Narcotic-Related Disorders: Clinical Trials

999 completed, 197 recruiting, 122 unknown, 95 terminated. 688 Not applicable, 310 Phase 2, 168 Phase 1, 166 Phase 3, 129 Phase 4.

By phase and status

Phase	Trials	Status
Not applicable	688	Completed 395, Recruiting 97, Active not recruiting 52, Unknown 50, Not yet recruiting 29, Terminated 27, Withdrawn 22, Enrolling by invitation 13, Suspended 3
Phase 2	310	Completed 203, Recruiting 33, Withdrawn 24, Terminated 21, Unknown 15, Not yet recruiting 8, Active not recruiting 6
Phase 1	168	Completed 119, Recruiting 17, Terminated 9, Unknown 8, Active not recruiting 5, Not yet recruiting 5, Withdrawn 5
Phase 3	166	Completed 104, Terminated 20, Unknown 15, Recruiting 12, Active not recruiting 6, Withdrawn 6, Not yet recruiting 3
Phase 4	129	Completed 70, Recruiting 15, Withdrawn 13, Terminated 11, Unknown 7, Not yet recruiting 6, Active not recruiting 4, Enrolling by invitation 2, Suspended 1
Early Phase 1	32	Completed 17, Recruiting 5, Terminated 3, Unknown 3, Not yet recruiting 2, Withdrawn 2

Follow Narcotic-Related Disorders: new trials by email Literature Review of Narcotic-Related Disorders trials Research Report on Narcotic-Related Disorders

