caffeine ECC0509, Metformin, Caffeine - Steatohepatitis, Nonalcoholic, Osteo Arthritis	Phase 1	Not yet recruiting	Eccogene	40	2026-11-01	2026-10-14
Predicting Response and Exposure Changes in Cirrhosis for Effectiveness Five-Drug CYP Probe Cocktail - Liver Cirrhosis	Not applicable	Not yet recruiting	Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)	45	2026-11-01	2026-08-11
A Study to Assess the Potential CYP3A Induction Effect of Brensocatib on the Pharmacokinetics (PK) of Midazolam in Healthy Participants Brensocatib, Midazolam - Healthy Volunteers	Phase 1	Not yet recruiting	Insmed Incorporated	26	2026-10-29	2026-10-05
A Comparison of Pulsed Field Ablation (PFA) vs Cryoablation for Atrial Fibrillation Under Deep Sedation Catheter ablation, Deep sedation with midazolam and fentanyl or midazolam and remifentanil, Sedation with midazolam and fentanyl - Atrial Fibrillation (AF)	Not applicable	Recruiting	East Sussex Healthcare NHS Trust	60	2026-10-19	2026-10-28
Comparative Evaluation of Intranasal Atomized Midazalom Combined With Nitrous Oxide Versus Nitrous Oxide Monotherapy Midazolam (Intranasal), Nitrous oxide/oxygen inhalation sedation alone, Intranasal normal saline placebo - Dental Anxiety in Children, Child Behaviour	Not applicable	Recruiting	Shaheed Zulfiqar Ali Bhutto Medical University	68	2026-10-15	2026-11-03
A Multiple-dose Study Investigating the Drug-drug Interaction Potential and QTc Effects of Fosmanogepix in Healthy Adult Subjects Fosmanogepix, Placebo, The medicine cocktail (caffeine, bupropion, flurbiprofen, omeprazole, dextromethorphan and midazolam) - Healthy Adult Participants	Phase 1	Recruiting	Basilea Pharmaceutica	42	2026-10-01	2026-10-19
A Study Comparing Oral Ketamine With Oral Midazolam for the Treatment of Major Depressive Episodes Oral ketamine, Oral midazolam - Major Depressive Episode	Phase 3	Not yet recruiting	Jawaharlal Institute of Postgraduate Medical Education & Research	220	2026-10-01	2026-10-01
A Trial in Healthy Participants to Assess Drug Interaction Potential of BGB-43395 BGB-43395, Midazolam, Celecoxib - Healthy Adult Participants	Phase 1	Recruiting	BeOne Medicines	24	2026-09-25	2026-10-23
A Phase I Study of the Interaction of D-2570 With Other Drugs in Healthy Adults Itraconazole, Rifampicin, Omeprazole - Healthy Subjects	Phase 1	Not yet recruiting	InventisBio Co., Ltd	60	2026-09-16	2026-10-15
A Study of Single and Multiple Doses of LY5625573 in Healthy Participants, Including Japanese and Chinese Populations, and Participants With Inflammation (High C-Reactive Protein) LY5625573, Midazolam, Placebo - C-Reactive Protein	Phase 1	Not yet recruiting	Eli Lilly and Company	96	2026-09-01	2026-10-09
A Study of Navlimetostat (BMS-986504) Drug Interactions and Food Effect in Healthy Participants Navlimetostat, Itraconazole, Rifampin - Healthy Female Adults	Phase 1	Recruiting	Bristol-Myers Squibb	80	2026-08-31	2026-10-05
A Trial of Lu AH69593 in Healthy Participants Lu AH69593, Itraconazole, Carbamazepine - Healthy Participants	Phase 1	Recruiting	H. Lundbeck A/S	46	2026-08-27	2026-10-14
A Study of LY4355756 in Healthy Participants LY4355756, Midazolam - Healthy	Phase 1	Recruiting	Eli Lilly and Company	123	2026-08-17	2026-10-08

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Conditions studied

Anxiety Disorders (46)  ·  Pain (29)  ·  Depression (27)  ·  Agnosia (22)  ·  Depressive Disorder, Major (22)  ·  Neoplasms (19)  ·  Pain, Postoperative (19)  ·  Delirium (18)  ·  Emergence Delirium (18)  ·  Depressive Disorder, Treatment-Resistant (13)  ·  Carcinoma, Non-Small-Cell Lung (12)  ·  Critical Illness (12)  ·  Bipolar Disorder (11)  ·  Breast Neoplasms (10)  ·  Diabetes Mellitus, Type 2 (10)

Sponsors

Pfizer (35)  ·  Boehringer Ingelheim (31)  ·  Eli Lilly and Company (26)  ·  AstraZeneca (19)  ·  GlaxoSmithKline (16)  ·  Janssen Research & Development, LLC (15)  ·  Bristol-Myers Squibb (13)  ·  Assiut University (12)  ·  Bayer (11)  ·  Cairo University (10)  ·  Seoul National University Hospital (10)  ·  Hoffmann-La Roche (9)  ·  Yonsei University (9)  ·  Merck Sharp & Dohme LLC (8)  ·  Novartis Pharmaceuticals (8)

Countries

United States (388)  ·  China (90)  ·  Egypt (62)  ·  Germany (62)  ·  United Kingdom (54)  ·  South Korea (45)  ·  Belgium (44)  ·  Canada (42)  ·  France (35)  ·  Turkey (Türkiye) (31)  ·  Spain (30)  ·  Brazil (26)  ·  Netherlands (26)  ·  Italy (25)  ·  Israel (20)

Results publications

PMID 39428602, PMID 19443532, PMID 22045879, PMID 19188334, PMID 19617584, PMID 21040558, PMID 24238862, PMID 24893689, PMID 27739142, PMID 28159539, PMID 29202655, PMID 8404160, PMID 10195546, PMID 10211042, PMID 10364865, PMID 10389815, PMID 10460554, PMID 10464905, PMID 10472223, PMID 10475291, PMID 10525595, PMID 10692189, PMID 10735670, PMID 10792142, PMID 10866915, PMID 10915627, PMID 11350323, PMID 11495870, PMID 11506101, PMID 11573581, PMID 11878707, PMID 11994056, PMID 12031757, PMID 12088814, PMID 12095019, PMID 12421743, PMID 12623040, PMID 12635389, PMID 14566537, PMID 14595310, PMID 15064269, PMID 15105196, PMID 15155300, PMID 15217302, PMID 15278085, PMID 15312228, PMID 15318468, PMID 15460178, PMID 15470169, PMID 15471636

NIH funding

2017 (13), 2018 (11), 2014 (10), 2016 (10), 2019 (10), 2023 (9), 2015 (7), U54AT008909 (3), 2025 (2), I01CX001789 (1), K23DA031771 (1), K23DK115827 (1), K23GM147350 (1), K23RR021874 (1), P01GM032165 (1)