Opioid-Related Disorders: Clinical Trials

937 completed, 193 recruiting, 114 unknown, 84 terminated. 682 Not applicable, 285 Phase 2, 162 Phase 1, 138 Phase 3, 118 Phase 4.

By phase and status

Phase	Trials	Status
Not applicable	682	Completed 391, Recruiting 97, Active not recruiting 51, Unknown 49, Not yet recruiting 29, Terminated 27, Withdrawn 22, Enrolling by invitation 13, Suspended 3
Phase 2	285	Completed 183, Recruiting 32, Withdrawn 24, Terminated 20, Unknown 12, Not yet recruiting 8, Active not recruiting 6
Phase 1	162	Completed 114, Recruiting 16, Terminated 9, Unknown 8, Active not recruiting 5, Not yet recruiting 5, Withdrawn 5
Phase 3	138	Completed 89, Recruiting 12, Terminated 11, Unknown 11, Active not recruiting 6, Withdrawn 6, Not yet recruiting 3
Phase 4	118	Completed 63, Recruiting 14, Withdrawn 12, Terminated 10, Unknown 7, Not yet recruiting 5, Active not recruiting 4, Enrolling by invitation 2, Suspended 1
Early Phase 1	32	Completed 17, Recruiting 5, Terminated 3, Unknown 3, Not yet recruiting 2, Withdrawn 2

Follow Opioid-Related Disorders: new trials by email Literature Review of Opioid-Related Disorders trials Research Report on Opioid-Related Disorders