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Dynamic Treatment Regimes for Opioid Use Disorder Medication for opioid use disorder, psychotherapy - Opioid Use Disorder	Phase 2	Not yet recruiting	Brigham and Women's Hospital	75	2028-07-01	2025-11-04
Integrated Care Versus Usual Care for Opioid Use Disorder and Infectious Diseases in Veterans Integrated care - Opioid Use Disorder, HIV	Not applicable	Not yet recruiting	VA Office of Research and Development	60	2028-04-03	2026-04-24
Family-Focused Study to Support Medication for Opioid Use Disorder FamilyCHESS, Standard of Care - Opioid Use Disorder, Opioid Use Disorder, Moderate	Not applicable	Not yet recruiting	University of Wisconsin, Madison	338	2027-08-31	2026-07-07
MedSMA℞T Mobile ED MedSMA℞T Mobile - Opiate-Related Disorders, Opiate Use Disorder	Not applicable	Not yet recruiting	Olufunmilola Abraham	244	2027-08-01	2026-10-09
Medically Supervised Ibogaine With 12-Month Digital Recovery Support for Opioid Use Disorder Ibogaine Hydrochloride, Extended-release naltrexone injection, 380 mg, Matching Oral Placebo - Opioid Use Disorder, Opioid Withdrawal	Phase 1 / Phase 2	Not yet recruiting	Clive Michelsen	60	2027-07-01	2026-10-13
Real-World Evaluation of Compl-AI for Predicting Early Medication Dropout in Opioid Use Disorder Treatment Opioid Use Disorder		Not yet recruiting	Tools4Patient	295	2027-06-01	2026-10-01
TMS to Improve Recovery Outcomes Among Patients With Opioid Use Disorder (OUD) and Alcohol Use Disorder (AUD) TMS Low-Dose, TMS High-Dose - Alcohol Use Disorder, Opioid Use Disorder	Not applicable	Recruiting	Washington State University	60	2027-06-01	2026-05-29
Inpatient Buprenorphine Induction With Psilocybin for Opioid Use Disorder Psilocybin - Opioid Use Disorder	Phase 2	Withdrawn	Johns Hopkins University		2027-04-01	2026-02-23
Naloxone for Opioid Associated Out of Hospital Cardiac Arrest Naloxone 2 MG, Saline 2ml - Heart Arrest, Out-Of-Hospital, Opioid Overdose	Phase 2	Not yet recruiting	University of California, San Francisco	98	2027-03-01	2026-09-11
Examining Analgesic Synergy and Efficacy in Trauma Care Buprenorphine, Oxycodone - Opioid Use Disorder	Phase 4	Not yet recruiting	Wake Forest University Health Sciences	282	2027-03-01	2026-10-28
The Community Paramedic Response and Overdose Outreach With Supportive Medical-Legal Services Study Community Paramedic Standard of Care (CP SOC), CROSSROADS - Opioid Use Disorder, Overdose, Drug	Not applicable	Not yet recruiting	Duke University	400	2027-02-01	2026-10-14
Improving Jail Response to the Overdose Crisis: A Hybrid Trial of Jail ECHO to Improve MOUD Implementation and Public Health Outcomes Project ECHO - Opioid Abuse (Disorder)	Not applicable	Recruiting	University of Massachusetts, Worcester	100	2027-01-01	2026-10-19
Clinician Practice Companion to Address Youth Substance Use Practice Companion - Substance Use, Substance-Related Disorders	Not applicable	Not yet recruiting	Massachusetts General Hospital	60	2027-01-01	2026-10-07
Deep Transcranial Magnetic Stimulation for Tobacco Cessation in Adults With Opioid Use Disorder Deep TMS System With H4 Coil - Opioid Use Disorder, Tobacco Use Disorder	Not applicable	Not yet recruiting	Payel Roy	12	2027-01-01	2026-08-27
Chicago Data-driven Opioid Use Disorder Screening, Engagement, Treatment and Planning System OUD screening, MOUD, Continuity of care - Opiod Use Disorder	Not applicable	Not yet recruiting	University of Illinois at Chicago	271031	2027-01-01	2026-10-08
Evaluation of the O'Neil Long Acting Naltrexone Implant in Opioid Dependent Persons naltrexone implant - Opioid Use Disorder	Phase 2	Not yet recruiting	Go Medical Industries Pty Ltd	250	2027-01-01	2026-09-28
Remote Intervention to Prevent Overdose Overdose prevention resources, Overdose prevention education - Accidental Overdose of Opiate	Not applicable	Not yet recruiting	University of Alabama at Birmingham	100	2027-01-01	2026-10-30
Peer-led, Mobile App Supported Linkage to Opioid Use Disorder Treatment Mobile phone-assisted intervention, Peer navigator, Standard of care referral for out-patient MAT - Opioid Use Disorder	Not applicable	Not yet recruiting	Johns Hopkins University	90	2027-01-01	2026-10-30
Treatment Education for Perinatal Women and Their Community Support substance abuse treatment education - Opioid Dependency	Not applicable	Not yet recruiting	Johns Hopkins University	80	2026-12-06	2026-07-22
Disease Intervention Specialist (DIS) for SUD Substance Use Disorder (SUD), Opioid Use Disorder		Not yet recruiting	Ohio State University	1200	2026-12-01	2026-10-15

Showing 20 of 1644. Sign in to see all of them.

Narrower conditions

Opioid-Related Disorders (1472)  ·  Substance-Related Disorders (252)  ·  Chronic Pain (111)  ·  Heroin Dependence (90)  ·  Opioid-Induced Constipation (84)  ·  Behavior, Addictive (75)  ·  Opiate Overdose (68)  ·  Pain (61)  ·  Cocaine-Related Disorders (46)  ·  Pain, Postoperative (39)  ·  Drug Overdose (38)  ·  Alcoholism (35)  ·  HIV Infections (32)  ·  Constipation (31)

Broader conditions

Chemically-Induced Disorders (1634)  ·  Mental Disorders (1625)  ·  Substance-Related Disorders (1392)  ·  Pathological Conditions, Signs and Symptoms (338)  ·  Signs and Symptoms (291)  ·  Behavior (228)  ·  Neurologic Manifestations (216)  ·  Pain (139)  ·  Drug Misuse (96)  ·  Prescription Drug Misuse (96)  ·  Pathologic Processes (93)  ·  Signs and Symptoms, Digestive (86)  ·  Opioid-Related Disorders (84)  ·  Infections (83)

