103 completed, 26 recruiting, 18 terminated, 18 unknown. 186 Phase 2, 28 Phase 1, 20 Phase 3.
Follow Chronic Pain: new trials by email Literature Review of Chronic Pain trials Research Report on Chronic Pain
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Ketamine and Midazolam Infusions for CRPS: Feasibility Study Ketamine, Midazolam, Normal Saline - Complex Regional Pain Syndromes | Phase 2 | Withdrawn | Stanford University | 2099-01-01 | 2024-11-22 | |
| Ketamine-Assisted Psychotherapy for Treatment-Resistant Depression Ketamine hydrochloride injection - Treatment Resistant Depression (TRD), Chronic Pain | Phase 2 | Not yet recruiting | University of Rochester | 25 | 2026-12-01 | 2026-09-24 |
| A Study of Cebranopadol for Opioid Withdrawal Symptoms in Adults With Chronic Pain Cebranopadol, Placebo - Chronic Pain, Pain | Phase 2 | Recruiting | Adneuris Therapeutics, Inc. | 45 | 2026-10-01 | 2026-10-23 |
| Effect of Post-Radiofrequency Corticosteroid Injection on the Incidence of Post-Neurotomy Neuritis Dexamethasone, Normal Saline, Bupivacaine - Facet Joint Pain, Arthropathy | Phase 2 | Enrolling by invitation | Siriraj Hospital | 126 | 2026-10-01 | 2026-09-28 |
| Post-traumatic Estradiol Administration and Care Evaluation (PEACE) 17β-estradiol, Placebo - Chronic Musculoskeletal Pain, Sexual Assault | Phase 2 | Not yet recruiting | University of North Carolina, Chapel Hill | 30 | 2026-09-28 | 2026-10-09 |
| Full-Spectrum Cannabis Extract for Chronic Pain and Bone Health Biomarkers in Women Full-Spectrum Cannabis Extract 5:1 (CBD:THC) - Chronic Pain, Fibromyalgia | Phase 2 | Not yet recruiting | Associação Pan-Americana Multidisciplinar de Endocanabinologia | 80 | 2026-09-01 | 2026-08-26 |
| Efficacy and Safety of Canadá Association in the Treatment of Chronic Pain Canadá, Canadá placebo, Dipyrone - Pain, Chronic | Phase 2 | Withdrawn | EMS | 2026-09-01 | 2023-09-08 | |
| A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Chronic Low Back Pain LY4065967, Placebo - Chronic Pain, Low Back Pain | Phase 2 | Recruiting | Eli Lilly and Company | 150 | 2026-08-12 | 2026-11-04 |
| A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Osteoarthritis Pain LY4065967, Placebo - Osteoarthritis, Knee, Chronic Pain | Phase 2 | Recruiting | Eli Lilly and Company | 150 | 2026-06-25 | 2026-11-04 |
| Ketamine Assisted Psychotherapy for Treating Comorbid Chronic Pain and PTSD Ketamine Infusion, Mindfulness-based cognitive therapy - Chronic Pain, Posttraumatic Stress Disorder (PTSD) | Phase 1 / Phase 2 | Recruiting | Dr. Yuliya Knyahnytska | 30 | 2026-03-31 | 2026-09-15 |
| Group Music Therapy for Chronic Pain Management in Active Duty Service Members Music intervention - Chronic Pain | Phase 2 | Recruiting | Henry M. Jackson Foundation for the Advancement of Military Medicine | 130 | 2026-03-17 | 2026-08-27 |
| Analgesic Efficacy and Safety of Topical VMD-3866 Gel in Management of Pain Induced by Chemotherapy (CIPN) VMD-3866 Gel, Placebo Gel - Chemotherapy-induced Peripheral Neuropathy, Chemotherapy-induced Neuropathic Pain | Phase 2 | Recruiting | VM Therapeutics LLC | 16 | 2025-12-12 | 2026-10-21 |
| Standardized Natural Psilocybin-assisted Psychotherapy for Tapering of Opioid Medication Psilocybin-assisted Psychotherapy - Opioid Dependence, Chronic Pain | Phase 2 | Recruiting | University of British Columbia | 10 | 2025-10-27 | 2025-12-04 |
| A Mobile Intervention to Reduce Pain and Improve Health-III MORPH, Measurement Only - Chronic Pain, Osteoarthritis | Phase 2 | Recruiting | Wake Forest University | 200 | 2025-08-14 | 2026-02-20 |
| Pain Reprocessing Therapy in Post-Operative Knee Pain Pain reprocessing therapy (PRT), Usual care - Pain, Chronic, Knee Pain Chronic | Phase 2 | Recruiting | Weill Medical College of Cornell University | 110 | 2025-08-13 | 2026-08-05 |
| Glycemic Regulation as Endometriosis Adjunct Treatment Metformin Hydrochloride, Placebo - Pelvic Pain, Endometriosis | Phase 2 | Active not recruiting | Boston Children's Hospital | 14 | 2025-05-22 | 2026-07-16 |
| Prescription Opioids, Brain Structure, and Cognition in Older Adults With Chronic Pain Opioid, Opioid Placebo - Pain, Chronic | Phase 2 | Recruiting | Mayo Clinic | 200 | 2025-04-16 | 2026-01-08 |
| Cannabidiol in Sickle Cell Disease Cannabidiol, Placebo - Sickle Cell Disease | Phase 1 / Phase 2 | Recruiting | Icahn School of Medicine at Mount Sinai | 52 | 2025-04-03 | 2025-06-25 |
| Treatment With Psilocybin for Chronic Neuropathic Pain and Depression (TRANSCEND) Psilocybin 25 mg - Treatment Resistant Depression, Chronic Pain | Phase 2 | Recruiting | Centre for Addiction and Mental Health | 16 | 2025-04-01 | 2026-10-21 |
| Psilocybin for Enhanced Analgesia in Chronic nEuropathic PAIN Psilocybin, Active Placebo - Chronic Neuropathic Pain, Pain Management | Phase 2 | Recruiting | Unity Health Toronto | 30 | 2025-03-05 | 2025-03-30 |
Showing 20 of 186. Sign in to see all of them.
