134 completed, 48 recruiting, 29 unknown, 23 terminated. 148 Phase 2, 58 Phase 1, 49 Phase 3, 24 Not applicable, 23 Early Phase 1.
Follow Cannabidiol: new trials by email Literature Review of Cannabidiol trials Research Report on Cannabidiol
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effects of Cannabidiol on Psychiatric Symptoms, Cognition, and Cannabis Consumption in Cannabis Users With Recent-Onset Psychosis Cannabidiol (CBD), Placebo - Schizophrenia Spectrum Disorders, Cannabis Use | Phase 2 | Withdrawn | University of Maryland, Baltimore | 2050-01-01 | 2021-04-19 | |
| A Study to Investigate the Transition of Children From 'Artisanal" Cannabidiol (CBD) to Epidiolex Epidiolex 100 mg/mL Oral Solution - Dravet Syndrome (DS), Lennox-Gastaut Syndrome (LGS) | Phase 4 | Not yet recruiting | Elizabeth Donner | 25 | 2027-01-01 | 2026-09-11 |
| Stratification and Treatment in Early Psychosis Study - PROMOTE Cannabidiol (CBD), Placebo - Clinical High Risk for Psychosis (CHR), Clinical High Risk for Psychosis | Phase 3 | Not yet recruiting | University of Oxford | 586 | 2026-12-01 | 2026-10-08 |
| A Study to Investigate the Effect of Gradual Titration to Optimize Cannabidiol Treatment in Adults With LGS Cannabidiol Oral Solution - Lennox-Gastaut Syndrome | Phase 4 | Not yet recruiting | Jazz Pharmaceuticals | 40 | 2026-11-18 | 2026-10-22 |
| CannaRiver CBD Calm for Anxiety, Sleep, and Well-Being in Adults With Generalized Anxiety Disorder Cannabidiol (CBD) With Cannabinol (CBN) and Cannabigerol (CBG) Oral Tincture (CannaRiver CBD Calm) - Generalized Anxiety Disorder | Not applicable | Not yet recruiting | Associação Pan-Americana Multidisciplinar de Endocanabinologia | 60 | 2026-11-01 | 2026-10-29 |
| Effects of Cannabidiol on Memory and Attention in Adults Aged 60-70: A Pilot Study Cannabidiol (CBD), Placebo - Healthy Aging, Cognition | Not applicable | Not yet recruiting | Medical University of Silesia | 50 | 2026-11-01 | 2026-11-02 |
| Cannabidiol as an Adjunct Treatment for Alcohol Withdrawal and Craving Cannabidiol (CBD), Placebo - Alcohol Use Disorder (AUD), Withdrawal From Addictive Substance; Detoxification | Phase 2 / Phase 3 | Recruiting | Johns Hopkins University | 105 | 2026-10-21 | 2026-11-03 |
| Dronabinol and Epidiolex to Manage Uncontrolled Residual Symptoms of Buprenorphine Initiation Trial Dronabinol Capsules, Epidiolex 100 mg/mL Oral Solution, Placebo Dronabinol - Opioid Use Disorder | Phase 3 | Not yet recruiting | Montefiore Medical Center | 40 | 2026-10-01 | 2026-06-09 |
| Epidiolex Trial for Presymptomatic Treatment of Sturge-Weber Syndrome Epidiolex 100 mg/mL Oral Solution - Sturge - Weber Syndrome (SWS) | Phase 2 | Recruiting | Johns Hopkins University | 10 | 2026-09-17 | 2026-10-02 |
| Wayne State Warriors Marijuana Clinical Research Program: Cannabinoid Adjunct to Prolonged Exposure & Recovery Cannabidiol (CBD) only, Placebo only, Delta-9-tetrahydrocannabinol (THC) only - PTSD, Post Traumatic Stress Disorder | Phase 1 / Phase 2 | Not yet recruiting | Leslie Lundahl | 280 | 2026-09-01 | 2026-08-26 |
| Repeated CBD Administration and Cannabis Outcomes Cannabidiol, Medium Dose, Cannabidiol, Higher Dose, Active Inhaled Cannabis - Cannabis, Abuse Liability | Early Phase 1 | Recruiting | Hannah Harris | 23 | 2026-08-05 | 2026-08-12 |
| Mechanisms of Cannabidiol and Sleep in the Context of Alcohol Use Cannabidiol, Placebo - Sleep, Alcohol Misuse | Phase 2 | Not yet recruiting | University of Colorado, Boulder | 58 | 2026-07-01 | 2026-06-11 |
| CBD Knee Osteoarthritis Study Cannabidiol (CBD), Castor Oil (Placebo) - Osteoarthitis | Phase 2 | Not yet recruiting | University of Tennessee | 30 | 2026-07-01 | 2026-06-10 |
| Cannabidiol for Pain Relief of Patients With End-stage mCRPC Cannabidiol, Placebo - Metastatic Castration Resistant Prostate Cancer (mCRPC) | Phase 2 | Recruiting | Regionshospital Nordjylland | 58 | 2026-06-12 | 2026-09-16 |