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Dynamic Treatment Regimes for Opioid Use Disorder Medication for opioid use disorder, psychotherapy - Opioid Use Disorder	Phase 2	Not yet recruiting	Brigham and Women's Hospital	75	2028-07-01	2025-11-04
Integrated Care Versus Usual Care for Opioid Use Disorder and Infectious Diseases in Veterans Integrated care - Opioid Use Disorder, HIV	Not applicable	Not yet recruiting	VA Office of Research and Development	60	2028-04-03	2026-04-24
Family-Focused Study to Support Medication for Opioid Use Disorder FamilyCHESS, Standard of Care - Opioid Use Disorder, Opioid Use Disorder, Moderate	Not applicable	Not yet recruiting	University of Wisconsin, Madison	338	2027-08-31	2026-07-07
MedSMA℞T Mobile ED MedSMA℞T Mobile - Opiate-Related Disorders, Opiate Use Disorder	Not applicable	Not yet recruiting	Olufunmilola Abraham	244	2027-08-01	2026-10-09
Medically Supervised Ibogaine With 12-Month Digital Recovery Support for Opioid Use Disorder Ibogaine Hydrochloride, Extended-release naltrexone injection, 380 mg, Matching Oral Placebo - Opioid Use Disorder, Opioid Withdrawal	Phase 1 / Phase 2	Not yet recruiting	Clive Michelsen	60	2027-07-01	2026-10-13
Real-World Evaluation of Compl-AI for Predicting Early Medication Dropout in Opioid Use Disorder Treatment Opioid Use Disorder		Not yet recruiting	Tools4Patient	295	2027-06-01	2026-10-01
TMS to Improve Recovery Outcomes Among Patients With Opioid Use Disorder (OUD) and Alcohol Use Disorder (AUD) TMS Low-Dose, TMS High-Dose - Alcohol Use Disorder, Opioid Use Disorder	Not applicable	Recruiting	Washington State University	60	2027-06-01	2026-05-29
Inpatient Buprenorphine Induction With Psilocybin for Opioid Use Disorder Psilocybin - Opioid Use Disorder	Phase 2	Withdrawn	Johns Hopkins University		2027-04-01	2026-02-23
Naloxone for Opioid Associated Out of Hospital Cardiac Arrest Naloxone 2 MG, Saline 2ml - Heart Arrest, Out-Of-Hospital, Opioid Overdose	Phase 2	Not yet recruiting	University of California, San Francisco	98	2027-03-01	2026-09-11
Examining Analgesic Synergy and Efficacy in Trauma Care Buprenorphine, Oxycodone - Opioid Use Disorder	Phase 4	Not yet recruiting	Wake Forest University Health Sciences	282	2027-03-01	2026-10-28
The Community Paramedic Response and Overdose Outreach With Supportive Medical-Legal Services Study Community Paramedic Standard of Care (CP SOC), CROSSROADS - Opioid Use Disorder, Overdose, Drug	Not applicable	Not yet recruiting	Duke University	400	2027-02-01	2026-10-14
Improving Jail Response to the Overdose Crisis: A Hybrid Trial of Jail ECHO to Improve MOUD Implementation and Public Health Outcomes Project ECHO - Opioid Abuse (Disorder)	Not applicable	Recruiting	University of Massachusetts, Worcester	100	2027-01-01	2026-10-19
Clinician Practice Companion to Address Youth Substance Use Practice Companion - Substance Use, Substance-Related Disorders	Not applicable	Not yet recruiting	Massachusetts General Hospital	60	2027-01-01	2026-10-07
Deep Transcranial Magnetic Stimulation for Tobacco Cessation in Adults With Opioid Use Disorder Deep TMS System With H4 Coil - Opioid Use Disorder, Tobacco Use Disorder	Not applicable	Not yet recruiting	Payel Roy	12	2027-01-01	2026-08-27
Chicago Data-driven Opioid Use Disorder Screening, Engagement, Treatment and Planning System OUD screening, MOUD, Continuity of care - Opiod Use Disorder	Not applicable	Not yet recruiting	University of Illinois at Chicago	271031	2027-01-01	2026-10-08
Evaluation of the O'Neil Long Acting Naltrexone Implant in Opioid Dependent Persons naltrexone implant - Opioid Use Disorder	Phase 2	Not yet recruiting	Go Medical Industries Pty Ltd	250	2027-01-01	2026-09-28
Remote Intervention to Prevent Overdose Overdose prevention resources, Overdose prevention education - Accidental Overdose of Opiate	Not applicable	Not yet recruiting	University of Alabama at Birmingham	100	2027-01-01	2026-10-30
Peer-led, Mobile App Supported Linkage to Opioid Use Disorder Treatment Mobile phone-assisted intervention, Peer navigator, Standard of care referral for out-patient MAT - Opioid Use Disorder	Not applicable	Not yet recruiting	Johns Hopkins University	90	2027-01-01	2026-10-30
Treatment Education for Perinatal Women and Their Community Support substance abuse treatment education - Opioid Dependency	Not applicable	Not yet recruiting	Johns Hopkins University	80	2026-12-06	2026-07-22
Disease Intervention Specialist (DIS) for SUD Substance Use Disorder (SUD), Opioid Use Disorder		Not yet recruiting	Ohio State University	1200	2026-12-01	2026-10-15

Showing 20 of 1556. Sign in to see all of them.

Narrower conditions

Substance-Related Disorders (251)  ·  Chronic Pain (105)  ·  Heroin Dependence (90)  ·  Behavior, Addictive (75)  ·  Opiate Overdose (68)  ·  Pain (52)  ·  Cocaine-Related Disorders (46)  ·  Drug Overdose (38)  ·  Pain, Postoperative (38)  ·  Narcotic-Related Disorders (37)  ·  Alcoholism (35)  ·  HIV Infections (31)  ·  Depression (28)  ·  Stress Disorders, Post-Traumatic (26)

Broader conditions

Chemically-Induced Disorders (1546)  ·  Mental Disorders (1537)  ·  Narcotic-Related Disorders (1519)  ·  Substance-Related Disorders (1305)  ·  Pathological Conditions, Signs and Symptoms (253)  ·  Behavior (228)  ·  Signs and Symptoms (207)  ·  Neurologic Manifestations (199)  ·  Pain (131)  ·  Drug Misuse (96)  ·  Prescription Drug Misuse (96)  ·  Pathologic Processes (91)  ·  Infections (82)  ·  Compulsive Behavior (75)