Pain (40) · Fibromyalgia (18) · Neuralgia (17) · Opioid-Related Disorders (16) · Low Back Pain (13) · Agnosia (11) · Acute Pain (10) · Back Pain (8) · Pain, Postoperative (8) · Osteoarthritis (7) · Spinal Cord Injuries (6) · Depression (5) · Diabetic Neuropathies (5) · Neoplasms (5)
Neurologic Manifestations (186) · Pathological Conditions, Signs and Symptoms (186) · Signs and Symptoms (186) · Pain (146) · Nervous System Diseases (55) · Mental Disorders (40) · Neuromuscular Diseases (38) · Musculoskeletal Diseases (31) · Rheumatic Diseases (29) · Chemically-Induced Disorders (24) · Substance-Related Disorders (22) · Muscular Diseases (21) · Pathologic Processes (20) · Peripheral Nervous System Diseases (20) · Narcotic-Related Disorders (16)
Ketamine (10) · Morphine (7) · Dronabinol (6) · Buprenorphine (5) · Lidocaine (5) · Oxytocin (5) · Saline Solution (5) · Cognitive Behavioral Therapy (4) · Gabapentin (4) · Cannabidiol (3) · Pregabalin (3) · Tapentadol (3) · Therapeutics (3) · Tramadol (3) · 6'-fluoro-4',9'-dihydro-N,N-dimethyl-4-phenylspiro(cyclohexane-1,1'(3'H)-pyrano(3,4-b)indol)-4-amine (2)
Wake Forest University Health Sciences (7) · Assiut University (5) · University of Washington (5) · Grünenthal GmbH (4) · Medical University of South Carolina (4) · University of Florida (4) · Yale University (4) · Brigham and Women's Hospital (3) · Hospital de Clinicas de Porto Alegre (3) · University of British Columbia (3) · University of California, San Diego (3) · University of North Carolina, Chapel Hill (3) · VA Office of Research and Development (3) · E-DA Hospital (2) · Eli Lilly and Company (2)
United States (112) · Canada (21) · France (7) · Denmark (6) · Germany (6) · Brazil (5) · Egypt (5) · Italy (5) · United Kingdom (5) · Belgium (4) · Netherlands (4) · Bulgaria (3) · Puerto Rico (3) · Spain (3) · Switzerland (3)
James C. Eisenach, M.D. (4) · James C Eisenach, MD (3) · Richard Rauck, M.D. (3) · Amir Minerbi, MD-PhD (2) · Christine N. Sang, MD, MPH (2) · Declan T Barry, Ph.D. (2) · Dennis C. Turk, PhD (2) · Jeanne M Zanca, PhD, MPT (2) · Jeremy Orr, MD (2) · Peggy Compton, RN, PhD (2) · Wolnei Caumo, MD, PhD (2) · Ajay Wasan, MD, MSc (1)
PMID 27720917, PMID 15556826, PMID 15943960, PMID 18648238, PMID 19695776, PMID 21668743, PMID 21674151, PMID 22511033, PMID 24550805, PMID 24604566, PMID 25775441, PMID 25985806, PMID 26118427, PMID 26968850, PMID 27101815, PMID 27574837, PMID 27578767, PMID 27755490, PMID 27838498, PMID 27852965, PMID 28416501, PMID 28704354, PMID 29577509, PMID 29578090, PMID 29764303, PMID 30646965, PMID 31611759, PMID 31743533, PMID 32068667, PMID 32371500, PMID 33112417, PMID 33264568, PMID 34556520, PMID 34867525, PMID 35001856, PMID 35612403, PMID 35799138, PMID 36044208, PMID 36269028, PMID 36384218, PMID 36532184, PMID 36657520, PMID 36694217, PMID 36715655, PMID 36798353, PMID 36997252, PMID 37084261, PMID 37584841, PMID 38086444, PMID 38408060
2009 (3), P01NS041386 (3), K23HL151880 (2), P01NS119159 (2), R01AR044724 (2), R01NS041503 (2), 1RM1NS128741-01 (1), 2014 (1), 2015 (1), 2023 (1), K01AT012066 (1), K23AT011389 (1), K23NS050485 (1), P30AG022845 (1), P30AG028740 (1)