Interventions

Buprenorphine (173)  ·  Buprenorphine, Naloxone Drug Combination (114)  ·  Naltrexone (45)  ·  Methadone (44)  ·  Naloxone (43)  ·  Therapeutics (42)  ·  vivitrol (39)  ·  Oxycodone (29)  ·  lofexidine (20)  ·  Morphine (19)  ·  naloxegol (19)  ·  Sublocade (18)  ·  Hydromorphone (16)  ·  Cannabidiol (13)  ·  Standard of Care (13)

Sponsors

Yale University (106)  ·  National Institute on Drug Abuse (NIDA) (82)  ·  New York State Psychiatric Institute (48)  ·  Johns Hopkins University (45)  ·  University of Pennsylvania (35)  ·  Indivior Inc. (32)  ·  NYU Langone Health (24)  ·  University of California, Los Angeles (23)  ·  Friends Research Institute, Inc. (22)  ·  University of Chicago (20)  ·  VA Office of Research and Development (18)  ·  Medical University of South Carolina (16)  ·  University of Maryland, Baltimore (16)  ·  University of Vermont (16)  ·  University of Wisconsin, Madison (16)

Countries

United States (1317)  ·  Canada (48)  ·  France (28)  ·  United Kingdom (27)  ·  Sweden (25)  ·  China (21)  ·  Germany (18)  ·  Norway (15)  ·  Australia (14)  ·  Spain (13)  ·  Taiwan (13)  ·  Belgium (11)  ·  Denmark (10)  ·  Malaysia (9)  ·  Italy (8)

Top investigators

Warren Bickel, Ph.D. (22)  ·  Walter Ling, M.D. (18)  ·  James Zacny, Ph.D. (17)  ·  Mark Greenwald, PhD (11)  ·  Eric C. Strain, MD (9)  ·  Kenneth Silverman, Ph.D. (9)  ·  Sandra D Comer, PhD (8)  ·  Charles O'Brien, M.D., Ph.D. (7)  ·  Zev Schuman-Olivier, MD (7)  ·  Adam Bisaga, MD (6)  ·  Frederick G Moeller, MD (6)  ·  Leslie Amass, Ph.D. (6)  ·  Marc Fishman, MD (6)  ·  Richard Schottenfeld, M.D. (6)

Results publications

PMID 40342086, PMID 25630964, PMID 35287034, PMID 36063082, PMID 25911999, PMID 22339949, PMID 24896818, PMID 26582720, PMID 27342744, PMID 32086791, PMID 32280263, PMID 33788162, PMID 34295186, PMID 37023858, PMID 37657559, PMID 40833692, PMID 10964347, PMID 16036506, PMID 19912069, PMID 20707781, PMID 21782353, PMID 24875677, PMID 25164154, PMID 25175864, PMID 26535126, PMID 27574837, PMID 28068780, PMID 28576452, PMID 31145214, PMID 32002194, PMID 33631356, PMID 33965574, PMID 34377150, PMID 34752714, PMID 35130200, PMID 35395811, PMID 35785613, PMID 36467036, PMID 37264472, PMID 37393415, PMID 37584841, PMID 37712113, PMID 37936553, PMID 38616571, PMID 40105313, PMID 41085955, PMID 41460640, PMID 10219684, PMID 10517548, PMID 10870744

NIH funding

R01DA008391 (17), R01DA006969 (6), R01DA011160 (6), K20DA000191 (5), R33DA059884 (5), UG1DA013732 (5), R01DA010017 (4), R01DA010746 (4), R01DA014718 (4), R01DA015462 (4), 1RM1DA055310-01 (3), 2025 (3), K12DA031794 (3), P50DA009236 (3), R01DA005626 (3)