Interventions

Buprenorphine (173)  ·  Buprenorphine, Naloxone Drug Combination (114)  ·  Naltrexone (45)  ·  Methadone (44)  ·  Therapeutics (42)  ·  Naloxone (39)  ·  vivitrol (39)  ·  Oxycodone (24)  ·  lofexidine (20)  ·  Morphine (19)  ·  Sublocade (18)  ·  Hydromorphone (16)  ·  Cannabidiol (13)  ·  Standard of Care (13)  ·  Transcranial Magnetic Stimulation (11)

Sponsors

Yale University (106)  ·  National Institute on Drug Abuse (NIDA) (82)  ·  New York State Psychiatric Institute (48)  ·  Johns Hopkins University (45)  ·  University of Pennsylvania (35)  ·  Indivior Inc. (32)  ·  NYU Langone Health (24)  ·  University of California, Los Angeles (23)  ·  Friends Research Institute, Inc. (22)  ·  University of Chicago (20)  ·  VA Office of Research and Development (18)  ·  Medical University of South Carolina (16)  ·  University of Maryland, Baltimore (16)  ·  University of Vermont (16)  ·  University of Wisconsin, Madison (16)

Countries

United States (1272)  ·  Canada (38)  ·  France (19)  ·  China (17)  ·  Sweden (17)  ·  Norway (12)  ·  Taiwan (11)  ·  United Kingdom (10)  ·  Malaysia (9)  ·  Australia (8)  ·  Germany (6)  ·  Vietnam (6)  ·  Denmark (5)  ·  Russia (5)  ·  Turkey (Türkiye) (5)

Top investigators

Warren Bickel, Ph.D. (22)  ·  Walter Ling, M.D. (18)  ·  James Zacny, Ph.D. (17)  ·  Mark Greenwald, PhD (11)  ·  Eric C. Strain, MD (9)  ·  Kenneth Silverman, Ph.D. (9)  ·  Sandra D Comer, PhD (8)  ·  Charles O'Brien, M.D., Ph.D. (7)  ·  Zev Schuman-Olivier, MD (7)  ·  Adam Bisaga, MD (6)  ·  Frederick G Moeller, MD (6)  ·  Leslie Amass, Ph.D. (6)  ·  Marc Fishman, MD (6)  ·  Richard Schottenfeld, M.D. (6)  ·  Yasmin Hurd, PhD (6)

Results publications

PMID 40342086, PMID 25630964, PMID 35287034, PMID 36063082, PMID 25911999, PMID 22339949, PMID 37023858, PMID 37657559, PMID 40833692, PMID 20707781, PMID 21782353, PMID 24875677, PMID 25175864, PMID 27574837, PMID 28068780, PMID 32002194, PMID 33631356, PMID 34752714, PMID 35130200, PMID 35395811, PMID 35785613, PMID 36467036, PMID 37264472, PMID 37393415, PMID 37584841, PMID 37712113, PMID 37936553, PMID 38616571, PMID 40105313, PMID 41085955, PMID 41460640, PMID 10219684, PMID 10517548, PMID 10870744, PMID 10928310, PMID 11058673, PMID 11165371, PMID 11351930, PMID 11786502, PMID 12738348, PMID 12873949, PMID 12954743, PMID 14581110, PMID 14621285, PMID 14756584, PMID 14982548, PMID 1517644, PMID 15647484, PMID 15734224, PMID 15734272

NIH funding

R01DA008391 (17), R01DA006969 (6), R01DA011160 (6), K20DA000191 (5), R33DA059884 (5), UG1DA013732 (5), R01DA010017 (4), R01DA010746 (4), R01DA014718 (4), R01DA015462 (4), 1RM1DA055310-01 (3), 2025 (3), K12DA031794 (3), P50DA009236 (3), R01DA005626 (3)