| nVNS, CBD, and SoC for Persistent Post-Traumatic Headache Non-Invasive Vagus Nerve Stimulation, Cannabidiol, Standard of Care - Persistent Post Traumatic Headache | Phase 2 | Not yet recruiting | American Society of Pain and Neuroscience, Inc. | 80 | 2026-06-01 | 2026-06-03 |
| Efficacy of Cannabidiol in the Management of Self-injuries in Children and Adolescents With Severe Neurodevelopmental Disorders. Cannabidiol - Neurodevelopmental Disorders With Severe Self-injuries | Phase 2 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 21 | 2026-05-01 | 2026-05-04 |
| Cannabidiol for the Treatment of Diabetic Peripheral Neuropathy: Pilot Study Cannabidiol (CBD) oral solution, Full-Spectrum CBD hemp extract oral solution, Placebo in MCT oil oral solution - Diabetic Peripheral Neuropathic Pain (DPN), Diabetic Neuropathies | Phase 1 / Phase 2 | Recruiting | Florida A&M University | 20 | 2026-04-02 | 2026-04-29 |
| Study of Cannabidiol in Sanfilippo Syndrome Epidiolex, Placebo - Sanfilippo Syndrome, Mucopolysaccharidosis III | Phase 2 / Phase 3 | Recruiting | Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center | 35 | 2026-04-01 | 2026-09-15 |
| The Effect of CBD on Sleep Quality Following Late Evening Exercise Cannabidiol or placebo, late evening exercise - Sleep Quality | Phase 2 | Recruiting | KU Leuven | 20 | 2026-03-19 | 2026-05-06 |
| Exploring The Effect Of Cannabidiol On Cannabis Tolerance Using A Novel Vaporiser Device In Heavy Users (Stage 1) delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) - Cannabis Intoxication | Not applicable | Not yet recruiting | King's College London | 10 | 2026-03-01 | 2026-03-13 |
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Marijuana Abuse (33) · Epilepsy (27) · Epilepsies, Myoclonic (15) · Lennox Gastaut Syndrome (14) · Pain (14) · Anxiety Disorders (13) · Opioid-Related Disorders (13) · Seizures (13) · Alcoholism (11) · Schizophrenia (11) · Psychotic Disorders (10) · Stress Disorders, Post-Traumatic (9) · Chronic Pain (8) · Drug Resistant Epilepsy (8) · Sleep Initiation and Maintenance Disorders (6)
Jazz Pharmaceuticals (27) · Central Institute of Mental Health, Mannheim (9) · University of California, San Diego (9) · University of Colorado, Denver (8) · Johns Hopkins University (6) · Yale University (6) · INSYS Therapeutics Inc (5) · NYU Langone Health (5) · Radius Pharmaceuticals, Inc. (5) · Colorado State University (4) · Hadassah Medical Organization (4) · Icahn School of Medicine at Mount Sinai (4) · King's College London (4) · Mclean Hospital (4) · Rabin Medical Center (4)
United States (173) · United Kingdom (22) · Canada (18) · Germany (14) · Spain (13) · Israel (12) · Australia (11) · Netherlands (11) · Poland (10) · Italy (9) · Brazil (8) · France (8) · Denmark (7) · Greece (2) · Mexico (2)
Neha Parikh (5) · Yasmin Hurd, PhD (5) · Ahmed Elkashef, MD (4) · F. Markus Leweke, MD (4) · Anne M Comi, MD (2) · Dennis McNamara, MD (2) · Elyad Davidson, MD (2) · Joao De Aquino, M.D. (2) · Kent Hutchison, PhD (2) · Moshe Yeshurun, MD (2) · Nathaniel M Schuster, MD (2) · Sebastian W Nielsen, MD (2) · Abdul Salama, PharmD (1) · Alexandra Sideris, PhD (1) · Alexandre O Kaup, MD, PhD (1)
PMID 28538134, PMID 29063814, PMID 29768152, PMID 31048098, PMID 33797076, PMID 33825230, PMID 34265088, PMID 34957550, PMID 37052803, PMID 40775196, PMID 20204561, PMID 21749363, PMID 26033282, PMID 26724101, PMID 26800377, PMID 27159993, PMID 27179600, PMID 27573936, PMID 28349233, PMID 29114823, PMID 29262425, PMID 29538683, PMID 29540584, PMID 29619533, PMID 29701252, PMID 30100226, PMID 30250864, PMID 30374683, PMID 30687209, PMID 30791225, PMID 30921490, PMID 30955420, PMID 31049885, PMID 31052254, PMID 31152723, PMID 31161980, PMID 31212965, PMID 31313338, PMID 32119035, PMID 32350749, PMID 32652616, PMID 32735782, PMID 33304282, PMID 33346789, PMID 33464660, PMID 33730032, PMID 33995015, PMID 34210360, PMID 34287833, PMID 34387679
2014 (8), 2015 (6), 2019 (3), P30CA033572 (3), 2018 (2), 2023 (2), 2025 (2), 2008 (1), 2009 (1), 2016 (1), 5UG3DA048388-03 (1), K01DA049219 (1), K01DA056692 (1), K23DA052682 (1), KL2TR002646 (1)